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Conserved domains on  [gi|2105466225|gb|UBU50619|]
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cryptochrome [Drosophila melanogaster]

Protein Classification

cryptochrome/deoxyribodipyrimidine photo-lyase family protein( domain architecture ID 18092249)

cryptochrome/deoxyribodipyrimidine photo-lyase family (CPF) protein is a flavoprotein that may be involved in DNA repair, circadian photoreception, and transcriptional regulation; similar to Drosophila cryptochrome-1, a blue light-dependent regulator that is the input of the circadian feedback loop

Gene Ontology:  GO:0050660
PubMed:  32087057|28720252
SCOP:  3001644|4001154

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
FAD_binding_7 pfam03441
FAD binding domain of DNA photolyase;
310-510 1.65e-80

FAD binding domain of DNA photolyase;


:

Pssm-ID: 427294 [Multi-domain]  Cd Length: 199  Bit Score: 250.06  E-value: 1.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 310 GQLIWREYFYTMSVNNPNY-DRMEGNDIClSIPWAKpNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFL 388
Cdd:pfam03441   1 SELAWREFYYQLLEHFPELeDRNLNPAFD-RIPWEE-DEELFEAWKEGRTGYPIVDAAMRQLRQTGWMHNRVRMIVASFL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 389 TRGgLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSaferLLDSSL---VTCPVALAKRLDPDGTYIKQYVPELMNVP 465
Cdd:pfam03441  79 TKD-LLIDWREGARWFAELLVDADPASNNGGWQWVAGT----GTDAAPyfrIFNPVTQGEKFDPDGEYIRRWVPELADLP 153
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2105466225 466 KEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMK 510
Cdd:pfam03441 154 AKYIHEPWKAPAPVQRLAGCRLGKDYPAPIVDHKEARKRALARYK 198
PhrB super family cl43137
Deoxyribodipyrimidine photolyase [Replication, recombination and repair];
4-504 6.27e-72

Deoxyribodipyrimidine photolyase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0415:

Pssm-ID: 223492 [Multi-domain]  Cd Length: 461  Bit Score: 236.83  E-value: 6.27e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   4 RGANVIWFRHGLRLHDNPALLAALADKDQgiALIPVFIFDGESAGtkNVGYNRMRFLLDSLQDIDDQLQAAtdgRGRLLV 83
Cdd:COG0415     1 TSTVLVWFRRDLRLTDNAALAAACQSGQP--VIIAVFILDPEQLG--HASPRHAAFLLQSLQALQQSLAEL---GIPLLV 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  84 FEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIeTNGGIPPLTYQMFLH 163
Cdd:COG0415    74 REGDPEQVLPELAKQLAATTVFWNRDYEEWERQRDAALAQPLTEVGIAVHSFWDALLHEPGEVR-TGSGEPYKVFTPFYK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 164 TVQIIGLPPRPTADar******veldPEFCRSLKLFEQLPTPEHFNvygDNMGFLAKInWRGGETQALLLLDERLKVEQH 243
Cdd:COG0415   153 AWRDRLRILRPVPA------------PDVLDALRDEEPPPEEISLP---DFSKFDVLL-FTGGEKAALARLQDFLAEGLD 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 244 AFERGFYLPNQalpnihDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLracvrgvqmtGGAHITGQLIWREYFYTMSV 323
Cdd:COG0415   217 DYERTRDFPAL------DGTSRLSPYLAFGVISPREVYAALLAAESDARE----------GTAALINELIWREFYQHLLY 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 324 NNPNYDR-MEGNDICLSIPWAKpNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRgGLWQSWEHGLQ 402
Cdd:COG0415   281 HYPSLSRfEPFAEKTLNIPWED-NPAHFQAWQEGKTGYPIVDAAMRQLNQTGYMHNRMRMIVASFLTK-DLLIDWREGEK 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 403 HFLKYLLDADWSVCAGNWMWVSSS-----AFERLLDsslvtcPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSA 477
Cdd:COG0415   359 YFMRQLIDGDPASNNGGWQWAASTgtdaaPYFRIFN------PVTQAEKFDPDGEFIRRWVPELRNLPDKYIHEPWELSE 432
                         490       500
                  ....*....|....*....|....*..
gi 2105466225 478 EQqeqyeclIGVHYPERIIDLSMAVKR 504
Cdd:COG0415   433 VV-------LGVDYPKPIVDHKESREQ 452
 
Name Accession Description Interval E-value
FAD_binding_7 pfam03441
FAD binding domain of DNA photolyase;
310-510 1.65e-80

FAD binding domain of DNA photolyase;


Pssm-ID: 427294 [Multi-domain]  Cd Length: 199  Bit Score: 250.06  E-value: 1.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 310 GQLIWREYFYTMSVNNPNY-DRMEGNDIClSIPWAKpNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFL 388
Cdd:pfam03441   1 SELAWREFYYQLLEHFPELeDRNLNPAFD-RIPWEE-DEELFEAWKEGRTGYPIVDAAMRQLRQTGWMHNRVRMIVASFL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 389 TRGgLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSaferLLDSSL---VTCPVALAKRLDPDGTYIKQYVPELMNVP 465
Cdd:pfam03441  79 TKD-LLIDWREGARWFAELLVDADPASNNGGWQWVAGT----GTDAAPyfrIFNPVTQGEKFDPDGEYIRRWVPELADLP 153
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2105466225 466 KEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMK 510
Cdd:pfam03441 154 AKYIHEPWKAPAPVQRLAGCRLGKDYPAPIVDHKEARKRALARYK 198
PhrB COG0415
Deoxyribodipyrimidine photolyase [Replication, recombination and repair];
4-504 6.27e-72

Deoxyribodipyrimidine photolyase [Replication, recombination and repair];


Pssm-ID: 223492 [Multi-domain]  Cd Length: 461  Bit Score: 236.83  E-value: 6.27e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   4 RGANVIWFRHGLRLHDNPALLAALADKDQgiALIPVFIFDGESAGtkNVGYNRMRFLLDSLQDIDDQLQAAtdgRGRLLV 83
Cdd:COG0415     1 TSTVLVWFRRDLRLTDNAALAAACQSGQP--VIIAVFILDPEQLG--HASPRHAAFLLQSLQALQQSLAEL---GIPLLV 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  84 FEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIeTNGGIPPLTYQMFLH 163
Cdd:COG0415    74 REGDPEQVLPELAKQLAATTVFWNRDYEEWERQRDAALAQPLTEVGIAVHSFWDALLHEPGEVR-TGSGEPYKVFTPFYK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 164 TVQIIGLPPRPTADar******veldPEFCRSLKLFEQLPTPEHFNvygDNMGFLAKInWRGGETQALLLLDERLKVEQH 243
Cdd:COG0415   153 AWRDRLRILRPVPA------------PDVLDALRDEEPPPEEISLP---DFSKFDVLL-FTGGEKAALARLQDFLAEGLD 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 244 AFERGFYLPNQalpnihDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLracvrgvqmtGGAHITGQLIWREYFYTMSV 323
Cdd:COG0415   217 DYERTRDFPAL------DGTSRLSPYLAFGVISPREVYAALLAAESDARE----------GTAALINELIWREFYQHLLY 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 324 NNPNYDR-MEGNDICLSIPWAKpNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRgGLWQSWEHGLQ 402
Cdd:COG0415   281 HYPSLSRfEPFAEKTLNIPWED-NPAHFQAWQEGKTGYPIVDAAMRQLNQTGYMHNRMRMIVASFLTK-DLLIDWREGEK 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 403 HFLKYLLDADWSVCAGNWMWVSSS-----AFERLLDsslvtcPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSA 477
Cdd:COG0415   359 YFMRQLIDGDPASNNGGWQWAASTgtdaaPYFRIFN------PVTQAEKFDPDGEFIRRWVPELRNLPDKYIHEPWELSE 432
                         490       500
                  ....*....|....*....|....*..
gi 2105466225 478 EQqeqyeclIGVHYPERIIDLSMAVKR 504
Cdd:COG0415   433 VV-------LGVDYPKPIVDHKESREQ 452
DNA_photolyase pfam00875
DNA photolyase; This domain binds a light harvesting cofactor.
8-175 1.36e-39

DNA photolyase; This domain binds a light harvesting cofactor.


Pssm-ID: 425921 [Multi-domain]  Cd Length: 161  Bit Score: 141.19  E-value: 1.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   8 VIWFRHGLRLHDNPALLAALAdkdQGIALIPVFIFDGESAGTknvGYNRMRFLLDSLQDIDDQLQAatdgRG-RLLVFEG 86
Cdd:pfam00875   2 LVWFRRDLRLHDNPALAAAAA---SGAPLIPVFILDPAFHDL---GAARRWFLLESLADLDEELRE----RGiRLVVRRG 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  87 EPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQlVIETNGGIPPLTYQMFLHTVQ 166
Cdd:pfam00875  72 DPADVLPELAKELGASAVFANRDYEPYERRRDAAVAEALRKAGIEVESFDGHTLVPPG-EVRTKSGKPYRVFTPFWKRWL 150

                  ....*....
gi 2105466225 167 IIGLPPRPT 175
Cdd:pfam00875 151 AELLEPLPA 159
crypto_DASH TIGR02765
cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. ...
8-461 2.84e-37

cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. Photolyases harness the energy of blue light to repair DNA damage by removing pyrimidine dimers. Cryptochromes do not repair DNA and are presumed to act instead in some other (possibly unknown) process such as entraining circadian rhythms. This model describes the cryptochrome DASH subfamily, one of at least five major subfamilies, which is found in plants, animals, marine bacteria, etc. Members of this family bind both folate and FAD. They may show weak photolyase activity in vitro but have not been shown to affect DNA repair in vivo. Rather, DASH family cryptochromes have been shown to bind RNA (Vibrio cholerae VC1814), or DNA, and seem likely to act in light-responsive regulatory processes. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 274288 [Multi-domain]  Cd Length: 429  Bit Score: 142.90  E-value: 2.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   8 VIWFRHGLRLHDNPALLAALADKDQgiaLIPVFIFD------GESAGTKNVGYNRMRFLLDSLQDIDDQLQAatdgRG-R 80
Cdd:TIGR02765   4 LYWFRNDLRVHDNPALYKASSSSDT---LIPLYCFDprqfklTHFFGFPKTGPARGKFLLESLKDLRTSLRK----LGsD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  81 LLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPlTYQM 160
Cdd:TIGR02765  77 LLVRSGKPEDVLPELIKELGVRTVFLHQEVGSEEKSVERLLQQALARLGIHVEQHWGSTLYHEDDLPFDLEDLPD-VFTQ 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 161 FLHTVQiiglpprPTADAR******VELDPefCRSLKLFEQLPTPEHFNVygDNMGFLAKINWRGGETQALLLLDErlkv 240
Cdd:TIGR02765 156 FRKQVE-------AKCSIRPPLPAPEKLPP--LPSVDDPGWIPTLEDLGE--ESSEVDRGLPFVGGETAGLARLKE---- 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 241 eqhafergfYLPNQALPNIHDSPKSM---------SAHLRFGCLSVRRFYwsvhdlfknvqlrACVRGVQMTGGAH---- 307
Cdd:TIGR02765 221 ---------YFWSKDLKSYKETRNGMlgpdystkfSPWLALGCVSPRQIY-------------EELQRYETERGANdsty 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 308 -ITGQLIWREYFYTMSVNNPN-YDRMEG-NDicLSIPWaKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTV 384
Cdd:TIGR02765 279 wVIFELLWRDYFRFYALKYGNrLFRFGGlRG--KHPKW-SFDAKRFEQWKTGTTGYPLVDANMRELNATGFMSNRGRQNV 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 385 ATFLTRG-GLwqSWEHGLQHFLKYLLDADWSVCAGNWMWVS--------SSAFErlldsslvtcPVALAKRLDPDGTYIK 455
Cdd:TIGR02765 356 ASFLVKDlGL--DWRYGAEWFETQLVDYDVCSNWGNWQYLAgvgndprgSRQFN----------IEKQAQDYDPDGEYVA 423

                  ....*.
gi 2105466225 456 QYVPEL 461
Cdd:TIGR02765 424 TWVPEL 429
PRK10674 PRK10674
deoxyribodipyrimidine photolyase; Provisional
1-514 3.34e-31

deoxyribodipyrimidine photolyase; Provisional


Pssm-ID: 236734 [Multi-domain]  Cd Length: 472  Bit Score: 126.29  E-value: 3.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   1 MATrgaNVIWFRHGLRLHDNPALLAALADKDQGIalIPVFIFDGESAGTKNVGYNRMRFLLDSLQDiddqLQAATDGRGR 80
Cdd:PRK10674    1 MTT---HLVWFRNDLRLHDNLALAAACRDPSARV--LALFIATPAQWAAHDMAPRQAAFINAQLNA----LQIALAEKGI 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  81 LLVFEGEPAYifrrlHEQVR-LHRICIEQDCEPI-------WNE--RDESIRSLCRELNID-FVEKVshtLWDPQLVIET 149
Cdd:PRK10674   72 PLLFHEVDDF-----AASVEwLKQFCQQHQVTHLfynyqyeVNErqRDAAVERALRNVVCQgFDDSV---LLPPGSVMTG 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 150 NGGIppltYQMF----------LHTVQIIGLP-PRPTADAR******VELD-PEfcrslklfeQLPTPEHFNVygdnmgf 217
Cdd:PRK10674  144 NHEM----YKVFtpfknaflkrLREGDPECVPaPKVRSSGAIEPLPPIPFNyPQ---------QSFDTALFPV------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 218 lakinwrgGETQALllldERLKveQHAFER-GFYLPNQALPNIhDSPKSMSAHLRFGCLSVRRFYwsvHDLfknvqLRAC 296
Cdd:PRK10674  204 --------GEKAAI----AQLR--QFCQQGaGEYEQQRDFPAV-DGTSRLSAYLATGVLSPRQCL---HRL-----LAEQ 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 297 VRGVQMTGGAHITGQLIWREYFYTMSVNNPnydrmegnDICLS---IPWAK-----PNENLLQSWRLGQTGFPLIDGAMR 368
Cdd:PRK10674  261 PQALDGGAGSVWLNELIWREFYRHLMVAYP--------SLCKHrpfIAWTDrvqwqSNPAHLQAWQQGKTGYPIVDAAMR 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 369 QLLAEGWLHHTLRNTVATFLTRgGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSA-----FERLLDsslvtcPVAL 443
Cdd:PRK10674  333 QLNSTGWMHNRLRMITASFLVK-DLLIDWREGERYFMSQLIDGDLAANNGGWQWAASTGtdaapYFRIFN------PTTQ 405
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2105466225 444 AKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMsAEQQEQYecligVHYPERIIDLSMAVKRNMLAMKSLRN 514
Cdd:PRK10674  406 GERFDRDGEFIRRWLPELRDVPGKAIHQPWRW-AEKAGVT-----LDYPQPIVDHKQARLATLAAYEAARK 470
 
Name Accession Description Interval E-value
FAD_binding_7 pfam03441
FAD binding domain of DNA photolyase;
310-510 1.65e-80

FAD binding domain of DNA photolyase;


Pssm-ID: 427294 [Multi-domain]  Cd Length: 199  Bit Score: 250.06  E-value: 1.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 310 GQLIWREYFYTMSVNNPNY-DRMEGNDIClSIPWAKpNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFL 388
Cdd:pfam03441   1 SELAWREFYYQLLEHFPELeDRNLNPAFD-RIPWEE-DEELFEAWKEGRTGYPIVDAAMRQLRQTGWMHNRVRMIVASFL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 389 TRGgLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSaferLLDSSL---VTCPVALAKRLDPDGTYIKQYVPELMNVP 465
Cdd:pfam03441  79 TKD-LLIDWREGARWFAELLVDADPASNNGGWQWVAGT----GTDAAPyfrIFNPVTQGEKFDPDGEYIRRWVPELADLP 153
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2105466225 466 KEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMK 510
Cdd:pfam03441 154 AKYIHEPWKAPAPVQRLAGCRLGKDYPAPIVDHKEARKRALARYK 198
PhrB COG0415
Deoxyribodipyrimidine photolyase [Replication, recombination and repair];
4-504 6.27e-72

Deoxyribodipyrimidine photolyase [Replication, recombination and repair];


Pssm-ID: 223492 [Multi-domain]  Cd Length: 461  Bit Score: 236.83  E-value: 6.27e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   4 RGANVIWFRHGLRLHDNPALLAALADKDQgiALIPVFIFDGESAGtkNVGYNRMRFLLDSLQDIDDQLQAAtdgRGRLLV 83
Cdd:COG0415     1 TSTVLVWFRRDLRLTDNAALAAACQSGQP--VIIAVFILDPEQLG--HASPRHAAFLLQSLQALQQSLAEL---GIPLLV 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  84 FEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIeTNGGIPPLTYQMFLH 163
Cdd:COG0415    74 REGDPEQVLPELAKQLAATTVFWNRDYEEWERQRDAALAQPLTEVGIAVHSFWDALLHEPGEVR-TGSGEPYKVFTPFYK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 164 TVQIIGLPPRPTADar******veldPEFCRSLKLFEQLPTPEHFNvygDNMGFLAKInWRGGETQALLLLDERLKVEQH 243
Cdd:COG0415   153 AWRDRLRILRPVPA------------PDVLDALRDEEPPPEEISLP---DFSKFDVLL-FTGGEKAALARLQDFLAEGLD 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 244 AFERGFYLPNQalpnihDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLracvrgvqmtGGAHITGQLIWREYFYTMSV 323
Cdd:COG0415   217 DYERTRDFPAL------DGTSRLSPYLAFGVISPREVYAALLAAESDARE----------GTAALINELIWREFYQHLLY 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 324 NNPNYDR-MEGNDICLSIPWAKpNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRgGLWQSWEHGLQ 402
Cdd:COG0415   281 HYPSLSRfEPFAEKTLNIPWED-NPAHFQAWQEGKTGYPIVDAAMRQLNQTGYMHNRMRMIVASFLTK-DLLIDWREGEK 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 403 HFLKYLLDADWSVCAGNWMWVSSS-----AFERLLDsslvtcPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSA 477
Cdd:COG0415   359 YFMRQLIDGDPASNNGGWQWAASTgtdaaPYFRIFN------PVTQAEKFDPDGEFIRRWVPELRNLPDKYIHEPWELSE 432
                         490       500
                  ....*....|....*....|....*..
gi 2105466225 478 EQqeqyeclIGVHYPERIIDLSMAVKR 504
Cdd:COG0415   433 VV-------LGVDYPKPIVDHKESREQ 452
DNA_photolyase pfam00875
DNA photolyase; This domain binds a light harvesting cofactor.
8-175 1.36e-39

DNA photolyase; This domain binds a light harvesting cofactor.


Pssm-ID: 425921 [Multi-domain]  Cd Length: 161  Bit Score: 141.19  E-value: 1.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   8 VIWFRHGLRLHDNPALLAALAdkdQGIALIPVFIFDGESAGTknvGYNRMRFLLDSLQDIDDQLQAatdgRG-RLLVFEG 86
Cdd:pfam00875   2 LVWFRRDLRLHDNPALAAAAA---SGAPLIPVFILDPAFHDL---GAARRWFLLESLADLDEELRE----RGiRLVVRRG 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  87 EPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQlVIETNGGIPPLTYQMFLHTVQ 166
Cdd:pfam00875  72 DPADVLPELAKELGASAVFANRDYEPYERRRDAAVAEALRKAGIEVESFDGHTLVPPG-EVRTKSGKPYRVFTPFWKRWL 150

                  ....*....
gi 2105466225 167 IIGLPPRPT 175
Cdd:pfam00875 151 AELLEPLPA 159
crypto_DASH TIGR02765
cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. ...
8-461 2.84e-37

cryptochrome, DASH family; Photolyases and cryptochromes are related flavoproteins. Photolyases harness the energy of blue light to repair DNA damage by removing pyrimidine dimers. Cryptochromes do not repair DNA and are presumed to act instead in some other (possibly unknown) process such as entraining circadian rhythms. This model describes the cryptochrome DASH subfamily, one of at least five major subfamilies, which is found in plants, animals, marine bacteria, etc. Members of this family bind both folate and FAD. They may show weak photolyase activity in vitro but have not been shown to affect DNA repair in vivo. Rather, DASH family cryptochromes have been shown to bind RNA (Vibrio cholerae VC1814), or DNA, and seem likely to act in light-responsive regulatory processes. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 274288 [Multi-domain]  Cd Length: 429  Bit Score: 142.90  E-value: 2.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   8 VIWFRHGLRLHDNPALLAALADKDQgiaLIPVFIFD------GESAGTKNVGYNRMRFLLDSLQDIDDQLQAatdgRG-R 80
Cdd:TIGR02765   4 LYWFRNDLRVHDNPALYKASSSSDT---LIPLYCFDprqfklTHFFGFPKTGPARGKFLLESLKDLRTSLRK----LGsD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  81 LLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPlTYQM 160
Cdd:TIGR02765  77 LLVRSGKPEDVLPELIKELGVRTVFLHQEVGSEEKSVERLLQQALARLGIHVEQHWGSTLYHEDDLPFDLEDLPD-VFTQ 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 161 FLHTVQiiglpprPTADAR******VELDPefCRSLKLFEQLPTPEHFNVygDNMGFLAKINWRGGETQALLLLDErlkv 240
Cdd:TIGR02765 156 FRKQVE-------AKCSIRPPLPAPEKLPP--LPSVDDPGWIPTLEDLGE--ESSEVDRGLPFVGGETAGLARLKE---- 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 241 eqhafergfYLPNQALPNIHDSPKSM---------SAHLRFGCLSVRRFYwsvhdlfknvqlrACVRGVQMTGGAH---- 307
Cdd:TIGR02765 221 ---------YFWSKDLKSYKETRNGMlgpdystkfSPWLALGCVSPRQIY-------------EELQRYETERGANdsty 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 308 -ITGQLIWREYFYTMSVNNPN-YDRMEG-NDicLSIPWaKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTV 384
Cdd:TIGR02765 279 wVIFELLWRDYFRFYALKYGNrLFRFGGlRG--KHPKW-SFDAKRFEQWKTGTTGYPLVDANMRELNATGFMSNRGRQNV 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 385 ATFLTRG-GLwqSWEHGLQHFLKYLLDADWSVCAGNWMWVS--------SSAFErlldsslvtcPVALAKRLDPDGTYIK 455
Cdd:TIGR02765 356 ASFLVKDlGL--DWRYGAEWFETQLVDYDVCSNWGNWQYLAgvgndprgSRQFN----------IEKQAQDYDPDGEYVA 423

                  ....*.
gi 2105466225 456 QYVPEL 461
Cdd:TIGR02765 424 TWVPEL 429
PRK10674 PRK10674
deoxyribodipyrimidine photolyase; Provisional
1-514 3.34e-31

deoxyribodipyrimidine photolyase; Provisional


Pssm-ID: 236734 [Multi-domain]  Cd Length: 472  Bit Score: 126.29  E-value: 3.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   1 MATrgaNVIWFRHGLRLHDNPALLAALADKDQGIalIPVFIFDGESAGTKNVGYNRMRFLLDSLQDiddqLQAATDGRGR 80
Cdd:PRK10674    1 MTT---HLVWFRNDLRLHDNLALAAACRDPSARV--LALFIATPAQWAAHDMAPRQAAFINAQLNA----LQIALAEKGI 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  81 LLVFEGEPAYifrrlHEQVR-LHRICIEQDCEPI-------WNE--RDESIRSLCRELNID-FVEKVshtLWDPQLVIET 149
Cdd:PRK10674   72 PLLFHEVDDF-----AASVEwLKQFCQQHQVTHLfynyqyeVNErqRDAAVERALRNVVCQgFDDSV---LLPPGSVMTG 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 150 NGGIppltYQMF----------LHTVQIIGLP-PRPTADAR******VELD-PEfcrslklfeQLPTPEHFNVygdnmgf 217
Cdd:PRK10674  144 NHEM----YKVFtpfknaflkrLREGDPECVPaPKVRSSGAIEPLPPIPFNyPQ---------QSFDTALFPV------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 218 lakinwrgGETQALllldERLKveQHAFER-GFYLPNQALPNIhDSPKSMSAHLRFGCLSVRRFYwsvHDLfknvqLRAC 296
Cdd:PRK10674  204 --------GEKAAI----AQLR--QFCQQGaGEYEQQRDFPAV-DGTSRLSAYLATGVLSPRQCL---HRL-----LAEQ 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 297 VRGVQMTGGAHITGQLIWREYFYTMSVNNPnydrmegnDICLS---IPWAK-----PNENLLQSWRLGQTGFPLIDGAMR 368
Cdd:PRK10674  261 PQALDGGAGSVWLNELIWREFYRHLMVAYP--------SLCKHrpfIAWTDrvqwqSNPAHLQAWQQGKTGYPIVDAAMR 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 369 QLLAEGWLHHTLRNTVATFLTRgGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSA-----FERLLDsslvtcPVAL 443
Cdd:PRK10674  333 QLNSTGWMHNRLRMITASFLVK-DLLIDWREGERYFMSQLIDGDLAANNGGWQWAASTGtdaapYFRIFN------PTTQ 405
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2105466225 444 AKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMsAEQQEQYecligVHYPERIIDLSMAVKRNMLAMKSLRN 514
Cdd:PRK10674  406 GERFDRDGEFIRRWLPELRDVPGKAIHQPWRW-AEKAGVT-----LDYPQPIVDHKQARLATLAAYEAARK 470
crypt_chrom_pln TIGR02766
cryptochrome, plant family; At least five major families of cryptochomes and photolyases share ...
8-504 1.84e-28

cryptochrome, plant family; At least five major families of cryptochomes and photolyases share FAD cofactor binding, sequence homology, and the ability to react to short wavelengths of visible light. Photolysases are responsible for light-dependent DNA repair by removal of two types of uv-induced DNA dimerizations. Cryptochromes have other functions, often regulatory and often largely unknown, which may include circadian clock entrainment and control of development. Members of this subfamily are known so far only in plants; they may show some photolyase activity in vitro but appear mostly to be regulatory proteins that respond to blue light.


Pssm-ID: 131813  Cd Length: 475  Bit Score: 118.43  E-value: 1.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225   8 VIWFRHGLRLHDNPALLAALADKdqgiALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQLQAAtdGRGRLLVFEGE 87
Cdd:TIGR02766   1 IVWFRRDLRVEDNPALAAAARAG----PVIPVFVWAPEEEGQYYPGRVSRWWLKQSLAHLDQSLRSL--GTCLVTIRSTD 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225  88 PAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIEtNGGIPPLTYQMFLHtvQI 167
Cdd:TIGR02766  75 TVAALLDCVRSTGATRLFFNHLYDPVSLVRDHRAKEVLTAQGISVQSFNADLLYEPWEVYD-ELGRPFTMFAAFWE--RC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 168 IGLPPRPTADAR******VElDPEFCRSLKLFEQLPTPEHFNvygdnmGFLAKInWRGGETQALLLLDERLKVEQHAFER 247
Cdd:TIGR02766 152 LSMPYDPESPLLPPKKIISG-DVSKCSADDLGFEDDSEKGSN------ALLARA-WSPGWSNADKALTEFINGPLLEYSK 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 248 GFYLPNQAlpnihdSPKSMSAHLRFGCLSVRRfywsvhdLFKNVQLRACVRGVQMTGGAHITGQLIW-----REYFYTMS 322
Cdd:TIGR02766 224 NRKKADSA------TTSLLSPYLHFGEVSVRK-------VFHLVRMKQIAWANEGNSAGEESVNLFLrsiglREYSRYIS 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 323 VNNPNYDRMEGNDICLSIPWaKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRgGLWQSWEHGLQ 402
Cdd:TIGR02766 291 FNHPFSHEKPLLGHLKFFPW-AVDENYFKAWRQGRTGYPLVDAGMRELWATGWLHDRIRVVVSSFFVK-VLQLPWRWGMK 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105466225 403 HFLKYLLDADWSVCAGNWMWVSSS-----AFERLLDsslvtcPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSA 477
Cdd:TIGR02766 369 YFWDTLLDADLESDALGWQYISGSlpdgrELDRIDN------PQLEGYKFDPNGEYVRRWLPELARLPTEWIHHPWDAPE 442
                         490       500
                  ....*....|....*....|....*..
gi 2105466225 478 EQQEQYECLIGVHYPERIIDLSMAVKR 504
Cdd:TIGR02766 443 SVLQAAGVELGSNYPLPIVGLDEARAR 469
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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