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Conserved domains on  [gi|2277963158|gb|UUB86858|]
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RS1 [Human alphaherpesvirus 1]

Protein Classification

PHA03307 family protein( domain architecture ID 11476204)

PHA03307 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 51-1249 0e+00

transcriptional regulator ICP4; Provisional


:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 860.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158   51 H-----PHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPdPAASPPRTPAFRADDDDGDEYDD 125
Cdd:PHA03307   134 LsemlrPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSP-PAEPPPSTPPAAASPRPPRRSSP 212

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  126 AADAAGDRAPARGRAREAPL-------------------RGAYPDPTDRLSPRPPAQPPRRRRHGRRRPSASSTSSDSGS 186
Cdd:PHA03307   213 ISASASSPAPAPGRSAADDAgasssdssssessgcgwgpENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPR 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  187 SSSSSASSSSSSSDEDEDDDGNDAAD---------------RAREARAVGRGPSSAAPEAPGQTPPPPGPPPLSEAAPKP 251
Cdd:PHA03307   293 ERSPSPSPSSPGSGPAPSSPRASSSSsssressssstssssESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPS 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  252 RAAARTPAASAGRIERRRARAAVAGRDA---TGRFTAGQPRRVELDADAASGAFYARYRDGYVSGEPWPGAGPPPPGRVL 328
Cdd:PHA03307   373 RAPSSPAASAGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPPPPGRVR 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  329 YGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACF 408
Cdd:PHA03307   453 YGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQ 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  409 RISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAAltga 488
Cdd:PHA03307   533 KKFQAPRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAA---- 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  489 agspgagaddegvaaavaaaaaapgerAVPAGYGAAGILAALGRLSAAPASPAggddpdaarhadadddagrrAQAGRVA 568
Cdd:PHA03307   609 ---------------------------DTGAGAAAPAPAAPRPDAAAAGGASA--------------------RPLRELA 641

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  569 VECLAACRGILEALAEGFDGDLaAVPGLAGARPASPPRPegpagpaspppPHADAPRLRAWLRELRFVRDALVLMRLRGD 648
Cdd:PHA03307   642 DACVLACRAVLEALLEGPDGLS-AVPGLAFPRPACPPRA-----------LEACPARLESWLRELRDLRDAVYLARLRGD 709

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  649 LRVAGGSEAAVAAVRAVSLVAGALGPALPRDPRLPSSAAAAAA--DLLFENQSLR------------------------P 702
Cdd:PHA03307   710 LPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDitDALFSNPSLVpaklaealallepaepqrgagsspP 789

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  703 LLAAAASAPDAADALAAAAASAAPREGRKRKSPGPARPPGGGGPRPPKTKKSGADAPG---------------------- 760
Cdd:PHA03307   790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPParssesskskpaaaggrargkn 869

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  761 ---SDARAPLPAPPSTPPGPEPAPAQPGAPRAAAAQARPRPVALSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAYC 837
Cdd:PHA03307   870 grrRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYC 949

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  838 SPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCagpaaaaqaacgggddddnpHPHGAAGGRLFGPLRASGPLRRMA 917
Cdd:PHA03307   950 PPEVVAELVDHPLFPEPWRPALAFDPEALAEIAARC--------------------GGPPPRSGSAFGPLRASGPLRRRA 1009

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  918 AWMRQIPDPEDVRVVVLYSPLPGEDL---AGGGASGGPPEWSAERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSAL 994
Cdd:PHA03307  1010 AWMRQIPDPEDVRVVVLYSPLPGEHLfgvPAPDASPGGPAWSPERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSAL 1089

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  995 GAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYLACDLLPAVQCAVRWPAARDLRR 1074
Cdd:PHA03307  1090 NAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLAR 1169

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1075 TVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDA 1154
Cdd:PHA03307  1170 AVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEG 1249

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1155 MAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGREAVRAGPARWRGPRRDFCARALLEPDDDAPPLVLRgdddDDDG 1234
Cdd:PHA03307  1250 LGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVVRAFCRAALLEPDPEAPPLVLP----PSAA 1325

                         1290
                   ....*....|....*
gi 2277963158 1235 PGALPPALPGIRWAS 1249
Cdd:PHA03307  1326 AEAAHARAPRVTWAK 1340
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 51-1249 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 860.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158   51 H-----PHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPdPAASPPRTPAFRADDDDGDEYDD 125
Cdd:PHA03307   134 LsemlrPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSP-PAEPPPSTPPAAASPRPPRRSSP 212

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  126 AADAAGDRAPARGRAREAPL-------------------RGAYPDPTDRLSPRPPAQPPRRRRHGRRRPSASSTSSDSGS 186
Cdd:PHA03307   213 ISASASSPAPAPGRSAADDAgasssdssssessgcgwgpENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPR 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  187 SSSSSASSSSSSSDEDEDDDGNDAAD---------------RAREARAVGRGPSSAAPEAPGQTPPPPGPPPLSEAAPKP 251
Cdd:PHA03307   293 ERSPSPSPSSPGSGPAPSSPRASSSSsssressssstssssESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPS 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  252 RAAARTPAASAGRIERRRARAAVAGRDA---TGRFTAGQPRRVELDADAASGAFYARYRDGYVSGEPWPGAGPPPPGRVL 328
Cdd:PHA03307   373 RAPSSPAASAGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPPPPGRVR 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  329 YGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACF 408
Cdd:PHA03307   453 YGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQ 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  409 RISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAAltga 488
Cdd:PHA03307   533 KKFQAPRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAA---- 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  489 agspgagaddegvaaavaaaaaapgerAVPAGYGAAGILAALGRLSAAPASPAggddpdaarhadadddagrrAQAGRVA 568
Cdd:PHA03307   609 ---------------------------DTGAGAAAPAPAAPRPDAAAAGGASA--------------------RPLRELA 641

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  569 VECLAACRGILEALAEGFDGDLaAVPGLAGARPASPPRPegpagpaspppPHADAPRLRAWLRELRFVRDALVLMRLRGD 648
Cdd:PHA03307   642 DACVLACRAVLEALLEGPDGLS-AVPGLAFPRPACPPRA-----------LEACPARLESWLRELRDLRDAVYLARLRGD 709

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  649 LRVAGGSEAAVAAVRAVSLVAGALGPALPRDPRLPSSAAAAAA--DLLFENQSLR------------------------P 702
Cdd:PHA03307   710 LPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDitDALFSNPSLVpaklaealallepaepqrgagsspP 789

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  703 LLAAAASAPDAADALAAAAASAAPREGRKRKSPGPARPPGGGGPRPPKTKKSGADAPG---------------------- 760
Cdd:PHA03307   790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPParssesskskpaaaggrargkn 869

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  761 ---SDARAPLPAPPSTPPGPEPAPAQPGAPRAAAAQARPRPVALSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAYC 837
Cdd:PHA03307   870 grrRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYC 949

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  838 SPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCagpaaaaqaacgggddddnpHPHGAAGGRLFGPLRASGPLRRMA 917
Cdd:PHA03307   950 PPEVVAELVDHPLFPEPWRPALAFDPEALAEIAARC--------------------GGPPPRSGSAFGPLRASGPLRRRA 1009

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  918 AWMRQIPDPEDVRVVVLYSPLPGEDL---AGGGASGGPPEWSAERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSAL 994
Cdd:PHA03307  1010 AWMRQIPDPEDVRVVVLYSPLPGEHLfgvPAPDASPGGPAWSPERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSAL 1089

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  995 GAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYLACDLLPAVQCAVRWPAARDLRR 1074
Cdd:PHA03307  1090 NAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLAR 1169

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1075 TVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDA 1154
Cdd:PHA03307  1170 AVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEG 1249

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1155 MAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGREAVRAGPARWRGPRRDFCARALLEPDDDAPPLVLRgdddDDDG 1234
Cdd:PHA03307  1250 LGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVVRAFCRAALLEPDPEAPPLVLP----PSAA 1325

                         1290
                   ....*....|....*
gi 2277963158 1235 PGALPPALPGIRWAS 1249
Cdd:PHA03307  1326 AEAAHARAPRVTWAK 1340
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 813-1257 0e+00

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 600.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  813 GGWRRQPPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAAAAQaacgggDDDDN 892
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGG------DYNSN 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  893 PHPHGAAGgRLFGPLRASGPLRRMAAWMRQIPDPEDVRVVVLYSPLPGEDLAGGGASGGPPEWSAERGGLSCLLAALANR 972
Cdd:pfam03585   75 EIITSAAS-RAFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPPKWSNKRGGLSFLLAALSNR 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  973 LCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYL 1052
Cdd:pfam03585  154 LCLPKTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYM 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1053 ACDLLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPR 1132
Cdd:pfam03585  234 KCIISPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPR 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1133 EYRRAVLPALDGRAAASGTTDAMAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGREAVRAGPARWRGP-RRDFCAR 1211
Cdd:pfam03585  314 EYRAAVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPtARNFCRS 393

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2277963158 1212 ALLEPDDDAPPLVLRGDDDDDD------GPGALPPAlPGIRWASATGRSGTV 1257
Cdd:pfam03585  394 ALLEPDPEARPLVLHIPEGTCSalaedmVASALPPC-PRITWGQGFGHEEGG 444
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 798-1300 3.83e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 44.86  E-value: 3.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  798 PVALSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAycSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPA 877
Cdd:COG3321    860 RVPLPTYPFQREDAAAALLAAALAAALAAAAALGALLL--AALAAALAAALLALAAAAAAALALAAAALAALLALVALAA 937

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  878 AAAQAACGGGDDDDNPHPHGAAGGRLFGPLRASGPLRRMAAWMRQIPDPEDVRVVVLYSPLPGEDLAGGGASGGPPEWSA 957
Cdd:COG3321    938 AAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAA 1017

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  958 ERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACD 1037
Cdd:COG3321   1018 AAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALAL 1097

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1038 WPADGPAVSRQHAYLACDLLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRV 1117
Cdd:COG3321   1098 ALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLAL 1177

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1118 RTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDAMAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGREAVRAG 1197
Cdd:COG3321   1178 ALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLA 1257

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1198 PARWRGPRRDFCARALLEPDDDAPPLVLRGDDDDDDGPGALPPALPGIRWASATGRSGTVLAAAGAVEVLGAEAGLATPP 1277
Cdd:COG3321   1258 ALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAV 1337

                          490       500
                   ....*....|....*....|...
gi 2277963158 1278 RREVVDWEGAWDEDDGGALEGDG 1300
Cdd:COG3321   1338 AAALALAAAAAAAAAAAAAAAAA 1360
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 51-1249 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 860.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158   51 H-----PHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPdPAASPPRTPAFRADDDDGDEYDD 125
Cdd:PHA03307   134 LsemlrPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSP-PAEPPPSTPPAAASPRPPRRSSP 212

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  126 AADAAGDRAPARGRAREAPL-------------------RGAYPDPTDRLSPRPPAQPPRRRRHGRRRPSASSTSSDSGS 186
Cdd:PHA03307   213 ISASASSPAPAPGRSAADDAgasssdssssessgcgwgpENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPR 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  187 SSSSSASSSSSSSDEDEDDDGNDAAD---------------RAREARAVGRGPSSAAPEAPGQTPPPPGPPPLSEAAPKP 251
Cdd:PHA03307   293 ERSPSPSPSSPGSGPAPSSPRASSSSsssressssstssssESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPS 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  252 RAAARTPAASAGRIERRRARAAVAGRDA---TGRFTAGQPRRVELDADAASGAFYARYRDGYVSGEPWPGAGPPPPGRVL 328
Cdd:PHA03307   373 RAPSSPAASAGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPPPPGRVR 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  329 YGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACF 408
Cdd:PHA03307   453 YGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQ 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  409 RISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAAltga 488
Cdd:PHA03307   533 KKFQAPRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAA---- 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  489 agspgagaddegvaaavaaaaaapgerAVPAGYGAAGILAALGRLSAAPASPAggddpdaarhadadddagrrAQAGRVA 568
Cdd:PHA03307   609 ---------------------------DTGAGAAAPAPAAPRPDAAAAGGASA--------------------RPLRELA 641

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  569 VECLAACRGILEALAEGFDGDLaAVPGLAGARPASPPRPegpagpaspppPHADAPRLRAWLRELRFVRDALVLMRLRGD 648
Cdd:PHA03307   642 DACVLACRAVLEALLEGPDGLS-AVPGLAFPRPACPPRA-----------LEACPARLESWLRELRDLRDAVYLARLRGD 709

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  649 LRVAGGSEAAVAAVRAVSLVAGALGPALPRDPRLPSSAAAAAA--DLLFENQSLR------------------------P 702
Cdd:PHA03307   710 LPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDitDALFSNPSLVpaklaealallepaepqrgagsspP 789

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  703 LLAAAASAPDAADALAAAAASAAPREGRKRKSPGPARPPGGGGPRPPKTKKSGADAPG---------------------- 760
Cdd:PHA03307   790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPParssesskskpaaaggrargkn 869

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  761 ---SDARAPLPAPPSTPPGPEPAPAQPGAPRAAAAQARPRPVALSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAYC 837
Cdd:PHA03307   870 grrRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYC 949

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  838 SPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCagpaaaaqaacgggddddnpHPHGAAGGRLFGPLRASGPLRRMA 917
Cdd:PHA03307   950 PPEVVAELVDHPLFPEPWRPALAFDPEALAEIAARC--------------------GGPPPRSGSAFGPLRASGPLRRRA 1009

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  918 AWMRQIPDPEDVRVVVLYSPLPGEDL---AGGGASGGPPEWSAERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSAL 994
Cdd:PHA03307  1010 AWMRQIPDPEDVRVVVLYSPLPGEHLfgvPAPDASPGGPAWSPERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSAL 1089

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  995 GAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYLACDLLPAVQCAVRWPAARDLRR 1074
Cdd:PHA03307  1090 NAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLAR 1169

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1075 TVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDA 1154
Cdd:PHA03307  1170 AVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEG 1249

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1155 MAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGREAVRAGPARWRGPRRDFCARALLEPDDDAPPLVLRgdddDDDG 1234
Cdd:PHA03307  1250 LGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVVRAFCRAALLEPDPEAPPLVLP----PSAA 1325

                         1290
                   ....*....|....*
gi 2277963158 1235 PGALPPALPGIRWAS 1249
Cdd:PHA03307  1326 AEAAHARAPRVTWAK 1340
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 813-1257 0e+00

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 600.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  813 GGWRRQPPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAAAAQaacgggDDDDN 892
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGG------DYNSN 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  893 PHPHGAAGgRLFGPLRASGPLRRMAAWMRQIPDPEDVRVVVLYSPLPGEDLAGGGASGGPPEWSAERGGLSCLLAALANR 972
Cdd:pfam03585   75 EIITSAAS-RAFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPPKWSNKRGGLSFLLAALSNR 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  973 LCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYL 1052
Cdd:pfam03585  154 LCLPKTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYM 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1053 ACDLLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPR 1132
Cdd:pfam03585  234 KCIISPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPR 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1133 EYRRAVLPALDGRAAASGTTDAMAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGREAVRAGPARWRGP-RRDFCAR 1211
Cdd:pfam03585  314 EYRAAVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPtARNFCRS 393

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2277963158 1212 ALLEPDDDAPPLVLRGDDDDDD------GPGALPPAlPGIRWASATGRSGTV 1257
Cdd:pfam03585  394 ALLEPDPEARPLVLHIPEGTCSalaedmVASALPPC-PRITWGQGFGHEEGG 444
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 326-483 8.62e-69

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 228.17  E-value: 8.62e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  326 RVLYGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQ 405
Cdd:pfam03584    6 RVLYGGLGDSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYTPDAEPLGWLQNPRLNPGDVALNQ 85

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277963158  406 ACFRISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENA 483
Cdd:pfam03584   86 ICQKISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQKTFLLTSLRRAYAPLAFPENA 163
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 328-478 9.07e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 60.21  E-value: 9.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  328 LYGGLGdSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYA-LITRLLYTPDAEAMGWLQNPRVVPGDVALDQA 406
Cdd:PHA03308   364 VYHGSG-YRQSLVDDPQVREAAAEFHANPKSASVYLEEYGMPVEQLErLVEEFMVHPLSRVSYGYGGPKLSPRDKRLCEL 442

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2277963158  407 CfRISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLL 478
Cdd:PHA03308   443 C-ALRGPGSSEGGLSRSAVPTCLPHVAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAALRRAFVPFV 513
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 327-478 1.90e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 52.55  E-value: 1.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  327 VLYGGLGdSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYA-LITRLLYTPDAEAMGWLQNPRVVPGDVALDQ 405
Cdd:PHA03309   638 VYYGKTG-YRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHErLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCK 716

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  406 ACFRISGA-------------ARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRR 472
Cdd:PHA03309   717 ICLPPDGGddrdgggksrggrGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRL 796


                   ....*.
gi 2277963158  473 AYAPLL 478
Cdd:PHA03309   797 AFAPLV 802
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 798-1300 3.83e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 44.86  E-value: 3.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  798 PVALSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAycSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPA 877
Cdd:COG3321    860 RVPLPTYPFQREDAAAALLAAALAAALAAAAALGALLL--AALAAALAAALLALAAAAAAALALAAAALAALLALVALAA 937

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  878 AAAQAACGGGDDDDNPHPHGAAGGRLFGPLRASGPLRRMAAWMRQIPDPEDVRVVVLYSPLPGEDLAGGGASGGPPEWSA 957
Cdd:COG3321    938 AAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAA 1017

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158  958 ERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACD 1037
Cdd:COG3321   1018 AAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALAL 1097

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1038 WPADGPAVSRQHAYLACDLLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRV 1117
Cdd:COG3321   1098 ALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLAL 1177

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1118 RTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDAMAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGREAVRAG 1197
Cdd:COG3321   1178 ALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLA 1257

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277963158 1198 PARWRGPRRDFCARALLEPDDDAPPLVLRGDDDDDDGPGALPPALPGIRWASATGRSGTVLAAAGAVEVLGAEAGLATPP 1277
Cdd:COG3321   1258 ALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAV 1337

                          490       500
                   ....*....|....*....|...
gi 2277963158 1278 RREVVDWEGAWDEDDGGALEGDG 1300
Cdd:COG3321   1338 AAALALAAAAAAAAAAAAAAAAA 1360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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