|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-389 |
3.93e-162 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 460.58 E-value: 3.93e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 11 CWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIM 90
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 91 TLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVT 170
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 171 GAFLFLSFLIVFFFLHEENHSAQAKK-VQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGpGTAHIE 249
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKPVEKKKmVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMG-DASNLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 250 MIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLK 329
Cdd:cd17391 240 FISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 330 QHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFH 389
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
3-388 |
4.04e-117 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 346.91 E-value: 4.04e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 3 SWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRA 82
Cdd:PRK09874 11 NWKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 83 SLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIG 162
Cdd:PRK09874 91 ALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 163 MRHVFLVTGAFLFLSFLIVFFFLhEENHSAQAKK--VQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNL 240
Cdd:PRK09874 171 LRPVFFITASVLFLCFLVTLFCI-RENFQPVSKKemLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVREL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 241 EGpGTAHIEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGL 320
Cdd:PRK09874 250 AG-NVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGAL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446101467 321 LPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:PRK09874 329 LPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWN 396
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-388 |
1.61e-56 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 189.71 E-value: 1.61e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 11 CWLGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIM 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVA-----QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 91 TLMGFVTDVYQLVALRFLMGAVSGFLST-AMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLV 169
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPaAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 170 TGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWT---MVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTA 246
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSglrLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 247 HIemiaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQT 326
Cdd:cd17325 236 QI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446101467 327 LLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-352 |
9.03e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 9.03e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-----PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 85 GMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGM 163
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGlGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 164 RHVFLVTGAFLFLSFLIVFFFLHEenhSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGP 243
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPE---SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 244 GTAHIemiaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPS 323
Cdd:COG2814 241 SASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340
....*....|....*....|....*....
gi 446101467 324 VQTLLKQHTPTHVTGRIFGYNQSFQFLGN 352
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
12-388 |
6.09e-35 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 131.93 E-value: 6.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 12 WLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAqwSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMT 91
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNKLGASGYY--VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 92 LMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTG 171
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 172 AFLFLSFLIVFFFLheenhsaqakkvqqkkvwtmvpakHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHIemi 251
Cdd:cd17330 160 ALALLNLVLVLFFL------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI--- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 252 aGAVMSATGLAVILA-APKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQ 330
Cdd:cd17330 213 -GLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446101467 331 HTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
8-386 |
4.06e-30 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 119.19 E-value: 4.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 8 LMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMA 87
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA-----GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 88 VIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHV 166
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGlAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 167 FLVTGAFLFLSFLIVFFFLHEENHSAqAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTA 246
Cdd:cd17324 156 FLAIAVLALLAALLLWRLLPSLPPKK-PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 247 HIemiaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQT 326
Cdd:cd17324 235 AI----IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 327 LLKQHTPTHvTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17324 311 RVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-389 |
3.02e-28 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 113.84 E-value: 3.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 21 GMSLVIPFLSFYIEELGvtGTSSIAqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVY 100
Cdd:cd17489 11 SFYLLLPVLPLYAHDLG--GSEAVA---GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 101 QLVALRFLMGAVSGFLSTA-MTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFL 179
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAaATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 180 IVFFfLHEENHSAQAKKVQQKKVWTMVPAKHVIISLFVTtFIIQLANMSIQPIITLYVKNLEGPGtahiemiAGAVMSAT 259
Cdd:cd17489 166 LVFL-VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALIL-FLASIAYGAISTFLPLYAAERGISN-------AGLFFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 260 GLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGR 339
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446101467 340 IFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFH 389
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-388 |
4.20e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 111.13 E-value: 4.20e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 2 ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIR 81
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 82 ASLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFL-STAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSEL 160
Cdd:COG2223 76 GLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 161 IGMRHVFLVTGAFLFLSFLIVFFFLHE-ENHSAQAKKVQQKKVWTMVPAKHVIIsLFVTTFIIQLANMSIQPIITLYVKN 239
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRDpPAGAAAAAKASLRDQLEALRDPRFWL-LSLLYFGTFGSFIGFSSWLPPYLVD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 240 LEGPGTAHiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVT-SAWQLLILRFLLGIAQA 318
Cdd:COG2223 235 QFGLSAAT----AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446101467 319 GLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG-FQYVFFSTSSLLFIACIWVYF 388
Cdd:COG2223 311 GGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-384 |
1.56e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 109.24 E-value: 1.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 12 WLGCFTTAAGMSLVIPFLSFYI-EELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIM 90
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLhQQLGLSAS-----IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 91 TLMGFVTDVYQLVALRFLMGAVSGFLSTAM-TFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELiGMRHVFLV 169
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASeAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 170 TGAFLFLSFLIVFFFLHEE-NHSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGtahi 248
Cdd:cd17329 159 AAVLFLLAALVLLFLLPETrPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG---- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 249 EMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLL 328
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 329 KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17329 315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-356 |
2.31e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 108.27 E-value: 2.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 12 WLGCFTTAAGMSLVIPFLSFYI-EELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIM 90
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEI-----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 91 TLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLV 169
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGlGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 170 TGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWT---MVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPgta 246
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIvawKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS--- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 247 hiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVA---LFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPS 323
Cdd:pfam07690 234 --ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAlllLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|...
gi 446101467 324 VQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGP 356
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-388 |
3.60e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 108.03 E-value: 3.60e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 8 LMICWLGCFTTAAGMSLVIPFLsfyIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMA 87
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAPPL---QADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 88 VIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHV 166
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGlGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 167 FLVTGAFLFLSFLIVFFFLheenhsaqakkvqqkkvwtmvpakhviislFVTTFIIQLANMSIQPIITLYVKNLEGPGTA 246
Cdd:COG2271 167 FLILGLPGLLLALLRFWLL------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 247 HiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQK--TLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSV 324
Cdd:COG2271 217 Q----AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446101467 325 QTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
216-404 |
9.34e-26 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 107.35 E-value: 9.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 216 FVTTFIIQLANMSIQPIITLYVKNLEGPGTAHIEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFI 295
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 296 PQAFVTSAWQLLILRFLLGIAqAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFST 375
Cdd:cd17391 82 LMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180
....*....|....*....|....*....
gi 446101467 376 SSLLFIACIWVYFHNKNEEVSEKQHLEVS 404
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKPVEKKKMVS 189
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-388 |
2.76e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 105.73 E-value: 2.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 15 CFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIrASLGMAVIM-TLM 93
Cdd:cd17474 8 TLLAVLGVSIVDPILPAIAEALGASPA-----QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLL-PGLLLFGIGgLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 94 GFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAI----STISTGGVSGSLLGPLLGgylseLIGMRHVFL 168
Cdd:cd17474 82 GLSDSFALLLAGRALQGiGAAGLGPLALTLIGDLFEGGERAKAMglyeAALGLGIAVGPLLGGLLA-----AISWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 169 VTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHI 248
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 249 emiaGAVMSATGLAVILAAPKLGRLSDH-IGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTL 327
Cdd:cd17474 237 ----GLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446101467 328 LKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
8-389 |
6.17e-23 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 99.25 E-value: 6.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 8 LMICWLGCFTTAAGMSLVIPFLSFYIEELgVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMA 87
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREF-VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 88 VIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKE----HSGWAISTISTGGVSGSLLGPLLGGylselIGM 163
Cdd:cd17388 80 LDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEqrarNFGLLGAAFGLGFIAGPALGGLLGE-----ISP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 164 RHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVP-----AKHVIISLFVTTFIIQLANMSIQPIITLYVK 238
Cdd:cd17388 155 RAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSlrwltGFPGLLGLLAVFFLIQLIGQVPATTWVLFTE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 239 NLEGPGTAHIemiaGAVMSATGLAVILA-APKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLIlrFLLGIAQ 317
Cdd:cd17388 235 DRFDWSPTMV----GLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFP--ILILLAL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 318 AGL-LPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQY---VFFSTSSLLFIACIWVYFH 389
Cdd:cd17388 309 GGIaGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWpglAWIIGAALYLICLVLAYRF 384
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-388 |
1.77e-22 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 98.07 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 12 WLGCFTTAAGMSLVIPFLSFYieelgVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMT 91
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWL-----VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 92 LMGFVTD-----VYQLVALRFLMGAVSGFLSTA-MTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRH 165
Cdd:cd06173 80 VLALLALlgslsLWLLLVLAFLLGIASAFFGPArQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 166 VFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQ----KKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLE 241
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlrdlREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 242 GPGTAHIemiaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLL 321
Cdd:cd06173 240 GGGAAGY----GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446101467 322 PSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-388 |
6.22e-22 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 96.10 E-value: 6.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 44 IAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTF 122
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGiGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 123 IAA----ETPKEHSGWAISTISTGGVSGSLLGPLLGGylselIGMRHVFLVTGaFLFLSFLIVFFFLHEENHSAQAKKVQ 198
Cdd:cd17473 113 IGDyfegEERAKMLGLQSAAMSLGGVVFLLLGGALAE-----IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 199 QKKVWTMVPAKHVIIsLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHIemiaGAVMSATGLAVILAAPKLGRLSDHIG 278
Cdd:cd17473 187 GAATAAALPWKRVLP-IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI----GLALAIASLAGAIGALLFGRLKRRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 279 PQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVL 358
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|.
gi 446101467 359 GGQI-AAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17473 342 LGPLvNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-388 |
1.73e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.19 E-value: 1.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 12 WLGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMT 91
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLS-----ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 92 LMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGV---SGSLLGPLLGGYLSELIGMRHVFL 168
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGsvgGILGPLLGGILASSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 169 VTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVPAKHV-----IISLFVTTFIIQLANMSIQPIITLYVKNLEGP 243
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVlknpgLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 244 GTAhiemIAGAVMSATGLAVILAAPKLGRLSD-HIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLP 322
Cdd:cd06174 237 SVA----VAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 323 SVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd06174 313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-369 |
5.33e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 94.20 E-value: 5.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 13 LGCFTTAAGMSLVIPFLS-FYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHG-----RKLMLIRASLGM 86
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLyFYTDVLGLS-----AALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 87 AVIMTLMGFVTDVYQLVALrFLMGAVSGFLSTAMTFI--------AAETPKEH-----SGW--AISTISTGGVSGSLLGP 151
Cdd:COG2211 92 ALSFVLLFTAPDLSPTGKL-IYALVTYLLLGLAYTLVnipysalgAELTPDYEertrlSSWrfAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 152 LLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEeNHSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQP 231
Cdd:COG2211 171 VAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKE-RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 232 IITLYVKNLEGPGTAhiemIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV--TSAWQLLIL 309
Cdd:COG2211 250 LLLYYFKYVLGLSAA----LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446101467 310 RFLLGIAQAGLLPSVQTLL-------KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQ 369
Cdd:COG2211 326 AALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-404 |
8.62e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 92.73 E-value: 8.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 208 AKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAhiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVAL 287
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ-----AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 288 FAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG 367
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190
....*....|....*....|....*....|....*..
gi 446101467 368 FQYVFFSTSSLLFIACIWVYFHNKNEEVSEKQHLEVS 404
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-364 |
1.13e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 92.64 E-value: 1.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 13 LGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTL 92
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQREFGTSAA-----AVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 93 MGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGA 172
Cdd:cd17504 78 AAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 173 FLFLSFLIVFFFlheenhsaQAKKVQQKKVWTmvpakhVIISLFVTTFIIQLANMsiqpIITLYVKNLEGPGTAHIEMIA 252
Cdd:cd17504 158 VAVLLAALVPLI--------DLRLLRRRNVLL------ANITALLAGFGMFMVFQ----LLPQLLQLPTPTGFGLGITEA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 253 GAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV-TSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:cd17504 220 GLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPNIVVES 299
|
330 340 350
....*....|....*....|....*....|...
gi 446101467 332 TPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAA 364
Cdd:cd17504 300 VPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
16-384 |
1.24e-18 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 86.48 E-value: 1.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTL-MG 94
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQLGLSPT-----QIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLsLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 95 FVTDVYQLVALRFLMGAVsgFLSTAMTFIAAET---PKEHS------------GWAISTISTGGVSGSLLGPllggylse 159
Cdd:cd17335 82 FVAQIFWLLLLLVILGAF--FSAPVVPLVDSITlqyLGEERerygkqrlwgsiGFGIAALLVGILIDRSSTY-------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 160 lIGMRHVFLVTGAFLFLSFLIVFFFLHEENHsaQAKKVQQKKVWTMVPAKHVIISLFVTTFIiqlaNMSIQPIITLYVKN 239
Cdd:cd17335 152 -KNYTIAFYVFAVLMLLALLLALKFPFRPKH--PEPNENTGGLLALLRNPRVLAFLLVAFLM----GFGHGLIYSFLFWH 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 240 LEGPGtaHIEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAG 319
Cdd:cd17335 225 LQDLG--GSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 320 LLPSVQTLLKQHTPTHVTGRIFGYNQSFQF-LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17335 303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLL 368
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
215-388 |
2.04e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 85.72 E-value: 2.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKNLEGPgtahiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGS-----EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170
....*....|....
gi 446101467 375 TSSLLFIACIWVYF 388
Cdd:cd17489 156 AAVLALLALLLVFL 169
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-384 |
6.42e-18 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 84.19 E-value: 6.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 24 LVIPFLSFYIEELGVTGTSSIaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLV 103
Cdd:cd17316 16 FLIGFVAPVLAAEFSLGLSLL--QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 104 ALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTI----STGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSF 178
Cdd:cd17316 94 VLRFLQGiGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 179 LI----VFFFLheenhsaqakkvqqkkVWTMVPAKHVIISLFVTTFIIQLANMSIQpiitlyvknlegpgtahiemIAGA 254
Cdd:cd17316 174 LLrrrtLLLIL----------------LWFFISFGYYGLTTFLPTYLQTVLGLSPA--------------------TSSL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 255 VMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIP--QAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17316 218 YLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELF 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446101467 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17316 298 PTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-389 |
7.10e-18 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 84.19 E-value: 7.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 21 GMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTL-MGFVTDV 99
Cdd:cd17490 11 SQYVYVPFLSPYAESLGAS-----LSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLiMILFPSP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 100 YQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFL 179
Cdd:cd17490 86 WGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 180 IVFFfLHEENHSAQAKKVQQKKVWTMVPAKHVIISLFVTtFIIQLANMSIQPIITLYVKNLEGPGTAHIEMIAGAVMSAT 259
Cdd:cd17490 166 LSLF-IKEERREKKPVLTELKELLSVLKDKKLLFFSLLA-ILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 260 GLAVILAAPKLGRLsdhIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGR 339
Cdd:cd17490 244 ALASLLSGTLFYKK---LGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRST 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446101467 340 IFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFH 389
Cdd:cd17490 321 AMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAY 370
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
28-382 |
5.14e-17 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 82.12 E-value: 5.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 28 FLSFYIEELGVTGTSSIAQ-WSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMT-LMGFVT-DVYQLVA 104
Cdd:COG2270 33 VFPPYFTSVAALGDPAAATaLWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATaALFFVApGGLWLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 105 LRFLMGAVsgFLSTAMTFIAA-----ETPKEH-----SGWAI----STISTGGVSGSLLGPLLGGYLSELIGMRHVFLVT 170
Cdd:COG2270 113 LLFVLANI--GFEGSLVFYNAflpdiATPEEIgrvsgLGWALgylgGVLLLLINLALFLKPEAFGLPDAGEAVRISFLLT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 171 GAFLFLSFLIVFFFLHEENHSAQAKK--------VQQKKVWTMVPAKHVIISLFVTTFIiqlANMSIQPIITL---YVKN 239
Cdd:COG2270 191 ALWWLLFALPLFLFLPERPRPGPAPPrgavragfRELRRTLRELRRYRDLLRFLLAYFF---YRDGVQTVIAFagiYAAG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 240 LEGPGTAHIeMIAGAVMSATGlavILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAG 319
Cdd:COG2270 268 VLGFSTTEL-IVFGLLVQIVA---ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGG 343
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 320 LLPSVQTLLKQHTPTHVTGRIFGYnqsFQFLGNM---IGPVLGGQIAAHAGFQYVFFSTSSLLFIA 382
Cdd:COG2270 344 IQALSRSLLARLIPPGREAEFFGL---YALSGKAasfLGPLLFGLVTQLTGSQRLGILSLIVFFVI 406
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-398 |
7.33e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.23 E-value: 7.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKNLEGPGtahiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGIS----PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180
....*....|....*....|....
gi 446101467 375 TSSLLFIACIWVYFHNKNEEVSEK 398
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRP 180
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-185 |
2.30e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 2.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 85 GMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAM-TFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGM 163
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
170 180
....*....|....*....|..
gi 446101467 164 RHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
13-384 |
2.30e-15 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 76.82 E-value: 2.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 13 LGCFTTAAGMSLVIPFLS-FYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVI-M 90
Cdd:cd17471 3 LATLLTGLAGAFVLPYLSlFLTEELGAS-----PLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALgY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 91 TLMGFVTDVYQLVALRFLmgaVSGFLSTAMTFI-------AAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGM 163
Cdd:cd17471 78 LLFAFLRNYWVLLLVGVV---LLSLGAAAFPQLfalareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 164 RHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVwTMVPAKHVIIsLFVTTFIIQLANMSIQPIITLYVKN-LEG 242
Cdd:cd17471 155 TGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLV-KAPVNRRLLL-LFAAFTLLFAANSMYIIAMPLYVTNeLGG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 243 PgtahiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIA---QAG 319
Cdd:cd17471 233 S-----ESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFigiTAG 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 320 L-LPSVQTLLKQHTPTHVTgrifGYNQSFQfLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17471 308 LgISYFQDLMPGQPGLATT----LYSNASR-IGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-384 |
4.13e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.45 E-value: 4.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 12 WLGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMT 91
Cdd:COG2807 24 VLVALNLRPAITSVGPLLPEIRADLGLSAT-----QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 92 LMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTG 171
Cdd:COG2807 99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 172 AFLFLSFLIVFFFLHEENHSAQAKKVQQKK--VWTMVPAKHVIISLFVTTFIiqlANMSIQPIITLYVKNLEGPGTAhie 249
Cdd:COG2807 179 LLALLALLLWLPLLRRRPAAAAAAPAAASLrsLWRSPLAWLLTLFFGLQSLL---YYAVVAWLPPILRDAGLSAATA--- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 250 miaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLK 329
Cdd:COG2807 253 ---GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446101467 330 QHTPT-HVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG-FQYVFFSTSSLLFIACI 384
Cdd:COG2807 330 LRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLV 386
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-366 |
8.32e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 75.29 E-value: 8.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 13 LGCFTTAAGMSLVIPFLSFYIEELGVTGTSsiAQWSGLAFGVTFlmgAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTL 92
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQ--LQWVVNAYLLAF---AALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 93 MGFVTDVYQLVALRFLMGAVSGFL-STAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTG 171
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAAImPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 172 AFLFLSFLIVFFFLheenhsaqakkvqqkkvwtmvpakhviiSLFVTTFIIQLANMSIQPIITLYVKNLEGpgtaHIEMI 251
Cdd:cd17321 158 PIGLVALLLARTFS----------------------------GAVLAAFLLGAALGGLLFLLPLYLQGVLG----YSPLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV---TSAWQLLILRFLLGIAQAGLLPSVQTLL 328
Cdd:cd17321 206 AGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAA 285
|
330 340 350
....*....|....*....|....*....|....*...
gi 446101467 329 KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHA 366
Cdd:cd17321 286 LSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
253-388 |
1.40e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.53 E-value: 1.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 253 GAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF 176
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
27-185 |
1.98e-14 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 74.22 E-value: 1.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 27 PFLSFYIEELGvTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALR 106
Cdd:cd17391 222 PILTLYIRQLM-GDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILR 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 107 FLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17391 301 FLLGlATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
212-388 |
3.17e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 3.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 212 IISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAhiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAG 291
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQ-----AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 292 IIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYV 371
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
|
170
....*....|....*..
gi 446101467 372 FFSTSSLLFIACIWVYF 388
Cdd:cd17324 156 FLAIAVLALLAALLLWR 172
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-386 |
5.33e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 72.59 E-value: 5.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 13 LGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGdihgRKLMLIRASLGMAVIMT- 91
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVS-----TALIGLVASAYYLGILLGSPLVPRLI----RRVGHIRAFAAGAAITAv 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 92 ---LMGFVTDVYQLVALRFLMGAVSGFLSTAM-TFIAAETPKEHSGWAI---STISTGGVSGSLLGPLLGGYLSELIgmr 164
Cdd:cd17477 74 svlLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLglySTVLGLGFALGPLLLALVGTAGALP--- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 165 hvFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVPAkhviisLFVTTFIIQLANMSIQPIITLYVKNLEGPG 244
Cdd:cd17477 151 --FLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPL------ALLGAFVAGFLEGAFYSLLPLYGLRLGLSV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 245 TAhiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV-TSAWQLLILRFLLGIAQAGLLPS 323
Cdd:cd17477 223 AQ-----AALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTL 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446101467 324 VQTLLKQHTPTHvtgRIFGYNQSFQF---LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17477 298 ALALAGDRLPGD---ELVAANAALLLlygLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
16-384 |
8.15e-14 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 72.25 E-value: 8.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVtgtssIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGF 95
Cdd:cd17331 10 VLYATCYWLQQPVLPYLTKKLGV-----DSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 96 VTDVYQLVALRFLMGAVSGFLSTAMtFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLF 175
Cdd:cd17331 85 ASSVPMLFLSRLPSVFMHAMQAAQM-VVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 176 LSFLIVFFFL----HEENHSAQAKKVQQKKVWTMVPAKHVII-----SLFVTTFIIQLANMSIQPIITLYVKNLEGPGTA 246
Cdd:cd17331 164 LSIVLVILLIpsntKSKREKEAKESASPPSVFNLKEILRLLRlpgvaFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 247 HiemiAGAVMSATGLAVILA-APKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQ 325
Cdd:cd17331 244 E----NGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVIT 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446101467 326 TLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17331 320 SLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTV 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-388 |
9.21e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 71.83 E-value: 9.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAET 127
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGvAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 128 PKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLheenhsaqakkvqqKKVWTMVP 207
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL--------------RQVWGLAL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 208 AKHVIISLFVT------TFIIQLANMSIQPIitlyvknlegpgtahiemiaGAVMSATGLAVILAAPKLGRLSDHIGPQ- 280
Cdd:cd17319 187 GYFGINYALYGlltwlpTYLKQARGFSLKQV--------------------GLLAAIPFLAGAIGMILGGRLSDRLLRGa 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 281 --KTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVL 358
Cdd:cd17319 247 rrLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
330 340 350
....*....|....*....|....*....|.
gi 446101467 359 -GGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17319 327 iGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
211-388 |
1.16e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.00 E-value: 1.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 211 VIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAhiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAA 290
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQ-----LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 291 GIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQY 370
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170
....*....|....*...
gi 446101467 371 VFFSTSSLLFIACIWVYF 388
Cdd:COG0477 170 IFLINAPLGLLALVLRLR 187
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-396 |
1.26e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.81 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGF 95
Cdd:COG0738 18 FLWGFATALWGPLIPALKDAFGLSDAQA-----GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 96 VTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKE---------HSGWAISTISTGGVSGSLLGPLLGgylselIGMRHV 166
Cdd:COG0738 93 APSYPLLLLALFLLGLGLGLLDVAANPYVAALGPEtaasrlnllHAFFSLGALLGPLLGGLLILLGLS------LSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 167 FLVTGAFLFLSFLIVFFF-LHEENHSAQAKKVQQKKVWTMVPAKHVIIsLFVTTFIIQLANMSIQPIITLYVKNLEGPGT 245
Cdd:COG0738 167 YLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSLLKNPRLLL-GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 246 AhiemIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQ 325
Cdd:COG0738 246 A----TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446101467 326 TLLKQHTPTHvTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVS 396
Cdd:COG0738 322 SLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
21-388 |
1.33e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 71.48 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 21 GMSLVIPFLSFYIEELGvtgtSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVY 100
Cdd:cd17472 11 GMFLVLPVLSVYAKSLP----GATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 101 QLVALRFL--MGAVSgflSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSF 178
Cdd:cd17472 87 GLILGRALqgSGAIS---SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 179 LIVFFFLHEENHSAQAKKVQQKKVWTMVpAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHIEMIAGAVMSA 258
Cdd:cd17472 164 LILLFFVPDPPKIVQISEKEKKKLKKLL-KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 259 TGLAVIL--AAPKLGRLSDHIGpqktLVVALFAAGIIFIpQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHV 336
Cdd:cd17472 243 FILMVPFviYAEKKGKMKQVFV----SSILLIAVGFLLL-LFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEY 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446101467 337 TGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSL--LFIACIWVYF 388
Cdd:cd17472 318 RGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILalLWLLVSFLLP 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-386 |
4.57e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 69.96 E-value: 4.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMGAV-SGFLSTAMTFIAAET 127
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGyGSVQPGGGRAIMRWF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 128 PKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVP 207
Cdd:cd17475 114 PPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 208 AKHV--IISLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQK---- 281
Cdd:cd17475 194 VLRNrdVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA----AGALLAVAQLGGALGRIGLGRVSDRVFGGRrrpv 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 282 ----TLVVALFAAGIIFIPQAfvTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPV 357
Cdd:cd17475 270 lvitAAIAAAALLVLSLLSPG--TPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPP 347
|
330 340 350
....*....|....*....|....*....|
gi 446101467 358 L-GGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17475 348 LfGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-267 |
7.83e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 68.68 E-value: 7.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSA-----QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 85 GMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGM 163
Cdd:COG0477 88 LFGLASLLCGLAPSPELLIAARALQGiGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 164 RHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGP 243
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260
....*....|....*....|....
gi 446101467 244 GTAHIEMIAGAVMSATGLAVILAA 267
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLL 271
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
13-384 |
1.53e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 68.35 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 13 LGCFTTAAGMSLVIPFLSFYIEELGVtgtsSIAQwSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTL 92
Cdd:cd17478 3 LGHFLNDFYQGFLPALLPLLIAKLGL----SYAQ-AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 93 MGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGA 172
Cdd:cd17478 78 LGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 173 FLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNlEGPGTAHIEMIA 252
Cdd:cd17478 158 PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 253 GAVMSATGLAVILAapklGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILrFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17478 237 SLFLFAGAIGTLIG----GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446101467 333 PTHV---TGRIFGYNQSfqfLGNMIGPVLGGqIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17478 312 PGNVglaSGLMMGLSFG---LGGIGAPVLGA-LADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-386 |
3.20e-12 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 67.18 E-value: 3.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 25 VIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVA 104
Cdd:cd17370 18 ARSILPLFLVVLGASAA-----AVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 105 LRFLMGAVS-GFLSTAM-TFIAAETPKEHSGWAIS---TISTGGVSGSLLGPLLGGYLSELiGMRHVFLVTGAFLFLSFL 179
Cdd:cd17370 93 LLRILERLGkGIRTPPRdALLADATPPSGRGKAFGlhrALDTLGAVLGPLLAALLLYLLGG-NYRTIFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 180 IVFFFLHEENHSAQAKKVQQKKVWTMVPAKHVIISLFVttFIIQLANMSIqPIITLYVKNLEGPgtahiEMIAGAVMSAT 259
Cdd:cd17370 172 ILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAV--ALFALGNFSF-AFLILRAQELGLS-----AALIPLLYALF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 260 GLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGR 339
Cdd:cd17370 244 NLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGT 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446101467 340 IFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17370 324 AYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-367 |
4.09e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.30 E-value: 4.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGF 95
Cdd:cd17355 13 ILSWGIRYYFGVFIIPIIAEFGWSRA-----VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 96 VTDVYQLVALRFLMG--AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAF 173
Cdd:cd17355 88 ATSLWQLYLLWGLLGggGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 174 LFLSFLIVFFFLHEEN--HSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQ-LANMSIQPIITLYVKNLEGPGTAHIEm 250
Cdd:cd17355 168 ALLVLVPVLLLLRRRPadLALRAYDDASPASPGSTLKEALRSASFWLLALAFfLCGFAVVGLIVHLVPYLADRGISPAA- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 251 iAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLIL-RFLLGIAQAGLLPSVQTLLK 329
Cdd:cd17355 247 -AAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAA 325
|
330 340 350
....*....|....*....|....*....|....*...
gi 446101467 330 QHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG 367
Cdd:cd17355 326 RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
215-400 |
2.31e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 64.50 E-value: 2.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKnLEGPGTAhiemIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLE-REGVSTA----LIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGqIAAHAGFQyVFFS 374
Cdd:cd17477 76 LLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGAL-PFLI 153
|
170 180
....*....|....*....|....*.
gi 446101467 375 TSSLLFIACIWVYFHNKNEEVSEKQH 400
Cdd:cd17477 154 AAVLLLLALVPLLLTRRAAPEIEEAE 179
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
255-373 |
3.29e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 64.12 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 255 VMSATGLAVILAAPKLGRLSDHIGPQKTLV--VALFAAGIIFIpqAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17321 36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLigLALFGLASLLC--ALAPSLAFLIAARALQGIGAAAIMPASLALIAATF 113
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446101467 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17321 114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL 154
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
215-388 |
3.56e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.17 E-value: 3.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKNLEGPGTahieMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSA----SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHaGFQYVFFS 374
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLA 158
|
170
....*....|....
gi 446101467 375 TSSLLFIACIWVYF 388
Cdd:cd17329 159 AAVLFLLAALVLLF 172
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
215-392 |
4.36e-11 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 63.78 E-value: 4.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKNLEGPGTahiemIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPT-----VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 295 IPQAFVTSAWQLLILRFLLGIAQaGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAA-HAGFQYVFF 373
Cdd:cd17390 76 VLLGFSTSLALLFLSRIPLGIFK-HTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVAL 154
|
170
....*....|....*....
gi 446101467 374 STSSLLFIACIWVYFHNKN 392
Cdd:cd17390 155 LCSAIFILNAGLVWFLLSK 173
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
52-360 |
6.52e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.53 E-value: 6.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 52 FGVTFlmGAIVSpiwGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKE 130
Cdd:TIGR00895 63 IGMAF--GALFF---GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGlGLGGLMPNLNALVSEYAPKR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 131 HSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQ--KKVWTMVPA 208
Cdd:TIGR00895 138 FRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETvrRIVNAIAPQ 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 209 KHVIISLFVTTfiiqlaNMSIQPIITLYVKNLEGPGTAHIEMI--------------------------------AGAVM 256
Cdd:TIGR00895 218 MQAEAQSALPE------QKSTQGTKRSVFKALFQGKTARITVLlwllyfmllvgvyfltnwlpklmvelgfslslAATGG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 257 SATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHV 336
Cdd:TIGR00895 292 ALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAI 371
|
330 340
....*....|....*....|....
gi 446101467 337 TGRIFGYNQSFQFLGNMIGPVLGG 360
Cdd:TIGR00895 372 RATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
215-388 |
1.02e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.83 E-value: 1.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKNLEGPgtahiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLS-----ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAH--AGFQYVF 372
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVF 155
|
170
....*....|....*.
gi 446101467 373 FSTSSLLFIACIWVYF 388
Cdd:cd06174 156 LIAAALALLAAILLLL 171
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
21-388 |
1.98e-10 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 61.86 E-value: 1.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 21 GMSLVIPFLSFYIEELGvtGTSSIAQWSGLAFGVTFLMGaivSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVY 100
Cdd:cd17390 11 GVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFS---SPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 101 QLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELI-GMRHVFLVTGAFLFLSFL 179
Cdd:cd17390 86 LLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIFILNAG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 180 IVFFFLheenhsaqakkvqqKKVWtmvpakhviiSLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHIEMIAgAVMSAT 259
Cdd:cd17390 166 LVWFLL--------------SKLW----------DLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLI-SYSGVL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 260 GLAVILAAPKLGRLSDHIGpQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGR 339
Cdd:cd17390 221 GALSGFLVGRILKLYKNNE-YLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGT 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446101467 340 IFGYNQSFQFLGNMIGPVLGGQIAAHAGFqYVFFSTSSLLFIACIWVYF 388
Cdd:cd17390 300 LLGVGQSVTSLARILAPLLSGLLQEFSVS-GPGLLGAVLALAAILLMLA 347
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
215-388 |
2.15e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.44 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKNLEGPGtaHIEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLG--ASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 295 IPQAFVTSAWQLLILRFLLGIAqAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:cd17330 79 VLLGLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170
....*....|....
gi 446101467 375 TSSLLFIACIWVYF 388
Cdd:cd17330 158 AAALALLNLVLVLF 171
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
271-388 |
3.08e-10 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 61.03 E-value: 3.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 271 GRLSDHIGPQKTLVVALFAAGII--FIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQ 348
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLAtlLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446101467 349 FLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIAC-IWVYF 388
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWAlVWLIY 175
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
27-382 |
4.38e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 60.78 E-value: 4.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 27 PFLSFYIEELGVTgtSSIAQWSGLAFGVTFLMGAIVSPIwgklGDIHGRKLMLIRASLGMAVIMTL-MGFVTDVYQLVAL 105
Cdd:cd06180 20 PLLPLMLAELGLS--YAQAGWIATANYAGYLVGALLASF----LRRRGRARRLIRGGLLLTVLLLAaMALTSGFAALLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 106 RFLMGAVSGFLSTAMTFIAAE-TPKEHSGWAISTISTG-GVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFF 183
Cdd:cd06180 94 RFLAGAASAFVFVFGSNLVLHhATAAGRGHLIGLLFAGvGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 184 FLHEENHSAQAKKVQQKKVWTMVPAKHVIIS--LFVTTFIIqlanmsIQPIITLYVKNLEGPgtahiEMIAGAVMSATGL 261
Cdd:cd06180 174 LLRRGPSAPTEASAAESAPGLNRPLWRLALAygLFGFGYII------TATFLPLIARETGAG-----SLLAGLLWSLFGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 262 AVILAAPKLGRLSDHIGPQKTLVVALFAAGI-IFIPQAFVTSAWqLLILRFLLGIAQAGLLPSVQTLLKQHTPtHVTGRI 340
Cdd:cd06180 243 AAVPSCFLWGALSDRWGTRRALAANLLVQAVgVLLPLLSPGPAG-LVLSAVLFGGTFMAITALVMALARELAP-PAAPRA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446101467 341 FGYNQSFQFLGNMIGPVLGGQIAA-HAGFQYVFFSTSSLLFIA 382
Cdd:cd06180 321 LALMTASFGVGQILGPLLAGWLADaTGGFAPALILAAAALVVA 363
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
20-372 |
1.59e-09 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 59.18 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 20 AGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDV 99
Cdd:pfam12832 13 AALGCLLPYWGLYLRSIGLN-----PSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVLFIPI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 100 YQLVALRFLMGAVSGFLSTAMTFIA--------AETPKEHS--------GWAISTISTGGVsgsllgpllggylSELIGM 163
Cdd:pfam12832 88 SLTFWWLALLVVLFSFFWNAILPQFevatlqhlGEKRKDYGrqrlwgsvGFALSVFGLGAL-------------FDHYSV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 164 RHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKNLEGP 243
Cdd:pfam12832 155 GLLPSVLFYLFAALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGAS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 244 GTahiemIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF-IPQAFVTSAWQLLILRFLLGIAQAGLLP 322
Cdd:pfam12832 235 NT-----LLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWlLYAFFVENPWLVLPIQFLHAISFGLTHA 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446101467 323 SVQTLLKQHTPTHVTGRIFGYNQSFQF-LGNMIGPVLGGQIAAHAGFQYVF 372
Cdd:pfam12832 310 AAIEYVRRIFPGSLQGTGQALYSGLYFgLGGALGSLIGGQLWDLFGARFTF 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-372 |
1.31e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.18 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 11 CWLGCFTTAAGMSLVIPFLSFYIEELGVTgtSSIAQWSGLAFGVTFLMGAIVSpiwGKLGDIHGRKLMLIRASLGMAVIM 90
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLN--VADVSVIFSSQNAGYLIGSLLA---GFLMKRLGRRRTLILGLLLISLAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 91 TLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTI-STGGVSGSLLGPLLGGYLSELIGMRHVFLV 169
Cdd:cd17333 76 ALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLhGFFGLGALIGPLIATSLLTSELSWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 170 TGAFLFLSFLIVFFFLHEEN-HSAQAKKVQQKKVWTMVPAKH--VIISLFVTTFIIQLANMSIQPIITLYVKNLEGPGta 246
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELpSARNPQQSVGAFSASASRLLRnpSIILGALALFLYVGAETAFSSWVPSYLVEKKHVS-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 247 hiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQT 326
Cdd:cd17333 234 --DGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILS 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446101467 327 LLKQHTPTHvTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVF 372
Cdd:cd17333 312 LGISNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAM 356
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-187 |
1.44e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.03 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 7 NLMICWLGCFTTAAGMSLVIPFL-SFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGR--KLMLIRAS 83
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLpTYLVEVRGLSLAQA-----GLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 84 LGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAE-TPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIG 162
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAElFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
170 180
....*....|....*....|....*
gi 446101467 163 MRHVFLVTGAFLFLSFLIVFFFLHE 187
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-382 |
3.26e-08 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 55.11 E-value: 3.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSgLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGF 95
Cdd:cd17314 9 FLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIA-TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 96 VTDVYQLV-ALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFL 174
Cdd:cd17314 88 VFNSFPLSyACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 175 F--LSFLIVFFFLHEENHSAQAKKVQQKKVWTMVPAKHVIIS-LFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHIEMI 251
Cdd:cd17314 168 AivLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWiLFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 252 agavMSATGLAVILAAPKLGRLSD-HIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRF--LLGIAQAGLLPSVQTLL 328
Cdd:cd17314 248 ----MSIYGLFNAFGRLLWGIVADfFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTgsLLGFSYGGLFTVYPATV 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446101467 329 KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQI-AAHAGFQYVFFSTSSLLFIA 382
Cdd:cd17314 324 STVFGTESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVYIYAVIVFLA 378
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
60-355 |
3.55e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.89 E-value: 3.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 60 AIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFL-STAMTFIAAETPKEHSGWAIST 138
Cdd:cd17503 45 AIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLiPLAQTILLRIYPPEKRGAAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 139 ISTGGVSGSLLGPLLGGYLSELIGMRHVFLV-----TGAFLFLSFLIVFFFLHeenhsaqakkvqqkkvwtmvpakHVII 213
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpigILALLLAPLLDLRLFKD-----------------------RNFT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 214 SLFVTTFIIQLANMSIQPIITLYVKNLEGPGTahieMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII 293
Cdd:cd17503 182 LGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA----FESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446101467 294 FIPQAFV---TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIG 355
Cdd:cd17503 258 TLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIG 322
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
5-381 |
4.64e-08 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 54.55 E-value: 4.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEG-----AFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 85 GMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGM 163
Cdd:PRK12307 92 AYSVGTGLSGLASGVIMLTLSRFIVGmGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 164 RHVFLVTgaflFLSFLIVFF---------------FLHEENHSAQAKKVQQKKVWTMVPAKHVIISL--FVTTFIIQLAN 226
Cdd:PRK12307 172 RAAFFVG----LLPVLLVIYirarapeskeweeakLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLcvFIVLFSIFGAN 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 227 MSIQPIITLYVKNlEGPGTAhiemIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQL 306
Cdd:PRK12307 248 WPIFGLLPTYLAG-EGFDTG----VVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 307 LILRFLLG-----IAQAGLLPSvqtLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG------FQYVFFST 375
Cdd:PRK12307 323 LLGACLFGlmatnVGVGGLVPK---FLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGlgaaltFIVAFWTA 399
|
....*.
gi 446101467 376 SSLLFI 381
Cdd:PRK12307 400 TILLII 405
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
252-372 |
5.52e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.28 E-value: 5.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446101467 332 TPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVF 372
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-373 |
2.12e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.20 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAET 127
Cdd:cd17365 37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGlGLGAAMPNAITLVSEYA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 128 PKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFfflheenhsaqakkvqqkkvwtmvp 207
Cdd:cd17365 117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 208 akhVIISLFVTTFIIQLanmSIQPIITLYVKNLEGPGTAHIEmiAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVAL 287
Cdd:cd17365 172 ---GTLLLWVTFFMGLL---LVYLLNSWLPKLMVEAGYSLSQ--ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 288 FAAGI-IFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQ-IAAH 365
Cdd:cd17365 244 ALGAVsLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAAG 323
|
....*...
gi 446101467 366 AGFQYVFF 373
Cdd:cd17365 324 LGPESVFL 331
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
16-367 |
2.93e-07 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 51.84 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSiAQWsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMT-LMG 94
Cdd:cd17482 11 FATTVTTAVFPVYFKAVAAQGASPVTST-ALW-GYANSIASLVIALLAPILGAIADYSGRKKRFLAFFCLIGVVSTaLLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 95 FVTDVYQLVALRFLMGAVSGFlSTAMTFIAAETPKEHS----------GWAISTISTG---GVSGSLLGPLLGGYLSELI 161
Cdd:cd17482 89 FVTPGQWLLALLLFILANIGF-SGANVFYDAFLPDVASpermdrvsslGYALGYIGGGllfAVNLVLILGPDAFGLDTAE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 162 GMRHVFLVTGA--FLF-------LSFLIVFFFLheenhsaqakkvqqkkvwtmvpakhviislfvttfiiqlaNMSIQPI 232
Cdd:cd17482 168 AVRLSFLSVALwwALFsiplkqlLLFLIAYFFY----------------------------------------IDGVQTI 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 233 ITL---YVKNLEGPGTAhiEMIAGAVMsaTGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLIL 309
Cdd:cd17482 208 IRMatiYGAEEGKLGSS--ALILALLL--TQFVAFPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWIL 283
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446101467 310 RFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG 367
Cdd:cd17482 284 AALIGLVQGGIQALSRSLFGRLIPKGKSAEFFGFYNISGKFAAIIGPLLFGLITQLTG 341
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
242-388 |
4.13e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 51.42 E-value: 4.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 242 GPGTAHIEMIAGAVMSATGLAVILAapklGRLSDHIGPQKTLVV--ALFAAGIIFIpqAFVTSAWQLLILRFLLGIAQAG 319
Cdd:cd17320 30 GASASAVQLTLSAYLLGFALGQLLY----GPLSDRFGRRPVLLAglLLFILASLLC--ALASSIEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446101467 320 LLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL 172
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
49-316 |
5.62e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.10 E-value: 5.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 49 GLAFGVTFLMGAIVSPIWGKLGDIHG-RKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAET 127
Cdd:cd17341 37 GLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 128 PKEHSGWAISTISTGGVS-------GSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQK 200
Cdd:cd17341 117 PKEKIGGAAGGIAGAGNMgvavsqlLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLK 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 201 KVWTMVPAKHVIIsLFVTTFIIQLANMSIQPIITLYVKNLEGPGTAHiemiAGAVMSATGLAVILAAPKLGRLSDHIGPQ 280
Cdd:cd17341 197 VQLAVLKNYRTWI-LSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVT----AGILAALFPLAGALARPAGGWLSDRFGGR 271
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446101467 281 KTL-----VVALFAAGIIFIPQAFVTSAWQLLILRFLLGIA 316
Cdd:cd17341 272 RRLwwlfiVMTIGAALLSLSLPTSGTNLVLFLALFVALGLG 312
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
252-373 |
7.07e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.66 E-value: 7.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:cd17365 36 LGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEY 115
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 446101467 332 TPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17365 116 APARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL 157
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-369 |
7.90e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.76 E-value: 7.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 28 FLSFYIEELGVTGTSSiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRF 107
Cdd:cd17371 17 LLGLVLPALIAEFGLD-EAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 108 LMGAVSGFLSTAMTFIAAET-PKEHSGWAISTI----STGGVSGSLLGPLLGGYLSELIGMRHVFLVtGAFLFLSFLIVF 182
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYvPARHRGKALGYVqsgwAVGWLLATLLAALLFPLLPPEIAWRVLFLL-GALPALLVLFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 183 FFLHEENHSAQAKKVQQK-----KVWTMVPAKHVIISLFVTTFII--QLANMSIQPIITLYVKnlegpGTAHIEMI-AGA 254
Cdd:cd17371 175 RFVKEPPQWQAARAARRHfadrpSLRELFSPPLLRTTLLASLLATgaLGGYYGITTWLPSYLT-----GERGLSFEgSAG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 255 VMSATGLAVILAAPKLGRLSDHIGpQKTLVVALFAAGIIFIPQAFV--TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17371 250 YLVVTILGGFLGYLAGGFLADRIG-RRNNFALFALGSAISILLYFFlpLSPTLILILGFPLGFFASGPFSGMGAYLTELF 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 446101467 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQ 369
Cdd:cd17371 329 PTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLG 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
277-389 |
1.48e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.94 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 277 IGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH-TPTHVTGRIfgynqSFQFLGNMIG 355
Cdd:cd17327 68 FPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWyKREEQAKRI-----AFFYAAAGLG 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 446101467 356 PVLGGQIAAH----------AGFQYVFFSTSSLLFIACIWVYFH 389
Cdd:cd17327 143 SIFGGLLAYGvfkilgvgglAGWRWLFIIEGLITIIIGLVIFFW 186
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
271-385 |
2.13e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.30 E-value: 2.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 271 GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFG-YNQSFQF 349
Cdd:TIGR00881 51 GSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSfWNCSHNV 130
|
90 100 110
....*....|....*....|....*....|....*.
gi 446101467 350 LGNMIGPVLGGQIAAHAGFQYVFFSTSsllFIACIW 385
Cdd:TIGR00881 131 GGGLLPPLVLFGIAELYSWHWVFIVPG---IIAIIV 163
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
211-388 |
2.34e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 49.11 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 211 VIISLfvTTFIIQLANMSIQPIITLYVKNLegpGTAHIEMIAGAVMSATGLAV--ILAAPklgrLSDHIGPQKTLVVALF 288
Cdd:cd17323 2 FIISF--LTFVVTFGSSIYSPALPQIAEDF---HVSEEVANLGVSLFVLGFGLgpLIWAP----LSELYGRRPVYLVSLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 289 AAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGF 368
Cdd:cd17323 73 IFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152
|
170 180
....*....|....*....|
gi 446101467 369 QYVFFSTSSLLFIACIWVYF 388
Cdd:cd17323 153 RWIFWFLAIISGFCLILIFL 172
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
50-363 |
2.43e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 49.45 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 50 LAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQ--------LVALRFLMG-AVSGFLSTAM 120
Cdd:cd17369 48 ATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGlALGGEWGGAV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 121 TFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELI--------GMRHVFLVtGAFLFLSFLIVFFFLHEENHSA 192
Cdd:cd17369 128 LMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLsdeaflswGWRIPFLL-SAVLVAVGLYIRLRLEETPVFR 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 193 QAKKVQQKKVwtmVPAKHVIISL---FVTTFIIQLANMSIQPIITLYVKNLegpGTAHIEMIAGAVMSATGLAVILAA-- 267
Cdd:cd17369 207 RAKEAGQVVR---APLVEVLRRHwraLLLAIGLRLAENVLFYLFTTFALSY---ATQTLGVDRSTVLLAVLIASVVAAit 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 268 -PKLGRLSDHIGPQKTLVVALFAAGIIFIP--QAFVTSAWQLLILRFL--LGIAQAGLLPSVQTLLKQHTPTHV--TGRI 340
Cdd:cd17369 281 iPLFGWLSDRVGRRPVYLAGALLAALFAFPffWLLDTGSTWLIVLAAVvvLGVLHGMMYGPQAAFLAELFPTRVryTGAS 360
|
330 340
....*....|....*....|...
gi 446101467 341 FGYNqsfqflgnmIGPVLGGQIA 363
Cdd:cd17369 361 LGYQ---------LGAILGGGFA 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-142 |
3.09e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 3 SWKRNLMICWLGCFTTAAGMSLVIpFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRA 82
Cdd:cd17473 195 PWKRVLPIYFLAFLAMLLFYVIPI-QLPFLLQERGGGSAALI----GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446101467 83 SLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFL-STAMTFIAAETPKEHSGWAISTISTG 142
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLlPTLNSWAMSLVPPELRGRAMGIVTSA 330
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-184 |
4.45e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 4.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 8 LMICWLGCFTTAAGMSLVIPFLSFYIEelgvtGTSSIAQWSGLAFGVTFLMGAIVSpiwGKLGDIHGRKLMLIRASLGMA 87
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLG-----GGAAGYGLLLAAFGVGALLGALLL---GRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 88 VIMTLMGFVTDVYQLVALRFLMGAVSG-FLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHV 166
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGlFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*...
gi 446101467 167 FLVTGAFLFLSFLIVFFF 184
Cdd:cd06173 366 FLLAGALLLLAALLLLLL 383
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
67-388 |
6.01e-06 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 48.21 E-value: 6.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 67 GKLGDIHG-RKLMLIRASLGMAVIMTLMGFV----TDVYQLVALRFLMGAVSGFLSTAMTFIAAE-TPKEHSGWAISTIS 140
Cdd:pfam05977 66 GALADNFDrRKIMLAGQLLLALVSTLLTLLAglglLSPWLLLGLTFLGGIGTALMDPAWQASVPElVPRRDLPAAVALNS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 141 TGGVSGSLLGPLLGGYLSELIGMRHVFlvtgAFLFLSFLIVFFFLHEENHSAQAKKVQQKKV-------WTMVPAKHVII 213
Cdd:pfam05977 146 VGYNIARSVGPALGGVLLAAFGPAFTF----ALNALSYFAVIAALWRWKRAAPASPLPRERIfgavragLRFTAMSRELR 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 214 SLFVTTFIIQLANMSIQPIITLYVKNLEGPGTahieMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII 293
Cdd:pfam05977 222 SVLVRAFAFGLSASAVWALLPLVARDLLDGDA----IFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALV 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 294 FIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:pfam05977 298 LLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALL 377
|
330
....*....|....*
gi 446101467 374 STSSLLFIACIWVYF 388
Cdd:pfam05977 378 GAAAALLAGAAAGLR 392
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-382 |
8.40e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.60 E-value: 8.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 48 SGLAFGVTFLMGAIVSPIWGKLGDIHG-RKLMLIrASLGMAVIMTLMGFVTdvyQLVALRFLMGAVSGF---------LS 117
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGpRKAILI-GGILFGLGFILSAFAI---SLPLLFLGYGVLGGIgagigyitpVS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 118 TAMTFIaaetpKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKV 197
Cdd:cd17353 116 TAVKWF-----PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 198 QQKKVWTMVPAKHVIIS----------LFVTTFIIQLANMSIQPIITLYVKNLEGPGTahieMIAGAVMSATGLAVILAA 267
Cdd:cd17353 191 DPLANNAENSPRDYTPRemlrtptfwlLWLMFFLNATAGLMLIGQAKPIGQEFAGLDA----GIAALAVSILSIFNGGGR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 268 PKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTS-AWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQS 346
Cdd:cd17353 267 PFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYT 346
|
330 340 350
....*....|....*....|....*....|....*.
gi 446101467 347 FQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIA 382
Cdd:cd17353 347 AKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVA 382
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
8-185 |
1.33e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 46.80 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 8 LMICWLGCFTTAAGmSLVIPFLSFYIEELGVTGTSSIaqwsgLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIrASLGMA 87
Cdd:cd17323 2 FIISFLTFVVTFGS-SIYSPALPQIAEDFHVSEEVAN-----LGVSLFVLGFGLGPLIWAPLSELYGRRPVYL-VSLFIF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 88 VIMTL-MGFVTDVYQLVALRFLMGAV-SGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRH 165
Cdd:cd17323 75 VIFQIgCALAPNIAMLIILRFLQGFFgSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRW 154
|
170 180
....*....|....*....|
gi 446101467 166 VFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17323 155 IFWFLAIISGFCLILIFLFL 174
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
271-388 |
1.43e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.88 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 271 GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQ-AGLLPSVQTLLKQHTPTHvTGRIFGYNQSFQF 349
Cdd:cd17312 59 GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQsMGWPPCVKLLGNWFSKKE-RGTVYGIWSTSHN 137
|
90 100 110
....*....|....*....|....*....|....*....
gi 446101467 350 LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17312 138 FGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFF 176
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
249-388 |
1.47e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.84 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 249 EMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII--FIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQT 326
Cdd:cd17318 55 EKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLtlLTPLAARGGYGALIVLRILQGLAQGVTFPAMHA 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446101467 327 LLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI-WVYF 388
Cdd:cd17318 135 LWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLlWFFL 197
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-184 |
1.51e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.79 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 25 VIPFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGD--IHGRKLMLIrASLGMAVIMTLMGFVTDVYQL 102
Cdd:cd17474 217 FLTYLPFLLELLYGISPIII----GLLFAGWSVLLALGSLFVGRLLKkrFGARRILVI-GLLLYALSLLLLGFVPSLALL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 103 VALRFLMGAVSG-FLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIV 181
Cdd:cd17474 292 LIAIVLFGLGLGlNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
...
gi 446101467 182 FFF 184
Cdd:cd17474 372 ALL 374
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
57-295 |
1.65e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 46.53 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 57 LMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVY-QLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWA 135
Cdd:TIGR00886 48 LAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYsVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 136 ISTISTGG-----------VSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHE----ENHSAQAKKVQQK 200
Cdd:TIGR00886 128 LGLAAGWGnmgggvaqfvmPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPALLIFFVGADtppgKPATGKLSFKEAL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 201 KVW----TMVPAKhviisLFVTTFIIQLAnmsIQPIITLYVKNLEGPGTAHiemiAGAVMSATGLAVILAAPKLGRLSDH 276
Cdd:TIGR00886 208 KVFgnrhTWILAL-----LYSVTFGSFLG---VSSIFAMLFKDQFGLSKVQ----AGAYASLGGFLGSLARPAGGAISDR 275
|
250 260
....*....|....*....|
gi 446101467 277 IG-PQKTLVVALFAAGIIFI 295
Cdd:TIGR00886 276 LGgARKLLMNFLGVAMGAFL 295
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-185 |
1.78e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 13 LGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTL 92
Cdd:cd17489 201 LILFLASIAYGAISTFLPLYAAERGISNA-------GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 93 MGFVTDVYQLVALRFLMGAVSGFLSTAMTFIA-AETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTG 171
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
170
....*....|....
gi 446101467 172 AFLFLSFLIVFFFL 185
Cdd:cd17489 354 VVVLLALVLYIFLL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
255-373 |
2.60e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 255 VMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPT 334
Cdd:cd17503 36 VITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPP 115
|
90 100 110
....*....|....*....|....*....|....*....
gi 446101467 335 HVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17503 116 EKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFY 154
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
265-367 |
3.26e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.69 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 265 LAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYn 344
Cdd:cd17328 49 VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGV- 127
|
90 100
....*....|....*....|....*.
gi 446101467 345 qsFQF---LGNMIGPVLGGQIAAHAG 367
Cdd:cd17328 128 --FYFaipLGSGLGYVVGGLVAQATG 151
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
215-388 |
3.50e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 3.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 215 LFVTTFIIQLANMSIQPIITLYVKNLEGpGTAhieMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVV--ALFAAGi 292
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPG-ATP---TLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFglLLFIAG- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 293 iFIPQAFVTSAWQLLILRFLLGiaqAGLLPSV-QTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYV 371
Cdd:cd17472 76 -SLLAAYATSIYGLILGRALQG---SGAISSVvMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGL 151
|
170
....*....|....*..
gi 446101467 372 FFSTSSLLFIACIWVYF 388
Cdd:cd17472 152 FLITAILSLVSLLILLF 168
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
52-139 |
3.89e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.78 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 52 FGVTFLMGaivSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKE 130
Cdd:TIGR00898 136 FFVGVLLG---SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGmGIGGIWVQAVVLNTEFLPKK 212
|
....*....
gi 446101467 131 HSGWAISTI 139
Cdd:TIGR00898 213 QRAIVGTLI 221
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
82-388 |
4.50e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 45.69 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 82 ASLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTA-MTFIAAETPKEHSGWA--------ISTISTGGVSGSLLGPL 152
Cdd:PRK08633 86 FEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAkYGIIPELVGKENLSRAnglleaftIVAILAGTALFSFLFES 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 153 LGGYLSELIGMRHvfLVTGAFLF-LSFLIVFFFLHEENHSAQAKKVQQKKVW--------TMVPAKH------VIISLFV 217
Cdd:PRK08633 166 VNGNTPSEILGRI--APAGLVLLaVAVLGLIFAYRLPKVPAAAPEVFDKKKYlfpkllwrNLKLLRSdrvlwlAIIGLSY 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 218 TTFIIQLANMSIQPIITLYVKNLEgpgtahiEMIAGAVMSATGLAVILAAPKLGRLS-DHIgpqKTLVVALFAAGI---I 293
Cdd:PRK08633 244 FWFISQLAQANFPAYAKEVLGLDN-------TFQVQYLLAASAIGIGIGSLLAGRLSgRHI---ELGLVPLGALGLalsL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 294 FIPQAFVTSAWQLLILrFLLGIAqAGL--LPsVQTLLKQHTPTHVTGRIFGYNQSFQFLGnMIGPVLGGQIAAHAGF--Q 369
Cdd:PRK08633 314 FLLPTAPSLASVLVLF-FLFGFS-AGLfiVP-LNALIQFRAPEKELGKVLAANNFLQNVG-MLLFLALTTLFSGLGLspA 389
|
330
....*....|....*....
gi 446101467 370 YVFFSTSSLLFIACIWVYF 388
Cdd:PRK08633 390 GLFYLIALVTLIGTLYTLL 408
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
212-387 |
4.98e-05 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 45.26 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 212 IISLFVTTFIIQLA-NMSIqPIITLYVKNLEGPGTahieMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAA 290
Cdd:PRK05122 17 IVSIVMFTFISYLTiGLPL-AVLPGYVHDQLGFSA----FLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGC 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 291 GI--IFIPQAFVTSAWQLLIL------RFLLGIAQ-----AGLLPSVQTLLKQHtpthvTGRIFGYNQSFQFLGNMIGPV 357
Cdd:PRK05122 92 ALsgLLYLLAGLLAAWPVLSLlllllgRLLLGIGEslagtGSILWGIGRVGALH-----TGRVISWNGIATYGALAIGAP 166
|
170 180 190
....*....|....*....|....*....|
gi 446101467 358 LGGQIAAHAGFQYVFFSTSSLLFIACIWVY 387
Cdd:PRK05122 167 LGVLLYHWGGLAGLGLLIMLLALLGLLLAR 196
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
256-388 |
5.64e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.07 E-value: 5.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 256 MSATGLAVILAAPKL--GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTP 333
Cdd:TIGR00710 44 MTLTLYLLGFAAGQLlwGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYP 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446101467 334 THVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:TIGR00710 124 GEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFF 178
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
253-373 |
7.04e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.57 E-value: 7.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 253 GAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAV 132
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446101467 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:PRK11551 133 GPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFY 173
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
16-320 |
7.40e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 44.54 E-value: 7.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLsfyiEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGD-----IHGRKLMLIRASLGMAVIM 90
Cdd:cd17313 13 FGWALENSYVPPIL----QTLGLS-----HALIGFVWTLGPILGLFVQPLVGSLSDrcnsrIGRRRPFILVGAPLAALGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 91 TLMGFVTDV-------YQLVALRFLMGAV-------SGFLSTAMTFIAAETPKEHSGWAISTIS--------TGGVSGSL 148
Cdd:cd17313 84 ILIPNAADIglalgdgPRTWALVLFVLGIvlldfamNVCQGPVRALLPDLVPPEQRSKANGIINfmgglggvLGYLLGAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 149 LGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQA-KKVQQKKVWTMVPAKHVIIS--------LFVTT 219
Cdd:cd17313 164 LWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAgEHSENPSLGEVLKSLLKLLKimprsllrLLLVI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 220 FIIQLANMSIQPIITLYVKN--LEGPGTAHIEMIAGAVMSATGLAV-----ILAAPKLGRLSDHIGPQKTLVVALFAAGI 292
Cdd:cd17313 244 FFWWIAFFPFELFFTDYMGEevYHGTSAASSHYGAGVRMGAWGLLIfslafLIFSLPIGKLGKKIGRKKVYLIGLVLFAV 323
|
330 340
....*....|....*....|....*...
gi 446101467 293 IFIPQAFVTSAWQLLILRFLLGIAQAGL 320
Cdd:cd17313 324 GMALMALVHNVTVALVLFALGGIGWATI 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-201 |
9.93e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 9.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 6 RNLMICWLGCFTTAAGMSLVIPFLSFYIEE-LGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLS-----AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 85 GMAVIMTLMGFV--TDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHS---------------------GWAISTIST 141
Cdd:COG2211 303 LAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrreglyfgiftfaiklGQALAGALA 382
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446101467 142 GGVSGSLLGPLLGGYLSELI-GMRHVF-LVTGAFLFLSFLIVFFF-LHEENHSAQAKKVQQKK 201
Cdd:COG2211 383 GLLLALFGYVAGAAQSPSALtGIRLLFfLLPAVLLLLAALLLLFYpLTRERHAEIRAELAARR 445
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-194 |
1.17e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.10 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLS-----AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 85 GMAVIMTLMGFVT-DVYQLVALRFLMGAVSGFLSTAM-TFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIG 162
Cdd:COG2223 280 LMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
170 180 190
....*....|....*....|....*....|...
gi 446101467 163 -MRHVFLVTGAFLFLSFLIVFFFLHEENHSAQA 194
Cdd:COG2223 360 sYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-316 |
1.39e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.72 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTgtSSIAQWSglaFGVTFLMGAIVSPIWGKLGDIHGRKLMLIrASLGMAVIMTL-MG 94
Cdd:cd17320 9 ALGPLAIDMYLPALPAIARDLGAS--ASAVQLT---LSAYLLGFALGQLLYGPLSDRFGRRPVLL-AGLLLFILASLlCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 95 FVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAF 173
Cdd:cd17320 83 LASSIEQLLIARFLQGlGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 174 LFLSFLIVFFFLhEENHSAQAKKVQQKKVW----TMVPAKHVIISLFVTTFIIQ--LANMSIQPIItlYVKNLEGPGTAH 247
Cdd:cd17320 163 GLLLLLLVLLFL-PETLPEEKRKPLLSSLLraykRVLKNRRFLGYALALGLSFAglFAYLAAAPFI--YIEQLGLSPAQF 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446101467 248 iemiaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIA 316
Cdd:cd17320 240 -----GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLF 303
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
6-182 |
2.28e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.92 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 6 RNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLG 85
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI----IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 86 MAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRH 165
Cdd:cd17324 274 AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAG 353
|
170
....*....|....*..
gi 446101467 166 VFLVTGAFLFLSFLIVF 182
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
49-204 |
2.32e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 49 GLAFGVTFlmgAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAET 127
Cdd:cd17328 40 QTVFIISY---MVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGiGEASYSPIAPTIIADLF 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446101467 128 PKEHSGWAISTISTGG-VSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWT 204
Cdd:cd17328 117 PKEKRTRALGVFYFAIpLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTAT 194
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
257-373 |
2.81e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.55 E-value: 2.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 257 SATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHV 336
Cdd:cd17502 37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110
....*....|....*....|....*....|....*..
gi 446101467 337 TGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY 153
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
16-384 |
2.88e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 42.59 E-value: 2.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGF 95
Cdd:cd17385 9 FSSMICYSILAPFFPREAEKKGVSDTII-----GLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 96 VTDV---YQLVALRFLMGAV-----SGFLSTAMTFIAAETPkEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVF 167
Cdd:cd17385 84 LDRVpdgTVFIALCFLVRIVeavgfAAFITASFAIIAKEFP-NNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 168 LVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKKVWTmvpakhvIISLFVTTFIIQLANMSI---QPIITLYVKNLEGPG 244
Cdd:cd17385 163 LVLGCLLLLTVPLNMFILPRYDDDPSPKSGSMLKLLK-------IPSVLLLCLSIVSGSVSLgflDPTLSPHLRQFKLSP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 245 TahiemIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVV---ALFAAGIIFI-PQAFV---TSAWQLLILRFLLGIA- 316
Cdd:cd17385 236 G-----QVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLMVigsIITGVGFLLLgPAPLLpikSELWMVIIGLVLLGLSl 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446101467 317 QAGLLPSVQTLL----KQHTPT--HVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17385 311 GAALVPTFPELLncarEYGFPDnlSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGI 384
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
271-374 |
3.05e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.57 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 271 GRLSDHIGPQKTLVV--ALFAAGIIFIpqAFVTSAWQLLILRFL--LGIAQAGLlpSVQTLLKQHTPTHVTGRIFGYNQS 346
Cdd:PRK11043 62 GPLSDRYGRKPVLLAglSLFALGSLGM--LWVESAAQLLVLRFVqaVGVCSAAV--IWQALVIDRYPAQKANRVFATIMP 137
|
90 100
....*....|....*....|....*...
gi 446101467 347 FQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:PRK11043 138 LVALSPALAPLLGAWLLNHFGWQAIFAT 165
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
10-186 |
4.77e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.23 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 10 ICWLGCFTTAAGMSLVIPFLSFYIEELGvtgTSSIAQWSGLAFGVTflmGAIVSPIWGKLGDIHGRKLMLIRASLGMAVI 89
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG---PSSNSTWISTAWSLA---QAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 90 MTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSE--LIGMRHVF 167
Cdd:cd06179 76 SIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIF 155
|
170
....*....|....*....
gi 446101467 168 LVTGAFLFLSFLIVFFFLH 186
Cdd:cd06179 156 YINAIFNALALILLFFFYH 174
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
210-388 |
4.78e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.82 E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 210 HVIISLFVTTFIIQlanmsiQPIITLYVKNLEGPGTAHiemiaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFA 289
Cdd:cd17331 6 HLNIVLYATCYWLQ------QPVLPYLTKKLGVDSVVF-----GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 290 AGIIFIPQAFVTSAWqLLILRFLLGIAQAGLlPSVQTLLKQHTPTHVTGRIFGY-NQSFQfLGNMIGPVLGGQIAAHAGF 368
Cdd:cd17331 75 SALSYLLLAFASSVP-MLFLSRLPSVFMHAM-QAAQMVVTDLTDPGERAAALGRlGLSYG-IGMVVGSFLGGLLTKKFGE 151
|
170 180
....*....|....*....|
gi 446101467 369 QYVFFSTSSLLFIACIWVYF 388
Cdd:cd17331 152 QAAALVAAVGSLLSIVLVIL 171
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
49-384 |
5.56e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.87 E-value: 5.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 49 GLAFGV-TF--LMGAIVSpiwGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAA 125
Cdd:PRK11551 53 GWAFSAgILglLPGALLG---GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTS 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 126 ET-PKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQKK--- 201
Cdd:PRK11551 130 EAvGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRapv 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 202 VWTMVPAKHVI------ISLFVTTFIIQLAnMSIQPIITLyvknleGPGTAHIEmiAGAVMSATGLAVILAAPKLGRLSD 275
Cdd:PRK11551 210 LRALFGEGRATatlllwISYFFTLIVLYFL-LNWLPSLLV------GQGLSRSQ--AGLVQIAFNIGGALGSLLIGALMD 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 276 HIGPqkTLVVALFAAGIIF--IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNM 353
Cdd:PRK11551 281 RLRP--RRVVLLIYAGILAslAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSM 358
|
330 340 350
....*....|....*....|....*....|..
gi 446101467 354 IGPVLGGQ-IAAHAGFQYVFFSTSSLLFIACI 384
Cdd:PRK11551 359 AGPLLAGQlLALGRSTVGVIGASIPVILVAAL 390
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
213-381 |
6.83e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.61 E-value: 6.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 213 ISLFVTTFIIQLANMSIQPIITLYVKNLEG--PGTAHIEMIAGAVMSATGLAVIlaapklGRLSDHIGPQKTLVVALFAA 290
Cdd:PRK03893 278 VMLMVVVLFAFLYSWPIQALLPTYLKTDLGydPHTVANVLFFSGFGAAVGCCVG------GFLGDWLGTRKAYVCSLLIS 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 291 GIIFIPQAFVTSA-----WQLLILRFLLGIAQAGLLPSvqtLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAH 365
Cdd:PRK03893 352 QLLIIPVFAIGGAnvwvlGLLLFFQQMLGQGISGLLPK---LIGGYFDTEQRAAGLGFTYNVGALGGALAPILGALIAQR 428
|
170
....*....|....*..
gi 446101467 366 AGFQYVFFSTS-SLLFI 381
Cdd:PRK03893 429 LDLGTALASLSfSLTFV 445
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
271-388 |
7.94e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.09 E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 271 GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLL-KQHTPTHVTGRIFGYNQSFQF 349
Cdd:cd17476 54 GRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLgRTYPPGPRKNIVFSLFGATAP 133
|
90 100 110
....*....|....*....|....*....|....*....
gi 446101467 350 LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17476 134 LGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIF 172
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
49-388 |
9.82e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 41.02 E-value: 9.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTA-MTFIAAET 127
Cdd:cd17384 34 GLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAgMGMLASLY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 128 PKEHSGWAISTISTGGVSGSLLG-PLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQQkkVWTMV 206
Cdd:cd17384 114 PDDKERGKAMGIALGGLALGVLVgPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTP--WKTLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 207 PAKHVIIslfvTTFIIQLANMSI---QPIITLY-VKNLEGP----GTAHIEMIAGAVMSATGLAVIlaAPKLGRLsdhig 278
Cdd:cd17384 192 KDPYILI----AAGAICFSNSGIailEPCLPIWmMETMCPPkwqlGTAFLPDSIGYLIGTNLFGPL--AHKIGRW----- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 279 pqKTLVVALFAAGI--IFIPqaFVTSAWQLLILRFLLGIA----QAGLLPSVQTLLKQHTpTHVTGRIFGYNQSFQFLGN 352
Cdd:cd17384 261 --LCSLLGMLLVGIslILIP--LAKNIYGLIIPHFGLGLGigmvDSSMMPLLAYLVDLRH-SSVYGSVYAIADVAFCLAF 335
|
330 340 350
....*....|....*....|....*....|....*.
gi 446101467 353 MIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17384 336 ALGPSLGGAIVKSIGFPWLMRIIGIINILYAPLLFF 371
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-187 |
1.82e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.40 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 57 LMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGFVTDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSGWA 135
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGfGAAFALVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 446101467 136 ISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHE 187
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
9-185 |
2.80e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 9 MICWLGCFTTAA---GMSLVIPFLSfyiEELGVTGTssiaqWSGLAFGvTFLMGAIVSPIW-GKLGDIHGRKLMLIRASL 84
Cdd:cd17380 2 ILLFLATCICYAdrvNMPIAIVPMA---KEFGWSKT-----DQGLVLS-SFFWGYALTQVLgGYLADRFGGKKVLLLAVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 85 --GMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAET-PKEHSGWAISTISTGGVSGSLLGPLLGGYLSELI 161
Cdd:cd17380 73 lwSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWvPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY 152
|
170 180
....*....|....*....|....
gi 446101467 162 GMRHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17380 153 GWPSVFYFFGLLGLLWALVWLIYL 176
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
200-321 |
3.27e-03 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 39.27 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 200 KKVWTMVPAKHVIISLFVTTFIIQLANMSIQ---PIITLYVKNLEGPGTAHIEMIAGAVMSATGLAVILAapklGRLSDH 276
Cdd:PRK12382 2 TAVSQTETRSSANFSLFRIAFAVFLTYMTVGlplPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYA----GRLADQ 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446101467 277 IGPQKTLVVALFAAGI--------IFIPQAFVTSAWQLLILRFLLGIAQAGLL 321
Cdd:PRK12382 78 YGAKRSALQGMLACGLaglayllaAILPVSAPFKFALLVVGRLILGFGESQLL 130
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
162-369 |
4.42e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.13 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 162 GMRHVFLVTGAFLFLSFLIVFFFLHEEN--HSAQAKKVQQKKVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVKN 239
Cdd:cd17332 171 GYFLTALIIGIIGIILLLICFFGTRERVvpPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKY 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 240 LEGPgtahiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVT--SAWQLLILRFLLGIAQ 317
Cdd:cd17332 251 VLGG-----RAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGY 325
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446101467 318 AG-------LLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQ 369
Cdd:cd17332 326 GGanllpwaMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYV 384
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
261-386 |
4.49e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 4.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 261 LAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRI 340
Cdd:cd17317 36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFV 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446101467 341 FGYNQSFQFLGNMIGPVLGGQIaAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17317 116 GILFGLFWALGYMLLALLAYLI-RDWRWLQLAISLPGLLFLLLLWW 160
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
28-388 |
5.20e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 28 FLSFYIEELGVtGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGdihGRKLMLIRASLgMAVIMTLMGFVTDVYQL-VALR 106
Cdd:cd17352 25 LFVELLEEFGE-STSDIAWIGSLLLGVSLFSGPLSSALVNRFG---CRPVAIAGGLL-AALGLLLSSFATSLWQLyLTYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 107 FLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFlh 186
Cdd:cd17352 100 VLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 187 eenhsaqakkvqqkKVWTMvpaKHVIISLFVTTFiiqlANMSIQPIITLYVKNLEGPGTAHIEmiAGAVMSATGLAVILA 266
Cdd:cd17352 178 --------------RLLKD---PTFVLLALGVSF----AMLGFFVPFVYLPSYAKSLGIDESD--AAFLLSIIGISDIVG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 267 APKLGRLSDH--IGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYN 344
Cdd:cd17352 235 RILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLV 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446101467 345 QSFQFLGNMIGPVLGGQIA-AHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17352 315 LLFQGLAALVGPPIAGLLRdYTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
3-182 |
5.55e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 5.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 3 SWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMlIRA 82
Cdd:cd17478 192 GVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFA-----GLLLSLFLFAGAIGTLIGGPLSDRFGRRRV-IIA 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 83 SLGMAVIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIG 162
Cdd:cd17478 266 SLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFG 345
|
170 180
....*....|....*....|
gi 446101467 163 MRHVFLVTGAFLFLSFLIVF 182
Cdd:cd17478 346 LESVLLILALLPLLGALLAF 365
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
52-344 |
6.49e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.43 E-value: 6.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 52 FGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAVIMTLMGfVTDVYQ---------LVALRFLMG-AVSGFLSTAMT 121
Cdd:cd17367 46 FAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIA-VTPTYAtigiwapiiLLLARLLQGlSVGGEYGTSAT 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 122 FIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELI--------GMRHVFLVTGAFLFLSFLIVFFFlhEENHSAQ 193
Cdd:cd17367 125 YLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaawGWRIPFLLGGVLAVVVLWLRRGL--EETESFE 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 194 AKKVQQKKVWTMVPA--KHVIISLFVTTFII--QLANMSIQPIITLYVKNlegpgTAHI-EMIAGAVMSATGLAVILAAP 268
Cdd:cd17367 203 AIAESNEASAGTLRElrRHPRELLLVVGLTAggTLAFYTWTTYLQKFLVN-----TAGFsKGDATWITTAALLVFMLLQP 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 269 KLGRLSDHIGpQKTLVVALFAAGIIFIPQAF-----VTSAWQLLILR---FLLGIAQAGLLPSVQTLLkqhTPTHV--TG 338
Cdd:cd17367 278 LGGRLSDRIG-RRPLLLFFGIGGTLATVPLLsaldhTDSPYTAFALVlvgLVFLSGYTSINAVVKAEL---FPTHVraLG 353
|
....*.
gi 446101467 339 RIFGYN 344
Cdd:cd17367 354 VGLPYA 359
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
20-133 |
6.67e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 6.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 20 AGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGM---AVIMTLMGFV 96
Cdd:pfam00083 20 GAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFvigAVLQGAAKGK 99
|
90 100 110
....*....|....*....|....*....|....*...
gi 446101467 97 TDVYQLVALRFLMG-AVSGFLSTAMTFIAAETPKEHSG 133
Cdd:pfam00083 100 WSVYQLIVGRVLVGiGVGGASVLAPMYISEIAPKKLRG 137
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
16-312 |
8.68e-03 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 38.06 E-value: 8.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 16 FTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLgmaviMTLMGF 95
Cdd:cd17479 6 FFHSAGKACLLPFLTLYFRQLGLT-----APQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSL-----LISLGT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 96 VTDVYQLVALRFLMGAVSGFLSTAMTFIA-------------AETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELI- 161
Cdd:cd17479 76 YLLYHQIFLLVLLVIIIWELLSAPLEKVAddslyeyldfvdaTERYGKLKVWSALGAAFGPCGITLLVDNLDCFLPPKIs 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446101467 162 -GMRHVFLVTGaFLFLSFLIVFFFlheENHSAQAKKVQQK--KVWTMVPAKHVIISLFVTTFIIQLANMSIQPIITLYVK 238
Cdd:cd17479 156 rILLHFYTYGG-FMILTFLLSFFY---PIPVPKKEEHSSKvvKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQ 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446101467 239 NLEGPgtahiEMIAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFL 312
Cdd:cd17479 232 DKGGS-----ELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELL 300
|
|
| |
