NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446526425|ref|WP_000603771|]
View 

endonuclease III [Streptococcus pneumoniae]

Protein Classification

endonuclease III( domain architecture ID 11415064)

endonuclease III is a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

EC:  4.2.99.18
Gene Symbol:  nth
Gene Ontology:  GO:0051539|GO:0140078

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-201 1.82e-102

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 293.93  E-value: 1.82e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  12 LEEIIALFPDAKPSLDFTNHFELLVAVMLSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRNKAKFL 91
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  92 KKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVkKSATPLEVEKRVMDILP 171
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLV-PGKDPEEVEKDLMKLIP 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 446526425 172 PEQWLAAHQAMIYFGRAICHPKNPECDQYP 201
Cdd:COG0177  160 KEYWGDLHHLLILHGRYICKARKPKCEECP 189
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-201 1.82e-102

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 293.93  E-value: 1.82e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  12 LEEIIALFPDAKPSLDFTNHFELLVAVMLSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRNKAKFL 91
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  92 KKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVkKSATPLEVEKRVMDILP 171
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLV-PGKDPEEVEKDLMKLIP 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 446526425 172 PEQWLAAHQAMIYFGRAICHPKNPECDQYP 201
Cdd:COG0177  160 KEYWGDLHHLLILHGRYICKARKPKCEECP 189
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 5-197 2.68e-86

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 253.07  E-value: 2.68e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425    5 KKRARKVLEEIIALFPDAKPSLDFTNHFELLVAVMLSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLY 84
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425   85 RNKAKFLKKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVkKSATPLEVEK 164
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLS-KGKDPIKVEE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446526425  165 RVMDILPPEQWLAAHQAMIYFGRAICHPKNPEC 197
Cdd:TIGR01083 160 DLMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 32-186 9.19e-60

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 184.37  E-value: 9.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  32 FELLVAVMLSAQTTDAAVNKATPGLFVVF-PTPQAMSVATESEIASHISRLGlYRNKAKFLKKCAQQLLDDFDGQV---P 107
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446526425 108 QTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPLEVEKRVMDILPPEQWLAAHQAMIYFG 186
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 40-187 7.41e-57

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 176.69  E-value: 7.41e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425    40 LSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDFDGQVPQTREELESLAGV 119
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446526425   120 GRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPLEVEKRVMDILPPEQWLAAHQAMIYFGR 187
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
PRK10702 PRK10702
endonuclease III; Provisional
 14-197 1.33e-46

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 152.86  E-value: 1.33e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  14 EIIALFPDAKP----SLDFTNHFELLVAVMLSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRNKAK 89
Cdd:PRK10702   8 EILTRLRDNNPhpttELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  90 FLKKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPlEVEKRVMDI 169
Cdd:PRK10702  88 NVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVE-QVEEKLLKV 166

                        170       180
                 ....*....|....*....|....*...
gi 446526425 170 LPPEQWLAAHQAMIYFGRAICHPKNPEC 197
Cdd:PRK10702 167 VPAEFKVDCHHWLILHGRYTCIARKPRC 194
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 36-172 6.93e-45

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 145.89  E-value: 6.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425   36 VAVMLSAQTTDAAVNKATPGLF-VVFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDFDGQVPQTREELE 114
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446526425  115 S-LAGVGRKTANVVMSVGFG--IPAFAVDTHVERICKHHDIVKKSATPLEVEKRVMDILPP 172
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKPTPKEVERELEELWPP 141
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-201 1.82e-102

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 293.93  E-value: 1.82e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  12 LEEIIALFPDAKPSLDFTNHFELLVAVMLSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRNKAKFL 91
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  92 KKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVkKSATPLEVEKRVMDILP 171
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLV-PGKDPEEVEKDLMKLIP 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 446526425 172 PEQWLAAHQAMIYFGRAICHPKNPECDQYP 201
Cdd:COG0177  160 KEYWGDLHHLLILHGRYICKARKPKCEECP 189
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 5-197 2.68e-86

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 253.07  E-value: 2.68e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425    5 KKRARKVLEEIIALFPDAKPSLDFTNHFELLVAVMLSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLY 84
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425   85 RNKAKFLKKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVkKSATPLEVEK 164
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLS-KGKDPIKVEE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446526425  165 RVMDILPPEQWLAAHQAMIYFGRAICHPKNPEC 197
Cdd:TIGR01083 160 DLMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 32-186 9.19e-60

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 184.37  E-value: 9.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  32 FELLVAVMLSAQTTDAAVNKATPGLFVVF-PTPQAMSVATESEIASHISRLGlYRNKAKFLKKCAQQLLDDFDGQV---P 107
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446526425 108 QTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPLEVEKRVMDILPPEQWLAAHQAMIYFG 186
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 40-187 7.41e-57

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 176.69  E-value: 7.41e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425    40 LSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDFDGQVPQTREELESLAGV 119
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446526425   120 GRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPLEVEKRVMDILPPEQWLAAHQAMIYFGR 187
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
PRK10702 PRK10702
endonuclease III; Provisional
 14-197 1.33e-46

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 152.86  E-value: 1.33e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  14 EIIALFPDAKP----SLDFTNHFELLVAVMLSAQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRNKAK 89
Cdd:PRK10702   8 EILTRLRDNNPhpttELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  90 FLKKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPlEVEKRVMDI 169
Cdd:PRK10702  88 NVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVE-QVEEKLLKV 166

                        170       180
                 ....*....|....*....|....*...
gi 446526425 170 LPPEQWLAAHQAMIYFGRAICHPKNPEC 197
Cdd:PRK10702 167 VPAEFKVDCHHWLILHGRYTCIARKPRC 194
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 36-172 6.93e-45

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 145.89  E-value: 6.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425   36 VAVMLSAQTTDAAVNKATPGLF-VVFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDFDGQVPQTREELE 114
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446526425  115 S-LAGVGRKTANVVMSVGFG--IPAFAVDTHVERICKHHDIVKKSATPLEVEKRVMDILPP 172
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKPTPKEVERELEELWPP 141
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 60-201 6.74e-25

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 99.44  E-value: 6.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  60 FPTPQAMSVATESEIASHISRLGLY---RNkakfLKKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPA 136
Cdd:COG1194   58 FPTVEALAAAPEDEVLKLWEGLGYYsraRN----LHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPA 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425 137 FAVDTHVER-ICKHHDI---VKKSATPLEVEKRVMDILPPEQwLAAH-QAMIYFGRAICHPKNPECDQYP 201
Cdd:COG1194  134 PIVDGNVKRvLSRLFAIegpIGSPAAKKELWALAEELLPPER-PGDFnQALMDLGATVCTPKKPKCLLCP 202
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 30-201 2.54e-17

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 76.81  E-value: 2.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  30 NHFELLVAVMLSAQTTDAAVNKA-----TPGLFvvfpTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDFDG 104
Cdd:COG2231   28 TPFEVIVGAILTQNTSWKNVEKAianlkEAGLL----DPEALAALDPEELAELIRPSGFYNQKAKRLKNLARWLVERYGG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425 105 QV--------PQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPLEVEKRVMDILPPEQWL 176
Cdd:COG2231  104 GLeklkalptEELREELLSLKGIGPETADSILLYAFNRPVFVVDAYTRRIFSRLGLIEEDASYDELQRLFEENLPPDVAL 183

                        170       180
                 ....*....|....*....|....*...
gi 446526425 177 AA--HqAMI-YFGRAICHPKnPECDQYP 201
Cdd:COG2231  184 YNefH-ALIvEHGKEYCKKK-PKCEECP 209
PRK10880 PRK10880
adenine DNA glycosylase;
35-201 4.42e-13

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 66.66  E-value: 4.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  35 LVAVMLSaQTTDAAVNKATPGLFVVFPTPQAMSVATESEIASHISRLGLYRnKAKFLKKCAQQLLDDFDGQVPQTREELE 114
Cdd:PRK10880  35 LSEVMLQ-QTQVATVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYA-RARNLHKAAQQVATLHGGEFPETFEEVA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425 115 SLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIV-----KKsatplEVEKRVMDI---LPPEQWLAA-HQAMIYF 185
Cdd:PRK10880 113 ALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARCYAVsgwpgKK-----EVENRLWQLseqVTPAVGVERfNQAMMDL 187

                        170
                 ....*....|....*.
gi 446526425 186 GRAICHPKNPECDQYP 201
Cdd:PRK10880 188 GAMVCTRSKPKCELCP 203
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 6-165 2.91e-11

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 60.67  E-value: 2.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425   6 KRARKVLEEIIALFPDAKPSLDFtNHFELLVAVMLSAQTTDAAVNKAT--------------PGLFVVFPTPQAMSVATE 71
Cdd:COG0122   60 AARDPVLAPLIERYPGLRLPRRP-DPFEALVRAILGQQVSVAAARTIWrrlvalfgepiegpGGGLYAFPTPEALAAASE 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  72 SEIAshisRLGLYRNKAKFLKKCAQQLLD---DFDGQV----PQTREELESLAGVGRKTANVVMSVGFGIP-AF-AVDTH 142
Cdd:COG0122  139 EELR----ACGLSRRKARYLRALARAVADgelDLEALAglddEEAIARLTALPGIGPWTAEMVLLFALGRPdAFpAGDLG 214

                        170       180
                 ....*....|....*....|...
gi 446526425 143 VERICKHHDIVKKSATPLEVEKR 165
Cdd:COG0122  215 LRRALGRLYGLGERPTPKELREL 237
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 60-175 4.36e-11

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 60.69  E-value: 4.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425   60 FPTPQAMsvaTESEIASHISRLGL-YRnkAKFLKKCAQQLLDDFDG----------QVPQTREELESLAGVGRKTANVVM 128
Cdd:TIGR00588 163 FPSLHAL---TGPEAEAHLRKLGLgYR--ARYIRETARALLEEQGGrawlqqirgaSYEDAREALCELPGVGPKVADCIC 237

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446526425  129 SVGFGIP-AFAVDTHVERICKH----HDIVKKSATPLEVEKRVMDILPPEQW 175
Cdd:TIGR00588 238 LMGLDKPqAVPVDVHVWRIANRdypwHPKTSRAKGPSPFARKELGNFFRSLW 289
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 60-201 5.61e-10

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 57.72  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  60 FPTPQAMSVATESEIASHISRLGLYrNKAKFLKKCAQQLLDDFDGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAV 139
Cdd:PRK13910  22 FPTLKDLANAPLEEVLLLWRGLGYY-SRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACV 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446526425 140 DTHVERICKHHDIVKKSATPLEVEKRVMDILPPEQWLAAHQAMIYFGRAICHPKnPECDQYP 201
Cdd:PRK13910 101 DANIKRVLLRLFGLDPNIHAKDLQIKANDFLNLNESFNHNQALIDLGALICSPK-PKCAICP 161
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 101-130 2.13e-07

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 45.49  E-value: 2.13e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 446526425  101 DFDGQVPQTREELESLAGVGRKTANVVMSV 130
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAILSY 30
PRK13913 PRK13913
3-methyladenine DNA glycosylase; Provisional
 21-152 1.83e-05

3-methyladenine DNA glycosylase; Provisional


Pssm-ID: 184390  Cd Length: 218  Bit Score: 44.07  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  21 DAKPSLDFTNH--FELLVAVMLSAQTTDAAVNKATPGLFVVFPTP-------QAMSVATESEIASHISRLGLYRNKAKFL 91
Cdd:PRK13913  18 KNAPAWWWPNAlkFEALLGAVLTQNTKFEAVEKSLENLKNAFILEnddeinlKKIAYIEFSKLAECVRPSGFYNQKAKRL 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446526425  92 KKCAQQLLDDFDG----QVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDI 152
Cdd:PRK13913  98 IDLSENILKDFGSfenfKQEVTREWLLDQKGIGKESADAILCYVCAKEVMVVDKYSYLFLKKLGI 162
PRK10308 PRK10308
3-methyl-adenine DNA glycosylase II; Provisional
 35-125 5.62e-03

3-methyl-adenine DNA glycosylase II; Provisional


Pssm-ID: 236671 [Multi-domain]  Cd Length: 283  Bit Score: 36.66  E-value: 5.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446526425  35 LVAVMLSAQTTDAAVN------KATPGlFVVFPTPQAMSVATESEIAShisrLGLYRNKAKFLKKCAQQLLddfDGQVPQ 108
Cdd:PRK10308 125 LVSVAMAAKLTAKVAQlygerlDDFPE-YVCFPTPERLAAADPQALKA----LGMPLKRAEALIHLANAAL---EGTLPL 196

                         90       100
                 ....*....|....*....|....*
gi 446526425 109 TREE--------LESLAGVGRKTAN 125
Cdd:PRK10308 197 TIPGdveqamktLQTFPGIGRWTAN 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH