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Conserved domains on  [gi|488216394|ref|WP_002287602|]
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MULTISPECIES: phosphocarrier protein HPr [Enterococcus]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10793862)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-88 1.03e-57

phosphocarrier protein HPr; Provisional


:

Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 171.80  E-value: 1.03e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394  1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVET 80
Cdd:PRK13780  1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAIEET 80


                ....*...
gi 488216394 81 MKKEGLSE 88
Cdd:PRK13780 81 MKKEGLAE 88
 
Name Accession Description Interval E-value
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-88 1.03e-57

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 171.80  E-value: 1.03e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394  1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVET 80
Cdd:PRK13780  1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAIEET 80


                ....*...
gi 488216394 81 MKKEGLSE 88
Cdd:PRK13780 81 MKKEGLAE 88
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-79 2.12e-37

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 120.21  E-value: 2.12e-37
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488216394  1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVE 79
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAA 79
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
4-82 4.84e-36

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 116.72  E-value: 4.84e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488216394   4 KEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVETMK 82
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 5-81 1.36e-31

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 105.28  E-value: 1.36e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488216394  5 EFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVETM 81
Cdd:cd00367   1 TVTITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 8.32e-31

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 103.50  E-value: 8.32e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394   1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVET 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 488216394  81 MK 82
Cdd:TIGR01003 81 FE 82
 
Name Accession Description Interval E-value
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-88 1.03e-57

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 171.80  E-value: 1.03e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394  1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVET 80
Cdd:PRK13780  1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAIEET 80


                ....*...
gi 488216394 81 MKKEGLSE 88
Cdd:PRK13780 81 MKKEGLAE 88
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-79 2.12e-37

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 120.21  E-value: 2.12e-37
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488216394  1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVE 79
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAA 79
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
4-82 4.84e-36

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 116.72  E-value: 4.84e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488216394   4 KEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVETMK 82
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 5-81 1.36e-31

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 105.28  E-value: 1.36e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488216394  5 EFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVETM 81
Cdd:cd00367   1 TVTITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 8.32e-31

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 103.50  E-value: 8.32e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394   1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVET 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 488216394  81 MK 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-78 9.79e-25

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 88.30  E-value: 9.79e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488216394  1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIV 78
Cdd:PRK13782  1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEALA 78
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
5-77 2.32e-18

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 77.30  E-value: 2.32e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488216394   5 EFHVVAETGIHARPATLLVQTASKFNSDV---NLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAI 77
Cdd:PRK11109 289 EFVIRNEHGLHARPGAMLVNTIKQFNSEItvtNLDGTGKPANGRSLMKVVALGVKKGHRLRFTAQGEDAEQALKAI 364
PRK10850 PRK10850
phosphocarrier protein Hpr;
1-81 7.77e-17

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 68.23  E-value: 7.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394  1 MEKKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVET 80
Cdd:PRK10850  1 MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKL 80


                .
gi 488216394 81 M 81
Cdd:PRK10850 81 M 81
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 6-88 6.52e-13

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 62.20  E-value: 6.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394   6 FHVVAETGIHARPATLLVQTASKFNSDV---NLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVETMk 82
Cdd:PRK13779 295 FTIRNEHGLHARPSANLVNEVKKFTAKItveNLTRGSAPVSAKSLMKIVALGVTQGHRLRFVAEGEDAQQAIEALAKAI- 373


                 ....*.
gi 488216394  83 KEGLSE 88
Cdd:PRK13779 374 AEGLGE 379
PRK11377 PRK11377
dihydroxyacetone kinase subunit M; Provisional
 1-76 2.15e-11

dihydroxyacetone kinase subunit M; Provisional


Pssm-ID: 183108 [Multi-domain]  Cd Length: 473  Bit Score: 57.84  E-value: 2.15e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488216394   1 MEKKEFHVVAET--GIHARPATLLVQTASKFNSDVNLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAA 76
Cdd:PRK11377 153 EEARSLSVVIKNrnGLHVRPASRLVYTLSTFNADMLLEKNGKCVTPESLNQIALLQVRYNDTLRLIAKGPEAEEALIA 230
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 6-88 8.58e-09

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 50.64  E-value: 8.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488216394   6 FHVVAETGIHARPATLLVQTASKFNSDV---NLEYKGKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVETMK 82
Cdd:PRK13779 419 FVIKNEHGLHARPSAVLVNEVKKYNASVavqNLDRNTQLVSAKSLMKIVALGVVKGHRLRFVATGEEAQQAIDGIGAAIA 498


                 ....*.
gi 488216394  83 KeGLSE 88
Cdd:PRK13779 499 A-GLGE 503
PRK10897 PRK10897
PTS phosphocarrier protein NPr;
3-79 1.80e-06

PTS phosphocarrier protein NPr;


Pssm-ID: 182819 [Multi-domain]  Cd Length: 90  Bit Score: 41.74  E-value: 1.80e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488216394  3 KKEFHVVAETGIHARPATLLVQTASKFNSDVNLEYK-GKSVNLKSIMGVMSLGVGQGSDVTITAEGADEADAMAAIVE 79
Cdd:PRK10897  4 KQTVEIKNKLGMHARPAMKLFELVQGFDAEVLLRNDeGTEAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIA 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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