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Conserved domains on  [gi|491627415|ref|WP_005484954|]
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MULTISPECIES: TDT family transporter [Vibrio]

Protein Classification

TDT family transporter( domain architecture ID 10174716)

tellurite resistance/dicarboxylate (TDT) family transporter with similarity to potassium-tellurite resistance protein TehA which functions as an ion channel

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TDT_C4-dicarb_trans cd09325
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ...
 13-309 1.05e-110

C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


:

Pssm-ID: 187765  Cd Length: 293  Bit Score: 323.34  E-value: 1.05e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  13 PTPMAGLALGIASLGWSWEnfAELHGYGQWISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVSNS 92
Cdd:cd09325    3 PIPIAGLALGLASLGNLLE--LSYGSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLSTY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  93 LGHFYPLAGDVLWLIAVVLHIVFLVSFVYHRAKDFELHHMVPSWFVPPVGIIVADVSFSGNPMLaPVAQGALMFGMVAYA 172
Cdd:cd09325   81 LKPFFPALAQLLWLLAIILHIILIIYFTYKRILKFNLEHVFPSWFVVYVGIVVASVTAPAFGQP-LLGQIAFWFGFVAYL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 173 IMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVLMTAIIYLAFFKLLRLPFSPGY 252
Cdd:cd09325  160 ILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFYPSF 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491627415 253 AAFTFPMVIGATALFKMANWMELQGlaaHYVQQVRGLAGLELIVATFVVSYVALQYI 309
Cdd:cd09325  240 AAFTFPLVISATALKKTSTYLASYG---LYLPILKYLALFEILIATVIVLYVLIRYL 293
 
Name Accession Description Interval E-value
TDT_C4-dicarb_trans cd09325
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ...
 13-309 1.05e-110

C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


Pssm-ID: 187765  Cd Length: 293  Bit Score: 323.34  E-value: 1.05e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  13 PTPMAGLALGIASLGWSWEnfAELHGYGQWISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVSNS 92
Cdd:cd09325    3 PIPIAGLALGLASLGNLLE--LSYGSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLSTY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  93 LGHFYPLAGDVLWLIAVVLHIVFLVSFVYHRAKDFELHHMVPSWFVPPVGIIVADVSFSGNPMLaPVAQGALMFGMVAYA 172
Cdd:cd09325   81 LKPFFPALAQLLWLLAIILHIILIIYFTYKRILKFNLEHVFPSWFVVYVGIVVASVTAPAFGQP-LLGQIAFWFGFVAYL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 173 IMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVLMTAIIYLAFFKLLRLPFSPGY 252
Cdd:cd09325  160 ILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFYPSF 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491627415 253 AAFTFPMVIGATALFKMANWMELQGlaaHYVQQVRGLAGLELIVATFVVSYVALQYI 309
Cdd:cd09325  240 AAFTFPLVISATALKKTSTYLASYG---LYLPILKYLALFEILIATVIVLYVLIRYL 293
TehA COG1275
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
1-313 1.11e-69

Tellurite resistance protein TehA and related permeases [Defense mechanisms];


Pssm-ID: 440886  Cd Length: 323  Bit Score: 219.72  E-value: 1.11e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   1 MIQRTKAKVMGAPTPMAGLALGIASLGWSWENFAELHGYGQWIS-------AGIASVLLAILATKFLLHNHLLRQDLAHP 73
Cdd:COG1275    1 MSTAPRSRLRNLPPAWFALVMGTGGLGLAWRLAAALLPGPAAIAevllalaALLFLVLLLLYLLKWLRYPAAVRADLRHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  74 VVGSVVPTFAMGTMVVSNSLGHFYPLAGDVLWLIAVVLHIVFLVSFVYH--RAKDFELHHMVPSWFVPPVGIIVADVSFS 151
Cdd:COG1275   81 VRGSFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRlfTGEKFEIEHITPAWFIPVVGNIVVAVAGA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 152 GNPMLAPVAQGALMFGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVL 231
Cdd:COG1275  161 LLGPLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 232 MTAIIYLAFFKLLRLPFSPGYAAFTFPMVIGATALFKMANWMELQGLaahyvqqvRGLAGLELIVATFVVSYVALQYINN 311
Cdd:COG1275  241 WLLLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATGLPFL--------AVLALALLVLATLVWLYVLVRTLRA 312


                 ..
gi 491627415 312 LL 313
Cdd:COG1275  313 LA 314
SLAC1 pfam03595
Voltage-dependent anion channel; This family of transporters has ten alpha helical ...
 42-280 4.73e-19

Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.


Pssm-ID: 460983  Cd Length: 321  Bit Score: 86.14  E-value: 4.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   42 WISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVSNSL-------GHFYPLAGDVLWLIAVVLHIV 114
Cdd:pfam03595  38 ILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFPMGFATIINGLvlvpvpgPWLVTLAWVLWWWIGVALALA 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  115 FLVSFVYH-RAKDFELHHMVPSWFVPPVGIIV-ADVSFSGNPMLAPVAQGALMF---GMVAYAIMLPMMIYRFMFTHEIP 189
Cdd:pfam03595 118 FAVGVPFLlFTRHHLLEAMTPAWLLPVVPLMVvAALGALLAALLLPILVVSYLLwglGLFLALVILAIYLYRLFTHGLPP 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  190 DAAKPTMAIMAAPASLSLAGYL-------------TVTATPSPVIIAMLFGIAVL--------MTAIIYLAFFKLLRLPF 248
Cdd:pfam03595 198 AELRPSLFIPLGPPGQGALALLllggaaptilpalTALAGEILYVVALLLALFLWgfglwwffIAALSVLSALRRGGLPF 277

                         250       260       270
                  ....*....|....*....|....*....|..
gi 491627415  249 SPGYAAFTFPMVIGATALFKMANWMELQGLAA 280
Cdd:pfam03595 278 NLGWWAFTFPLGAFALATIELGKALDSPFFRV 309
tdt TIGR00816
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ...
 18-279 1.71e-16

C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273285  Cd Length: 320  Bit Score: 78.60  E-value: 1.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   18 GLALGIASLGWSWENFAELHGYGQWISAG-------IASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVS 90
Cdd:TIGR00816   7 AIVLGTGGLALASLSYSFYLPILKDLSDVlfilaiaLFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPISTMLLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   91 NSLGHFYPLAGDVLWLIAVVLHIVFLVSFVYH--RAKDFELHHMVPSWFVPPVGIIVADVSFSGNPMLAPVAQGALMF-- 166
Cdd:TIGR00816  87 IDFIIWGYPLALGLWYIGAIGQLLFSVIVPFYlfKNESIEIEHTHPGWYLPPVALIFISAAALAILPYLTHELTVLFYfg 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  167 ---GMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTV-------TATPSPVIIAML---FGIAVLMT 233
Cdd:TIGR00816 167 wgaGFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINIvnhgefiTIKEPFLILAIIlwgFGLWQLLF 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 491627415  234 AIIYLAFFKLLRLPFSPGYAAFTFP---MVIGATALFKMANWMELQGLA 279
Cdd:TIGR00816 247 AIRLLLWYVKLKLPFAMGWWAFIFPlaaYANSTHLVYKGFDFKVFQYIG 295
PRK10764 PRK10764
potassium-tellurite ethidium and proflavin transporter; Provisional
 18-270 2.03e-12

potassium-tellurite ethidium and proflavin transporter; Provisional


Pssm-ID: 236756  Cd Length: 324  Bit Score: 66.90  E-value: 2.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  18 GLALGIASLGWSWENFAELHGYGQWISAG-------IASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVS 90
Cdd:PRK10764  15 GIVLGLIGLGFAWRYAAQLWPLPAWIGEAlvalasiIWALLILAYLYKWIRFPESVLAELRHPVQSSFVSLIPITTMLVA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  91 NSLGHFYPLAGDVLWLIAVVLHIVFLVsfvYHRAK----DFELHHMVPSWFVPPVG---IIVADVSFSGNPMLAPVAQGA 163
Cdd:PRK10764  95 IGLVPYSRPLAVVLFSFGVVGQLAFAA---WRTAGlwrgGHPEEATTPGLYLPTVAnnfVSAMALGALGYHDAGLLFLGA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 164 lmfGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVLMtaiiylaFFKL 243
Cdd:PRK10764 172 ---GVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQ-------LLFL 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 491627415 244 LRL-------PFSPGYAAFTFpmviGATALFKMA 270
Cdd:PRK10764 242 LRLmpwilsqGFNASFWSFSF----GVAALATTG 271
 
Name Accession Description Interval E-value
TDT_C4-dicarb_trans cd09325
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ...
 13-309 1.05e-110

C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


Pssm-ID: 187765  Cd Length: 293  Bit Score: 323.34  E-value: 1.05e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  13 PTPMAGLALGIASLGWSWEnfAELHGYGQWISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVSNS 92
Cdd:cd09325    3 PIPIAGLALGLASLGNLLE--LSYGSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLSTY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  93 LGHFYPLAGDVLWLIAVVLHIVFLVSFVYHRAKDFELHHMVPSWFVPPVGIIVADVSFSGNPMLaPVAQGALMFGMVAYA 172
Cdd:cd09325   81 LKPFFPALAQLLWLLAIILHIILIIYFTYKRILKFNLEHVFPSWFVVYVGIVVASVTAPAFGQP-LLGQIAFWFGFVAYL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 173 IMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVLMTAIIYLAFFKLLRLPFSPGY 252
Cdd:cd09325  160 ILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFYPSF 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491627415 253 AAFTFPMVIGATALFKMANWMELQGlaaHYVQQVRGLAGLELIVATFVVSYVALQYI 309
Cdd:cd09325  240 AAFTFPLVISATALKKTSTYLASYG---LYLPILKYLALFEILIATVIVLYVLIRYL 293
TehA COG1275
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
1-313 1.11e-69

Tellurite resistance protein TehA and related permeases [Defense mechanisms];


Pssm-ID: 440886  Cd Length: 323  Bit Score: 219.72  E-value: 1.11e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   1 MIQRTKAKVMGAPTPMAGLALGIASLGWSWENFAELHGYGQWIS-------AGIASVLLAILATKFLLHNHLLRQDLAHP 73
Cdd:COG1275    1 MSTAPRSRLRNLPPAWFALVMGTGGLGLAWRLAAALLPGPAAIAevllalaALLFLVLLLLYLLKWLRYPAAVRADLRHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  74 VVGSVVPTFAMGTMVVSNSLGHFYPLAGDVLWLIAVVLHIVFLVSFVYH--RAKDFELHHMVPSWFVPPVGIIVADVSFS 151
Cdd:COG1275   81 VRGSFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRlfTGEKFEIEHITPAWFIPVVGNIVVAVAGA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 152 GNPMLAPVAQGALMFGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVL 231
Cdd:COG1275  161 LLGPLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 232 MTAIIYLAFFKLLRLPFSPGYAAFTFPMVIGATALFKMANWMELQGLaahyvqqvRGLAGLELIVATFVVSYVALQYINN 311
Cdd:COG1275  241 WLLLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATGLPFL--------AVLALALLVLATLVWLYVLVRTLRA 312


                 ..
gi 491627415 312 LL 313
Cdd:COG1275  313 LA 314
TDT_TehA_like cd09322
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The ...
 13-303 2.61e-67

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).


Pssm-ID: 187762  Cd Length: 289  Bit Score: 212.40  E-value: 2.61e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  13 PTPMAGLALGIASLGWSWenfaeLHGYGQWIS---AGIASVLLAILATKFLL----HNHLLRQDLAHPVVGSVVPTFAMG 85
Cdd:cd09322    3 PIVLGLLGLGLAWLGALL-----LLGLPSIVGeilGILALLLWLLLLLKYLLkllrYPEAVKAELRHPVRASFFATFSMS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  86 TMVVSNSLGHFYPLAGDVLWLIAVVLHIVFLVSFVYHRAKDF-ELHHMVPSWFVPPVGIIVADVSFSGNPMlAPVAQGAL 164
Cdd:cd09322   78 LMLLSIYLLPYSPLLARVLWILGAVLHLVFTLYFVSRWIRGGkFLEHVTPSWFIPYVGNIVVPVTGPALGG-PELGWFFF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 165 MFGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVLMTAIIYLAFFKLL 244
Cdd:cd09322  157 GVGLIFWLVLLPLVLYRLIFHEPLPEPLRPTLAILLAPPSLGLAAYLALFGGPIDLFALILLGLALFLFLLLLRLLPRLL 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491627415 245 RLPFSPGYAAFTFPMVIGATALFKMANWMelqglaAHYVQQVRGLAGLELIVATFVVSY 303
Cdd:cd09322  237 KLPFSPSWWAFTFPLAALAIALLKMAAYL------GSGFLQLLALVLLELLTAVILVLY 289
TDT_SLAC1_like cd09323
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion ...
 13-306 6.45e-30

Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); SLAC1 (Slow Anion Channel-Associated 1) is a plasma membrane protein, preferentially expressed in guard cells, which encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. It is essential for stomatal closure in response to carbon dioxide, abscisic acid, ozone, light/dark transitions, humidity change, calcium ions, hydrogen peroxide and nitric oxide. In the Arabidopsis genome, SLAC1 is part of a gene family with five members and encodes a membrane protein that has ten putative transmembrane domains flanked by large N- and C-terminal domains. Mutations in SLAC1 impair slow (S-type) anion channel currents that are activated by cytosolic calcium ions and abscisic acid, but do not affect rapid (R-type) anion channel currents or calcium ion channel function.


Pssm-ID: 187763  Cd Length: 297  Bit Score: 115.34  E-value: 6.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  13 PTPMAGLALGIASLGWSWENFAELHGYGQWISAGIAS-------VLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMG 85
Cdd:cd09323    3 PVSLFAIVMGLSGLALAWRKAAELLGLPAAISEALGWlavavfvVLAALYALKILRYPEAVKAEFNHPVRINFFPAISIS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  86 TMVVSNSLGHFYPLAGDVLWLIAVVLHIVF---LVSFVYHRAKdFELHHMVPSWFVPPVGIIVadVSFSGNPM-LAPVAQ 161
Cdd:cd09323   83 LLLLSIALLPYSPVLALALWIIGAVLQLALtlyVVSRWISHRQ-FQIGHANPAWFIPVVGNLV--VPIAGVPLgYAEVSW 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 162 GALMFGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPViIAMLFGIAVLMTAIIYLAFF 241
Cdd:cd09323  160 FFFSVGLFFWLVLFTIVFNRLIFHEPLPAKLLPTLFILIAPPAVGFLAYLKLTGSLDAF-ARILYYIALFLFLLLLFQVR 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491627415 242 KLLRLPFSPGYAAFTFPMVIGATALFKMAnwmELQGLAAHYVqqvrgLAGLELIVATFVVSYVAL 306
Cdd:cd09323  239 RFRKLPFFLSWWAYSFPLAALAIATLRMA---ELTGSLFLQV-----LALVLLALLTLVVAVLLV 295
SLAC1 pfam03595
Voltage-dependent anion channel; This family of transporters has ten alpha helical ...
 42-280 4.73e-19

Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.


Pssm-ID: 460983  Cd Length: 321  Bit Score: 86.14  E-value: 4.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   42 WISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVSNSL-------GHFYPLAGDVLWLIAVVLHIV 114
Cdd:pfam03595  38 ILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFPMGFATIINGLvlvpvpgPWLVTLAWVLWWWIGVALALA 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  115 FLVSFVYH-RAKDFELHHMVPSWFVPPVGIIV-ADVSFSGNPMLAPVAQGALMF---GMVAYAIMLPMMIYRFMFTHEIP 189
Cdd:pfam03595 118 FAVGVPFLlFTRHHLLEAMTPAWLLPVVPLMVvAALGALLAALLLPILVVSYLLwglGLFLALVILAIYLYRLFTHGLPP 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  190 DAAKPTMAIMAAPASLSLAGYL-------------TVTATPSPVIIAMLFGIAVL--------MTAIIYLAFFKLLRLPF 248
Cdd:pfam03595 198 AELRPSLFIPLGPPGQGALALLllggaaptilpalTALAGEILYVVALLLALFLWgfglwwffIAALSVLSALRRGGLPF 277

                         250       260       270
                  ....*....|....*....|....*....|..
gi 491627415  249 SPGYAAFTFPMVIGATALFKMANWMELQGLAA 280
Cdd:pfam03595 278 NLGWWAFTFPLGAFALATIELGKALDSPFFRV 309
TDT_like_3 cd09321
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 16-270 9.91e-17

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).


Pssm-ID: 187761  Cd Length: 327  Bit Score: 79.27  E-value: 9.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  16 MAGLALGIASLGWSwENFAELHGYGQ---WISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVS-- 90
Cdd:cd09321   10 MGTGALAIASYLYS-AYFPFLKTLAVfltYLNFLLFFVLLVPWLLRWILYPKEALADLKHPVLSNFYPTMPIALLVLAtn 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  91 ---NSLGHFYPLAGDVLWLIAVVLHIVF--LVSFVYHRAKDFELHHMVPSWFVPPVGIIVadVSFSGNPMLA--PVAQGA 163
Cdd:cd09321   89 iliVGQGPLGYSLALTLWILGSILIFIFsfIVSYIMFINEEIPIEHINPAWFIPPVGLIV--IPLAGNFLIPhfPGAWQE 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 164 LMF---------GMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAP------ASLSLAGYLTVTATPSPVIIAMLFGI 228
Cdd:cd09321  167 SILvinlfgfgiGFFLFLFLLAIILHRLILHEPPPPELAPTFWINLAPigagvvALINLVKALPFAGLENLVDLANIFAL 246

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 491627415 229 AV--------LMTAIIYLAFFKLLRLPFSPGYAAFTFPMVIGATALFKMA 270
Cdd:cd09321  247 ILwgfglwwlILAVLLTLYYLKRGNLPFSLGWWAFIFPLGAYTIATYLVA 296
tdt TIGR00816
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ...
 18-279 1.71e-16

C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273285  Cd Length: 320  Bit Score: 78.60  E-value: 1.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   18 GLALGIASLGWSWENFAELHGYGQWISAG-------IASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVS 90
Cdd:TIGR00816   7 AIVLGTGGLALASLSYSFYLPILKDLSDVlfilaiaLFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPISTMLLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415   91 NSLGHFYPLAGDVLWLIAVVLHIVFLVSFVYH--RAKDFELHHMVPSWFVPPVGIIVADVSFSGNPMLAPVAQGALMF-- 166
Cdd:TIGR00816  87 IDFIIWGYPLALGLWYIGAIGQLLFSVIVPFYlfKNESIEIEHTHPGWYLPPVALIFISAAALAILPYLTHELTVLFYfg 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  167 ---GMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTV-------TATPSPVIIAML---FGIAVLMT 233
Cdd:TIGR00816 167 wgaGFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINIvnhgefiTIKEPFLILAIIlwgFGLWQLLF 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 491627415  234 AIIYLAFFKLLRLPFSPGYAAFTFP---MVIGATALFKMANWMELQGLA 279
Cdd:TIGR00816 247 AIRLLLWYVKLKLPFAMGWWAFIFPlaaYANSTHLVYKGFDFKVFQYIG 295
TDT_TehA cd09324
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This ...
 13-306 5.27e-16

Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


Pssm-ID: 187764  Cd Length: 301  Bit Score: 76.92  E-value: 5.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  13 PTPMAGLALGIASLGWSWENFAELHGYGQWISAGIAS-------VLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMG 85
Cdd:cd09324    1 PVGYFGIVLGLAALGLAWRYAAQLWPLPAIVGESLLAlasvvwlLLIGAYAYKWLKYREEARAELRHPVQCCFISLIPIT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  86 TMVVSNSLGHFYPLAGDVLWLIAVVLHIVFLVsfvYHRAK----DFELHHMVPSWFVPPVG---IIVADVSFSGNPMLAP 158
Cdd:cd09324   81 TMLVGIALYPYSRLLAEVLIVLGIIGQLAFAA---WRTGGlwqgGHFPEATTPVLYLPTVAgnfVSASALAALGYHDLGM 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 159 VAQGAlmfGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVLMTAIIYL 238
Cdd:cd09324  158 LFFGA---GMFSWLSLEPVILQRLRTSPPLPPALRPTLGIQLAPAFVGCSAYLSLNGGEVDLLAKMLWGYGLLQLLFLLR 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491627415 239 AFFKLLRLPFSPGYAAFTFpmviGATALFKMAnwmelQGLAAHYVQQVRGLAGLEL-IVATFVVSYVAL 306
Cdd:cd09324  235 LLPWIAEQGFSMGFWAFSF----GLAAMATSG-----LHLYHGGVLGPLSLLALALfNVANGLIALLTL 294
PRK10764 PRK10764
potassium-tellurite ethidium and proflavin transporter; Provisional
 18-270 2.03e-12

potassium-tellurite ethidium and proflavin transporter; Provisional


Pssm-ID: 236756  Cd Length: 324  Bit Score: 66.90  E-value: 2.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  18 GLALGIASLGWSWENFAELHGYGQWISAG-------IASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVS 90
Cdd:PRK10764  15 GIVLGLIGLGFAWRYAAQLWPLPAWIGEAlvalasiIWALLILAYLYKWIRFPESVLAELRHPVQSSFVSLIPITTMLVA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  91 NSLGHFYPLAGDVLWLIAVVLHIVFLVsfvYHRAK----DFELHHMVPSWFVPPVG---IIVADVSFSGNPMLAPVAQGA 163
Cdd:PRK10764  95 IGLVPYSRPLAVVLFSFGVVGQLAFAA---WRTAGlwrgGHPEEATTPGLYLPTVAnnfVSAMALGALGYHDAGLLFLGA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 164 lmfGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVTATPSPVIIAMLFGIAVLMtaiiylaFFKL 243
Cdd:PRK10764 172 ---GVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQ-------LLFL 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 491627415 244 LRL-------PFSPGYAAFTFpmviGATALFKMA 270
Cdd:PRK10764 242 LRLmpwilsqGFNASFWSFSF----GVAALATTG 271
TDT cd09299
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 47-278 6.64e-07

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187756  Cd Length: 326  Bit Score: 50.02  E-value: 6.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  47 IASVLLAILATKFLLH-----NHLLRQDLAHPVVGSVVPTFAMGTMVVSN--------SLGHFYPLAGDVLWLIAVVLHI 113
Cdd:cd09299   35 LAIVIFILFFALWLLRlirypRHVVRESHHNPVEASFLAAVPISLFTIIDflalyggaNTGRLVILIAYVLWWIGLALSL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 114 V--FLVSFVYHRAKDFELHHMVPSWFVPPVGIIVadVSFSGNPMLAPVAQGALMF------------GMVAYAIMLPMMI 179
Cdd:cd09299  115 VsaVGVPYLLFTNHVYEIEHISPAWLLPIVPPMT--SAALAGALLPYSPGGAIQLsviflgylffgiGFFLFIFIGAIIF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 180 YRFMFTHEIPDAAKPTMAIMAAPASLSLAGYLTVT---------ATPSPVIIAMLFGIAV-------LMTAIIYLAFFKL 243
Cdd:cd09299  193 SRLVINKLPPGQLAPTLMIVLGPMGQSIFALLLLGknarlifflYASFLQALAVFASIILwgfglwwLLLALVSILRTLR 272

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 491627415 244 LRLPFSPGYAAFTFPMVIGATALFKMANWMELQGL 278
Cdd:cd09299  273 KKLPFSLGWWSYVFPLGVYTNGTYALYKLMDLPAF 307
TDT_like_1 cd09319
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 19-280 1.14e-05

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187759  Cd Length: 317  Bit Score: 46.15  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  19 LALGIASLGwswenfAELHGYGQ------WISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGTMVVSNS 92
Cdd:cd09319    8 MATGIVSIA------LHLLGLEVlsrallVLNLVAYVVLWVLTLARLLFYPRALRADLADPARGPGFFTAVAGTNVLGSQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  93 LG-HFYPLAGDVLWLIAVVLHIVFLVSFVYH---RAKDFELHHMVPSWFVPPVGI--------IVADVSFSGNPMLAPVA 160
Cdd:cd09319   82 LVlLGWNAVALVLWAVALVLWLVLTYAVFRAltvRRLKPTERGVNGAWLLAVVATqslavlgaLLAPAVPAGREWLLFLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 161 QGALMFGMVAYAIMLPMMIYRFMFTHEIPDAAKPTMAI-MAAPASLSLAGYLTVTATPSPVIIAMLFG------------ 227
Cdd:cd09319  162 LVLWLLGLALYLVVISLIDYRLVFFPFKPEDLAPPYWInMGALAISTLAGAKLILAASASPFLADLRPflkgttlllwaa 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491627415 228 ----IAVLMTAIIYLAFFKLLRLPFSPGYAAFTFPMVIGATALFKMANWMELQGLAA 280
Cdd:cd09319  242 atwwIPLLVALGIWRHVVHRIPLRYDPLRWSTVFPLGMYAAATLALARALGLPWLMA 298
TDT_SSU1 cd09318
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity ...
 42-270 3.10e-05

Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); This family contains the sulfite sensitivity protein (sulfite efflux pump; SSU1) and belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family. The SSU1 gene encodes the sulfite pump required for efficient sulfite efflux. Mutations in the SSU1 gene cause sensitivity to sulfite while overexpression confers heightened resistance to sulfite toxicity. In dematophytes and other filamentous fungi, sulfite is excreted as a reducing agent during keratin degradation; thus sulfite transporters in keratinolytic fungi could be a new target for antifungal drugs in dermatology. The number of genes encoding sulfite efflux pumps in fungal genomes varies from species to species.


Pssm-ID: 187758  Cd Length: 341  Bit Score: 45.26  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  42 WISAGIASVLLAILATKFLLHNHLLRQDLAHPVVGSVVPTFAMGT--------MVVSNSLGHFYPLAGDVLWLIAVVLHI 113
Cdd:cd09318   42 GINVLLFILFTVLFIARYVLYPERFRAMLKHPTQSLFLGTIPMGLatiingivLLCGPVWGPWAIILAWVLWWIDVALSL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 114 ---VFLVSFVYHRAKDFELHHMVPSWFVPPVGIIVADVS---FSGNPMLAPVAQGALMFGMVAYAIMLPM------MIYR 181
Cdd:cd09318  122 ataWGVPFLMFTRQNKHALEKMTAVWLLPIVALVVAASSgglVAPHLPNPNHALLTLVVSYVLWGIGVPLafiiltIYLL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 182 FMFTHEIPDAAKPT-------------MAIM--------AAPASLSLAGYLTVTATPSPVIIAML---FGIAVLMTAIIY 237
Cdd:cd09318  202 RLALHKLPPKALIFssflplgplgqgaFGILllgknakkLFPSTYTLSAAVGQIFYVLGLLIALIlwgFGLWWLFLAVAS 281

                        250       260       270
                 ....*....|....*....|....*....|...
gi 491627415 238 LAFFKLLRLPFSPGYAAFTFPMVIGATALFKMA 270
Cdd:cd09318  282 ILSYIRPGLPFNKGWWGFTFPLGVMALATIELG 314
TDT_like_2 cd09320
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 45-280 1.71e-03

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187760  Cd Length: 327  Bit Score: 39.61  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415  45 AGIASVLLAILATKFLLHNHLLR--QDLAHPVVGSVVPTFAMGTM--------VVSNSLGHFYPLAGD-VLWLIAVVLHI 113
Cdd:cd09320   35 WLVAALLLVALTAGFAAHWRRHPafARARDPVMMPFWGMVSMGLLavgaatltVGPDVIGHDAAVAVDtVLWVIGTVLGL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 114 VFLVSFVYHRAKDfELHHMVPSWFVPPVGIIVADVSF--------SGNPMLAPVAQGALMFGM--VAYAIMLPMMIYRFM 183
Cdd:cd09320  115 VTAVVIPRRLIRR-HRGTPTPVWGLPVVPPMVSATTGaqlvphlpAGQPRLTLLLACYACFGLslLAAAIIFALVYRRLW 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627415 184 FTHEIPDAAKPTMAIMAAPASLSLA----------GYLTVTATPSPVIIAMLFGIAVLMTAIIYLAFFKLL-------RL 246
Cdd:cd09320  194 RGGPLPLAAAPTAWIPLGVVGQSTAaaqllaaaagHVLPPPTAQTLHVFAVLYGVVMLGFGVPLLALAAAVtvravrrGM 273

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 491627415 247 PFSPGYAAFTFPM---VIGATALFKMANWMELQGLAA 280
Cdd:cd09320  274 PFSPTWWAFTFPVgtcVLGAHALAVHTGLAWFDWLAA 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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