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Conserved domains on  [gi|499168173|ref|WP_010866449|]
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CDGSH iron-sulfur domain-containing protein [Aeropyrum pernix]

Protein Classification

CDGSH iron-sulfur domain-containing protein( domain architecture ID 11465273)

CDGSH iron-sulfur domain (CISD)-containing protein similar to Ralstonia solanacearum type 4 CDGSH iron-sulfur protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
1-54 1.37e-22

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


:

Pssm-ID: 442596  Cd Length: 68  Bit Score: 80.90  E-value: 1.37e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499168173  1 MARVRIVAKKNGPYLLEVDGKV------------QTALCRCGHSNNKPYCDGTHARVGFQADEKVA 54
Cdd:COG3369   1 MSEVKITVAKNGPLLVEGDVEIvdadgneyeegkRYALCRCGLSKNKPFCDGSHKGTGFEPEGEAA 66
 
Name Accession Description Interval E-value
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
1-54 1.37e-22

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 80.90  E-value: 1.37e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499168173  1 MARVRIVAKKNGPYLLEVDGKV------------QTALCRCGHSNNKPYCDGTHARVGFQADEKVA 54
Cdd:COG3369   1 MSEVKITVAKNGPLLVEGDVEIvdadgneyeegkRYALCRCGLSKNKPFCDGSHKGTGFEPEGEAA 66
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
11-48 1.28e-14

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 60.05  E-value: 1.28e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 499168173   11 NGPYLLEVDGKVQTALCRCGHSNNKPYCDGTHARVGFQ 48
Cdd:smart00704  1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 12-43 1.30e-13

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 57.69  E-value: 1.30e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 499168173  12 GPYLLEV---------DGKVQTALCRCGHSNNKPYCDGTHA 43
Cdd:pfam09360  1 GPLLVEDadgetvesrEGRFVVALCRCGRSKNKPFCDGSHK 41
 
Name Accession Description Interval E-value
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
1-54 1.37e-22

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 80.90  E-value: 1.37e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499168173  1 MARVRIVAKKNGPYLLEVDGKV------------QTALCRCGHSNNKPYCDGTHARVGFQADEKVA 54
Cdd:COG3369   1 MSEVKITVAKNGPLLVEGDVEIvdadgneyeegkRYALCRCGLSKNKPFCDGSHKGTGFEPEGEAA 66
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
11-48 1.28e-14

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 60.05  E-value: 1.28e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 499168173   11 NGPYLLEVDGKVQTALCRCGHSNNKPYCDGTHARVGFQ 48
Cdd:smart00704  1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 12-43 1.30e-13

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 57.69  E-value: 1.30e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 499168173  12 GPYLLEV---------DGKVQTALCRCGHSNNKPYCDGTHA 43
Cdd:pfam09360  1 GPLLVEDadgetvesrEGRFVVALCRCGRSKNKPFCDGSHK 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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