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Conserved domains on  [gi|503264639|ref|WP_013499300|]
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BspA family leucine-rich repeat surface protein [Ruminococcus albus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDI_toxin_Bp1026b-like cd13442
C-terminal (CT) toxin domain of the contact-dependent growth inhibition (CDI) system of ...
 787-931 2.28e-32

C-terminal (CT) toxin domain of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal (CT) toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular example from Burkholderia pseudomallei 1026b and other bacteria appears to function as a Mg2+-dependent RNAse cleaving tRNA, most likely in the aminoacyl acceptor stem. This CdiA-Ct is structurally similar to another CDI toxin domain from B. pseudomallei E479 which is unrelated in sequence but has a similar nuclease domain, and shares similar fold and active-site architecture; it contains a core alpha/beta-fold that is characteristic of PD(D/E)XK superfamily nucleases.


:

Pssm-ID: 412041  Cd Length: 129  Bit Score: 121.88  E-value: 2.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 787 SNKKSWGDMGEKQAAEHLAENGYDVEMLPEVyKEVDGKiigngygkdiktNPDCRIEGKVYDIYSPSTQNLTTIKKEVLK 866
Cdd:cd13442   13 DPDTLRSLERENESADILAKNGYDVEQNPPV-PGKGGK------------NPDYLIEGEVFDCYAPTGSNKRNIWSTIRK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503264639 867 KSRQQTSNVVLNLNnpekyfddgtlvsDWQ-SVDEIVKMFKynsNNSLNELDELIILYNEEVLYAY 931
Cdd:cd13442   80 KVKKQADRIVLNLD-------------DSPlSVEEIRRQLK---RWPIKGLKELIVIKDGKIIRIY 129
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 322-440 1.14e-31

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


:

Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 119.67  E-value: 1.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  322 TDMREMFYFCNGLTSlDLRRFDTSKVTNMSGMFFYCKNLTTlDVSGFDTSKVTDMREMFYSCHDLTSlDLRRFDTSNVTD 401
Cdd:pfam03382   1 TDMSSMFSGATSFNQ-DIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVTD 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 503264639  402 LKSMFYGCKDLTSlDLSSFDTSSATNMTDMFKDCKKLKS 440
Cdd:pfam03382  78 MSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAFNQ 115
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 117-238 2.04e-31

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


:

Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 118.90  E-value: 2.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  117 MSFMFSRCYNLTSlNIRNFDTSNVTSMGQMFSYCSNLTSvDVSSFDTSKVTDMVAMFtsSGLTSL--DLSGFNTSNVTNM 194
Cdd:pfam03382   3 MSSMFSGATSFNQ-DIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMF--AGATSFnqDISSWNTSNVTDM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 503264639  195 TQMFKNCTKLTSvDVSSFDTSNVTNMIQMFDSCYALtSLDVSGF 238
Cdd:pfam03382  79 SRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAF-NQDLSNW 120
DUF285 super family cl37689
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 244-360 6.01e-25

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


The actual alignment was detected with superfamily member pfam03382:

Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 100.41  E-value: 6.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  244 TSMGAMFFNCYNLTtLDVSGFDTGKVTSMGNMFYFCDKLTKlDVSGFDTSNATTTRGMFYFCQSLTTlDVSGFDTSKVTD 323
Cdd:pfam03382   1 TDMSSMFSGATSFN-QDIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVTD 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 503264639  324 MREMFYFCNGLTSlDLRRFDTSKVTNMSGMFFYCKNL 360
Cdd:pfam03382  78 MSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAF 113
 
Name Accession Description Interval E-value
CDI_toxin_Bp1026b-like cd13442
C-terminal (CT) toxin domain of the contact-dependent growth inhibition (CDI) system of ...
 787-931 2.28e-32

C-terminal (CT) toxin domain of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal (CT) toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular example from Burkholderia pseudomallei 1026b and other bacteria appears to function as a Mg2+-dependent RNAse cleaving tRNA, most likely in the aminoacyl acceptor stem. This CdiA-Ct is structurally similar to another CDI toxin domain from B. pseudomallei E479 which is unrelated in sequence but has a similar nuclease domain, and shares similar fold and active-site architecture; it contains a core alpha/beta-fold that is characteristic of PD(D/E)XK superfamily nucleases.


Pssm-ID: 412041  Cd Length: 129  Bit Score: 121.88  E-value: 2.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 787 SNKKSWGDMGEKQAAEHLAENGYDVEMLPEVyKEVDGKiigngygkdiktNPDCRIEGKVYDIYSPSTQNLTTIKKEVLK 866
Cdd:cd13442   13 DPDTLRSLERENESADILAKNGYDVEQNPPV-PGKGGK------------NPDYLIEGEVFDCYAPTGSNKRNIWSTIRK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503264639 867 KSRQQTSNVVLNLNnpekyfddgtlvsDWQ-SVDEIVKMFKynsNNSLNELDELIILYNEEVLYAY 931
Cdd:cd13442   80 KVKKQADRIVLNLD-------------DSPlSVEEIRRQLK---RWPIKGLKELIVIKDGKIIRIY 129
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 322-440 1.14e-31

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 119.67  E-value: 1.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  322 TDMREMFYFCNGLTSlDLRRFDTSKVTNMSGMFFYCKNLTTlDVSGFDTSKVTDMREMFYSCHDLTSlDLRRFDTSNVTD 401
Cdd:pfam03382   1 TDMSSMFSGATSFNQ-DIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVTD 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 503264639  402 LKSMFYGCKDLTSlDLSSFDTSSATNMTDMFKDCKKLKS 440
Cdd:pfam03382  78 MSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAFNQ 115
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 117-238 2.04e-31

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 118.90  E-value: 2.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  117 MSFMFSRCYNLTSlNIRNFDTSNVTSMGQMFSYCSNLTSvDVSSFDTSKVTDMVAMFtsSGLTSL--DLSGFNTSNVTNM 194
Cdd:pfam03382   3 MSSMFSGATSFNQ-DIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMF--AGATSFnqDISSWNTSNVTDM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 503264639  195 TQMFKNCTKLTSvDVSSFDTSNVTNMIQMFDSCYALtSLDVSGF 238
Cdd:pfam03382  79 SRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAF-NQDLSNW 120
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 244-360 6.01e-25

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 100.41  E-value: 6.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  244 TSMGAMFFNCYNLTtLDVSGFDTGKVTSMGNMFYFCDKLTKlDVSGFDTSNATTTRGMFYFCQSLTTlDVSGFDTSKVTD 323
Cdd:pfam03382   1 TDMSSMFSGATSFN-QDIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVTD 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 503264639  324 MREMFYFCNGLTSlDLRRFDTSKVTNMSGMFFYCKNL 360
Cdd:pfam03382  78 MSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAF 113
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
281-471 1.64e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 281 KLTKLDVSGFDTsnatttrgmFYFCQSLTTLDVSGfdtSKVTDMREMFYFCNGLTSLDLRRfdtSKVTNMSGMFFYCKNL 360
Cdd:COG4886   97 NLTELDLSGNEE---------LSNLTNLESLDLSG---NQLTDLPEELANLTNLKELDLSN---NQLTDLPEPLGNLTNL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 361 TTLDVSGfdtSKVTDMREMFYSCHDLTSLDLRRfdtSNVTDLKSMFYGCKDLTSLDLSSfdtssaTNMTDM---FKDCKK 437
Cdd:COG4886  162 KSLDLSN---NQLTDLPEELGNLTNLKELDLSN---NQITDLPEPLGNLTNLEELDLSG------NQLTDLpepLANLTN 229

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 503264639 438 LKSLTLGIN-FRNIPEKAALRN------GYGWIKRIPKLKH 471
Cdd:COG4886  230 LETLDLSNNqLTDLPELGNLTNleeldlSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-417 1.97e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 1.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  29 QSITAQAATSDNGCYSFNATTGELTLSGVVDKDTLSEFKRSINIKTDIKSVvaKNGTVLPENCSYLFSYLENCTSIDLSK 108
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL--TNLTELDLSGNEELSNLTNLESLDLSG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 109 adtSNVKKMSFMFSRCYNLTSLNIRNfdtSNVTSMGQMFSYCSNLTSVDVSSfdtSKVTDM-VAMFTSSGLTSLDLSGfn 187
Cdd:COG4886  123 ---NQLTDLPEELANLTNLKELDLSN---NQLTDLPEPLGNLTNLKSLDLSN---NQLTDLpEELGNLTNLKELDLSN-- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 188 tSNVTNMTQMFKNCTKLTSVDVSSfdtSNVTNMIQMFDSCYALTSLDVSGfdtSKVTSMGAmFFNCYNLTTLDVSGFDTG 267
Cdd:COG4886  192 -NQITDLPEPLGNLTNLEELDLSG---NQLTDLPEPLANLTNLETLDLSN---NQLTDLPE-LGNLTNLEELDLSNNQLT 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 268 KVTSMGNMfyfcDKLTKLDVSGfdtsNATTTRGMfyfcQSLTTLDVSGFDTSKVTDMREMFYFCNGLTSLDLRRFDTSKV 347
Cdd:COG4886  264 DLPPLANL----TNLKTLDLSN----NQLTDLKL----KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 348 TNMSGMFFYCKNLTTLDVSGFDTSKVTDMREMFYSCHDLTSLDLRRFDTSNVTDLKSMFYGCKDLTSLDL 417
Cdd:COG4886  332 GLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
CdiA_C pfam18451
Contact-dependent growth inhibition CdiA C-terminal domain; Contact-dependent growth ...
 836-927 9.57e-10

Contact-dependent growth inhibition CdiA C-terminal domain; Contact-dependent growth inhibition (CDI) systems encode polymorphic toxin/immunity proteins that mediate competition between neighboring bacterial cells. CDI is mediated by the CdiB/CdiA family of two-partner secretion proteins. This domain represents the C-terminal of CdiA proteins (CdiA-CT), which contains the CDI toxin activity. The C-terminal nuclease domain forms a stable complex with its cognate immunity protein. It is also sufficient to inhibit growth when expressed in E. coli cells, consolidating the idea that they constitute the functional CDI toxin. The CdiA-CT C-terminal domains are structurally similar to type IIS restriction endonucleases suggesting that the toxins have metal-dependent DNase activity.


Pssm-ID: 436511  Cd Length: 81  Bit Score: 55.78  E-value: 9.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  836 TNPDCRIEGKVYDIYSPSTQNLTTIKKEVLKKSRQQTSNVVLNLNNPEKYFDDgtlvsdwqsVDEIVKMFKYNSNNSLNE 915
Cdd:pfam18451   1 KTPDYLINGEIFDFKSPTSGNGKNIIRNIIKKAKKQAGNIVLNLNDSPLSIEE---------IIEGIKRALKWPVKGLKE 71

                          90
                  ....*....|..
gi 503264639  916 LdeLIILYNEEV 927
Cdd:pfam18451  72 V--IIIDKDGEI 81
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 353-378 1.89e-08

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 50.55  E-value: 1.89e-08
                          10        20
                  ....*....|....*....|....*.
gi 503264639  353 MFFYCKNLTTLDVSGFDTSKVTDMRE 378
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 146-169 5.03e-08

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 49.40  E-value: 5.03e-08
                          10        20
                  ....*....|....*....|....
gi 503264639  146 MFSYCSNLTSVDVSSFDTSKVTDM 169
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNM 24
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 301-326 5.08e-08

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 49.40  E-value: 5.08e-08
                          10        20
                  ....*....|....*....|....*.
gi 503264639  301 MFYFCQSLTTLDVSGFDTSKVTDMRE 326
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 221-390 1.45e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 221 IQMFDSCYALTSLDVSGfdtSKVTSMGaMFFNCYNLTTLDVSGFDTGKVTSMGNmfyfCDKLTKLDVSG----------F 290
Cdd:cd21340   39 IENLEFLTNLTHLYLQN---NQIEKIE-NLENLVNLKKLYLGGNRISVVEGLEN----LTNLEELHIENqrlppgekltF 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 291 DTsnatttRGMFYFCQSLTTLDVSGfdtSKVTDMREMFYFCNgLTSLDLRRFDTSKVTNMSGMFFYCKNLTTLDVSGFDT 370
Cdd:cd21340  111 DP------RSLAALSNSLRVLNISG---NNIDSLEPLAPLRN-LEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180

                        170       180
                 ....*....|....*....|.
gi 503264639 371 SKVTDMRE-MFYSCHDLTSLD 390
Cdd:cd21340  181 CKKPKYRDkIILASKSLEVLD 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-418 5.78e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 5.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503264639 358 KNLTTLDVSGfdtSKVTDMREmFYSCHDLTSLDLRRFDTSNVTDLKSMFYGCKDLTSLDLS 418
Cdd:cd21340  120 NSLRVLNISG---NNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLT 176
 
Name Accession Description Interval E-value
CDI_toxin_Bp1026b-like cd13442
C-terminal (CT) toxin domain of the contact-dependent growth inhibition (CDI) system of ...
 787-931 2.28e-32

C-terminal (CT) toxin domain of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal (CT) toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular example from Burkholderia pseudomallei 1026b and other bacteria appears to function as a Mg2+-dependent RNAse cleaving tRNA, most likely in the aminoacyl acceptor stem. This CdiA-Ct is structurally similar to another CDI toxin domain from B. pseudomallei E479 which is unrelated in sequence but has a similar nuclease domain, and shares similar fold and active-site architecture; it contains a core alpha/beta-fold that is characteristic of PD(D/E)XK superfamily nucleases.


Pssm-ID: 412041  Cd Length: 129  Bit Score: 121.88  E-value: 2.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 787 SNKKSWGDMGEKQAAEHLAENGYDVEMLPEVyKEVDGKiigngygkdiktNPDCRIEGKVYDIYSPSTQNLTTIKKEVLK 866
Cdd:cd13442   13 DPDTLRSLERENESADILAKNGYDVEQNPPV-PGKGGK------------NPDYLIEGEVFDCYAPTGSNKRNIWSTIRK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503264639 867 KSRQQTSNVVLNLNnpekyfddgtlvsDWQ-SVDEIVKMFKynsNNSLNELDELIILYNEEVLYAY 931
Cdd:cd13442   80 KVKKQADRIVLNLD-------------DSPlSVEEIRRQLK---RWPIKGLKELIVIKDGKIIRIY 129
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 322-440 1.14e-31

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 119.67  E-value: 1.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  322 TDMREMFYFCNGLTSlDLRRFDTSKVTNMSGMFFYCKNLTTlDVSGFDTSKVTDMREMFYSCHDLTSlDLRRFDTSNVTD 401
Cdd:pfam03382   1 TDMSSMFSGATSFNQ-DIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVTD 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 503264639  402 LKSMFYGCKDLTSlDLSSFDTSSATNMTDMFKDCKKLKS 440
Cdd:pfam03382  78 MSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAFNQ 115
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 117-238 2.04e-31

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 118.90  E-value: 2.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  117 MSFMFSRCYNLTSlNIRNFDTSNVTSMGQMFSYCSNLTSvDVSSFDTSKVTDMVAMFtsSGLTSL--DLSGFNTSNVTNM 194
Cdd:pfam03382   3 MSSMFSGATSFNQ-DIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMF--AGATSFnqDISSWNTSNVTDM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 503264639  195 TQMFKNCTKLTSvDVSSFDTSNVTNMIQMFDSCYALtSLDVSGF 238
Cdd:pfam03382  79 SRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAF-NQDLSNW 120
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 141-253 4.38e-30

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 115.05  E-value: 4.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  141 TSMGQMFSYCSNLTSvDVSSFDTSKVTDMVAMFtsSGLTSL--DLSGFNTSNVTNMTQMFKNCTKLTSvDVSSFDTSNVT 218
Cdd:pfam03382   1 TDMSSMFSGATSFNQ-DIGNWDTSNVTDMSGMF--YGATNFnqDISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVT 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 503264639  219 NMIQMFDSCYALTSlDVSGFDTSKVTSMGAMFFNC 253
Cdd:pfam03382  77 DMSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGA 110
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 167-290 8.45e-29

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 111.58  E-value: 8.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  167 TDMVAMFTSSGLTSLDLSGFNTSNVTNMTQMFKNCTKLTSvDVSSFDTSNVTNMIQMFDSCYALTSlDVSGFDTSKVTSM 246
Cdd:pfam03382   1 TDMSSMFSGATSFNQDIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVTDM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 503264639  247 GAMFFNCYNLtTLDVSGFDTGKVTSMGNMFYFCDKLtKLDVSGF 290
Cdd:pfam03382  79 SRMFYNATSF-NQDISSWNTSNVTDMSSMFAGATAF-NQDLSNW 120
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 244-360 6.01e-25

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 100.41  E-value: 6.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  244 TSMGAMFFNCYNLTtLDVSGFDTGKVTSMGNMFYFCDKLTKlDVSGFDTSNATTTRGMFYFCQSLTTlDVSGFDTSKVTD 323
Cdd:pfam03382   1 TDMSSMFSGATSFN-QDIGNWDTSNVTDMSGMFYGATNFNQ-DISKWDTSSVTNMSYMFAGATSFNQ-DISSWNTSNVTD 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 503264639  324 MREMFYFCNGLTSlDLRRFDTSKVTNMSGMFFYCKNL 360
Cdd:pfam03382  78 MSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAF 113
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
281-471 1.64e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 281 KLTKLDVSGFDTsnatttrgmFYFCQSLTTLDVSGfdtSKVTDMREMFYFCNGLTSLDLRRfdtSKVTNMSGMFFYCKNL 360
Cdd:COG4886   97 NLTELDLSGNEE---------LSNLTNLESLDLSG---NQLTDLPEELANLTNLKELDLSN---NQLTDLPEPLGNLTNL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 361 TTLDVSGfdtSKVTDMREMFYSCHDLTSLDLRRfdtSNVTDLKSMFYGCKDLTSLDLSSfdtssaTNMTDM---FKDCKK 437
Cdd:COG4886  162 KSLDLSN---NQLTDLPEELGNLTNLKELDLSN---NQITDLPEPLGNLTNLEELDLSG------NQLTDLpepLANLTN 229

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 503264639 438 LKSLTLGIN-FRNIPEKAALRN------GYGWIKRIPKLKH 471
Cdd:COG4886  230 LETLDLSNNqLTDLPELGNLTNleeldlSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-417 1.97e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 1.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  29 QSITAQAATSDNGCYSFNATTGELTLSGVVDKDTLSEFKRSINIKTDIKSVvaKNGTVLPENCSYLFSYLENCTSIDLSK 108
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL--TNLTELDLSGNEELSNLTNLESLDLSG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 109 adtSNVKKMSFMFSRCYNLTSLNIRNfdtSNVTSMGQMFSYCSNLTSVDVSSfdtSKVTDM-VAMFTSSGLTSLDLSGfn 187
Cdd:COG4886  123 ---NQLTDLPEELANLTNLKELDLSN---NQLTDLPEPLGNLTNLKSLDLSN---NQLTDLpEELGNLTNLKELDLSN-- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 188 tSNVTNMTQMFKNCTKLTSVDVSSfdtSNVTNMIQMFDSCYALTSLDVSGfdtSKVTSMGAmFFNCYNLTTLDVSGFDTG 267
Cdd:COG4886  192 -NQITDLPEPLGNLTNLEELDLSG---NQLTDLPEPLANLTNLETLDLSN---NQLTDLPE-LGNLTNLEELDLSNNQLT 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 268 KVTSMGNMfyfcDKLTKLDVSGfdtsNATTTRGMfyfcQSLTTLDVSGFDTSKVTDMREMFYFCNGLTSLDLRRFDTSKV 347
Cdd:COG4886  264 DLPPLANL----TNLKTLDLSN----NQLTDLKL----KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 348 TNMSGMFFYCKNLTTLDVSGFDTSKVTDMREMFYSCHDLTSLDLRRFDTSNVTDLKSMFYGCKDLTSLDL 417
Cdd:COG4886  332 GLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
CdiA_C pfam18451
Contact-dependent growth inhibition CdiA C-terminal domain; Contact-dependent growth ...
 836-927 9.57e-10

Contact-dependent growth inhibition CdiA C-terminal domain; Contact-dependent growth inhibition (CDI) systems encode polymorphic toxin/immunity proteins that mediate competition between neighboring bacterial cells. CDI is mediated by the CdiB/CdiA family of two-partner secretion proteins. This domain represents the C-terminal of CdiA proteins (CdiA-CT), which contains the CDI toxin activity. The C-terminal nuclease domain forms a stable complex with its cognate immunity protein. It is also sufficient to inhibit growth when expressed in E. coli cells, consolidating the idea that they constitute the functional CDI toxin. The CdiA-CT C-terminal domains are structurally similar to type IIS restriction endonucleases suggesting that the toxins have metal-dependent DNase activity.


Pssm-ID: 436511  Cd Length: 81  Bit Score: 55.78  E-value: 9.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  836 TNPDCRIEGKVYDIYSPSTQNLTTIKKEVLKKSRQQTSNVVLNLNNPEKYFDDgtlvsdwqsVDEIVKMFKYNSNNSLNE 915
Cdd:pfam18451   1 KTPDYLINGEIFDFKSPTSGNGKNIIRNIIKKAKKQAGNIVLNLNDSPLSIEE---------IIEGIKRALKWPVKGLKE 71

                          90
                  ....*....|..
gi 503264639  916 LdeLIILYNEEV 927
Cdd:pfam18451  72 V--IIIDKDGEI 81
CDI_toxin_Bp_tRNase-like cd20727
C-terminal (CT) toxin domain of a contact-dependent growth inhibition (CDI) system (CdiA-CT) ...
 797-881 5.63e-09

C-terminal (CT) toxin domain of a contact-dependent growth inhibition (CDI) system (CdiA-CT) similar to that of Burkholderia pseudomallei, and related proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal (CT) toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular model contains the C-terminal (CT) toxin domains that are similar to Burkholderia pseudomallei E479 and 1026b CdiA toxins, both of which are tRNAses.


Pssm-ID: 412044  Cd Length: 105  Bit Score: 54.56  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 797 EKQAAEHLAENGYDVEMLPEVykevdGKIIGNGygkdiKTnPDCRIEGKVYDIYSPSTQNLTTIKKEVLKKsRQQTSNVV 876
Cdd:cd20727    5 EIRAAQYLASLGYDVTLRPPA-----SDRIAGG-----RT-SDLLVDGGRVDVYTPTTSNPKNIVRAIEKK-NSQAGGVV 72


                 ....*
gi 503264639 877 LNLNN 881
Cdd:cd20727   73 VDLDL 77
DUF285 pfam03382
Mycoplasma protein of unknown function, DUF285; This region appears distantly related to ...
 105-161 6.29e-09

Mycoplasma protein of unknown function, DUF285; This region appears distantly related to leucine rich repeats.


Pssm-ID: 427272 [Multi-domain]  Cd Length: 120  Bit Score: 54.95  E-value: 6.29e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 503264639  105 DLSKADTSNVKKMSFMFSRCYNLTSlNIRNFDTSNVTSMGQMFSYCSNLtSVDVSSF 161
Cdd:pfam03382  66 DISSWNTSNVTDMSRMFYNATSFNQ-DISSWNTSNVTDMSSMFAGATAF-NQDLSNW 120
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 353-378 1.89e-08

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 50.55  E-value: 1.89e-08
                          10        20
                  ....*....|....*....|....*.
gi 503264639  353 MFFYCKNLTTLDVSGFDTSKVTDMRE 378
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 146-169 5.03e-08

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 49.40  E-value: 5.03e-08
                          10        20
                  ....*....|....*....|....
gi 503264639  146 MFSYCSNLTSVDVSSFDTSKVTDM 169
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNM 24
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 301-326 5.08e-08

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 49.40  E-value: 5.08e-08
                          10        20
                  ....*....|....*....|....*.
gi 503264639  301 MFYFCQSLTTLDVSGFDTSKVTDMRE 326
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 197-220 7.51e-08

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 49.01  E-value: 7.51e-08
                          10        20
                  ....*....|....*....|....
gi 503264639  197 MFKNCTKLTSVDVSSFDTSNVTNM 220
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNM 24
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 405-429 1.49e-07

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 47.86  E-value: 1.49e-07
                          10        20
                  ....*....|....*....|....*
gi 503264639  405 MFYGCKDLTSLDLSSFDTSSATNMT 429
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMS 25
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 249-274 6.66e-07

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 46.32  E-value: 6.66e-07
                          10        20
                  ....*....|....*....|....*.
gi 503264639  249 MFFNCYNLTTLDVSGFDTGKVTSMGN 274
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 223-246 1.74e-06

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 45.16  E-value: 1.74e-06
                          10        20
                  ....*....|....*....|....
gi 503264639  223 MFDSCYALTSLDVSGFDTSKVTSM 246
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNM 24
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 327-352 2.55e-06

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 44.39  E-value: 2.55e-06
                          10        20
                  ....*....|....*....|....*.
gi 503264639  327 MFYFCNGLTSLDLRRFDTSKVTNMSG 352
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 121-257 7.44e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 46.00  E-value: 7.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  121 FSRCyNLTSLNIrnfdTSNVTSMGQM-FSYCSNLTSVD----VSSFDTSkvtdmvaMFTSSGLTSLDLSgfntSNVTNMT 195
Cdd:pfam13306   8 FYNC-SLTSITI----PSSLTSIGEYaFSNCTSLKSITlpssLTSIGSY-------AFYNCSLTSITIP----SSLTSIG 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503264639  196 Q-MFKNCTKLTSVDVSsfdtSNVTNM-IQMFDSCYaLTSLDVsgfdTSKVTSMGAM-FFNCYNLT 257
Cdd:pfam13306  72 EyAFSNCSNLKSITLP----SNLTSIgSYAFSNCS-LKSITI----PSSVTTIGSYaFSNCSNLK 127
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 120-143 7.55e-06

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 43.24  E-value: 7.55e-06
                          10        20
                  ....*....|....*....|....
gi 503264639  120 MFSRCYNLTSLNIRNFDTSNVTSM 143
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNM 24
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 86-205 7.73e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 46.00  E-value: 7.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639   86 VLPEN----CSYLFSYLENCTSIDLSkadtSNVKKM-SFMFSRCyNLTSLNIrnfdTSNVTSMGQ-MFSYCSNLTSVDVS 159
Cdd:pfam13306  17 TIPSSltsiGEYAFSNCTSLKSITLP----SSLTSIgSYAFYNC-SLTSITI----PSSLTSIGEyAFSNCSNLKSITLP 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 503264639  160 sfdtSKVTDM-VAMFTSSGLTSLDLsgfnTSNVTNMTQM-FKNCTKLT 205
Cdd:pfam13306  88 ----SNLTSIgSYAFSNCSLKSITI----PSSVTTIGSYaFSNCSNLK 127
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 275-300 3.07e-05

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 41.31  E-value: 3.07e-05
                          10        20
                  ....*....|....*....|....*.
gi 503264639  275 MFYFCDKLTKLDVSGFDTSNATTTRG 300
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
CDI_toxin_Bp_tRNase-like cd20689
C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) of ...
 796-883 5.19e-05

C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) of Burkholderia pseudomallei, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal (CT) toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular model includes the C-terminal (CT) toxin domains of Burkholderia pseudomallei E479 and 1026b, both appearing to be RNAses acting on tRNA.


Pssm-ID: 412042  Cd Length: 99  Bit Score: 43.05  E-value: 5.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 796 GEKQAAEHLAENGYDVEMLPEVYKEvdgkiigngygkdikTNPDCRIE-GKVYDIYSPSTQNLTTIKKEVLKKSrQQTSN 874
Cdd:cd20689    2 NEVRAAQGLSNLGYDVTQQTTASAQ---------------RTADLHVDgGGSIDVYTPKNLNPTNIVRTISKKS-NQAGG 65


                 ....*....
gi 503264639 875 VVLNLNNPE 883
Cdd:cd20689   66 VLVQADLPS 74
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 172-195 5.97e-05

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 40.54  E-value: 5.97e-05
                          10        20
                  ....*....|....*....|....*
gi 503264639  172 MFTS-SGLTSLDLSGFNTSNVTNMT 195
Cdd:TIGR02167   1 MFSGcSSLTSLDLSNWDTSNVTNMS 25
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 328-454 9.40e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.92  E-value: 9.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  328 FYFCNgLTSLDLrrfdTSKVTNM-SGMFFYCKNLTTLDVSgfdtSKVTDMREM-FYSCHdLTSLDLrrfdTSNVTDL-KS 404
Cdd:pfam13306   8 FYNCS-LTSITI----PSSLTSIgEYAFSNCTSLKSITLP----SSLTSIGSYaFYNCS-LTSITI----PSSLTSIgEY 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 503264639  405 MFYGCKDLTSLDLSSFDTSSATNMtdmFKDCKkLKSLTLGINFRNIPEKA 454
Cdd:pfam13306  74 AFSNCSNLKSITLPSNLTSIGSYA---FSNCS-LKSITIPSSVTTIGSYA 119
Liste_lipo_26 TIGR02167
bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat ...
 379-404 9.84e-05

bacterial surface protein 26-residue repeat; This model describes a tandem peptide repeat sequence of 25 or 26 residues, found in predicted surface proteins (often lipoproteins) from Listeria monocytogenes, L. innocua, Enterococcus faecalis, Lactobacillus plantarum, Mycoplasma mycoides, Helicobacter hepaticus, and other species.


Pssm-ID: 274007 [Multi-domain]  Cd Length: 26  Bit Score: 40.15  E-value: 9.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 503264639  379 MFYSCHDLTSLDLRRFDTSNVTDLKS 404
Cdd:TIGR02167   1 MFSGCSSLTSLDLSNWDTSNVTNMSS 26
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 221-390 1.45e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 221 IQMFDSCYALTSLDVSGfdtSKVTSMGaMFFNCYNLTTLDVSGFDTGKVTSMGNmfyfCDKLTKLDVSG----------F 290
Cdd:cd21340   39 IENLEFLTNLTHLYLQN---NQIEKIE-NLENLVNLKKLYLGGNRISVVEGLEN----LTNLEELHIENqrlppgekltF 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 291 DTsnatttRGMFYFCQSLTTLDVSGfdtSKVTDMREMFYFCNgLTSLDLRRFDTSKVTNMSGMFFYCKNLTTLDVSGFDT 370
Cdd:cd21340  111 DP------RSLAALSNSLRVLNISG---NNIDSLEPLAPLRN-LEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180

                        170       180
                 ....*....|....*....|.
gi 503264639 371 SKVTDMRE-MFYSCHDLTSLD 390
Cdd:cd21340  181 CKKPKYRDkIILASKSLEVLD 201
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 224-361 1.74e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639  224 FDSCYaLTSLDVSgfdtSKVTSMGAM-FFNCYNLTTLDVSgfdtGKVTSMGNM-FYFCdKLTKLDvsgFDTSNATTTRGM 301
Cdd:pfam13306   8 FYNCS-LTSITIP----SSLTSIGEYaFSNCTSLKSITLP----SSLTSIGSYaFYNC-SLTSIT---IPSSLTSIGEYA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503264639  302 FYFCQSLTTLDVSgfdtSKVTDMRE-MFYFCNgLTSLDLrrfdTSKVTNMSGM-FFYCKNLT 361
Cdd:pfam13306  75 FSNCSNLKSITLP----SNLTSIGSyAFSNCS-LKSITI----PSSVTTIGSYaFSNCSNLK 127
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-418 5.78e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 5.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503264639 358 KNLTTLDVSGfdtSKVTDMREmFYSCHDLTSLDLRRFDTSNVTDLKSMFYGCKDLTSLDLS 418
Cdd:cd21340  120 NSLRVLNISG---NNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLT 176
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 252-392 7.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503264639 252 NCYNLTTLDVSGfdtGKVTSMGNMFYfCDKLTKLD--------VSGFDTsnatttrgmfyfCQSLTTLDVSG-------- 315
Cdd:cd21340   44 FLTNLTHLYLQN---NQIEKIENLEN-LVNLKKLYlggnrisvVEGLEN------------LTNLEELHIENqrlppgek 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503264639 316 --FDTskvtdmREMFYFCNGLTSLDLRRfdtSKVTNMSGmFFYCKNLTTLDVSGFDTSKVTDMREMFYSCHDLTSLDLR 392
Cdd:cd21340  108 ltFDP------RSLAALSNSLRVLNISG---NNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLT 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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