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Conserved domains on  [gi|563943544|ref|WP_023812382|]
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MULTISPECIES: NADH-quinone oxidoreductase subunit NuoI [Mesorhizobium]

Protein Classification

NADH-quinone oxidoreductase subunit I( domain architecture ID 11481829)

NADH-quinone oxidoreductase subunit I (NuoI) is part of the connecting domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

EC:  7.1.1.-
Gene Ontology:  GO:0016651|GO:0051539|GO:0016020
PubMed:  23417064

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
4-163 1.47e-92

NADH-quinone oxidoreductase subunit NuoI;


:

Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 265.59  E-value: 1.47e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544   4 LSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAG 83
Cdd:PRK05888   1 IKQYLKSMLLKELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  84 PrRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNISLDSPYR 163
Cdd:PRK05888  81 E-REDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
4-163 1.47e-92

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 265.59  E-value: 1.47e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544   4 LSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAG 83
Cdd:PRK05888   1 IKQYLKSMLLKELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  84 PrRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNISLDSPYR 163
Cdd:PRK05888  81 E-REDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 20-141 8.51e-60

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 181.46  E-value: 8.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544   20 FFLSMRQFFAPKETINYPHEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGpRRNDGTRRTVRYDID 99
Cdd:TIGR01971   2 LGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPA-EGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 563943544  100 MVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKL 141
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 60-133 6.61e-22

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 83.26  E-value: 6.61e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRRndgtrrtVRYDIDMVKCIYCGFCQEACPVDAIVEGPnFEFATETREE 133
Cdd:COG1143    1 EDKCIGCGLCVRVCPVDAITIEDGEPG-------KVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 60-119 3.41e-15

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 67.81  E-value: 3.41e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRrndgtrrtvrYDIDMVKCIYCGFCQEACPVDAIV 119
Cdd:cd10549   77 EEKCIGCGLCVKVCPVDAITLEDELE----------IVIDKEKCIGCGICAEVCPVNAIK 126
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 63-117 1.11e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 56.77  E-value: 1.11e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 563943544   63 CIACKLCEAICPAQAITIeagpRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDA 117
Cdd:pfam12838   1 CIGCGACVAACPVGAITL----DEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 25-118 4.85e-07

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.55  E-value: 4.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  25 RQFFAPKETINYPHEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAG-PRRNDgtrrtvrydidmvKC 103
Cdd:NF038196 149 KKGPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGkPVWGH-------------NC 215

                         90
                 ....*....|....*
gi 563943544 104 IYCGFCQEACPVDAI 118
Cdd:NF038196 216 THCLACIHRCPKEAI 230
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
4-163 1.47e-92

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 265.59  E-value: 1.47e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544   4 LSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAG 83
Cdd:PRK05888   1 IKQYLKSMLLKELLKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  84 PrRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNISLDSPYR 163
Cdd:PRK05888  81 E-REDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGDRVEREIAPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 20-141 8.51e-60

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 181.46  E-value: 8.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544   20 FFLSMRQFFAPKETINYPHEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGpRRNDGTRRTVRYDID 99
Cdd:TIGR01971   2 LGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPA-EGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 563943544  100 MVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKL 141
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 60-133 6.61e-22

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 83.26  E-value: 6.61e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRRndgtrrtVRYDIDMVKCIYCGFCQEACPVDAIVEGPnFEFATETREE 133
Cdd:COG1143    1 EDKCIGCGLCVRVCPVDAITIEDGEPG-------KVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 31-136 6.23e-17

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 73.53  E-value: 6.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  31 KETINYPHEKGPTSPRFRG--EHALrrypngeERCIACKLCEAICPAQAITIEAgprrnDGTRRTVRYDIDMVKCIYCGF 108
Cdd:PRK12387  13 TATSSYPLEPIAVDKNFRGkpEYNP-------QQCIGCAACVNACPSNALTVET-----DLATGELAWEFNLGRCIFCGR 80

                         90       100
                 ....*....|....*....|....*...
gi 563943544 109 CQEACPVDAIVEGPNFEFATETREELYY 136
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQ 108
ndhI CHL00014
NADH dehydrogenase subunit I
 33-138 1.98e-16

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 72.10  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  33 TINYPHEKGPTSPRFRGehalrRYPNGEERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEA 112
Cdd:CHL00014  36 TIQYPYEKLITSERFRG-----RIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGVCIFCGNCVEY 110

                         90       100
                 ....*....|....*....|....*.
gi 563943544 113 CPVDAIVEGPNFEFATETREELYYDK 138
Cdd:CHL00014 111 CPTNCLSMTEEYELSTYDRHELNYNQ 136
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 60-119 3.41e-15

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 67.81  E-value: 3.41e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRrndgtrrtvrYDIDMVKCIYCGFCQEACPVDAIV 119
Cdd:cd10549   77 EEKCIGCGLCVKVCPVDAITLEDELE----------IVIDKEKCIGCGICAEVCPVNAIK 126
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 33-135 1.20e-14

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 67.86  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  33 TINYPHEKGPTSPRFRGEHALrrypnGEERCIACKLCEAICPAQAITIEagprrNDGTRRTVRYDIDMVKCIYCGFCQEA 112
Cdd:PRK08222  15 TVKYPFAPLEVSPGFRGKPDL-----MPSQCIACGACTCACPANALTIQ-----TDDQQNSRTWQLYLGRCIYCGRCEEV 84

                         90       100
                 ....*....|....*....|...
gi 563943544 113 CPVDAIVEGPNFEFATETREELY 135
Cdd:PRK08222  85 CPTRAIQLTNNFELTVTNKADLY 107
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
51-125 1.61e-14

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 64.75  E-value: 1.61e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 563943544  51 HALRRYPNGEERCIACKLCEAICPAQAITIEAGPRRndgtrrtvrydIDMVKCIYCGFCQEACPVDAIVEGPNFE 125
Cdd:COG2768    1 HSLGKPYVDEEKCIGCGACVKVCPVGAISIEDGKAV-----------IDPEKCIGCGACIEVCPVGAIKIEWEED 64
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 60-140 2.26e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 65.50  E-value: 2.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  60 EERCIACKLCEAICPAQAITIEagprRNDGTRRTVryDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKD 139
Cdd:cd10549    5 PEKCIGCGICVKACPTDAIELG----PNGAIARGP--EIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDEE 78


                 .
gi 563943544 140 K 140
Cdd:cd10549   79 K 79
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 60-126 3.81e-14

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 63.53  E-value: 3.81e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGprrndgtrrtvRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEF 126
Cdd:COG2221   14 EEKCIGCGLCVAVCPTGAISLDDG-----------KLVIDEEKCIGCGACIRVCPTGAIKGEKPKKF 69
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 60-118 4.09e-13

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 62.41  E-value: 4.09e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITIeaGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:cd10549   39 EDKCVFCGACVEVCPTGAIEL--TPEGKEYVPKEKEAEIDEEKCIGCGLCVKVCPVDAI 95
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 60-119 6.14e-13

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 60.44  E-value: 6.14e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRRndgtrrtvrydIDMVKCIYCGFCQEACPVDAIV 119
Cdd:COG4231   21 EDKCTGCGACVKVCPADAIEEGDGKAV-----------IDPDLCIGCGSCVQVCPVDAIK 69
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 60-119 3.34e-12

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 58.91  E-value: 3.34e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPrrndgtrrtvRYDIDMVKCIYCGFCQEACPVDAIV 119
Cdd:COG1144   29 EDKCIGCGLCWIVCPDGAIRVDDGK----------YYGIDYDYCKGCGICAEVCPVKAIE 78
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 63-117 1.11e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 56.77  E-value: 1.11e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 563943544   63 CIACKLCEAICPAQAITIeagpRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDA 117
Cdd:pfam12838   1 CIGCGACVAACPVGAITL----DEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
NapF COG1145
Ferredoxin [Energy production and conversion];
60-118 1.67e-11

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 60.51  E-value: 1.67e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGprrndgtrrTVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:COG1145  181 AEKCIGCGLCVKVCPTGAIRLKDG---------KPQIVVDPDKCIGCGACVKVCPVGAI 230
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 60-118 1.86e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 56.26  E-value: 1.86e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITIEagprrnDGTRRTVRYDIDmvKCIYCGFCQEACPVDAI 118
Cdd:COG1146    7 TDKCIGCGACVEVCPVDVLELD------EEGKKALVINPE--ECIGCGACELVCPVGAI 57
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 60-122 2.61e-11

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 55.89  E-value: 2.61e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGprrndgtrrtVRYDIDMVKCIYCGFCQEACPVDAIVEGP 122
Cdd:COG1149   10 EEKCIGCGLCVEVCPEGAIKLDDG----------GAPVVDPDLCTGCGACVGVCPTGAITLEE 62
PRK13984 PRK13984
putative oxidoreductase; Provisional
 22-139 1.42e-10

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 58.62  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  22 LSMRQFFAPKE----------TINYPHEKGPTSPRFRGEHAlrrypNGEERCIACKLCEAICPAQAIT-IEAGPRRNDGT 90
Cdd:PRK13984   1 MPEKDFFAPLKawkflfrkpvTIKVPNVKREAAERYRGFHI-----NDWEKCIGCGTCSKICPTDAITmVEVPDLPQEYG 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 563943544  91 RRTVRYDIDMVKCIYCGFCQEACPVDAIvegpnfefaTETREELYYDKD 139
Cdd:PRK13984  76 KKPQRPVIDYGRCSFCALCVDICTTGSL---------KMTREYIHISPD 115
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
60-120 7.30e-10

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 56.19  E-value: 7.30e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRRndgtrrtvrydIDMVKCIYCGFCQEACPVDAIVE 120
Cdd:COG4624   90 KEKCKNCYPCVRACPVKAIKVDDGKAE-----------IDEEKCISCGQCVAVCPFGAITE 139
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
63-120 1.93e-09

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 54.55  E-value: 1.93e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 563943544  63 CIACKLCEAICPAQAITIEAGprrndgtrrtvRYDIDMVKCIYCGFCQEACPVDAIVE 120
Cdd:PRK07118 215 CIGCGKCVKACPAGAITMENN-----------LAVIDQEKCTSCGKCVEKCPTKAIRI 261
Fer4_9 pfam13187
4Fe-4S dicluster domain;
62-118 2.26e-09

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 50.63  E-value: 2.26e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 563943544   62 RCIACKLCEAICPAQAITIEAGPrrndgtrRTVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVG-------QTIRGDIAGLACIGCGACVDACPRGAI 50
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 24-131 3.22e-09

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 52.15  E-value: 3.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  24 MRQFFAPKETINYPH-EKGPTSPRFRGEHALRRypngeERCIACKLCEAICPAQAITIeagprrndgTRRTVRYDIDMVK 102
Cdd:PRK08348   9 LRNLFKKPATNLFPAtEPVPVPEDFRGKILYDV-----DKCVGCRMCVTVCPAGVFVY---------LPEIRKVALWTGR 74

                         90       100
                 ....*....|....*....|....*....
gi 563943544 103 CIYCGFCQEACPVDAIVEGPNFEFATETR 131
Cdd:PRK08348  75 CVFCGQCVDVCPTGALQMSDDFLLASYDR 103
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
60-118 9.80e-09

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 52.94  E-value: 9.80e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPrrndgtrrtvRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:COG1148  495 PEKCTGCGRCVEVCPYGAISIDEKG----------VAEVNPALCKGCGTCAAACPSGAI 543
PRK13795 PRK13795
hypothetical protein; Provisional
 26-115 1.53e-08

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 52.69  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  26 QFFAPKETINYPHEKGPTSPRFR-GEHALRRypngEERCIACKLCEAICPAQAITIEAGprrndgtRRTVRYDIDmvKCI 104
Cdd:PRK13795 549 KVFASGNIWARSEDKEAAASLFKdAARLLRR----AAECVGCGVCVGACPTGAIRIEEG-------KRKISVDEE--KCI 615

                         90
                 ....*....|.
gi 563943544 105 YCGFCQEACPV 115
Cdd:PRK13795 616 HCGKCTEVCPV 626
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 51-119 1.37e-07

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 48.79  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  51 HALRRYPNG-----EERCIACKLCEAICPAQAitieagPRRNDGTRRtvrydidMVKCIYCGF---------CQEACPVD 116
Cdd:COG0437   75 GATYKREDGivlvdYDKCIGCRYCVAACPYGA------PRFNPETGV-------VEKCTFCADrldegllpaCVEACPTG 141


                 ...
gi 563943544 117 AIV 119
Cdd:COG0437  142 ALV 144
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
60-118 1.57e-07

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 49.29  E-value: 1.57e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQaITIEAGprrndgtrrtvryDIDMVKCIYCGFCQEACPVDAI 118
Cdd:COG0348  209 RGDCIDCGLCVKVCPMG-IDIRKG-------------EINQSECINCGRCIDACPKDAI 253
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 54-119 3.43e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 46.80  E-value: 3.43e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 563943544  54 RRYPNGEERCIACKLCE-----AICPAQAITieagprRNDGTRRTVrydIDMVKCIYCGFCQEACPVDAIV 119
Cdd:cd10550   37 RFEPEGLDVPVVCRQCEdapcvEACPVGAIS------RDEETGAVV---VDEDKCIGCGMCVEACPFGAIR 98
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 60-118 4.29e-07

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 46.87  E-value: 4.29e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 563943544  60 EERCIACKLCEAICPAQAITI---EAGPRRNDGTRRTVrydidMVKCIYCGF------CQEACPVDAI 118
Cdd:cd10554   84 EERCIGCKLCVLACPFGAIEMaptTVPGVDWERGPRAV-----AVKCDLCAGreggpaCVEACPTKAL 146
PRK06273 PRK06273
ferredoxin; Provisional
 60-115 4.64e-07

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 47.01  E-value: 4.64e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 563943544  60 EERCIACKLCEAICPAQAIT-IEAGPRR-NDGTRRTVRYDIDMVKCIYCGFCQEACPV 115
Cdd:PRK06273  48 EELCIGCGGCANVCPTKAIEmIPVEPVKiTEGYVKTKIPKIDYEKCVYCLYCHDFCPV 105
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 25-118 4.85e-07

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.55  E-value: 4.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  25 RQFFAPKETINYPHEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAG-PRRNDgtrrtvrydidmvKC 103
Cdd:NF038196 149 KKGPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGkPVWGH-------------NC 215

                         90
                 ....*....|....*
gi 563943544 104 IYCGFCQEACPVDAI 118
Cdd:NF038196 216 THCLACIHRCPKEAI 230
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 50-119 9.38e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 45.84  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  50 EHALRRYPNG-----EERCIACKLCEAICPAQAITIEAGPRRndgtrrtvrydidMVKCIYCGF---------CQEACPV 115
Cdd:cd04410   64 TGAIYKDEDGivlidEDKCIGCGSCVEACPYGAIVFDPEPGK-------------AVKCDLCGDrldeglepaCVKACPT 130


                 ....
gi 563943544 116 DAIV 119
Cdd:cd04410  131 GALT 134
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
60-119 9.65e-07

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 45.80  E-value: 9.65e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPrrndgTRRTVrydidmVKCIYCGF------CQEACPVDAIV 119
Cdd:COG1142   80 EEKCIGCGLCVLACPFGAITMVGEK-----SRAVA------VKCDLCGGreggpaCVEACPTGALR 134
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 62-118 1.12e-06

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 46.91  E-value: 1.12e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 563943544  62 RCIACKLCEAICPAQAItIEAGpRRNDGTR----RTVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:PRK14028 248 KCIMCRKCWLYCPDDAI-IEAW-REAEGPRgrkfRMKMIDFDYQYCKGCGVCAEVCPTGAI 306
FeFe_hydrog_B1 TIGR04105
[FeFe] hydrogenase, group B1/B3; See for descriptions of different groups.
 61-120 1.12e-06

[FeFe] hydrogenase, group B1/B3; See for descriptions of different groups.


Pssm-ID: 274983 [Multi-domain]  Cd Length: 462  Bit Score: 47.20  E-value: 1.12e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 563943544   61 ERCIACKLCEAICPAQAIT------IEAGP-----RRNDGtrrtvRYDIDMVKCIYCGFCQEACPVDAIVE 120
Cdd:TIGR04105 142 EKCIECGKCKKACPYNAIVeierpcEKACPvgaisSDEDG-----RAVIDYDKCISCGACMVACPFGAISD 207
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 61-119 2.00e-06

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 45.60  E-value: 2.00e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 563943544  61 ERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIdMVKCIYC------G---FCQEACPVDAIV 119
Cdd:cd10551   83 DKCIGCRYCMAACPYGARYFNPEEPHEFGEVPVRPKGV-VEKCTFCyhrldeGllpACVEACPTGARI 149
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 63-122 2.13e-06

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 46.41  E-value: 2.13e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  63 CIACKLCEAICPAQAItIEAGPRRndgtrrtvRYDIDMVKCIYCGFCQEACPVDAIVEGP 122
Cdd:PRK12771 512 CFECDNCYGACPQDAI-IKLGPGR--------RYHFDYDKCTGCHICADVCPCGAIEMGP 562
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 60-119 2.48e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 44.94  E-value: 2.48e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIA------CKLCEAICPAQAITIEAgprRNDGTRRTVRYDidmvKCIYCGFCQEACPVD---AIV 119
Cdd:cd16373   90 KDRCLAwqggtdCGVCVEACPTEAIAIVL---EDDVLRPVVDED----KCVGCGLCEYVCPVEppkAIV 151
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 69-118 7.82e-06

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 43.78  E-value: 7.82e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 563943544  69 CEAICPAQAITieagpRRNDGTrrtVRYDIDmvKCIYCGFCQEACPVDAI 118
Cdd:COG0437   68 CVKVCPTGATY-----KREDGI---VLVDYD--KCIGCRYCVAACPYGAP 107
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 60-114 8.63e-06

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 41.08  E-value: 8.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 563943544   60 EERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDidmvKCIYCGFCQEACP 114
Cdd:pfam13237   6 PDKCIGCGRCTAACPAGLTRVGAIVERLEGEAVRIGVW----KCIGCGACVEACP 56
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 63-118 1.06e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 42.64  E-value: 1.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 563943544  63 CIACKL--CEAICPAQAITieagpRRNDGTrrtVRYDIDmvKCIYCGFCQEACPVDAI 118
Cdd:cd16370   53 CRACEDppCAEACPTGALE-----PRKGGG---VVLDKE--KCIGCGNCVKACIVGAI 100
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
62-118 1.38e-05

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 43.86  E-value: 1.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 563943544  62 RCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:COG4624   52 PRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAI 108
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 69-119 2.25e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 41.78  E-value: 2.25e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 563943544  69 CEAICPAQAITieagpRRNDGTrrtVRYDIDmvKCIYCGFCQEACPVDAIV 119
Cdd:cd16371   62 CVKVCPTGAIT-----KREDGI---VVVDQD--KCIGCGYCVWACPYGAPQ 102
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 64-118 2.56e-05

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 41.85  E-value: 2.56e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 563943544  64 IACKLCEAICPAQAITIeagprrNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:cd10564   86 VECRSCQDACPTQAIRF------RPRLGGIALPELDADACTGCGACVSVCPVGAI 134
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
63-114 3.08e-05

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 40.17  E-value: 3.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 563943544   63 CIACKLCEAICPAQAITieaGPRRNDGTRRTVRYDIDMVK--------------CIYCGFCQEACP 114
Cdd:pfam13484   1 CGSCGKCIDACPTGAIV---GPEGVLDARRCISYLTIEKKglipdelrcllgnrCYGCDICQDVCP 63
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
60-118 3.83e-05

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 40.70  E-value: 3.83e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITIeagprRNDGTrrtvrYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:PRK09623  50 ESKCVKCYICWKFCPEPAIYI-----KEDGY-----VAIDYDYCKGCGICANECPTKAI 98
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
61-124 4.99e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 40.80  E-value: 4.99e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 563943544  61 ERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYC--GFCQEACPVDAIVEGPNF 124
Cdd:COG1142   10 EKCIGCRTCEAACAVAHEGEEGEPFLPRIRVVRKAGVSAPVQCRHCedAPCAEVCPVGAITRDDGA 75
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 60-132 5.08e-05

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 40.47  E-value: 5.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDidmVKCIYCGFCQEACPVDAI--VEGPNFEFATETRE 132
Cdd:PRK09626  15 ESRCKACDICVSVCPAGVLAMRIDPHAVLGKMIKVVHP---ESCIGCRECELHCPDFAIyvADRKEFKFAKLSKE 86
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
60-119 5.15e-05

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.84  E-value: 5.15e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRR------NDGTRRTVRyDIDMVKCIYCGFCQEACPVDAIV 119
Cdd:PRK07118 167 EDKCTGCGACVKACPRNVIELIPKSARvfvacnSKDKGKAVK-KVCEVGCIGCGKCVKACPAGAIT 231
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 96-118 5.33e-05

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 38.38  E-value: 5.33e-05
                          10        20
                  ....*....|....*....|...
gi 563943544   96 YDIDMVKCIYCGFCQEACPVDAI 118
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGAI 23
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 62-118 7.40e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 40.70  E-value: 7.40e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 563943544  62 RCIACKLCEAICPAQAI---TIEAGPRRNdgtrRTVRYDIDMVKCIYCG-FCQEACPVDAI 118
Cdd:cd16373   15 LCIRCGLCVEACPTGVIqpaGLEDGLEGG----RTPYLDPREGPCDLCCdACVEVCPTGAL 71
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 60-122 7.74e-05

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 40.45  E-value: 7.74e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPaQAITIEAGPRRNdGTRRTVRYDIDM----VKCIYCGF--CQEACPVDAIVEGP 122
Cdd:cd04410    5 LDRCIGCGTCEVACK-QEHGLRPGPDWS-RIKVIEGGGLERaflpVSCMHCEDppCVKACPTGAIYKDE 71
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 95-123 8.75e-05

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 38.87  E-value: 8.75e-05
                         10        20
                 ....*....|....*....|....*....
gi 563943544  95 RYDIDMVKCIYCGFCQEACPVDAIVEGPN 123
Cdd:COG4231   16 RYVIDEDKCTGCGACVKVCPADAIEEGDG 44
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 60-118 1.04e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 41.13  E-value: 1.04e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITIEagprrNDGTRrTVRYDidmvKCIYCGFCQEACPVDAI 118
Cdd:COG2878  136 EYGCIGCGDCIKACPFDAIVGA-----AKGMH-TVDED----KCTGCGLCVEACPVDCI 184
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 63-157 1.15e-04

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 41.15  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  63 CIACKLCEAICPAQAITIEAGP------------RRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPnfefATET 130
Cdd:PRK06259 135 CIECLSCVSTCPARKVSDYPGPtfmrqlarfafdPRDEGDREKEAFDEGLYNCTTCGKCVEVCPKEIDIPGK----AIEK 210

                         90       100
                 ....*....|....*....|....*..
gi 563943544 131 REELYYDKDKLLANgdrwERELARNIS 157
Cdd:PRK06259 211 LRALAFKKGLGLPA----HLEVRENVL 233
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 69-118 1.28e-04

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 40.21  E-value: 1.28e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 563943544  69 CEAICPAQAITieagpRRNDGTrrtVryDIDMVKCIYCGFCQEACPVDAI 118
Cdd:cd10551   61 CVKVCPTGATY-----KREDGI---V--LVDYDKCIGCRYCMAACPYGAR 100
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 60-118 1.38e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 39.48  E-value: 1.38e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 563943544  60 EERCIACKLCEAICPAQAITIeagprrNDGTRRtvrydidMVKCIYCG---FCQEACPVDAI 118
Cdd:cd10550   79 EDKCIGCGMCVEACPFGAIRV------DPETGK-------AIKCDLCGgdpACVKVCPTGAL 127
NapF COG1145
Ferredoxin [Energy production and conversion];
38-123 1.50e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 40.86  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  38 HEKGPTSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIE-AGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVD 116
Cdd:COG1145  118 VKLVAGLVVAAGEVLLVIAAALAEAGLAILGAAAPVDALAISGGkKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTG 197


                 ....*..
gi 563943544 117 AIVEGPN 123
Cdd:COG1145  198 AIRLKDG 204
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 98-133 2.11e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 37.77  E-value: 2.11e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 563943544  98 IDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREE 133
Cdd:COG1146    5 IDTDKCIGCGACVEVCPVDVLELDEEGKKALVINPE 40
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
60-120 2.23e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 40.31  E-value: 2.23e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 563943544  60 EERCIACKLCEAIC---PAQAITIEAgprrnDGTRRtvrYDIDMVKCIYCGFCQEACPVDAIVE 120
Cdd:PRK08318 341 QDKCIGCGRCYIACedtSHQAIEWDE-----DGTRT---PEVIEEECVGCNLCAHVCPVEGCIT 396
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 77-129 2.30e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 38.11  E-value: 2.30e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 563943544  77 AITIEAGPRRND-GTRRTVRYDIDMVKCIYCGFCQEACPVDAI--VEGPNFEFATE 129
Cdd:COG1144    5 AITEPGGTAAYKtGGWRVERPVVDEDKCIGCGLCWIVCPDGAIrvDDGKYYGIDYD 60
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 60-81 2.64e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 37.38  E-value: 2.64e-04
                         10        20
                 ....*....|....*....|..
gi 563943544  60 EERCIACKLCEAICPAQAITIE 81
Cdd:COG1146   39 PEECIGCGACELVCPVGAITVE 60
PRK12576 PRK12576
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
63-116 3.07e-04

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 237143 [Multi-domain]  Cd Length: 279  Bit Score: 39.73  E-value: 3.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 563943544  63 CIACKLCEAICPAQAITIE-AGPR------------RNDGTRRTVRYDIDMV-KCIYCGFCQEACPVD 116
Cdd:PRK12576 154 CIWCGLCVSACPVVAIDPEfLGPAahakgyrfladpRDTITEERMKILIDSSwRCTYCYSCSNVCPRD 221
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 92-124 3.50e-04

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 39.01  E-value: 3.50e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 563943544   92 RTVRYdIDMVKCIYCGFCQEACPVDAIVEGPNF 124
Cdd:TIGR01944 105 PMVAL-IDEDNCIGCTKCIQACPVDAIVGAAKA 136
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 97-140 3.71e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 38.53  E-value: 3.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 563943544  97 DIDMVKCIYCGFCQEACPVDAIVEGPNfefaTETREELYYDKDK 140
Cdd:cd10549    2 KYDPEKCIGCGICVKACPTDAIELGPN----GAIARGPEIDEDK 41
PRK09898 PRK09898
ferredoxin-like protein;
60-118 5.78e-04

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 38.66  E-value: 5.78e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRRNDgtrrtvrydidmvKCIYCGFCQEACPVDAI 118
Cdd:PRK09898 153 HKRCIGCSACTTACPWMMATVNTESKKSS-------------KCVLCGECANACPTGAL 198
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-131 5.85e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 38.02  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  52 ALRRYPNG-----EERCIACKLCEAICPAQAITIEAGPRRndgtrrtvrydidMVKCIYCG---------FCQEACPVDA 117
Cdd:cd16374   59 AIYRDEDGavlvdPDKCIGCGMCAMACPFGVPRFDPSLKV-------------AVKCDLCIdrrregklpACVEACPTGA 125

                         90
                 ....*....|....
gi 563943544 118 IVEGPNFEFATETR 131
Cdd:cd16374  126 LKFGDIEELLKEKR 139
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-118 5.97e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 38.02  E-value: 5.97e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 563943544  52 ALRRYPNG-----EERCIACKLCEAICPAQAItieagpRRNDGTRRTVrydidmvKCIYCGFCQEACPVDAI 118
Cdd:cd16370   69 ALEPRKGGgvvldKEKCIGCGNCVKACIVGAI------FWDEETNKPI-------ICIHCGYCARYCPHDVL 127
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 63-119 6.50e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 37.70  E-value: 6.50e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 563943544  63 CIACKLCEAICPAQAITieagpRRNDGTrrtvrYDIDMVKCIYCGFCQEACPVDAIV 119
Cdd:cd16372   49 CNQCGECIDVCPTGAIT-----RDANGV-----VMINKKLCVGCLMCVGFCPEGAMF 95
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 60-118 6.87e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 38.96  E-value: 6.87e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 563943544  60 EERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRydidmvKCIYCG------FCQEACPVDAI 118
Cdd:PRK12769  84 QQKCIGCKSCVVACPFGTMQIVLTPVAAGKVKATAH------KCDLCAgrengpACVENCPADAL 142
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 50-130 7.26e-04

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 38.71  E-value: 7.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  50 EHA---------LRRYPNGE--ERCIACKLCEAICPAQAITIEAGPRRNDgtrrtvrydiDMVKCIYCGFCQEACPVDAI 118
Cdd:PRK00783 147 EHAkwqpgsacgYKYYPRIEvsEDCDECEKCVEACPRGVLELKEGKLVVT----------DLLNCSLCKLCERACPGKAI 216

                         90
                 ....*....|....*
gi 563943544 119 VEG--PN-FEFATET 130
Cdd:PRK00783 217 RVSddENkFIFTVES 231
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 98-119 9.18e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 36.24  E-value: 9.18e-04
                         10        20
                 ....*....|....*....|..
gi 563943544  98 IDMVKCIYCGFCQEACPVDAIV 119
Cdd:COG1149    8 IDEEKCIGCGLCVEVCPEGAIK 29
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 61-124 1.08e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 37.24  E-value: 1.08e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 563943544  61 ERCIACKLCEAICPA---QAITIEAGPRRNDGTRR-TVRYDIDMVKCIYC-----GFCQEACPVDAIVEGPNF 124
Cdd:cd10554    7 DKCIGCRTCEVACAAahsGKGIFEAGTDGLPFLPRlRVVKTGEVTAPVQCrqcedAPCANVCPVGAISQEDGV 79
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 61-118 1.10e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 37.17  E-value: 1.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 563943544  61 ERCIACKLCEAICpAQAITIEAGPRRNdgtR-RTVRY----DIDMVKCIYCG--FCQEACPVDAI 118
Cdd:cd10550    6 EKCTGCRTCELAC-SLKHEGVFNPSLS---RiRVVRFepegLDVPVVCRQCEdaPCVEACPVGAI 66
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-118 1.36e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 36.93  E-value: 1.36e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 563943544  52 ALRRYPNG-----EERCIACKLCEAICPAQAItieagpRRNDGTrrtvrydIDMVKCIYCGFCQEACPVDAI 118
Cdd:cd16372   63 AITRDANGvvminKKLCVGCLMCVGFCPEGAM------FKHEDY-------PEPFKCIACGICVKACPTGAL 121
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 60-119 1.47e-03

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 36.55  E-value: 1.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  60 EERCIACKLCEAICPAQAITIEagprrnDGTRRTVRYDIdmvkCIYCGFCQEACPVDAIV 119
Cdd:PRK09624  50 RDKCVRCYLCYIYCPEPAIYLD------EEGYPVFDYDY----CKGCGICANECPTKAIE 99
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 62-118 1.59e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 36.87  E-value: 1.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  62 RCIACK--LCEAICPAQAITIEagprrNDGTrrtVRYDIDmvKCIYCGFCQEACPVDAI 118
Cdd:cd16374   42 RCRHCEdaPCMEVCPTGAIYRD-----EDGA---VLVDPD--KCIGCGMCAMACPFGVP 90
PRK06991 PRK06991
electron transport complex subunit RsxB;
98-122 1.62e-03

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 37.47  E-value: 1.62e-03
                         10        20
                 ....*....|....*....|....*
gi 563943544  98 IDMVKCIYCGFCQEACPVDAIVEGP 122
Cdd:PRK06991  82 IDEQLCIGCTLCMQACPVDAIVGAP 106
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 60-120 1.70e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 37.67  E-value: 1.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 563943544  60 EERCIACKLCEAICPAQAITIEagPRRNDGTRRTVRYDIDMVKCIYC-GFCQEACPVDAIVE 120
Cdd:COG2878  166 EDKCTGCGLCVEACPVDCIEMV--PVSPTVVVSSWDKGKAVRKVVGCiGLCCKKCCPAAAIT 225
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 60-79 2.04e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 34.15  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|
gi 563943544   60 EERCIACKLCEAICPAQAIT 79
Cdd:pfam00037   5 EEKCIGCGACVEVCPVGAIT 24
PRK12576 PRK12576
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
103-145 2.36e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 237143 [Multi-domain]  Cd Length: 279  Bit Score: 37.04  E-value: 2.36e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 563943544 103 CIYCGFCQEACPVDAIVE---GPN-----FEFATETREELYYDKDKLLANG 145
Cdd:PRK12576 154 CIWCGLCVSACPVVAIDPeflGPAahakgYRFLADPRDTITEERMKILIDS 204
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 69-118 2.47e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 36.51  E-value: 2.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 563943544  69 CEAICPAQAITIEAgprrnDGTrrtVRYDIDmvKCIYCGFCQEACPVDAI 118
Cdd:cd10562   78 CVKVCPTGALYKTE-----NGA---VVVDED--KCIGCGYCVAACPFDVP 117
PRK06991 PRK06991
electron transport complex subunit RsxB;
60-118 2.57e-03

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 37.08  E-value: 2.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICPAQAITieAGPRRndgtRRTVRYDIdmvkCIYCGFCQEACPVDAI 118
Cdd:PRK06991  84 EQLCIGCTLCMQACPVDAIV--GAPKQ----MHTVLADL----CTGCDLCVPPCPVDCI 132
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 60-81 2.97e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 35.84  E-value: 2.97e-03
                         10        20
                 ....*....|....*....|..
gi 563943544  60 EERCIACKLCEAICPAQAITIE 81
Cdd:cd10549  107 KEKCIGCGICAEVCPVNAIKLV 128
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 92-119 3.29e-03

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 36.46  E-value: 3.29e-03
                         10        20
                 ....*....|....*....|....*...
gi 563943544  92 RTVRYdIDMVKCIYCGFCQEACPVDAIV 119
Cdd:PRK05113 106 RKVAF-IDEDNCIGCTKCIQACPVDAIV 132
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 60-81 3.41e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 34.63  E-value: 3.41e-03
                         10        20
                 ....*....|....*....|..
gi 563943544  60 EERCIACKLCEAICPAQAITIE 81
Cdd:COG4231   50 PDLCIGCGSCVQVCPVDAIKLE 71
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 93-118 3.87e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 34.26  E-value: 3.87e-03
                         10        20
                 ....*....|....*....|....*.
gi 563943544  93 TVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:COG2221    7 TWPPKIDEEKCIGCGLCVAVCPTGAI 32
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 52-121 5.31e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 35.45  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  52 ALRRYPNG-----EERCIACKLCEAICPAQAitieagPRRNDGTRRtvrydidMVKCIYC------GF---CQEACPVDA 117
Cdd:cd16366   86 AIIRTETGtvvvdPETCIGCGYCVNACPFDI------PRFDEETGR-------VAKCTLCydrisnGLqpaCVKTCPTGA 152


                 ....
gi 563943544 118 IVEG 121
Cdd:cd16366  153 LTFG 156
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 52-119 5.68e-03

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 35.31  E-value: 5.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  52 ALRRYP-NG-----EERCIACKLCEAICPAQAITIEAGPRRndgtrrtvrydidMVKCIYCGF-----CQEACPVDAIV 119
Cdd:cd10563   73 AMHKDPeTGivihdEEKCVGCWMCVMVCPYGAIRPDKERKV-------------ALKCDLCPDretpaCVEACPTGALV 138
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 60-143 6.07e-03

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 35.95  E-value: 6.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544  60 EERCIACKLCEAICPAQAITieaGPRRNDGtRRTVRY-------DID------MVKCIY-CGFCQEACPVdaivegpNfE 125
Cdd:COG1600  183 EDHCGSCTRCLDACPTGAIV---APYVLDA-RRCISYltielkgPIPeelrpkMGNRIYgCDDCQDVCPW-------N-R 250

                         90
                 ....*....|....*...
gi 563943544 126 FATETREELYYDKDKLLA 143
Cdd:COG1600  251 FAQPTREPDFQPRPELAA 268
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 60-118 6.19e-03

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 35.69  E-value: 6.19e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 563943544  60 EERCIACKLCEAICPAQAITieagprrndGTRR---TVRYDIdmvkCIYCGFCQEACPVDAI 118
Cdd:PRK05113 113 EDNCIGCTKCIQACPVDAIV---------GATKamhTVISDL----CTGCDLCVAPCPTDCI 161
HdrC COG1150
Heterodisulfide reductase, subunit C [Energy production and conversion];
61-116 6.36e-03

Heterodisulfide reductase, subunit C [Energy production and conversion];


Pssm-ID: 440764 [Multi-domain]  Cd Length: 79  Bit Score: 34.11  E-value: 6.36e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 563943544  61 ERCIACKLCEAICPAQAITiEAGPRR-----NDGTRRTVRYDIDMVKCIYCGFCQEACPVD 116
Cdd:COG1150    3 KKCYQCGTCTASCPVARAM-DYNPRKiirlaQLGLKEEVLKSDSIWLCVSCYTCTERCPRG 62
NapF COG1145
Ferredoxin [Energy production and conversion];
60-81 6.38e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 35.85  E-value: 6.38e-03
                         10        20
                 ....*....|....*....|..
gi 563943544  60 EERCIACKLCEAICPAQAITIE 81
Cdd:COG1145  212 PDKCIGCGACVKVCPVGAISLE 233
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 103-123 6.87e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 35.74  E-value: 6.87e-03
                         10        20
                 ....*....|....*....|.
gi 563943544 103 CIYCGFCQEACPVDAIVEGPN 123
Cdd:COG2878  139 CIGCGDCIKACPFDAIVGAAK 159
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 62-131 7.47e-03

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 34.15  E-value: 7.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563943544   62 RCIACKLCEAICPAQAItieagpRRNDGTRRTVRydIDMVKCIYCGFCQEACPVDAIveGPNFEFATETR 131
Cdd:TIGR00402  35 VCTRCGECASACENNIL------QLGQQGQPTVE--FDNAECDFCGKCAEACPTNAF--HPRFPGDWLLR 94
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 60-123 7.95e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 34.62  E-value: 7.95e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 563943544  60 EERCIACKLCEAICpAQAITIEagprrNDGTRRTVR-----YDIDMVKCIYCGFCQEACPVDAIVEGPN 123
Cdd:cd16372    7 PEKCIGCLQCEEAC-SKTFFKE-----EDREKSCIRiteteGGYAINVCNQCGECIDVCPTGAITRDAN 69
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 69-118 9.32e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 34.68  E-value: 9.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 563943544  69 CEAICPAQAITieagpRRNDGTrrtVRYDIDmvKCIYCGFCQEACPVDAI 118
Cdd:cd16366   78 CLAACPTGAII-----RTETGT---VVVDPE--TCIGCGYCVNACPFDIP 117
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 61-118 9.81e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 34.53  E-value: 9.81e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 563943544  61 ERCIACKLCEAICPAQAITIeagprrndGTRRTVRYDIDMVKCIYCGFCQEACPVDAI 118
Cdd:cd10564   13 DLCTRCGDCVEACPEGIIVR--------GDGGFPELDFSRGECTFCGACAEACPEGAL 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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