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Conserved domains on  [gi|1608675807|ref|WP_135302956|]
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carbonic anhydrase [Halomicroarcula amylolytica]

Protein Classification

carbonic anhydrase( domain architecture ID 10658772)

carbonic anhydrase (CA) catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton

CATH:  3.40.1050.10
EC:  4.2.1.1
Gene Ontology:  GO:0004089|GO:0008270
PubMed:  11696553|9336012

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-168 5.74e-29

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


:

Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 106.05  E-value: 5.74e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807   28 DGQAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQTEAgevVSGDVLYPLAHTGTETAIVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1608675807  108 TYDAltdgvdepagiehCLGLLKPHLEPGVEALPDDLDRTDAINHLVEYNVDRQVELLRES 168
Cdd:smart00947  78 ALDD-------------EPGLIDNWLERIRPARERALEELGDVDALEELNVRDQVENLRTS 125
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-168 5.74e-29

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 106.05  E-value: 5.74e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807   28 DGQAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQTEAgevVSGDVLYPLAHTGTETAIVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1608675807  108 TYDAltdgvdepagiehCLGLLKPHLEPGVEALPDDLDRTDAINHLVEYNVDRQVELLRES 168
Cdd:smart00947  78 ALDD-------------EPGLIDNWLERIRPARERALEELGDVDALEELNVRDQVENLRTS 125
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-168 2.12e-28

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 104.90  E-value: 2.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  34 AVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQTEAgevVSGDVLYPLAHTGTETAIVVGHTGCGAVTATYDAlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFD-TGPGDLFVVRNAGNLVPPYDLN---VLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1608675807 114 DGVDEPAGIEHCLGLLKPHLEPGVEALPDDLDRTDAINHLVEYNVDRQVELLRES 168
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTF 130
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
7-168 2.89e-26

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 100.62  E-value: 2.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807   7 DLLAQN----ESHAEEFDTRFDDVQDGQAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNrVVQQTEAGevVSGDV 82
Cdd:COG0288     6 RLLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGN-VVPPYDPG--VLASI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  83 LYPLAHTGTETAIVVGHTGCGAVTATYDALTDgvDEPAGIEHCLGLLKPHLEPgVEALPDDLDRTDAINHLVEYNVDRQV 162
Cdd:COG0288    82 EYAVEVLGVKLIVVLGHSGCGAVKAALDGLEL--EELGLIGNWLRHIRPAVER-VRAELPAADGEERLDRLVELNVREQV 158


                  ....*.
gi 1608675807 163 ELLRES 168
Cdd:COG0288   159 ENLRTS 164
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 22-166 3.56e-17

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 76.43  E-value: 3.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  22 RFDDVQDGQAPDAVTVCCSDSRVLQDHIWGNeEPGHLFTCGNIGNRV--VQQTEAGEVVSGDVLYPLAHTGTETAIVVGH 99
Cdd:cd00884    16 LFEKLAKGQSPKALFIACSDSRVVPALITQT-QPGELFVVRNVGNLVppYEPDGGFHGTSAAIEYAVAVLKVEHIVVCGH 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1608675807 100 TGCGAVTATYDaLTDGVDEPAGIEHCLGLLKPHLEPgVEALPDDLDRTDAINHLVEYNVDRQVELLR 166
Cdd:cd00884    95 SDCGGIRALLS-PEDLLDKLPFIGKWLRIAEPAKEV-VLAELSHADFDDQLRALEKENVLLSLENLL 159
PLN00416 PLN00416
carbonate dehydratase
 21-105 4.85e-11

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 60.82  E-value: 4.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  21 TRFDDVQDGQAPDAVTVCCSDSRVLQDHIWgNEEPGHLFTCGNIGNRVV---QQTEAGevVSGDVLYPLAHTGTETAIVV 97
Cdd:PLN00416   69 TLFNHLAKTQTPKFLVFACSDSRVCPSHIL-NFQPGEAFVVRNIANMVPpfdQKRHSG--VGAAVEYAVVHLKVENILVI 145


                  ....*...
gi 1608675807  98 GHTGCGAV 105
Cdd:PLN00416  146 GHSCCGGI 153
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-168 5.74e-29

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 106.05  E-value: 5.74e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807   28 DGQAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQTEAgevVSGDVLYPLAHTGTETAIVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1608675807  108 TYDAltdgvdepagiehCLGLLKPHLEPGVEALPDDLDRTDAINHLVEYNVDRQVELLRES 168
Cdd:smart00947  78 ALDD-------------EPGLIDNWLERIRPARERALEELGDVDALEELNVRDQVENLRTS 125
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-168 2.12e-28

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 104.90  E-value: 2.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  34 AVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQTEAgevVSGDVLYPLAHTGTETAIVVGHTGCGAVTATYDAlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFD-TGPGDLFVVRNAGNLVPPYDLN---VLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1608675807 114 DGVDEPAGIEHCLGLLKPHLEPGVEALPDDLDRTDAINHLVEYNVDRQVELLRES 168
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTF 130
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
7-168 2.89e-26

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 100.62  E-value: 2.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807   7 DLLAQN----ESHAEEFDTRFDDVQDGQAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNrVVQQTEAGevVSGDV 82
Cdd:COG0288     6 RLLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGN-VVPPYDPG--VLASI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  83 LYPLAHTGTETAIVVGHTGCGAVTATYDALTDgvDEPAGIEHCLGLLKPHLEPgVEALPDDLDRTDAINHLVEYNVDRQV 162
Cdd:COG0288    82 EYAVEVLGVKLIVVLGHSGCGAVKAALDGLEL--EELGLIGNWLRHIRPAVER-VRAELPAADGEERLDRLVELNVREQV 158


                  ....*.
gi 1608675807 163 ELLRES 168
Cdd:COG0288   159 ENLRTS 164
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 22-166 3.56e-17

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 76.43  E-value: 3.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  22 RFDDVQDGQAPDAVTVCCSDSRVLQDHIWGNeEPGHLFTCGNIGNRV--VQQTEAGEVVSGDVLYPLAHTGTETAIVVGH 99
Cdd:cd00884    16 LFEKLAKGQSPKALFIACSDSRVVPALITQT-QPGELFVVRNVGNLVppYEPDGGFHGTSAAIEYAVAVLKVEHIVVCGH 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1608675807 100 TGCGAVTATYDaLTDGVDEPAGIEHCLGLLKPHLEPgVEALPDDLDRTDAINHLVEYNVDRQVELLR 166
Cdd:cd00884    95 SDCGGIRALLS-PEDLLDKLPFIGKWLRIAEPAKEV-VLAELSHADFDDQLRALEKENVLLSLENLL 159
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 22-108 5.45e-14

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 66.78  E-value: 5.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  22 RFDDVQDGQAPDAVTVCCSDSRVLQDHIWgNEEPGHLFTCgnignRVvqqteAGEVVSGDVL----YPLAHTGTETAIVV 97
Cdd:cd03378    29 RRRELAKGQKPFAVILSCSDSRVPPEIIF-DQGLGDLFVV-----RV-----AGNIVDDDVLgsleYAVEVLGVPLVVVL 97

                          90
                  ....*....|.
gi 1608675807  98 GHTGCGAVTAT 108
Cdd:cd03378    98 GHESCGAVAAA 108
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-107 1.05e-13

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 65.21  E-value: 1.05e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1608675807  30 QAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVvqqTEAGEVVSGDVLYPLAHTGTETAIVVGHTGCGAVTA 107
Cdd:cd00382     1 QKPKALIIGCSDSRVPPELIFG-LGPGDLFVVRNAGNLV---PPYDLDVLASLEYAVEVLGVKHIIVCGHTDCGAVKA 74
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 11-168 2.32e-11

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 60.27  E-value: 2.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  11 QNESHAEEFDTRFDdvqdGQAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQ-TEAGEVVSgdvlYPLAHT 89
Cdd:cd00883     8 KKAKDPDFFPRLAK----GQTPEYLWIGCSDSRVPENTILG-LLPGEVFVHRNIANLVSPTdLNCLSVLQ----YAVDVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  90 GTETAIVVGHTGCGAVTAtydALTDgvdepagieHCLGLLKPHL-------EPGVEALPDDLDRTDAINHLVEYNVDRQV 162
Cdd:cd00883    79 KVKHIIVCGHYGCGGVKA---ALTG---------KRLGLLDNWLrpirdvyRLHAAELDALEDEEERVDRLVELNVVEQV 146


                  ....*.
gi 1608675807 163 ELLRES 168
Cdd:cd00883   147 KNLCKT 152
PLN00416 PLN00416
carbonate dehydratase
 21-105 4.85e-11

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 60.82  E-value: 4.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  21 TRFDDVQDGQAPDAVTVCCSDSRVLQDHIWgNEEPGHLFTCGNIGNRVV---QQTEAGevVSGDVLYPLAHTGTETAIVV 97
Cdd:PLN00416   69 TLFNHLAKTQTPKFLVFACSDSRVCPSHIL-NFQPGEAFVVRNIANMVPpfdQKRHSG--VGAAVEYAVVHLKVENILVI 145


                  ....*...
gi 1608675807  98 GHTGCGAV 105
Cdd:PLN00416  146 GHSCCGGI 153
PLN03014 PLN03014
carbonic anhydrase
 17-142 1.01e-08

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 54.36  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  17 EEFDTR---FDDVQDGQAPDAVTVCCSDSRVLQDHIWgNEEPGHLFTCGNIGNRV--VQQTEAGEVVSGdVLYPLAHTGT 91
Cdd:PLN03014  142 EKYETNpalYGELAKGQSPKYMVFACSDSRVCPSHVL-DFQPGDAFVVRNIANMVppFDKVKYGGVGAA-IEYAVLHLKV 219

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1608675807  92 ETAIVVGHTGCGAVTATYDALTDGVDEPAGIEHCLGLLKPHLEPGVEALPD 142
Cdd:PLN03014  220 ENIVVIGHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLPAKSKVISELGD 270
PLN03019 PLN03019
carbonic anhydrase
 17-131 1.28e-07

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 51.30  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  17 EEFDTR---FDDVQDGQAPDAVTVCCSDSRVLQDHIWgNEEPGHLFTCGNIGNRVV---QQTEAGevVSGDVLYPLAHTG 90
Cdd:PLN03019  137 EKYETNpalYGELAKGQSPKYMVFACSDSRVCPSHVL-DFHPGDAFVVRNIANMVPpfdKVKYAG--VGAAIEYAVLHLK 213

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1608675807  91 TETAIVVGHTGCGAVTATYDALTDGVDEPAGIEHCLGLLKP 131
Cdd:PLN03019  214 VENIVVIGHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLP 254
PLN03006 PLN03006
carbonate dehydratase
 23-107 2.40e-07

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 50.12  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  23 FDDVQDGQAPDAVTVCCSDSRVLQDHIWGNeEPGHLFTCGNIGNrVVQQTEAGEVVSGDVL-YPLAHTGTETAIVVGHTG 101
Cdd:PLN03006  104 YKNLADAQAPKFLVIACADSRVCPSAVLGF-QPGDAFTVRNIAN-LVPPYESGPTETKAALeFSVNTLNVENILVIGHSR 181


                  ....*.
gi 1608675807 102 CGAVTA 107
Cdd:PLN03006  182 CGGIQA 187
PLN02154 PLN02154
carbonic anhydrase
 22-107 1.09e-06

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 48.20  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  22 RFDDVQDGQAPDAVTVCCSDSRVLQDHIWGNeEPGHLFTCGNIGNRVVQQTEAGEVVSGDVLYPLAHTGTETAIVVGHTG 101
Cdd:PLN02154   97 KFKALAIAQSPKVMVIGCADSRVCPSYVLGF-QPGEAFTIRNVANLVTPVQNGPTETNSALEFAVTTLQVENIIVMGHSN 175


                  ....*.
gi 1608675807 102 CGAVTA 107
Cdd:PLN02154  176 CGGIAA 181
PRK15219 PRK15219
carbonic anhydrase; Provisional
 7-166 2.26e-06

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 47.13  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807   7 DLLAQNESHAEefdtrfddvqdGQAPDAVTVCCSDSRVLQDHIWgNEEPGHLFTCgnignRVvqqteAGEVVSGDVL--- 83
Cdd:PRK15219   76 DYLAQKRASAA-----------GQYPAAVILSCIDSRAPAEIIL-DTGIGETFNS-----RV-----AGNISNDDLLgsm 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  84 -YPLAHTGTETAIVVGHTGCGAVTATYDALTDGvdepagieHCLGLLKpHLEPGVEALPDDLDRT----DAINHLVEYNV 158
Cdd:PRK15219  134 eFACAVAGAKVVLVMGHTACGAVKGAIDNVELG--------NLTGLLD-RIKPAIEVTEFDGERSsknyKFVDAVARKNV 204


                  ....*...
gi 1608675807 159 DRQVELLR 166
Cdd:PRK15219  205 ELTIENIR 212
PRK10437 PRK10437
carbonic anhydrase; Provisional
 17-162 9.29e-06

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 44.92  E-value: 9.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  17 EEFDTRFDDVQDGQAPDAVTVCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQTEAGEVVsgdVLYPLAHTGTETAIV 96
Cdd:PRK10437   20 EEDPGFFEKLAQAQKPRFLWIGCSDSRVPAERLTG-LEPGELFVHRNVANLVIHTDLNCLSV---VQYAVDVLEVEHIII 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1608675807  97 VGHTGCGAVTAtydaltdGVDEPAgiehcLGLLKP---HLEP---GVEALPDDLDRTDAINHLVEYNVDRQV 162
Cdd:PRK10437   96 CGHYGCGGVQA-------AVENPE-----LGLINNwllHIRDiwfKHSSLLGEMPQERRLDTLCELNVMEQV 155
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-168 2.38e-03

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 37.23  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608675807  37 VCCSDSRVLQDHIWGnEEPGHLFTCGNIGNRVVQQTEAGEVVSGDVLyplahtGTETAIVVGHTGCGAVTATYDALTDGV 116
Cdd:cd03379     8 VTCMDARLDPEKALG-LKLGDAKVIRNAGGRVTDDAIRSLVVSVYLL------GTREIIVIHHTDCGMLTFTDEELKEKM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1608675807 117 DEpAGIEHCLGLLKPHLEPGvealpddldrtdAINHLVEyNVDRQVELLRES 168
Cdd:cd03379    81 KE-RGIAEAYGGIDKEFWFL------------GFDDLEE-SVREDVERIRNH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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