Immune inhibitor A peptidase M6; The insect pathogenic Gram-positive Bacillus thuringiensis ...
115-736
0e+00
Immune inhibitor A peptidase M6; The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.
The actual alignment was detected with superfamily member pfam05547:
Pssm-ID: 398926 [Multi-domain] Cd Length: 644 Bit Score: 564.47 E-value: 0e+00
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
748-827
4.73e-16
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
:
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 73.68 E-value: 4.73e-16
Immune inhibitor A peptidase M6; The insect pathogenic Gram-positive Bacillus thuringiensis ...
115-736
0e+00
Immune inhibitor A peptidase M6; The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.
Pssm-ID: 398926 [Multi-domain] Cd Length: 644 Bit Score: 564.47 E-value: 0e+00
M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a ...
122-445
3.33e-80
M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.
Pssm-ID: 274507 [Multi-domain] Cd Length: 285 Bit Score: 260.42 E-value: 3.33e-80
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
748-827
4.73e-16
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 73.68 E-value: 4.73e-16
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
753-829
5.71e-15
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 70.56 E-value: 5.71e-15
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
455-586
1.24e-05
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 49.27 E-value: 1.24e-05
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
762-814
2.56e-04
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 45.07 E-value: 2.56e-04
choice-of-anchor J domain; The choice-of-anchor J domain, about 160 amino acids long, occurs ...
525-567
8.44e-03
choice-of-anchor J domain; The choice-of-anchor J domain, about 160 amino acids long, occurs as many as times in a protein, although most often only once. Proteins with the domain include proteins with serine hydrolase, metallohydrolase, or adhesin-associated domains. Notably, many members are also found with either the PEP-CTERM term domain, or the type IX secretion system type A domain, both associated with protein-sorting system expected to leave target proteins covalently attached to the bacterial outer membrane.
Pssm-ID: 468371 [Multi-domain] Cd Length: 161 Bit Score: 38.07 E-value: 8.44e-03
Immune inhibitor A peptidase M6; The insect pathogenic Gram-positive Bacillus thuringiensis ...
115-736
0e+00
Immune inhibitor A peptidase M6; The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.
Pssm-ID: 398926 [Multi-domain] Cd Length: 644 Bit Score: 564.47 E-value: 0e+00
M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a ...
122-445
3.33e-80
M6 family metalloprotease domain; This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.
Pssm-ID: 274507 [Multi-domain] Cd Length: 285 Bit Score: 260.42 E-value: 3.33e-80
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
748-827
4.73e-16
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 73.68 E-value: 4.73e-16
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
753-829
5.71e-15
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.
Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 70.56 E-value: 5.71e-15
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
455-586
1.24e-05
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 49.27 E-value: 1.24e-05
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
762-814
2.56e-04
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 45.07 E-value: 2.56e-04
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat ...
796-828
4.43e-03
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.
Pssm-ID: 398814 [Multi-domain] Cd Length: 95 Bit Score: 37.45 E-value: 4.43e-03
choice-of-anchor J domain; The choice-of-anchor J domain, about 160 amino acids long, occurs ...
525-567
8.44e-03
choice-of-anchor J domain; The choice-of-anchor J domain, about 160 amino acids long, occurs as many as times in a protein, although most often only once. Proteins with the domain include proteins with serine hydrolase, metallohydrolase, or adhesin-associated domains. Notably, many members are also found with either the PEP-CTERM term domain, or the type IX secretion system type A domain, both associated with protein-sorting system expected to leave target proteins covalently attached to the bacterial outer membrane.
Pssm-ID: 468371 [Multi-domain] Cd Length: 161 Bit Score: 38.07 E-value: 8.44e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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