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Conserved domains on  [gi|2177016396|ref|WP_234255639|]
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MULTISPECIES: universal stress protein [Halomonas]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
24-171 4.13e-13

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 64.56  E-value: 4.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  24 RVLALLDASRHSLAALTAAVDLASLRHAELVALYVEDmdllscaafpfsceigaqSGLSRPLTHDSLETSIARQLQRVHQ 103
Cdd:COG0589     4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVVD------------------PPPSAAAGPEELEEELREEAEEALE 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396 104 ALAGAVAGRSLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:COG0589    66 EAAERLEEAGVEVETVVREGDPAEAILEAAEELdaDLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
24-171 4.13e-13

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 64.56  E-value: 4.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  24 RVLALLDASRHSLAALTAAVDLASLRHAELVALYVEDmdllscaafpfsceigaqSGLSRPLTHDSLETSIARQLQRVHQ 103
Cdd:COG0589     4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVVD------------------PPPSAAAGPEELEEELREEAEEALE 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396 104 ALAGAVAGRSLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:COG0589    66 EAAERLEEAGVEVETVVREGDPAEAILEAAEELdaDLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 24-171 1.60e-09

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 54.66  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  24 RVLALLDASRHSLAALTAAVDLASLRHAELVALYVEDMDLLScaafpfsceigaQSGLSRPLTHDSLETSIARQLQRVHQ 103
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSS------------SLSGGLEELADELKEEAEELLEEAKK 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396 104 ALAGAVagrsLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:cd00293    69 LAEEAG----VEVETIVVEGDPAEAILEEAKELgaDLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 25-171 2.76e-08

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 51.25  E-value: 2.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  25 VLALLDASRHSLAALTAAVDLASLRHAELVALYVedmdllscaafpfsCEIGAQSGLSRPLTHDSLETSIARQLQRVHQA 104
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHV--------------IDPPPSGAASLADESAEEEELELELAEAEALA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2177016396 105 LAGAVAGRSLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:pfam00582  67 AAAAAEAGGVKVEVVVVVGDPAEEILEVAEEEdaDLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLV 135
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
24-171 4.13e-13

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 64.56  E-value: 4.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  24 RVLALLDASRHSLAALTAAVDLASLRHAELVALYVEDmdllscaafpfsceigaqSGLSRPLTHDSLETSIARQLQRVHQ 103
Cdd:COG0589     4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVVD------------------PPPSAAAGPEELEEELREEAEEALE 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396 104 ALAGAVAGRSLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:COG0589    66 EAAERLEEAGVEVETVVREGDPAEAILEAAEELdaDLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 24-171 1.60e-09

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 54.66  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  24 RVLALLDASRHSLAALTAAVDLASLRHAELVALYVEDMDLLScaafpfsceigaQSGLSRPLTHDSLETSIARQLQRVHQ 103
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSS------------SLSGGLEELADELKEEAEELLEEAKK 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396 104 ALAGAVagrsLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:cd00293    69 LAEEAG----VEVETIVVEGDPAEAILEEAKELgaDLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 25-171 2.76e-08

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 51.25  E-value: 2.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  25 VLALLDASRHSLAALTAAVDLASLRHAELVALYVedmdllscaafpfsCEIGAQSGLSRPLTHDSLETSIARQLQRVHQA 104
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHV--------------IDPPPSGAASLADESAEEEELELELAEAEALA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2177016396 105 LAGAVAGRSLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:pfam00582  67 AAAAAEAGGVKVEVVVVVGDPAEEILEVAEEEdaDLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLV 135
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 25-171 2.45e-03

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 37.10  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  25 VLALLDASRHSLAALTAAVDLASLRHAELVALYV-EDMDLLscaAFPfsceigaqsGLSRPLTHDSLETSIARQLQRVHQ 103
Cdd:cd23661     2 VVVGVDGSPASELATEIAFDEASRRGVDLVALHAwSDMGPG---GFL---------GIDWRESEQDQERMLAERLAGWQE 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2177016396 104 ALAGAVAGRslrhrlEITRGQVASAALTMAAPEDVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVLL 171
Cdd:cd23661    70 RYPDVHVHK------VVVRDRPARVLLEASERAQLVVVGSHGRGGFAGMLLGSVSRAVLHSAPCPVIV 131
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 24-170 2.90e-03

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 37.21  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2177016396  24 RVLALLDASRHSLAALTAAVDLASLRHAELVALYVEDMDLLSCAAFPFSCEIGAQSGLSRPLTHDSLETSIARQLQRVHQ 103
Cdd:cd23659     2 KVLIAVDGSEESEYALEWALENLHRPGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKAEKLLEKYEKKLKEEKG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2177016396 104 alagavagrsLRHRLEITRGQVASAALTMAAPE--DVLVLGKAGTTERWGTRLGSTSRRLILEAPCTVL 170
Cdd:cd23659    82 ----------IKVKVEVVAGDPGEVICKAAEELkaDLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVL 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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