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Conserved domains on  [gi|2179174277|ref|WP_234710942|]
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CPBP family glutamic-type intramembrane protease [Nostoc punctiforme]

Protein Classification

COG4449 family protein( domain architecture ID 10008561)

COG4449 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4449 COG4449
Predicted protease, Abi (CAAX) family [General function prediction only];
628-802 7.08e-53

Predicted protease, Abi (CAAX) family [General function prediction only];


:

Pssm-ID: 443548  Cd Length: 176  Bit Score: 181.37  E-value: 7.08e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 628 APLPIILNRFLTS-LVIPTRQDWLILVLLLIIYSIIALPYGWRLGFLQLQLWSANWIDQCLLTLRCLFAPAIIEELIFRV 706
Cdd:COG4449     1 PLLSLILSRLLRAvRTLPSLRDWLVALLILLIYAAIALPLGFITGFLQWSPWAASPLSLLAVILILLLFPAIGEELLFRG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 707 ILLPHPSEITNWLRWSLWAIVSLVLFVLYHPLNAKTFFKAGNPTFFNRGFLTLTLWLGIICTVAYTLTGSFWVIVLIHWV 786
Cdd:COG4449    81 LLLPHPVELASGLNWWLWILLSLVLFVLYHPLNALTFYPAGRPTFLNPRFLLLAGLLGLACTIAYLLTGSLWPAVIIHWL 160

                         170
                  ....*....|....*.
gi 2179174277 787 VVVVWLIVFGGITKLD 802
Cdd:COG4449   161 VVVVWLLLLGGYEKLL 176
 
Name Accession Description Interval E-value
COG4449 COG4449
Predicted protease, Abi (CAAX) family [General function prediction only];
628-802 7.08e-53

Predicted protease, Abi (CAAX) family [General function prediction only];


Pssm-ID: 443548  Cd Length: 176  Bit Score: 181.37  E-value: 7.08e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 628 APLPIILNRFLTS-LVIPTRQDWLILVLLLIIYSIIALPYGWRLGFLQLQLWSANWIDQCLLTLRCLFAPAIIEELIFRV 706
Cdd:COG4449     1 PLLSLILSRLLRAvRTLPSLRDWLVALLILLIYAAIALPLGFITGFLQWSPWAASPLSLLAVILILLLFPAIGEELLFRG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 707 ILLPHPSEITNWLRWSLWAIVSLVLFVLYHPLNAKTFFKAGNPTFFNRGFLTLTLWLGIICTVAYTLTGSFWVIVLIHWV 786
Cdd:COG4449    81 LLLPHPVELASGLNWWLWILLSLVLFVLYHPLNALTFYPAGRPTFLNPRFLLLAGLLGLACTIAYLLTGSLWPAVIIHWL 160

                         170
                  ....*....|....*.
gi 2179174277 787 VVVVWLIVFGGITKLD 802
Cdd:COG4449   161 VVVVWLLLLGGYEKLL 176
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 687-779 8.32e-08

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 50.63  E-value: 8.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 687 LLTLRCLFAPAIIEELIFRVILLPHPSEitnwLRWSLWAI-VSLVLFVLYHPLNAKTFFkagnptffnrgflTLTLWLGI 765
Cdd:pfam02517   5 LLLLLLALLAPIGEELLFRGYLLPRLRR----RLWPVLAIlISSLLFGLAHLPNGPQLF-------------LLAFLLGL 67

                          90
                  ....*....|....
gi 2179174277 766 ICTVAYTLTGSFWV 779
Cdd:pfam02517  68 ILGYLYLRTGSLWA 81
 
Name Accession Description Interval E-value
COG4449 COG4449
Predicted protease, Abi (CAAX) family [General function prediction only];
628-802 7.08e-53

Predicted protease, Abi (CAAX) family [General function prediction only];


Pssm-ID: 443548  Cd Length: 176  Bit Score: 181.37  E-value: 7.08e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 628 APLPIILNRFLTS-LVIPTRQDWLILVLLLIIYSIIALPYGWRLGFLQLQLWSANWIDQCLLTLRCLFAPAIIEELIFRV 706
Cdd:COG4449     1 PLLSLILSRLLRAvRTLPSLRDWLVALLILLIYAAIALPLGFITGFLQWSPWAASPLSLLAVILILLLFPAIGEELLFRG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 707 ILLPHPSEITNWLRWSLWAIVSLVLFVLYHPLNAKTFFKAGNPTFFNRGFLTLTLWLGIICTVAYTLTGSFWVIVLIHWV 786
Cdd:COG4449    81 LLLPHPVELASGLNWWLWILLSLVLFVLYHPLNALTFYPAGRPTFLNPRFLLLAGLLGLACTIAYLLTGSLWPAVIIHWL 160

                         170
                  ....*....|....*.
gi 2179174277 787 VVVVWLIVFGGITKLD 802
Cdd:COG4449   161 VVVVWLLLLGGYEKLL 176
Rce1-like pfam02517
Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive ...
 687-779 8.32e-08

Type II CAAX prenyl endopeptidase Rce1-like; This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologs in all three domains of life, including Rce1 from S. cerevisiae. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs. There is a conserved sequence motif EExxxR.


Pssm-ID: 460578 [Multi-domain]  Cd Length: 92  Bit Score: 50.63  E-value: 8.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 687 LLTLRCLFAPAIIEELIFRVILLPHPSEitnwLRWSLWAI-VSLVLFVLYHPLNAKTFFkagnptffnrgflTLTLWLGI 765
Cdd:pfam02517   5 LLLLLLALLAPIGEELLFRGYLLPRLRR----RLWPVLAIlISSLLFGLAHLPNGPQLF-------------LLAFLLGL 67

                          90
                  ....*....|....
gi 2179174277 766 ICTVAYTLTGSFWV 779
Cdd:pfam02517  68 ILGYLYLRTGSLWA 81
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 693-779 6.41e-05

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 42.47  E-value: 6.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2179174277 693 LFAPAIIEELIFRVILLPhpsEITNWLRWSLWAIVSLVLFVLYHPLNAKTFFkagnPTFFnrgfltltlwLGIICTVAYT 772
Cdd:COG1266    12 VILAPIAEELLFRGYLLG---RLRRRFGPWLAILLSSLLFGLLHLPNLLGFL----PAFL----------LGLVLGLLYL 74


                  ....*..
gi 2179174277 773 LTGSFWV 779
Cdd:COG1266    75 RTGSLWV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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