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Conserved domains on  [gi|2188506585|ref|WP_236976403|]
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MULTISPECIES: FABP family protein [Mycobacterium]

Protein Classification

FABP family protein( domain architecture ID 10555674)

fatty acid-binding protein (FABP) family protein may have roles in the recognition, transport, and/or storage of small molecules in the bacterial cytosol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP4_heme-bd pfam08768
THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals ...
 8-159 4.33e-65

THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).


:

Pssm-ID: 462593  Cd Length: 151  Bit Score: 195.49  E-value: 4.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188506585   8 ELAELAPLLGTWAGKGSGEYPTIEPFEYLEEVVFSHVGKPFLIYGQKTRAVTDGKPLHAETGYLRV-PQRGHLELVLAHP 86
Cdd:pfam08768   1 ELGPLAWLLGTWRGEGEGGYPTIEDFTYGEEITFSHDGRPFLNYTSRTWRLDDGKPLHRETGFWRWePGTGEVELVLAHP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2188506585  87 SGVTEIEVGNYSVSGDVIEMEtvTSDIGLTPTAKHVTALGRSLRIDGDQLSYSLRMGAVGQPVQHHLSAVLHR 159
Cdd:pfam08768  81 TGVVEIEEGTVKNGGNTIELA--TDAIARTSFAKEVTAGKRLYGLVDGDLSYTVDMATVGGPLQHHLSATLKR 151
 
Name Accession Description Interval E-value
THAP4_heme-bd pfam08768
THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals ...
 8-159 4.33e-65

THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).


Pssm-ID: 462593  Cd Length: 151  Bit Score: 195.49  E-value: 4.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188506585   8 ELAELAPLLGTWAGKGSGEYPTIEPFEYLEEVVFSHVGKPFLIYGQKTRAVTDGKPLHAETGYLRV-PQRGHLELVLAHP 86
Cdd:pfam08768   1 ELGPLAWLLGTWRGEGEGGYPTIEDFTYGEEITFSHDGRPFLNYTSRTWRLDDGKPLHRETGFWRWePGTGEVELVLAHP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2188506585  87 SGVTEIEVGNYSVSGDVIEMEtvTSDIGLTPTAKHVTALGRSLRIDGDQLSYSLRMGAVGQPVQHHLSAVLHR 159
Cdd:pfam08768  81 TGVVEIEEGTVKNGGNTIELA--TDAIARTSFAKEVTAGKRLYGLVDGDLSYTVDMATVGGPLQHHLSATLKR 151
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 9-159 6.55e-56

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381185  Cd Length: 150  Bit Score: 172.43  E-value: 6.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188506585   9 LAELAPLLGTWAGKGSGEYPTIEPFEYLEEVVFSHVGKPFLIYGQKTRAVTDGKPLHAETGYLRV-PQRGHLELVLAHPS 87
Cdd:cd07828     1 LEPLSWLLGTWRGSGKGGYPTIKDFSYGEEITFSHDGQPFLNYTARTWTLDTGKPMHRESGFLRIkPDGNKVELLIAHNT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2188506585  88 GVTEIEVGNysVSGDVIEMETVtsDIGLTPTAKHVTALGRSLRI-DGDQLSYSLRMGAVGQPVQHHLSAVLHR 159
Cdd:cd07828    81 GLVEIEEGE--VTGNTLELTTD--AVARTSFAPEVTAIKRLFGLvDGNTLEYTVDMATAGKPLTPHLSARLKK 149
 
Name Accession Description Interval E-value
THAP4_heme-bd pfam08768
THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals ...
 8-159 4.33e-65

THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).


Pssm-ID: 462593  Cd Length: 151  Bit Score: 195.49  E-value: 4.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188506585   8 ELAELAPLLGTWAGKGSGEYPTIEPFEYLEEVVFSHVGKPFLIYGQKTRAVTDGKPLHAETGYLRV-PQRGHLELVLAHP 86
Cdd:pfam08768   1 ELGPLAWLLGTWRGEGEGGYPTIEDFTYGEEITFSHDGRPFLNYTSRTWRLDDGKPLHRETGFWRWePGTGEVELVLAHP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2188506585  87 SGVTEIEVGNYSVSGDVIEMEtvTSDIGLTPTAKHVTALGRSLRIDGDQLSYSLRMGAVGQPVQHHLSAVLHR 159
Cdd:pfam08768  81 TGVVEIEEGTVKNGGNTIELA--TDAIARTSFAKEVTAGKRLYGLVDGDLSYTVDMATVGGPLQHHLSATLKR 151
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 9-159 6.55e-56

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381185  Cd Length: 150  Bit Score: 172.43  E-value: 6.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188506585   9 LAELAPLLGTWAGKGSGEYPTIEPFEYLEEVVFSHVGKPFLIYGQKTRAVTDGKPLHAETGYLRV-PQRGHLELVLAHPS 87
Cdd:cd07828     1 LEPLSWLLGTWRGSGKGGYPTIKDFSYGEEITFSHDGQPFLNYTARTWTLDTGKPMHRESGFLRIkPDGNKVELLIAHNT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2188506585  88 GVTEIEVGNysVSGDVIEMETVtsDIGLTPTAKHVTALGRSLRI-DGDQLSYSLRMGAVGQPVQHHLSAVLHR 159
Cdd:cd07828    81 GLVEIEEGE--VTGNTLELTTD--AVARTSFAPEVTAIKRLFGLvDGNTLEYTVDMATAGKPLTPHLSARLKK 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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