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Conserved domains on  [gi|823474068|ref|XP_002195332|]
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alpha-2,8-sialyltransferase 8E isoform X1 [Taeniopygia guttata]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467718  Cd Length: 273  Bit Score: 593.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 134 TEANLFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSR 213
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 214 CGREIDSADFVFRCNLPPISEKYLMDVGVKTDVVTVNPSIITERFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 294 SIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHY 373
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 823474068 374 YDNVKPRPGFHAMPSEIFNFLHMHSKGILRVHT 406
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 593.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 134 TEANLFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSR 213
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 214 CGREIDSADFVFRCNLPPISEKYLMDVGVKTDVVTVNPSIITERFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 294 SIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHY 373
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 823474068 374 YDNVKPRPGFHAMPSEIFNFLHMHSKGILRVHT 406
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 5.87e-93

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 279.88  E-value: 5.87e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068  154 FTTQKNTPLGTKLKYEvDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIs 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068  234 EKYLMDVGVKTDVVTVNP-SIITERFHKL--EKWRKPFYDVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFESQQ 308
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068  309 A---VYYFHPQYLINVSRYWL-SQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSgifITHHYYDNVKPRP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 823474068  382 -GFHAMPSEIFNFLHMHSKGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 593.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 134 TEANLFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSR 213
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 214 CGREIDSADFVFRCNLPPISEKYLMDVGVKTDVVTVNPSIITERFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 294 SIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHY 373
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 823474068 374 YDNVKPRPGFHAMPSEIFNFLHMHSKGILRVHT 406
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 134-406 8.78e-173

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 483.30  E-value: 8.78e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 134 TEANLFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSR 213
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 214 CGREIDSADFVFRCNLPPISEKylMDVGVKTDVVTVNPSIITERFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLNDS--KDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 294 SIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHY 373
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                        250       260       270
                 ....*....|....*....|....*....|...
gi 823474068 374 YDNVKPRPGFHAMPSEIFNFLHMHSKGILRVHT 406
Cdd:cd23971  239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 139-404 2.91e-127

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 367.93  E-value: 2.91e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 139 FKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSRCGREI 218
Cdd:cd23991    6 FRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 219 DSADFVFRCNLPPISEKYLMDVGVKTDVVTVNPSIITERFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDVSIRVK 298
Cdd:cd23991   86 DQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 299 YVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHYYDNVK 378
Cdd:cd23991  166 YTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQL 245

                        250       260
                 ....*....|....*....|....*.
gi 823474068 379 PRPGFHAMPSEIFNFLHMHSKGILRV 404
Cdd:cd23991  246 PKPGFHSMPKEFYQLLQLHSKGILKL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 134-405 3.31e-109

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 322.17  E-value: 3.31e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 134 TEANLFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRsQFKRCAVVGNGGILKNSR 213
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQL-PLKKCSVVGNGGILKNSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 214 CGREIDSADFVFRCNLPPISEKYLMDVGVKTDVVTVNPSIITERFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDV 293
Cdd:cd23989   80 CGQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 294 SIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHY 373
Cdd:cd23989  160 SLRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHY 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 823474068 374 YDNVKPRPGFHAMPSEIFNFLHMHSKGILRVH 405
Cdd:cd23989  240 YDNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 134-406 2.44e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 286.85  E-value: 2.44e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 134 TEANLFKSTLSRCCNaPSFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSR 213
Cdd:cd23963    1 TALDKFRKELERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 214 CGREIDSADFVFRCNLPPISEKYlMDVGVKTDVVTVNPSIITERFHKL--EKWRKPFYDVLQVYENASVLLPAFYNTRNT 291
Cdd:cd23963   80 CGKEIDSHDFVIRCNLPPIKGFE-KDVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSST 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 292 DVSIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRaKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITH 371
Cdd:cd23963  159 NLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPY 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 823474068 372 HYYDNVKPRP--GFHAMPSEiFNFLH-MHSKGILRVHT 406
Cdd:cd23963  238 HYYDDLSPSTknKVHNMPEE-FKLLReLHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 5.87e-93

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 279.88  E-value: 5.87e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068  154 FTTQKNTPLGTKLKYEvDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIs 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068  234 EKYLMDVGVKTDVVTVNP-SIITERFHKL--EKWRKPFYDVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFESQQ 308
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068  309 A---VYYFHPQYLINVSRYWL-SQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSgifITHHYYDNVKPRP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 823474068  382 -GFHAMPSEIFNFLHMHSKGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 175-406 8.66e-64

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 206.09  E-value: 8.66e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 175 IFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIsEKYLMDVGVKTDVVTVNPSII 254
Cdd:cd23970   46 VFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSIL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 255 TERFHKL--EKWRKPFYDVLQVYENASVLLPAF-YNTRNTDVSIRVKYvLDDFESQQAVYYFHP-QYLINVSRYWLSQGV 330
Cdd:cd23970  125 EKYYNNLltIQDRNNFFLSLKKLDGAILWIPAFfFHTSATVTRTLVDF-FVEHRGQLKVQLAWPgNIMQHVNRYWKTKHL 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 331 RAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHYYD------NVKPRPgFHAMPSEIFNFLHMHSKGILRV 404
Cdd:cd23970  204 SPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDkkgtkfTTKWQE-SHQLPAEFVLLYKMHGAGVLKL 282


                 ..
gi 823474068 405 HT 406
Cdd:cd23970  283 TL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 163-406 1.92e-62

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 202.26  E-value: 1.92e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 163 GTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIsEKYLMDVGV 242
Cdd:cd23969   30 GDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-EGYEKDVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 243 KTDVVTVNPSIITERFHKL--EKWRKPFYDVLQVYENASVLLPAFYNTRNTDvsiRVKYVLDDF--ESQQAVYYFHPQYL 318
Cdd:cd23969  109 KSNLTTMNPSVIPHAYGDLvnATDKEKFVERLRQLGDSILWIPAFVSKGGEE---HVQWTNEIIlkHKLNVKTAYPPLRL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 319 IN-VSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHYYDNVKPR--PGFHAMPSEIFNFLH 395
Cdd:cd23969  186 NHaIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRKYLttARPHKMPEEFRALRS 265

                        250
                 ....*....|.
gi 823474068 396 MHSKGILRVHT 406
Cdd:cd23969  266 LHQRGALRLHT 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 163-406 3.52e-58

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 191.31  E-value: 3.52e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 163 GTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPISEkYLMDVGV 242
Cdd:cd23987   30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 243 KTDVVTVNPSIITERFHKL--EKWRKPFYDVLQVYENASVLLPAFYNTRNTDvsiRVKYVLD-DFESQQAVYYFHP--QY 317
Cdd:cd23987  109 KTDLVTMNPSVVQRAFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDlILKHHINVRTAYPslRL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 318 LINVSRYWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHYYDNVK----PRPGFHAMPSEIFNF 393
Cdd:cd23987  186 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 265

                        250
                 ....*....|...
gi 823474068 394 LHMHSKGILRVHT 406
Cdd:cd23987  266 KNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 163-406 5.04e-53

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 178.22  E-value: 5.04e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 163 GTKLKYEVDTSGIFHINQEIFKMFPKDMPYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPISEkYLMDVGV 242
Cdd:cd23988   30 GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 243 KTDVVTVNPSIITERFHKL--EKWRKPFYDVLQVYENASVLLPAFYNTRNTDVSIRVKYVLddFESQQAVYYFHPQY-LI 319
Cdd:cd23988  109 KSDFITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALI--LKNKLKVRTAYPSLrLI 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 320 NVSR-YWLSQGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHYYDNVKPR----PGFHAMPSEIFNFL 394
Cdd:cd23988  187 HAVRgYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRyfsnAGPHRMPLEFKTLN 266

                        250
                 ....*....|..
gi 823474068 395 HMHSKGILRVHT 406
Cdd:cd23988  267 VLHNRGALKLTT 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 200-382 2.11e-32

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 120.93  E-value: 2.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 200 CAVVGNGGILKNSRCGREIDSADFVFRCNLPPISEKYLmDVGVKTDVVTVNPSIiterFHKLEKWRKPFYDVLQVYENAS 279
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEK-DVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPLEEEVV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 280 VLLpafyntrntdvsIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAK-------------RVSTGLILVTAAL 346
Cdd:cd19952   76 LIL------------SRAAAADFKRLKRRKKRHDNAVLLLTDPAPDLLSYVRKRleklglksffggnAPSSGLLAVLLAL 143

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 823474068 347 ELCEEVHLFGFWAFPMNPSGIFitHHYYDNVKPRPG 382
Cdd:cd19952  144 QLCDSVDLYGFGVDSGHAPKVP--YHYYDLVEAEEG 177
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 148-406 1.72e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 93.48  E-value: 1.72e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 148 NAPSFLFTTQKNTPLGTK-LKYEVDTSGIFHINQ-EIFKMFPKDMpyQRSQFKRCAVVGNGGILKNSRCGREIDSADFVF 225
Cdd:cd23964   33 NPEEYNRLSHYKLPFGWGgLNREVVERLLRNLNLtSSRYMFVLRG--GRPRCIRCAVVGNGGILNGSGKGKEIDAHDYVF 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 226 RCNLPPISEKYlMDVGVKTD--VVTVNPSIITERFHKLEKwrkpfYDVLQVYE-----NASVLLPAFYNTRNTDVSIRVK 298
Cdd:cd23964  111 RVNHALTKGFE-KDVGTKTSfyTFFPESLHNSLLKHVPQD-----KDTKYLFIpfkirDYDYLDAVLSGKPVPDGCDKGK 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 299 YVLDDFES---QQAVYYFHPQYLINVSRYWLSQGvRAKRVSTGLILVTAALELCEEVHLFGF---WAFPMnpsgifithH 372
Cdd:cd23964  185 RPPPLFGPklnATNVRLLHPDFIRYLFNRWLNSS-TSYRPTTGALMLLTALHTCDQVSVYGFgydPRFSL---------H 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 823474068 373 YYDN----VKPRPGFHAMPSEI--FNFLhmHSKGILRVHT 406
Cdd:cd23964  255 YYDKtfvkFTVFYANHDFTNERklWRKL--HEEGIINLYR 292
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 185-406 1.81e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 88.27  E-value: 1.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 185 MFPKDM-PYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNlPPISEKYLMDVGVKTDVVTVNPSIIterFHKLEK 263
Cdd:cd23974   71 MFDWWDrPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTL---MNSLRA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 264 WRKPFYDVL-QVYENASVLLP-----------AFYNT---RNTDVSIR-VKYVLDDFESQQaVYYFHP---QYLINvsRY 324
Cdd:cd23974  147 YAGVGFNGPpQSKETRYIFLPdhdrdyllvkaALTHTpidRGRDKSKRpSKYFGKDVTAEK-FKIYHPdfiRYLRN--RF 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 325 WLSQGVRAK-----RVSTGLILVTAALELCEEVHLFGFwafpMNPSGIFITHHYYDNVKPRPGF---HAMPSEIFNFLHM 396
Cdd:cd23974  224 LWSPILNTKqrdiyRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKL 299

                        250
                 ....*....|
gi 823474068 397 HSKGILRVHT 406
Cdd:cd23974  300 HKAGLIKLYM 309
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 198-395 1.84e-19

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 85.81  E-value: 1.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIsEKYLMDVGVKTdvvtvnpsiiTERFhklekwrkpfydvlqVYEN 277
Cdd:cd23967    3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPV-KGYEKDVGSKT----------TFRM---------------FYPE 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 278 ASVLLPAFYNtRNTDVSIrVKYVLDDFESQQAVYY---------------------------FHPQYLINVSRYWLS--- 327
Cdd:cd23967   57 SAFRDPEEYD-SDWLLVL-VPFKSMDLLWLQAVIKgkkpngkggfwkkiatsvpkppkkiriLNPYILQEAAFDLIGlpm 134

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 823474068 328 -QGVRAKRVSTGLILVTAALELCEEVHLFGFWAFPMNPSgifITHHYYDNVKprpgfhaMPSEIFNFLH 395
Cdd:cd23967  135 nGKQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLT-------MKAIKRSWTH 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 180-405 3.21e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 86.95  E-value: 3.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 180 QEIFKMFPKDMPY---QRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIsEKYLMDVGVKTdvvtvnpsiiTE 256
Cdd:cd23966   57 EKLFQVVPGENPYrtrDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT-KGFEKDVGSKT----------TH 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 257 RFHKLEKwrkpFYDVLQvyENASVLLP-----------AFYNTRNTDVSIRVKYVLDdfESQQAVYYFHPQYLINVSRYW 325
Cdd:cd23966  126 HFMYPES----AVDLDP--GVHLVLVPfkvldlqwlisALTTGEITRTYTPVKRFIK--ADKDKVLVINPAFIKYVHDNW 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 326 LSQgvRAKRVSTGLILVTAALELCEEVHLFGFWAfpmNPSGIFitHHYYDN-----VKPRPGFHAMPSEiFNFLHM-HSK 399
Cdd:cd23966  198 TEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGNW--HHYWEKnrsagAFRKTGVHDADFE-SDIIKKlAKE 269


                 ....*.
gi 823474068 400 GILRVH 405
Cdd:cd23966  270 GKIRVY 275
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 165-376 1.45e-17

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 82.24  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 165 KLKYEVDTSGIFHINQEIFKMFP--KDMPYQRSQF--KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPiSEKYLMDV 240
Cdd:cd23980   45 RLQREKKPKNLNDTIRELFQVVPgnVDPLLEKRLVscRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADV 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 241 GVKTDVVTVNPSIITERFHKLEKWRKPFyDVLQVYENASVLLPAFYNTRNTDVSIRVKYvlddfeSQQAVYYFHPQYLIN 320
Cdd:cd23980  124 GSKTTHHFVYPESFRELAQNVSMILVPF-KTLDLEWVISATTTGTISHTYVPVPRKIKV------KKEKILIYHPAFIKY 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 823474068 321 VSRYWLsQGvRAKRVSTGLILVTAALELCEEVHLFGFWAfpmNPSGIFitHHYYDN 376
Cdd:cd23980  197 VFDRWL-QG-HGRYPSTGILSVIFSLHVCDEVDLYGFGA---DSKGNW--HHYWEN 245
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 197-378 1.21e-16

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 79.24  E-value: 1.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 197 FKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPiSEKYLMDVGVKTDVVTVNPSIITERFHKLekWRKPfydvlqVYE 276
Cdd:cd23968   45 YNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAP-TKGFEKDVGSKTTLRLINSQILSKPEFNF--LTDP------LYR 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 277 NASVLL--PAFYNTRNTDVSIRVKYvlDDFES---------QQAVYYFHPQYLINVsRYWLSQGVRAKRV----STGLIL 341
Cdd:cd23968  116 NVTLLVwdPSSYNVNLEKWYKKPDF--DFFPNyikyrrrhpEEPFYLIDPRFLWRL-WDILQEYTPEKIKpnppSSGFIG 192

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 823474068 342 VTAALELCEEVHLFGFWafpmnPSgIFITH--HYYDNVK 378
Cdd:cd23968  193 IVLMLHLCDWVDVYEYV-----PS-VRQTDrcHYYDVEK 225
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 196-357 6.89e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 74.36  E-value: 6.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 196 QFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPISeKYLMDVGVKTDVVTVNPSIITERFHKLEKwrKPFYdvlqvy 275
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGTKTTIRLINSQLVTTEKHKFLK--DSLY------ 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 276 eNASVLL---PAFYNT------RNTDVSIrvkyvlddFESQQAVYYFHPQ---YLINVSRYW----LSQGVRAKRV---- 335
Cdd:cd23985  115 -NEGILIvwdPAPYHSdipewyKNPDYNF--------FENYKTYRRLNPNqpfYILHPQMQWelwdIIQENSPEEIqpnp 185

                        170       180
                 ....*....|....*....|...
gi 823474068 336 -STGLILVTAALELCEEVHLFGF 357
Cdd:cd23985  186 pSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 180-407 8.63e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 74.40  E-value: 8.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 180 QEIFKMFPK--------DMPYQRSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIsEKYLMDVGVKTDVVTVNP 251
Cdd:cd23973   58 KEVVELIPKpkeqqllaLSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVI-KGYEEDVGTRTSFYVHTA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 252 SIITERFHKLEKwrKPFYDVLQVYENASVLLPAF---YN-----TRNTDVSIRV-------KYVLDDFeSQQAVYYFHPQ 316
Cdd:cd23973  137 HSITSSLMILQK--RGFKNIPQDKDIKYILFPEGprdYQwlealLKNKTIPSGAyygrrprSYFSGDF-TEDKYLVLHPD 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 317 YLinvsRYWLSQGVRAK----------RVSTGLILVTAALELCEEVHLFGFwafpMNPSGIFITHHYYDNVKPRPGF--- 383
Cdd:cd23973  214 FL----RYVKNRFLRSKtlkgkywaiyRPTTGAFLLLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKKTKLVFyin 285

                        250       260
                 ....*....|....*....|....
gi 823474068 384 HAMPSEIFNFLHMHSKGILRVHTG 407
Cdd:cd23973  286 HDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 199-405 3.68e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 72.55  E-value: 3.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 199 RCAVVGNGGILKNSRCGREIDSADFVFRCNlPPISEKYLMDVGVKTDV--VTVNpsiiTERFHKLEKWRKPFYDVLQVYE 276
Cdd:cd23972   84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygFTVN----TMKNSLISYWNLGFTRTPQGQD 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 277 NASVLLPA----FYNTRNTDVSIRVKYVLDDFESQQAvyYF------------HPQYLinvsRYWLSQGVRAKRV----- 335
Cdd:cd23972  159 LQYIFIPSdirdYVMLRSAILGVPVPEGLDKGDRPHK--YFgpeasakkfkllHPDFI----SYLTDRFLKSKLLnthyg 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 336 -----STGLILVTAALELCEEVHLFGF-----WAFpmnpsgifiTHHYYDNVKPRPGF---HAMPSEIFNFLHMHSKGIL 402
Cdd:cd23972  233 hlympSTGALMLLTALHTCDQVSAYGFitsnyWKF---------SDHYYERKKKPLVFyanHDMLLEAALWRRLHKAGIL 303


                 ...
gi 823474068 403 RVH 405
Cdd:cd23972  304 QLY 306
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 198-395 3.63e-13

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 67.77  E-value: 3.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPISEkYLMDVGVKTDV-------VTVNPSI----------------- 253
Cdd:cd23982    3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTIrlfypesAQFDPGIendpdtllvlvpfkpld 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 254 --------ITERFHKLEKWRKPfydvlqvyenasvllPAFYNTRNTDVSIrvkyvLDDFESQQAVYyfhpqYLINVSryw 325
Cdd:cd23982   82 fywlyeilSNEKRVRKGFWKQP---------------PRIWDANPKQIRI-----LNPYYTYVAAT-----KLLQVP--- 133

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 823474068 326 lSQGVRAKRVSTGLILVTAALELCEEVHLFGFwAFPMN-PSGIFIthHYYDNVKPRpgfhAMPSEIFNFLH 395
Cdd:cd23982  134 -GQRKKKQKPTTGLLAITLALHLCDEVHIAGF-GYPDNgNSNQPI--HYYNQITLK----SMANSGHNLNA 196
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 198-377 3.19e-12

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 65.15  E-value: 3.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPISeKYLMDVGVKT-------DVVTVNPS---------IITERFHKL 261
Cdd:cd23984    3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTtfrlcypESIFSDPShydpnttvvLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 262 eKWrkpfydVLQVYENASVLLPAFYNTRNTDV-----SIRvkyVLDDFESQQAVYYFhpqylINVSRYWLSQGvRAKRVS 336
Cdd:cd23984   82 -RW------LLDLLMGKKVSAKGFWKKPALNLiykpnQIR---ILNPFILRIAAYEL-----LHFPKRFPKEK-KPKHPT 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 823474068 337 TGLILVTAALELCEEVHLFGfwaFPMNPSGIFITHHYYDNV 377
Cdd:cd23984  146 TGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 180-376 1.20e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 64.89  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 180 QEIFKMFPKDMPYQ---RSQFKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPiSEKYLMDVGVKTdvvtvnpsiiTE 256
Cdd:cd23979   60 SKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRT----------TH 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 257 RFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDVSIRVKYV-LDDF--ESQQAVYYFHPQYLINVSRYWLSQGVRAK 333
Cdd:cd23979  129 HFMYPESAKNLPANVSFVLVPFKTLDLLWITSALSTGQIRFTYApVKQFlrVDKDKVQIYNPAFFKYIHDRWTEHHGRYP 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 823474068 334 rvSTGLILVTAALELCEEVHLFGFWAfpmNPSGIFitHHYYDN 376
Cdd:cd23979  209 --STGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 244
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 197-357 1.44e-11

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 64.47  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 197 FKRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPiSEKYLMDVGVKTDVVTVNPSIITERFHK---------------- 260
Cdd:cd23986   49 FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNPNHHfidsslykdvilvawd 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 261 -------LEKW-RKPFYDVLQVYENasvllpafYNTRNTDvsirvkyvlddfesqQAVYYFHPQY---LINVSRYWLSQG 329
Cdd:cd23986  128 papysanLHKWyKKPDYNLFTPYVQ--------YRKRNPN---------------QPFYILHPKFiwqLWDIIQENTQEK 184

                        170       180
                 ....*....|....*....|....*...
gi 823474068 330 VRAKRVSTGLILVTAALELCEEVHLFGF 357
Cdd:cd23986  185 IQPNPPSSGFIGILIMMSMCREVHVYEY 212
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 198-378 1.39e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 60.71  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIsEKYLMDVGVKTDVVTVNPSIITERFHKLE----------KWRKP 267
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAIQKPEQYEkdslfvlagfKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 268 FYDVLQVYENASVLLPAFYNTRNTDV-----SIRvkyVLDDFESQQAVYYFhpqylINVSrywLSQGV--RAKRVSTGLI 340
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVprephEIR---ILNPYFIQEAAFSF-----IGLP---FNNGLmgRGNIPTLGSV 150

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 823474068 341 LVTAALELCEEVHLFGFwAFPMN-PSGIFithHYYDNVK 378
Cdd:cd23981  151 AITMALHNCDEVAVAGF-GYDMNtPNAPL---HYYETIK 185
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 198-375 5.08e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 59.18  E-value: 5.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIS--EKylmDVGVKTDV----------VTVNPSIITER-------- 257
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRgyEK---DVGRRTTIrvvshsslprLLRNAILLLAGtraptvvv 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 258 ----FHKLEKWRKPFYDVLQvyeNASVLLPafyntrNTDVsirvkYVLDDFESQQAVYYFHPQYLIN--VSRYWLsqgvr 331
Cdd:cd23965   79 fwgpETKMNKDGAGKYNLLR---SLSKKYP------DVEF-----YSLTPEKMDYADELFEKETGKSriKSGTWL----- 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 823474068 332 akrvSTGLILVTAALELCEEVHLFGfwafpMNPSGIFITH-------HYYD 375
Cdd:cd23965  140 ----STGWFTMLLALDVCDEIKVYG-----MVPENYCREHpnskvpyHYYE 181
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 198-377 1.24e-07

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 52.05  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPIsEKYLMDVGVKTDVVTVNPSiiTERFHKLEKWRKPFYdVLQVYEN 277
Cdd:cd23983    3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPE--GAPKSEQEYDPTSLF-VAVLFKS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 278 ASV-LLPAFYNTRNTDVSIRV---KYVLDD--FESQQaVYYFHP-----------QYLINVSRYWlsqgVRAKRVST-GL 339
Cdd:cd23983   79 VDFaWLKAMVKKEPLSFWSRLffwKEVADSipLKPSQ-FRILNPliiketaldilQYPEPQSRLW----GWDKNVPTlGV 153

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 823474068 340 ILVTAALELCEEVHLFGFwAFPMNPSGIFIthHYYDNV 377
Cdd:cd23983  154 TAVVLATHLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 198-375 2.48e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 51.40  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPiSEKYLMDVGVKTDVVTVN----PSIITERFHKLEKWRKPFYDVLQ 273
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRVVShtsvPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 274 VYENASVLLPAfyNTRNTDVSIRVKYvlddfeSQQAVYYFHPQYLINVSRYWLSQGVRAKR-----VSTGLILVTAALEL 348
Cdd:cd23977   81 PERNMDRDGGG--KTYRALLTLAKMY------PHLQVYTLTEEKMAYCDGVFQNETGKNRMksgsfLSTGWFTMILALEL 152

                        170       180
                 ....*....|....*....|....*....
gi 823474068 349 CEEVHLFGFW--AFPMNPSGIFITHHYYD 375
Cdd:cd23977  153 CEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 198-379 2.22e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 42.55  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 198 KRCAVVGNGGILKNSRCGREIDSADFVFRCNLPPiSEKYLMDVGVKTDVVTVNPSIITERFHKLekwrkpfYDVLQVYEN 277
Cdd:cd23976   16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLRVIAHSSIQRILRNR-------NELLNVSQG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 278 ASVLL--PAFYNTRNTDVSIRVK-YVLDDFESQQAVYYFHPQYLINVSRYWLSQGVRAKRV-----STGLILVTAALELC 349
Cdd:cd23976   88 TVFIFwgPSNYMRRDGKGLVYNNlQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKIsntwlSTGWFTMIIALELC 167

                        170       180       190
                 ....*....|....*....|....*....|..
gi 823474068 350 EEVHLFGFWA--FPMNPSGIFITHHYYDNVKP 379
Cdd:cd23976  168 DRINVYGMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 200-375 2.77e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 42.23  E-value: 2.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 200 CAVVGNGGILKNSRCGREIDSADFVFRCNLPPiSEKYLMDVGVKTDVVTVN----PSIIterfhklekwRKPFYDVLQVY 275
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTIRVVShtsvPLLL----------KNPDYFFKETN 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 823474068 276 ENASVLLPAFYNTRNTDVSIRVKYVLDDFES-QQAVYYFHPQYLINVSRYWLSQGVRAKRVSTGLILVTA------ALEL 348
Cdd:cd23975   73 ETIYVIWGPFRNMRKDGKGIVYNMLKKAVESyPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGwftlilAMDA 152

                        170       180
                 ....*....|....*....|....*....
gi 823474068 349 CEEVHLFGFWAFPMNPSGIF--ITHHYYD 375
Cdd:cd23975  153 CYGIHVYGMINDTYCKTEGYrkVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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