NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1785343116|ref|XP_002937042|]
View 

major facilitator superfamily domain-containing protein 6-like [Xenopus tropicalis]

Protein Classification

major facilitator superfamily domain-containing protein 6-like( domain architecture ID 13024730)

major facilitator superfamily domain-containing protein 6-like (MFSD6L)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 16-561 2.29e-171

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 491.82  E-value: 2.29e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116  16 ASLFHFFHNVGKFCLIPFLTLYFRQLGLAAPLVGIVIGFKHAVHLLWAPLCSFLAKSHRKRRFFIMASLLLSAGAGGvfa 95
Cdd:cd17479     1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116  96 fyppldkniasmfcntsmpwkeqfnppvgisvsvdeyfnttyaapsdhhttagapttlrdgelttdisidttttspldle 175
Cdd:cd17479       --------------------------------------------------------------------------------

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 176 tsappfsssspatsnktlehrtrkvpgsgkthkangtkasasnskqksppshrtsasgthpnvsqhpsanrrkvrdvgld 255
Cdd:cd17479       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 256 fadtfldPEHKVFLIVLGLVIIWELMAAPLEWIADDSLYEYLDFVDATDRHGKLWIWGYLGASMGSIFIAFLVDNLNCFV 335
Cdd:cd17479    78 -------LYHQIFLLVLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFL 150

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 336 IFNIPRVSFHFFCYGGFLVSTLFLSALYPIHVSKKTEHSNKTVKALGFLGSDGRIVLTALTVFLLGAVGSTTQNFLFWQM 415
Cdd:cd17479   151 PPKISRILLHFYTYGGFMILTFLLSFFYPIPVPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLM 230

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 416 QDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIWW 495
Cdd:cd17479   231 QDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWW 310

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1785343116 496 AINSQVVDVASPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQACCIILLLWIAVFL 561
Cdd:cd17479   311 AVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 16-561 2.29e-171

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 491.82  E-value: 2.29e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116  16 ASLFHFFHNVGKFCLIPFLTLYFRQLGLAAPLVGIVIGFKHAVHLLWAPLCSFLAKSHRKRRFFIMASLLLSAGAGGvfa 95
Cdd:cd17479     1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116  96 fyppldkniasmfcntsmpwkeqfnppvgisvsvdeyfnttyaapsdhhttagapttlrdgelttdisidttttspldle 175
Cdd:cd17479       --------------------------------------------------------------------------------

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 176 tsappfsssspatsnktlehrtrkvpgsgkthkangtkasasnskqksppshrtsasgthpnvsqhpsanrrkvrdvgld 255
Cdd:cd17479       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 256 fadtfldPEHKVFLIVLGLVIIWELMAAPLEWIADDSLYEYLDFVDATDRHGKLWIWGYLGASMGSIFIAFLVDNLNCFV 335
Cdd:cd17479    78 -------LYHQIFLLVLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFL 150

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 336 IFNIPRVSFHFFCYGGFLVSTLFLSALYPIHVSKKTEHSNKTVKALGFLGSDGRIVLTALTVFLLGAVGSTTQNFLFWQM 415
Cdd:cd17479   151 PPKISRILLHFYTYGGFMILTFLLSFFYPIPVPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLM 230

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 416 QDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIWW 495
Cdd:cd17479   231 QDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWW 310

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1785343116 496 AINSQVVDVASPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQACCIILLLWIAVFL 561
Cdd:cd17479   311 AVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 256-548 2.67e-22

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 98.86  E-value: 2.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 256 FADTFLDPEHKVFLIVLGLVIIWELMAAPLEWIADDSLYEYLDfvDATDRHGKLWIWGYLGASMGSIFIAFLVDNLNcfv 335
Cdd:pfam12832  79 FLSVLFIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLG--EKRKDYGRQRLWGSVGFALSVFGLGALFDHYS--- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 336 IFNIPRVSFHFFcyGGFLVSTLFLSALYPihvSKKTEHSNKTVKALGFLGSDGRIVLTALTVFLLGAVGSTTQNFLFWQM 415
Cdd:pfam12832 154 VGLLPSVLFYLF--AALMLLSLLLPLAPP---EMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYL 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 416 QDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFL-WAPWSVLAVQLLNAFSSGVIW 494
Cdd:pfam12832 229 ENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAISFGLTH 308

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1785343116 495 WAINSQVVDVASPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQA 548
Cdd:pfam12832 309 AAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFRA 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
390-568 4.29e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.12  E-value: 4.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 390 IVLTALTVFLLGAVGSTTQNFLFWQMQDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLY 469
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 470 YSFLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDVASPGtERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQAC 549
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170

                         170       180
                  ....*....|....*....|
gi 1785343116 550 CII-LLLWIAVFLLVQPKLP 568
Cdd:COG2814   171 AVLaLLALLLLLRLLPESRP 190
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 16-561 2.29e-171

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 491.82  E-value: 2.29e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116  16 ASLFHFFHNVGKFCLIPFLTLYFRQLGLAAPLVGIVIGFKHAVHLLWAPLCSFLAKSHRKRRFFIMASLLLSAGAGGvfa 95
Cdd:cd17479     1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116  96 fyppldkniasmfcntsmpwkeqfnppvgisvsvdeyfnttyaapsdhhttagapttlrdgelttdisidttttspldle 175
Cdd:cd17479       --------------------------------------------------------------------------------

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 176 tsappfsssspatsnktlehrtrkvpgsgkthkangtkasasnskqksppshrtsasgthpnvsqhpsanrrkvrdvgld 255
Cdd:cd17479       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 256 fadtfldPEHKVFLIVLGLVIIWELMAAPLEWIADDSLYEYLDFVDATDRHGKLWIWGYLGASMGSIFIAFLVDNLNCFV 335
Cdd:cd17479    78 -------LYHQIFLLVLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFL 150

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 336 IFNIPRVSFHFFCYGGFLVSTLFLSALYPIHVSKKTEHSNKTVKALGFLGSDGRIVLTALTVFLLGAVGSTTQNFLFWQM 415
Cdd:cd17479   151 PPKISRILLHFYTYGGFMILTFLLSFFYPIPVPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLM 230

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 416 QDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIWW 495
Cdd:cd17479   231 QDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWW 310

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1785343116 496 AINSQVVDVASPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQACCIILLLWIAVFL 561
Cdd:cd17479   311 AVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 265-559 3.87e-35

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 136.56  E-value: 3.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 265 HKVFLIVLGLVIIWELMAAPLEWIADDSLYEYLDfvDATDRHGKLWIWGYLGASMGSIFIAFLVDNLNCFVIFNIprvSF 344
Cdd:cd17335    84 AQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLG--EERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTI---AF 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 345 HFFCygGFLVSTLFLSALYPihVSKKTEHSNKTVKALGFLGSDGRIVLTALTVFLLGAVGSTTQNFLFWQMQDAGSGELY 424
Cdd:cd17335   159 YVFA--VLMLLALLLALKFP--FRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 425 MGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDV 504
Cdd:cd17335   235 IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAA 314

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1785343116 505 ASPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQ----ACCIILLLWIAV 559
Cdd:cd17335   315 APPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRffaiAALAGLLAFFLI 373
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 256-548 2.67e-22

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 98.86  E-value: 2.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 256 FADTFLDPEHKVFLIVLGLVIIWELMAAPLEWIADDSLYEYLDfvDATDRHGKLWIWGYLGASMGSIFIAFLVDNLNcfv 335
Cdd:pfam12832  79 FLSVLFIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLG--EKRKDYGRQRLWGSVGFALSVFGLGALFDHYS--- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 336 IFNIPRVSFHFFcyGGFLVSTLFLSALYPihvSKKTEHSNKTVKALGFLGSDGRIVLTALTVFLLGAVGSTTQNFLFWQM 415
Cdd:pfam12832 154 VGLLPSVLFYLF--AALMLLSLLLPLAPP---EMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYL 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 416 QDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFL-WAPWSVLAVQLLNAFSSGVIW 494
Cdd:pfam12832 229 ENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAISFGLTH 308

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1785343116 495 WAINSQVVDVASPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQA 548
Cdd:pfam12832 309 AAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFRA 362
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 453-562 4.11e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 55.70  E-value: 4.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 453 KWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDVASPGtERSLQLALRWLAYGSGASTGSFA 532
Cdd:cd17329    65 KPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPE-NRTRAFSLLYWAINLGVAIGPLL 143

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1785343116 533 SGFVITR-FSLAVLYQACCIILLLWIAVFLL 562
Cdd:cd17329   144 GGLLLLYsFRLLFLAAAVLFLLAALVLLFLL 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 314-562 4.93e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 55.27  E-value: 4.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 314 YLGASMGSIFIAFLVDNLNCFVIFNIPRVSFHFFCYGGFLVSTLFLSALY---PIHVSKKTEHSNKTVKA-LGFLGSDGR 389
Cdd:cd17325   121 AMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLlpePRPPPNKRAVSAARLRSgLRLLLRDRR 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 390 IVLTALTVFLLGAVGSTTQNFL-FWQMQDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVL 468
Cdd:cd17325   201 LLALFLAIFVLAFAFGALEPFLpLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 469 YYSFLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDVASPGtERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQA 548
Cdd:cd17325   281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE-GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359

                         250
                  ....*....|....
gi 1785343116 549 CCIILLLWIAVFLL 562
Cdd:cd17325   360 AAALLLLAAVLFLL 373
MFS_1 pfam07690
Major Facilitator Superfamily;
393-566 9.45e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.35  E-value: 9.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 393 TALTVFLLGAVGSTTQNFLFWQMQDA-GSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYS 471
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 472 FLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDVAsPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQACCI 551
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWF-PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170
                  ....*....|....*
gi 1785343116 552 ILLLWIAVFLLVQPK 566
Cdd:pfam07690 160 LSLLAAVLLLLPRPP 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 394-572 6.19e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.81  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 394 ALTVFLLGAVGSTTQNFLFWQMQDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFL 473
Cdd:cd17325     2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 474 WAPWSVLAVQLLNAFSSGVIWWAINSQVVDVASPGtERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQACCIIL 553
Cdd:cd17325    82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                         170       180
                  ....*....|....*....|
gi 1785343116 554 LL-WIAVFLLVQPKLPNIKK 572
Cdd:cd17325   161 LLaLVLALLLLPEPRPPPNK 180
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 314-562 9.26e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 9.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 314 YLGASMGSIFIAFLVDNLNCFVIFNIPrvsfhffcyGGFLVSTLFLSALYPIHVSKKTEHSNKTVKALGFLgSDGRIVLT 393
Cdd:cd17489   130 TLAMALGPALGLFLYQHLGFAVLFIVA---------AVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRL-VEKKVLPP 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 394 ALTVFLLGAVGSTTQNFLFWQMQDAGSGELYMGLSVAAGLLaeLTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFL 473
Cdd:cd17489   200 ALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIAL--LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 474 WAPWSVLAVQLLNAFSSGVIWWAINSQVVDVAsPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQACCIIL 553
Cdd:cd17489   278 GSPWMLLLAAVLYGLGFGLLFPALQALAVDLV-PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVV 356


                  ....*....
gi 1785343116 554 LLWIAVFLL 562
Cdd:cd17489   357 LLALVLYIF 365
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 415-569 1.69e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 415 MQDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIW 494
Cdd:cd06174    23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLID 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1785343116 495 WAINSQVVDVAsPGTERSLQLALRWLAYGSGASTGSFASGFVITR--FSLAVLYQACCIILLLWIAVFLLVQPKLPN 569
Cdd:cd06174   103 PAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPE 178
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
390-568 4.29e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.12  E-value: 4.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 390 IVLTALTVFLLGAVGSTTQNFLFWQMQDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLY 469
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 470 YSFLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDVASPGtERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQAC 549
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170

                         170       180
                  ....*....|....*....|
gi 1785343116 550 CII-LLLWIAVFLLVQPKLP 568
Cdd:COG2814   171 AVLaLLALLLLLRLLPESRP 190
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 416-574 1.49e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.51  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 416 QDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIWW 495
Cdd:cd17489    24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1785343116 496 AINSQVVDVAsPGTERSLQLALRWLAYGSGASTGSFASGFVITRFSLAVLYQACCIILLLWIAVFLLVQPKLPNIKKIN 574
Cdd:cd17489   104 AAATLVADII-PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEA 181
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-98 2.77e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.66  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116  11 KALAVASLFHFFHNVGKFCLIPFLTLYFRQ-LGLAAPLVGIVIGFKHAVHLLWAPLCSFLAKSHRKRRFFIMASLLLSAG 89
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307


                  ....*....
gi 1785343116  90 AGGVFAFYP 98
Cdd:COG2211   308 LLLLFFLGP 316
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
346-527 2.79e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 346 FFCYGGFLVSTLFLSALYpIHVSKKTEHSNKTVKALGFLgSDGRIVLTALTVFLLGAVGSTTQNFL-FWQMQDAGSGELY 424
Cdd:COG2814   167 FLVNAVLALLALLLLLRL-LPESRPAARARLRGSLRELL-RRPRLLLLLLLAFLLGFGFFALFTYLpLYLQEVLGLSASA 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 425 MGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLYYSFLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDV 504
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                         170       180
                  ....*....|....*....|...
gi 1785343116 505 AsPGTERSLQLALRWLAYGSGAS 527
Cdd:COG2814   325 A-PPEARGRASGLYNSAFFLGGP 346
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
315-561 5.38e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 315 LGASMGSIFIAFLVDnlncfvifniPRVSFHFFCYGGFLVSTLFLSALYPI-HVSKKTEHSNKTVKALGFLGSDGRIVLT 393
Cdd:COG0738   146 LGPLLGGLLILLGLS----------LSWHLPYLILAVLLLLLALLFLRSKLpEIEEEEEEAAGSAASLKSLLKNPRLLLG 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 394 ALTVFLL----GAVGSTTQNFLfwqMQDAGSGELYMGLSVAAGLLAELTLYFFRNKILKVLTFKWMVVLGLLSLGVQVLY 469
Cdd:COG0738   216 GLAIFLYvgaeGAIGDWLPLYL---KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785343116 470 YSFLWAPWSVLAVQLLNAFSSGVIWWAINSQVVDVASPGTERSLQLALrWLAYgSGASTGSFASGFVITRFSLAVLYQ-- 547
Cdd:COG0738   293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGI-VGGAIGPPLIGFLADAFGLRAAFLvp 370

                         250
                  ....*....|....
gi 1785343116 548 ACCIILLLWIAVFL 561
Cdd:COG0738   371 LVCYLLILLLALAL 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH