|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
806-1215 |
4.99e-72 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 246.36 E-value: 4.99e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 806 STWSADGSQIICAARNTVFVFDVETSDLLLELKTSRLSTIQFCHACPNSSLLAVALSHYTVELWNFESSKKKAECSGHLS 885
Cdd:COG2319 42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 886 WVHCVQFSPDGSLLLSSSDDQTIRLWETDrvhtssavalkrdtdvlfshsdatiiapdSSNRLQVLSGSTGAVvleseel 965
Cdd:COG2319 122 AVRSVAFSPDGKTLASGSADGTVRLWDLA-----------------------------TGKLLRTLTGHSGAV------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 966 ssriRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECM-V 1044
Cdd:COG2319 166 ----TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLrT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1045 LQGHMEPVRK--FHllsssssP---RLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKV 1119
Cdd:COG2319 242 LTGHSGSVRSvaFS-------PdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1120 WSSASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICSRdtkdsmdsyHGGWVTDLHFSPDNR 1199
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---------HTGAVTSVAFSPDGR 385
|
410
....*....|....*...
gi 528476538 1200 VLVSTG--GYIKWWSVES 1215
Cdd:COG2319 386 TLASGSadGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
567-1039 |
5.41e-63 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 220.55 E-value: 5.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 567 QLALSQPDRSEVYRQALMQAQKRASRGQIYLNWVNKNIEEGLSRLVMHPHQGAVYYACFSKDGSKIASCGASKALRVFKS 646
Cdd:COG2319 28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 647 TSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWNVERGVLIREFEvEHEEQINHCQFTNTGRRvlLATCSNDK 726
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKL--LASGSDDG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 727 ftNTKLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFEVSSANEWKSIDVDSffpesdeeikAMVKCS 806
Cdd:COG2319 185 --TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS----------GSVRSV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 807 TWSADGSqiicaarntvfvfdvetsdlllelktsrlstiqfchacpnssLLAVALSHYTVELWNFESSKKKAECSGHLSW 886
Cdd:COG2319 253 AFSPDGR------------------------------------------LLASGSADGTVRLWDLATGELLRTLTGHSGG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 887 VHCVQFSPDGSLLLSSSDDQTIRLWETDrvhtssavalkrdtdvlfshsdatiiapdSSNRLQVLSGSTGAVvleseels 966
Cdd:COG2319 291 VNSVAFSPDGKLLASGSDDGTVRLWDLA-----------------------------TGKLLRTLTGHTGAV-------- 333
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528476538 967 sriRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRT 1039
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
616-912 |
2.61e-59 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 206.03 E-value: 2.61e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 616 HQGAVYYACFSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWNVERGVLIR 695
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 696 EFEvEHEEQINHCQFTNTGRrvLLATCSNDKftNTKLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLF 775
Cdd:cd00200 88 TLT-GHTSYVSSVAFSPDGR--ILSSSSRDK--TIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 776 EVSSANEwksidVDSFFPESDEeikamVKCSTWSADGSQII-CAARNTVFVFDVETSDLLLELkTSRLSTIQFCHACPNS 854
Cdd:cd00200 163 DLRTGKC-----VATLTGHTGE-----VNSVAFSPDGEKLLsSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDG 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 528476538 855 SLLAVALSHYTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWE 912
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
877-1212 |
3.56e-57 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 199.87 E-value: 3.56e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 877 KAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETDRVHTssavalkrdtdvlfshsdatiiapdssnrLQVLSGSTG 956
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----------------------------LRTLKGHTG 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 957 AVVleseelssRIRCSCISRnaaFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWK 1036
Cdd:cd00200 53 PVR--------DVAASADGT---YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1037 WRTGEC-MVLQGHMEPVR--KFHLLSSssspRLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSA 1113
Cdd:cd00200 122 VETGKClTTLRGHTDWVNsvAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1114 NRTAKVWSSASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICSRdtkdsmdsyHGGWVTDLH 1193
Cdd:cd00200 198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---------HTNSVTSLA 268
|
330 340
....*....|....*....|.
gi 528476538 1194 FSPDNRVLVSTG--GYIKWWS 1212
Cdd:cd00200 269 WSPDGKRLASGSadGTIRIWD 289
|
|
| APAF1_C |
pfam17908 |
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ... |
457-589 |
2.99e-56 |
|
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.
Pssm-ID: 465560 Cd Length: 135 Bit Score: 191.10 E-value: 2.99e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 457 ELHKKMVRQYQRFYSKRPPDSADKDSLYWYQFIPYHMAKAGLSKELYSLMFSLDWVKEKARIMGSAHLINDYVEYGEILD 536
Cdd:pfam17908 3 DLHRKLVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHILD 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 528476538 537 KENSEVRVQFQEFLSLNGHHLEQRPFPDVVQLALSQPDRSEVYRQALMQAQKR 589
Cdd:pfam17908 83 ENDCAVLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
|
|
| CARD_APAF1 |
cd08323 |
Caspase activation and recruitment domain similar to that found in Apoptotic ... |
7-92 |
5.76e-45 |
|
Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1; Caspase activation and recruitment domain (CARD) similar to that found in apoptotic protease-activating factor 1 (APAF-1), which is an activator of caspase-9. APAF-1 contains WD-40 repeats, a CARD, and an ATPase domain. Upon stimulation, APAF-1, together with caspase-9, forms the heptameric 'apoptosome', which leads to the processing and activation of caspase-9, starting a caspase cascade which leads to apoptosis. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260034 Cd Length: 86 Bit Score: 156.90 E-value: 5.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 7 SRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASL 86
Cdd:cd08323 1 SCLLQHRAALERDIKTSYIMDHMISDGVLTLSEEEKVRAQPTQQERAAALIKIILRKDNDAYISFYNALLHEGYKDLAAL 80
|
....*.
gi 528476538 87 LHSDLP 92
Cdd:cd08323 81 LHDGLP 86
|
|
| NB-ARC |
pfam00931 |
NB-ARC domain; |
145-370 |
2.46e-44 |
|
NB-ARC domain;
Pssm-ID: 395745 [Multi-domain] Cd Length: 245 Bit Score: 161.01 E-value: 2.46e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 145 DTPGWVTVFGMAGSGKSVMAAEVVRDRSLIKECFpDGVHWLSVGQC--ERADLLVRMQSLCFRLEQCQSSDTSqrppstv 222
Cdd:pfam00931 16 DEPGIVGIHGMGGVGKTTLAAQIFNDFDEVEGHF-DSVAWVVVSKTftISTLQQTILQNLGLSEDDWDNKEEG------- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 223 eEAKERLRFLMLRRfpRSLLILDDVWDSSSLR-------SFDIQCRVLLTTRNRALTDSVSGvRYEVPVENGLDEEKALE 295
Cdd:pfam00931 88 -ELARKIRRALLTK--RFLLVLDDVWDEEDWDkigiplpDRENGCRVLLTTRSEEVAGRVGG-PSDPHEVELLEPDEAWE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 296 ILALYVN----GKMHKLPEQARSIVSECKGSPLVVSLIGALL--REFPDRWSYYLRQLQQKQfkrirKSSSYDYEALDQA 369
Cdd:pfam00931 164 LFENKVFpktlGECELLEDVAKEIVEKCRGLPLALKVLGGLLscKKTVEEWKHVYDVLQSEL-----KSNSYSLNSVRSI 238
|
.
gi 528476538 370 M 370
Cdd:pfam00931 239 L 239
|
|
| CARD |
pfam00619 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. ... |
6-90 |
2.20e-17 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.
Pssm-ID: 459874 [Multi-domain] Cd Length: 85 Bit Score: 77.99 E-value: 2.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 6 RSRLLRSKATLEQDIK-ASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALiRESYGDLA 84
Cdd:pfam00619 1 RKLLKKNRVALVERLGtLDGLLDYLLEKNVLTEEEEEKIKANPTRLDKARELLDLVLKKGPKACQIFLEAL-KEGDPDLA 79
|
....*.
gi 528476538 85 SLLHSD 90
Cdd:pfam00619 80 SDLEGL 85
|
|
| FxSxx_TPR |
NF040586 |
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ... |
119-386 |
1.09e-10 |
|
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.
Pssm-ID: 468560 [Multi-domain] Cd Length: 836 Bit Score: 66.10 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 119 VPQRPVVFVSRPPLLNLIREMLYRLRDTPGWVTVFGMAGSGKSVMAAEVV-RDRSLIkecfpDGVHWLSVGQCER----- 192
Cdd:NF040586 1 VPPRNPNFTGREELLERLRDQLRSGGAAVVPQALHGLGGVGKTQLALEYAhRFRADY-----DLVWWIPADQPELvrasl 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 193 ADLLVRMqslcfRLEqcqssdtsqRPPSTVEEAKERLRfLMLRR---FPRSLLILDDVWDSSSLRSF---DIQCRVLLTT 266
Cdd:NF040586 76 AELARRL-----GLP---------LGPDDVDEAARAVL-DALRRgepYRRWLLVFDNADDPEDLRDLlptGGPGHVLITS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 267 RNRALTDsVSGVRYEVPVengLDEEKALEILALYVNGKMhkLPEQARSIVSECKGSPLVVSLIGALLREFPDRWSYYLRQ 346
Cdd:NF040586 141 RNRAWSE-VAAATLEVDV---FSREESVALLRRRVPGLT--SEEDADRLAEALGDLPLALEQAAAWLAETGMPVDEYLRL 214
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 528476538 347 LQQKQFKRI-RKSSSYDYEALDQAM-DASLQVLEAEHQELYR 386
Cdd:NF040586 215 LDEQATAALlLELKPPGYPTSVAATwRLSLDRLRERSPAAAR 256
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
873-912 |
4.61e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.09 E-value: 4.61e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 528476538 873 SSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWE 912
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
648-687 |
7.31e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 52.31 E-value: 7.31e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 528476538 648 SGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWN 687
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
874-912 |
2.40e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.81 E-value: 2.40e-08
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 874 SKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWE 912
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
649-687 |
7.85e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 49.65 E-value: 7.85e-08
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 649 GEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWN 687
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
630-826 |
5.25e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 54.32 E-value: 5.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 630 SKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSP-DDRHIATCASDKKVKLWNVERGVLIREFEVeheeQINHC 708
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKT----KANIC 621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 709 --QFTNTGRRVLLATCSNDKFTNTKLWNPnkKTSQNTMFGHMEPVNHCCFSPNDLyLATSSSDGSLKLFEVS-SANEWKS 785
Cdd:PLN00181 622 cvQFPSESGRSLAFGSADHKVYYYDLRNP--KLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSmSISGINE 698
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 528476538 786 IDVDSFFPESDeeIKAMVKCSTwsADGSQIICAARNTVFVF 826
Cdd:PLN00181 699 TPLHSFMGHTN--VKNFVGLSV--SDGYIATGSETNEVFVY 735
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
940-1164 |
5.50e-06 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 50.72 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 940 IAPDSSNRLqvlsgstgavvLESEELSSRIRCSC-ISRNAAFVALGSE---DGTVQVIEVPSSKAS---VKLSGHTKTVH 1012
Cdd:PTZ00420 10 LYPDPSNNL-----------FDDLRICSRVIDSCgIACSSGFVAVPWEvegGGLIGAIRLENQMRKppvIKLKGHTSSIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1013 HCQFtDDC--EILITSSEDSTIRVWKWRTGE----------CmVLQGHMEPVrkfhllssssspRLFSW----------- 1069
Cdd:PTZ00420 79 DLQF-NPCfsEILASGSEDLTIRVWEIPHNDesvkeikdpqC-ILKGHKKKI------------SIIDWnpmnyyimcss 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1070 SFDGTVKVWDL-TRGQMLQDLVCHEGAVLSCDVSsdGRLFATTSAN--------RTAKVWSS-------ASWKMIFL--L 1131
Cdd:PTZ00420 145 GFDSFVNIWDIeNEKRAFQINMPKKLSSLKWNIK--GNLLSGTCVGkhmhiidpRKQEIASSfhihdggKNTKNIWIdgL 222
|
250 260 270
....*....|....*....|....*....|...
gi 528476538 1132 EGHKDCVRSCRFSWDNKRlatgddngEIRLWSM 1164
Cdd:PTZ00420 223 GGDDNYILSTGFSKNNMR--------EMKLWDL 247
|
|
| CARD |
smart00114 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. ... |
1-87 |
9.46e-05 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.
Pssm-ID: 128424 Cd Length: 88 Bit Score: 42.32 E-value: 9.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1 MEERARSRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALiRESY 80
Cdd:smart00114 1 MAERDKRLLRRNRVRLGEELGVDGLLDYLVEKNVLTEKEIEAIKAATTKLRDKRELVDSLQKRGSQAFDTFLDSL-QETD 79
|
....*..
gi 528476538 81 GDLASLL 87
Cdd:smart00114 80 QKLADFL 86
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
806-1215 |
4.99e-72 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 246.36 E-value: 4.99e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 806 STWSADGSQIICAARNTVFVFDVETSDLLLELKTSRLSTIQFCHACPNSSLLAVALSHYTVELWNFESSKKKAECSGHLS 885
Cdd:COG2319 42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 886 WVHCVQFSPDGSLLLSSSDDQTIRLWETDrvhtssavalkrdtdvlfshsdatiiapdSSNRLQVLSGSTGAVvleseel 965
Cdd:COG2319 122 AVRSVAFSPDGKTLASGSADGTVRLWDLA-----------------------------TGKLLRTLTGHSGAV------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 966 ssriRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECM-V 1044
Cdd:COG2319 166 ----TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLrT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1045 LQGHMEPVRK--FHllsssssP---RLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKV 1119
Cdd:COG2319 242 LTGHSGSVRSvaFS-------PdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1120 WSSASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICSRdtkdsmdsyHGGWVTDLHFSPDNR 1199
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---------HTGAVTSVAFSPDGR 385
|
410
....*....|....*...
gi 528476538 1200 VLVSTG--GYIKWWSVES 1215
Cdd:COG2319 386 TLASGSadGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
809-1243 |
5.02e-69 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 237.89 E-value: 5.02e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 809 SADGSQIICAARNTVFVFDVETSDLLLELKTSRLSTIQFCHACPNSSLLAVALSHYTVELWNFESSKKKAECSGHLSWVH 888
Cdd:COG2319 3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 889 CVQFSPDGSLLLSSSDDQTIRLWETDrvhtssavalkrdtdvlfshsdatiiapdssnrlqvlsgsTGAVVLESEELSSR 968
Cdd:COG2319 83 SVAFSPDGRLLASASADGTVRLWDLA----------------------------------------TGLLLRTLTGHTGA 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 969 IRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECM-VLQG 1047
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLrTLTG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1048 HMEPVRK--FHllsssssP---RLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWSS 1122
Cdd:COG2319 203 HTGAVRSvaFS-------PdgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1123 ASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICSRdtkdsmdsyHGGWVTDLHFSPDNRVLV 1202
Cdd:COG2319 276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG---------HTGAVRSVAFSPDGKTLA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 528476538 1203 STG--GYIKWWSVESGEALQTFYTMGGNLKKIHVSPDFSTFIT 1243
Cdd:COG2319 347 SGSddGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
607-1164 |
2.87e-63 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 221.32 E-value: 2.87e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 607 GLSRLVMHPHQGAVYYACFSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLW 686
Cdd:COG2319 26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 687 NVERGVLIREFEveheeqinhcqftntgrrvllatcsndkftntklwnpnkktsqntmfGHMEPVNHCCFSPNDLYLATS 766
Cdd:COG2319 106 DLATGLLLRTLT-----------------------------------------------GHTGAVRSVAFSPDGKTLASG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 767 SSDGslklfevssanewksidvdsffpesdeeikamvkcstwsadgsqiicaarntvfvfdvetsdlllelktsrlstiq 846
Cdd:COG2319 139 SADG---------------------------------------------------------------------------- 142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 847 fchacpnssllavalshyTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETdrvhtssavalkr 926
Cdd:COG2319 143 ------------------TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL------------- 191
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 927 dtdvlfshsdatiiapDSSNRLQVLSGSTGAVvleseelssriRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSG 1006
Cdd:COG2319 192 ----------------ATGKLLRTLTGHTGAV-----------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG 244
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1007 HTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECM-VLQGHMEPVRK--FHllsssssP---RLFSWSFDGTVKVWDL 1080
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSvaFS-------PdgkLLASGSDDGTVRLWDL 317
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1081 TRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWSSASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIR 1160
Cdd:COG2319 318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397
|
....
gi 528476538 1161 LWSM 1164
Cdd:COG2319 398 LWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
567-1039 |
5.41e-63 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 220.55 E-value: 5.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 567 QLALSQPDRSEVYRQALMQAQKRASRGQIYLNWVNKNIEEGLSRLVMHPHQGAVYYACFSKDGSKIASCGASKALRVFKS 646
Cdd:COG2319 28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 647 TSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWNVERGVLIREFEvEHEEQINHCQFTNTGRRvlLATCSNDK 726
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKL--LASGSDDG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 727 ftNTKLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFEVSSANEWKSIDVDSffpesdeeikAMVKCS 806
Cdd:COG2319 185 --TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS----------GSVRSV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 807 TWSADGSqiicaarntvfvfdvetsdlllelktsrlstiqfchacpnssLLAVALSHYTVELWNFESSKKKAECSGHLSW 886
Cdd:COG2319 253 AFSPDGR------------------------------------------LLASGSADGTVRLWDLATGELLRTLTGHSGG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 887 VHCVQFSPDGSLLLSSSDDQTIRLWETDrvhtssavalkrdtdvlfshsdatiiapdSSNRLQVLSGSTGAVvleseels 966
Cdd:COG2319 291 VNSVAFSPDGKLLASGSDDGTVRLWDLA-----------------------------TGKLLRTLTGHTGAV-------- 333
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528476538 967 sriRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRT 1039
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
625-1124 |
2.42e-62 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 218.63 E-value: 2.42e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 625 FSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWNVERGVLIREFEvEHEEQ 704
Cdd:COG2319 2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-GHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 705 INHCQFTNTGRRvlLATCSNDKftNTKLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFEVSSANEWK 784
Cdd:COG2319 81 VLSVAFSPDGRL--LASASADG--TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 785 SIDVDSffpesdeeikAMVKCSTWSADGSQIICAAR-NTVFVFDVETSDLLLELKtsrlstiqfchacpnssllavalsh 863
Cdd:COG2319 157 TLTGHS----------GAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLT------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 864 ytvelwnfesskkkaecsGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETDrvhtssavalkrdtdvlfshsdatiiapd 943
Cdd:COG2319 202 ------------------GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA----------------------------- 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 944 SSNRLQVLSGSTGAVvleseelssriRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEIL 1023
Cdd:COG2319 235 TGKLLRTLTGHSGSV-----------RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1024 ITSSEDSTIRVWKWRTGECM-VLQGHMEPVRK--FHllsssssP---RLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVL 1097
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSvaFS-------PdgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
|
490 500
....*....|....*....|....*..
gi 528476538 1098 SCDVSSDGRLFATTSANRTAKVWSSAS 1124
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
891-1252 |
5.97e-61 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 214.78 E-value: 5.97e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 891 QFSPDGSLLLSSSDDQTIRLW--ETDRVHTSSAVALKRDTDVLFSHSDATIIAPDSSNRLQVLSGSTGAVVLESEELSSR 968
Cdd:COG2319 1 ALSADGAALAAASADLALALLaaALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 969 IRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECM-VLQG 1047
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLrTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1048 HMEPVR--KFHllsssssP---RLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWSS 1122
Cdd:COG2319 161 HSGAVTsvAFS-------PdgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1123 ASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICSRdtkdsmdsyHGGWVTDLHFSPDNRVLV 1202
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---------HSGGVNSVAFSPDGKLLA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 528476538 1203 STG--GYIKWWSVESGEALQTFYTMGGNLKKIHVSPDFSTFITVDSIGILYI 1252
Cdd:COG2319 305 SGSddGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
616-912 |
2.61e-59 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 206.03 E-value: 2.61e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 616 HQGAVYYACFSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWNVERGVLIR 695
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 696 EFEvEHEEQINHCQFTNTGRrvLLATCSNDKftNTKLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLF 775
Cdd:cd00200 88 TLT-GHTSYVSSVAFSPDGR--ILSSSSRDK--TIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 776 EVSSANEwksidVDSFFPESDEeikamVKCSTWSADGSQII-CAARNTVFVFDVETSDLLLELkTSRLSTIQFCHACPNS 854
Cdd:cd00200 163 DLRTGKC-----VATLTGHTGE-----VNSVAFSPDGEKLLsSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDG 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 528476538 855 SLLAVALSHYTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWE 912
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
877-1212 |
3.56e-57 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 199.87 E-value: 3.56e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 877 KAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWETDRVHTssavalkrdtdvlfshsdatiiapdssnrLQVLSGSTG 956
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----------------------------LRTLKGHTG 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 957 AVVleseelssRIRCSCISRnaaFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWK 1036
Cdd:cd00200 53 PVR--------DVAASADGT---YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1037 WRTGEC-MVLQGHMEPVR--KFHLLSSssspRLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSA 1113
Cdd:cd00200 122 VETGKClTTLRGHTDWVNsvAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1114 NRTAKVWSSASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICSRdtkdsmdsyHGGWVTDLH 1193
Cdd:cd00200 198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---------HTNSVTSLA 268
|
330 340
....*....|....*....|.
gi 528476538 1194 FSPDNRVLVSTG--GYIKWWS 1212
Cdd:cd00200 269 WSPDGKRLASGSadGTIRIWD 289
|
|
| APAF1_C |
pfam17908 |
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ... |
457-589 |
2.99e-56 |
|
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.
Pssm-ID: 465560 Cd Length: 135 Bit Score: 191.10 E-value: 2.99e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 457 ELHKKMVRQYQRFYSKRPPDSADKDSLYWYQFIPYHMAKAGLSKELYSLMFSLDWVKEKARIMGSAHLINDYVEYGEILD 536
Cdd:pfam17908 3 DLHRKLVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHILD 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 528476538 537 KENSEVRVQFQEFLSLNGHHLEQRPFPDVVQLALSQPDRSEVYRQALMQAQKR 589
Cdd:pfam17908 83 ENDCAVLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
654-1079 |
3.70e-53 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 188.31 E-value: 3.70e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 654 ELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWNVERGVLIREFEVeHEEQINHCQFTNTGRRvlLATCSNDKFtnTKLW 733
Cdd:cd00200 4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTY--LASGSSDKT--IRLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 734 NPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKlfevssanewksidvdsffpesdeeikamvkcstwsadgs 813
Cdd:cd00200 79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK---------------------------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 814 qiicaarntvfvfdvetsdlllelktsrlstiqfchacpnssllavalshytveLWNFESSKKKAECSGHLSWVHCVQFS 893
Cdd:cd00200 119 ------------------------------------------------------VWDVETGKCLTTLRGHTDWVNSVAFS 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 894 PDGSLLLSSSDDQTIRLWEtdrvhtssavalkrdtdvlfshsdatiiaPDSSNRLQVLSGSTGAVvleseelssriRCSC 973
Cdd:cd00200 145 PDGTFVASSSQDGTIKLWD-----------------------------LRTGKCVATLTGHTGEV-----------NSVA 184
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 974 ISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGECM-VLQGHMEPV 1052
Cdd:cd00200 185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVqTLSGHTNSV 264
|
410 420
....*....|....*....|....*....
gi 528476538 1053 R--KFHllssSSSPRLFSWSFDGTVKVWD 1079
Cdd:cd00200 265 TslAWS----PDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
966-1243 |
9.15e-53 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 187.16 E-value: 9.15e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 966 SSRIRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGEC-MV 1044
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECvRT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1045 LQGHMEPVR--KFHLLSsssspRLFSWS-FDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWS 1121
Cdd:cd00200 89 LTGHTSYVSsvAFSPDG-----RILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1122 SASWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWSMLDGALLKICSrdtkdsmdsYHGGWVTDLHFSPDNRVL 1201
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR---------GHENGVNSVAFSPDGYLL 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 528476538 1202 VSTG--GYIKWWSVESGEALQTFYTMGGNLKKIHVSPDFSTFIT 1243
Cdd:cd00200 235 ASGSedGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
743-1121 |
1.14e-49 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 177.91 E-value: 1.14e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 743 TMFGHMEPVNHCCFSPNDLYLATSSSDGSLKlfevssanewksidvdsffpesdeeikamvkcstwsadgsqiicaarnt 822
Cdd:cd00200 4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIK------------------------------------------------- 34
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 823 vfVFDVETSDLLLELKTSRLStIQFCHACPNSSLLAVALSHYTVELWNFESSKKKAECSGHLSWVHCVQFSPDGSLLLSS 902
Cdd:cd00200 35 --VWDLETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSS 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 903 SDDQTIRLWETdrvhtssavalkrdtdvlfshsdatiiapDSSNRLQVLSGSTGAVvleseelssriRCSCISRNAAFVA 982
Cdd:cd00200 112 SRDKTIKVWDV-----------------------------ETGKCLTTLRGHTDWV-----------NSVAFSPDGTFVA 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 983 LGSEDGTVQVIEVPSSKASVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRVWKWRTGEC-MVLQGHMEPVR--KFHLLS 1059
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNsvAFSPDG 231
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528476538 1060 SSssprLFSWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWS 1121
Cdd:cd00200 232 YL----LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| CARD_APAF1 |
cd08323 |
Caspase activation and recruitment domain similar to that found in Apoptotic ... |
7-92 |
5.76e-45 |
|
Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1; Caspase activation and recruitment domain (CARD) similar to that found in apoptotic protease-activating factor 1 (APAF-1), which is an activator of caspase-9. APAF-1 contains WD-40 repeats, a CARD, and an ATPase domain. Upon stimulation, APAF-1, together with caspase-9, forms the heptameric 'apoptosome', which leads to the processing and activation of caspase-9, starting a caspase cascade which leads to apoptosis. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260034 Cd Length: 86 Bit Score: 156.90 E-value: 5.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 7 SRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASL 86
Cdd:cd08323 1 SCLLQHRAALERDIKTSYIMDHMISDGVLTLSEEEKVRAQPTQQERAAALIKIILRKDNDAYISFYNALLHEGYKDLAAL 80
|
....*.
gi 528476538 87 LHSDLP 92
Cdd:cd08323 81 LHDGLP 86
|
|
| NB-ARC |
pfam00931 |
NB-ARC domain; |
145-370 |
2.46e-44 |
|
NB-ARC domain;
Pssm-ID: 395745 [Multi-domain] Cd Length: 245 Bit Score: 161.01 E-value: 2.46e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 145 DTPGWVTVFGMAGSGKSVMAAEVVRDRSLIKECFpDGVHWLSVGQC--ERADLLVRMQSLCFRLEQCQSSDTSqrppstv 222
Cdd:pfam00931 16 DEPGIVGIHGMGGVGKTTLAAQIFNDFDEVEGHF-DSVAWVVVSKTftISTLQQTILQNLGLSEDDWDNKEEG------- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 223 eEAKERLRFLMLRRfpRSLLILDDVWDSSSLR-------SFDIQCRVLLTTRNRALTDSVSGvRYEVPVENGLDEEKALE 295
Cdd:pfam00931 88 -ELARKIRRALLTK--RFLLVLDDVWDEEDWDkigiplpDRENGCRVLLTTRSEEVAGRVGG-PSDPHEVELLEPDEAWE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 296 ILALYVN----GKMHKLPEQARSIVSECKGSPLVVSLIGALL--REFPDRWSYYLRQLQQKQfkrirKSSSYDYEALDQA 369
Cdd:pfam00931 164 LFENKVFpktlGECELLEDVAKEIVEKCRGLPLALKVLGGLLscKKTVEEWKHVYDVLQSEL-----KSNSYSLNSVRSI 238
|
.
gi 528476538 370 M 370
Cdd:pfam00931 239 L 239
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
603-776 |
5.53e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 115.12 E-value: 5.53e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 603 NIEEGLSRLVMHPHQGAVYYACFSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKK 682
Cdd:cd00200 121 DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 683 VKLWNVERGVLIREFEVeHEEQINHCQFTNTGRrvLLATCSNDKftNTKLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLY 762
Cdd:cd00200 201 IKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGY--LLASGSEDG--TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
|
170
....*....|....
gi 528476538 763 LATSSSDGSLKLFE 776
Cdd:cd00200 276 LASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
593-734 |
4.75e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 92.01 E-value: 4.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 593 GQIYLnWvnkNIEEGLSRLVMHPHQGAVYYACFSKDGSKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSPDDR 672
Cdd:cd00200 157 GTIKL-W---DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY 232
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528476538 673 HIATCASDKKVKLWNVERGVLIREFEvEHEEQINHCQFTNTGRRvlLATCSNDKftNTKLWN 734
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKR--LASGSADG--TIRIWD 289
|
|
| CARD |
pfam00619 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. ... |
6-90 |
2.20e-17 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.
Pssm-ID: 459874 [Multi-domain] Cd Length: 85 Bit Score: 77.99 E-value: 2.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 6 RSRLLRSKATLEQDIK-ASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALiRESYGDLA 84
Cdd:pfam00619 1 RKLLKKNRVALVERLGtLDGLLDYLLEKNVLTEEEEEKIKANPTRLDKARELLDLVLKKGPKACQIFLEAL-KEGDPDLA 79
|
....*.
gi 528476538 85 SLLHSD 90
Cdd:pfam00619 80 SDLEGL 85
|
|
| CARD |
cd01671 |
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase ... |
9-87 |
7.97e-16 |
|
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260018 [Multi-domain] Cd Length: 79 Bit Score: 73.32 E-value: 7.97e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528476538 9 LLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASLL 87
Cdd:cd01671 1 LRKNRVELVEDLDVEDILDHLIQKGVLTEEDKEEILSEKTRQDKARKLLDILPRRGPKAFEVFCEALRETGQPHLAELL 79
|
|
| COG3903 |
COG3903 |
Predicted ATPase [General function prediction only]; |
47-590 |
3.81e-13 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443109 [Multi-domain] Cd Length: 933 Bit Score: 74.28 E-value: 3.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 47 ATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASLLHSDLPLLSPEGEKSFADGVSPSVQAILSVGGVPQRPVVF 126
Cdd:COG3903 76 LLLLLAARLLARLAAAAAAALARAAAAALALLLRLRLAARRLLLARALAAAALAAAAAAAAAAAAAPAPPPPAPPPPAPL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 127 VSRPPLLNLIREMLYRLRDTPGWVTVFGMAGSGKSVMAAEVVRDRSlikECFPDGVHWLSVGQCERADLLVRM--QSLCF 204
Cdd:COG3903 156 AALARRAAALAAAARALLSAARLVTLTGPGGVGKTRLALEVAHRLA---DRFPDGVWFVDLAGVTDPALVLAAvaRALGV 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 205 RleqcqssDTSQRPPStveeakERLR-FLMLRrfpRSLLILD---DVWDSSS-----LRSFDIQCRVLLTTRnRALTdsV 275
Cdd:COG3903 233 R-------DAPGRDPA------ARLRaALADR---RLLLVLDnceHVVDAAAalvrpLLPAAPGLRVLATSR-EPLG--L 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 276 SG-VRYEVPV------ENGLDEEKALEILALYVNGKMHKL------PEQARSIVSECKGSPLVVSLIGALLREFP----- 337
Cdd:COG3903 294 PGeRVLPLPPlavpppGAEALASEAVALFVERAGAARPGFaldaaeAAAVAEICRRLDGLPLAIELAAARLRTLSlaela 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 338 DRWSYYLRQLQqkqfkRIRKSSSYDYEALDQAMDASLQVLEAEHQELYRDLSVMQKDIKVPAkVLSVLWGLELEEVEDVL 417
Cdd:COG3903 374 ARLDDRLRLLT-----GGRRDAPPRHRTLRAALDWSYDLLSPAERRLLRRLSVFPGGFTLEA-AEAVCGGDGPADVLDLL 447
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 418 QEFVNKSLLFRDCNQRPYRYYLHDLQLDFLAEQ--NRDQIAELHKKMVRQYQRFYSKRPPDSADKDSLYWYqfipyhmak 495
Cdd:COG3903 448 AALVDKSLLEVEGGGGGPRYRLLETVREYAAERlaEAGERAAARRRHADYYLALAERAAAELRGPDQLAWL--------- 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 496 AGLSKELYSLMFSLDWVKEKARIMGSAHLINDYVEYGEILDkENSEVRVQFQEFLSLNGHHLEQRPFPDVVQLALSQPDR 575
Cdd:COG3903 519 ARLDAEHDNLRAALRWALAHGDAELALRLAAALAPFWFLRG-LLREGRRWLERALAAAGEAAAALAAAAALAAAAAAARA 597
|
570
....*....|....*
gi 528476538 576 SEVYRQALMQAQKRA 590
Cdd:COG3903 598 AAAAAAAAAAAAAAA 612
|
|
| FxSxx_TPR |
NF040586 |
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ... |
119-386 |
1.09e-10 |
|
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.
Pssm-ID: 468560 [Multi-domain] Cd Length: 836 Bit Score: 66.10 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 119 VPQRPVVFVSRPPLLNLIREMLYRLRDTPGWVTVFGMAGSGKSVMAAEVV-RDRSLIkecfpDGVHWLSVGQCER----- 192
Cdd:NF040586 1 VPPRNPNFTGREELLERLRDQLRSGGAAVVPQALHGLGGVGKTQLALEYAhRFRADY-----DLVWWIPADQPELvrasl 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 193 ADLLVRMqslcfRLEqcqssdtsqRPPSTVEEAKERLRfLMLRR---FPRSLLILDDVWDSSSLRSF---DIQCRVLLTT 266
Cdd:NF040586 76 AELARRL-----GLP---------LGPDDVDEAARAVL-DALRRgepYRRWLLVFDNADDPEDLRDLlptGGPGHVLITS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 267 RNRALTDsVSGVRYEVPVengLDEEKALEILALYVNGKMhkLPEQARSIVSECKGSPLVVSLIGALLREFPDRWSYYLRQ 346
Cdd:NF040586 141 RNRAWSE-VAAATLEVDV---FSREESVALLRRRVPGLT--SEEDADRLAEALGDLPLALEQAAAWLAETGMPVDEYLRL 214
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 528476538 347 LQQKQFKRI-RKSSSYDYEALDQAM-DASLQVLEAEHQELYR 386
Cdd:NF040586 215 LDEQATAALlLELKPPGYPTSVAATwRLSLDRLRERSPAAAR 256
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
873-912 |
4.61e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.09 E-value: 4.61e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 528476538 873 SSKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWE 912
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
648-687 |
7.31e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 52.31 E-value: 7.31e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 528476538 648 SGEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWN 687
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| CARD_CASP2 |
cd08332 |
Caspase activation and recruitment domain of Caspase-2; Caspase activation and recruitment ... |
1-87 |
1.95e-08 |
|
Caspase activation and recruitment domain of Caspase-2; Caspase activation and recruitment domain (CARD) similar to that found in caspase-2. Caspases are aspartate-specific cysteine proteases with functions in apoptosis and immune signaling. Caspase-2 (also known as ICH1, NEDD2, or CASP2) is one of the most evolutionarily conserved caspases, and plays a role in apoptosis, DNA damage response, cell cycle regulation, and tumor suppression. It is localized in the nucleus and exhibits properties of both an initiator and an effector caspase. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260040 Cd Length: 87 Bit Score: 52.81 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1 MEERARSRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALIRESY 80
Cdd:cd08332 1 MQKRHREALKKNRVKLAKELVLDELLIHLLQKDILTDSMVESIMAKPTSFSQNVALLNLLPKRGPRAFSAFCEALRETSQ 80
|
....*..
gi 528476538 81 GDLASLL 87
Cdd:cd08332 81 EHLADLL 87
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
874-912 |
2.40e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.81 E-value: 2.40e-08
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 874 SKKKAECSGHLSWVHCVQFSPDGSLLLSSSDDQTIRLWE 912
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| CARD_CASP9 |
cd08326 |
Caspase activation and recruitment domain of Caspase-9; Caspase activation and recruitment ... |
6-87 |
2.48e-08 |
|
Caspase activation and recruitment domain of Caspase-9; Caspase activation and recruitment domain (CARD) similar to that found in caspase-9 (CASP9, MCH6, APAF3), which interacts with the CARD of apoptotic protease-activating factor 1 (APAF-1). Caspases are aspartate-specific cysteine proteases with functions in apoptosis and immune signaling. Initiator caspases are the first to be activated following death- or inflammation-inducing signals. Caspase-9 is the initiator caspase associated with the intrinsic or mitochondrial pathway of apoptosis, induced by many pro-apoptotic signals. Together with APAF-1, it forms the heptameric 'apoptosome' in response to the release of cytochrome c from mitochondria. Activated caspase-9 cleaves and activates downstream effector caspases, like caspase-3, caspase-6, and caspase-7, resulting in apoptosis. In general, CARDs are death domains (DDs) associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 176740 Cd Length: 84 Bit Score: 52.43 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 6 RSRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLAS 85
Cdd:cd08326 2 RQILRRHRARLVEELQPKYLWDHLLSRGVFTPDMIEEIQAAGSRRDQARQLLIDLETRGKQAFPAFLSALRETGQTDLAE 81
|
..
gi 528476538 86 LL 87
Cdd:cd08326 82 LL 83
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
649-687 |
7.85e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 49.65 E-value: 7.85e-08
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 649 GEKLLELQAHEEDVLCCAFSPDDRHIATCASDKKVKLWN 687
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
630-826 |
5.25e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 54.32 E-value: 5.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 630 SKIASCGASKALRVFKSTSGEKLLELQAHEEDVLCCAFSP-DDRHIATCASDKKVKLWNVERGVLIREFEVeheeQINHC 708
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKT----KANIC 621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 709 --QFTNTGRRVLLATCSNDKFTNTKLWNPnkKTSQNTMFGHMEPVNHCCFSPNDLyLATSSSDGSLKLFEVS-SANEWKS 785
Cdd:PLN00181 622 cvQFPSESGRSLAFGSADHKVYYYDLRNP--KLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSmSISGINE 698
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 528476538 786 IDVDSFFPESDeeIKAMVKCSTwsADGSQIICAARNTVFVF 826
Cdd:PLN00181 699 TPLHSFMGHTN--VKNFVGLSV--SDGYIATGSETNEVFVY 735
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1124-1163 |
1.84e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.77 E-value: 1.84e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 528476538 1124 SWKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWS 1163
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
940-1164 |
5.50e-06 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 50.72 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 940 IAPDSSNRLqvlsgstgavvLESEELSSRIRCSC-ISRNAAFVALGSE---DGTVQVIEVPSSKAS---VKLSGHTKTVH 1012
Cdd:PTZ00420 10 LYPDPSNNL-----------FDDLRICSRVIDSCgIACSSGFVAVPWEvegGGLIGAIRLENQMRKppvIKLKGHTSSIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1013 HCQFtDDC--EILITSSEDSTIRVWKWRTGE----------CmVLQGHMEPVrkfhllssssspRLFSW----------- 1069
Cdd:PTZ00420 79 DLQF-NPCfsEILASGSEDLTIRVWEIPHNDesvkeikdpqC-ILKGHKKKI------------SIIDWnpmnyyimcss 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1070 SFDGTVKVWDL-TRGQMLQDLVCHEGAVLSCDVSsdGRLFATTSAN--------RTAKVWSS-------ASWKMIFL--L 1131
Cdd:PTZ00420 145 GFDSFVNIWDIeNEKRAFQINMPKKLSSLKWNIK--GNLLSGTCVGkhmhiidpRKQEIASSfhihdggKNTKNIWIdgL 222
|
250 260 270
....*....|....*....|....*....|...
gi 528476538 1132 EGHKDCVRSCRFSWDNKRlatgddngEIRLWSM 1164
Cdd:PTZ00420 223 GGDDNYILSTGFSKNNMR--------EMKLWDL 247
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
742-776 |
9.09e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.84 E-value: 9.09e-06
10 20 30
....*....|....*....|....*....|....*
gi 528476538 742 NTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFE 776
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1125-1163 |
1.39e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.10 E-value: 1.39e-05
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 1125 WKMIFLLEGHKDCVRSCRFSWDNKRLATGDDNGEIRLWS 1163
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1004-1036 |
1.44e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.07 E-value: 1.44e-05
10 20 30
....*....|....*....|....*....|...
gi 528476538 1004 LSGHTKTVHHCQFTDDCEILITSSEDSTIRVWK 1036
Cdd:smart00320 8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
1019-1145 |
1.83e-05 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 48.74 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1019 DCEILITSSEDSTIRVW-------KWRTGECMV-LQGHMEPV--RKFHLLSSSSsprLFSWSFDGTVKVWDLTRGQMLQD 1088
Cdd:PTZ00421 87 DPQKLFTASEDGTIMGWgipeeglTQNISDPIVhLQGHTKKVgiVSFHPSAMNV---LASAGADMVVNVWDVERGKAVEV 163
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 528476538 1089 LVCHEGAVLSCDVSSDGRLFATTSANRTAKVWSSASWKMIFLLEGHKDcVRSCRFSW 1145
Cdd:PTZ00421 164 IKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS-AKSQRCLW 219
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
1068-1121 |
3.05e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 48.54 E-value: 3.05e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 528476538 1068 SWSFDGTVKVWDLTRGQMLQDLVCHEGAVLSCDVSS-DGRLFATTSANRTAKVWS 1121
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWS 604
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1003-1035 |
3.54e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 3.54e-05
10 20 30
....*....|....*....|....*....|...
gi 528476538 1003 KLSGHTKTVHHCQFTDDCEILITSSEDSTIRVW 1035
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1083-1121 |
3.56e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 3.56e-05
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 1083 GQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWS 1121
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
897-1035 |
4.87e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 47.77 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 897 SLLLSSSDDQTIRLWETDRVH--TSSAVALKRDTDVLFSHSDATIIAPDSSNRLQVLSGSTGAVVLESEELSSRIRCSCI 974
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQlvTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528476538 975 -SRNAAFVALGSEDGTVQVIEVPSSKASV-KLSGHTKTVHHCQFTDDcEILITSSEDSTIRVW 1035
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLW 687
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1083-1121 |
5.40e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.56 E-value: 5.40e-05
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 1083 GQMLQDLVCHEGAVLSCDVSSDGRLFATTSANRTAKVWS 1121
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
738-776 |
7.91e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.18 E-value: 7.91e-05
10 20 30
....*....|....*....|....*....|....*....
gi 528476538 738 KTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDGSLKLFE 776
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| CARD |
smart00114 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. ... |
1-87 |
9.46e-05 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.
Pssm-ID: 128424 Cd Length: 88 Bit Score: 42.32 E-value: 9.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 1 MEERARSRLLRSKATLEQDIKASYLMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNALiRESY 80
Cdd:smart00114 1 MAERDKRLLRRNRVRLGEELGVDGLLDYLVEKNVLTEKEIEAIKAATTKLRDKRELVDSLQKRGSQAFDTFLDSL-QETD 79
|
....*..
gi 528476538 81 GDLASLL 87
Cdd:smart00114 80 QKLADFL 86
|
|
| CARD_BIRC2_BIRC3 |
cd08329 |
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, ... |
11-75 |
9.13e-04 |
|
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2); Caspase activation and recruitment domain (CARD) similar to those found in Baculoviral IAP repeat (BIR)-containing protein 2 (BIRC2) or cellular Inhibitor of Apoptosis Protein 1 (c-IAP1), and BIRC3 (or c-IAP2). IAPs are anti-apoptotic proteins that contain at least one BIR domain. Most IAPs also contain a C-terminal RING domain. In addition, both BIRC2 and BIRC3 contain a CARD. BIRC2 and BIRC3, through their binding with TRAF (TNF receptor-associated factor) 2, are recruited to TNFR-1/2 signaling complexes, where they regulate caspase-8 activity. They also play important roles in pro-survival NF-kB signaling pathways. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260038 Cd Length: 94 Bit Score: 39.74 E-value: 9.13e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528476538 11 RSKATLEQDIKASY-LMDHMISDGVLTNDEEAKVLSKATRKEQAVALLETLLRKDNRAYISFYNAL 75
Cdd:cd08329 13 KNRMALFQHLTCVLpILDHLLSANVITEQEYDVIKQKTQTPLQARELIDTILVKGNAAAEVFRNCL 78
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
883-1011 |
5.36e-03 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 40.44 E-value: 5.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528476538 883 HLSWVHCVQFSPDGSLLLSSSDDQTIRLWETDRVHTSSAVAlkRDTDVLFSHSDATIIApdssNRLQVLSGSTGAvvles 962
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRS--RNTQTEFPRKDHVIAE----TPFHILCGHDDI----- 191
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528476538 963 eelssrIRCSCISRNAAFVALGSEDGT-----------VQVIEVPSSKASVKL--SGHTKTV 1011
Cdd:pfam20426 192 ------ITCLYVSVELDIVISGSKDGTcifhtlregryVRSIRHPSGCPLSKLvaSRHGRIV 247
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1185-1212 |
5.53e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 35.75 E-value: 5.53e-03
10 20 30
....*....|....*....|....*....|
gi 528476538 1185 HGGWVTDLHFSPDNRVLVSTG--GYIKWWS 1212
Cdd:smart00320 11 HTGPVTSVAFSPDGKYLASGSddGTIKLWD 40
|
|
| |
