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Conserved domains on  [gi|530379851|ref|XP_005272021|]
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AF4/FMR2 family member 4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 521-784 9.78e-157

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 456.05  E-value: 9.78e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  521 SKPRRTKLVFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIK 600
Cdd:pfam18876   1 SKPRRPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  601 YTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLKNSYNNSQAPSPGlGSKAVGMPSPVS 680
Cdd:pfam18876  81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPC-VAKSTGTPSPLS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  681 PKLSPGNSGNYSSGASSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNA 760
Cdd:pfam18876 160 PMPSPASSVSSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNS 239

                         250       260
                  ....*....|....*....|....
gi 530379851  761 SiMTDLVRYTRQGLHWLRQDAKLI 784
Cdd:pfam18876 240 S-MTELVRYTRQGLHWLRLDAKLP 262
AF-4 super family cl25851
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 1-101 4.53e-17

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


The actual alignment was detected with superfamily member pfam05110:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 85.18  E-value: 4.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851    1 MLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQ 80
Cdd:pfam05110 414 MLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDSESSSESDSESESSSSDSEANEPPR 493

                          90       100
                  ....*....|....*....|.
gi 530379851   81 SASPEPEPPPTNKWQLDNWLN 101
Cdd:pfam05110 494 SATPEPEPPSSNKWQLDNWLN 514
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 336-350 3.87e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


:

Pssm-ID: 436798  Cd Length: 15  Bit Score: 35.48  E-value: 3.87e-03
                          10
                  ....*....|....*
gi 530379851  336 LIVKIDLNLLTRIPG 350
Cdd:pfam18875   1 LVVKIDLSLLSRVPQ 15
 
Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 521-784 9.78e-157

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 456.05  E-value: 9.78e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  521 SKPRRTKLVFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIK 600
Cdd:pfam18876   1 SKPRRPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  601 YTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLKNSYNNSQAPSPGlGSKAVGMPSPVS 680
Cdd:pfam18876  81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPC-VAKSTGTPSPLS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  681 PKLSPGNSGNYSSGASSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNA 760
Cdd:pfam18876 160 PMPSPASSVSSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNS 239

                         250       260
                  ....*....|....*....|....
gi 530379851  761 SiMTDLVRYTRQGLHWLRQDAKLI 784
Cdd:pfam18876 240 S-MTELVRYTRQGLHWLRLDAKLP 262
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 1-101 4.53e-17

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 85.18  E-value: 4.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851    1 MLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQ 80
Cdd:pfam05110 414 MLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDSESSSESDSESESSSSDSEANEPPR 493

                          90       100
                  ....*....|....*....|.
gi 530379851   81 SASPEPEPPPTNKWQLDNWLN 101
Cdd:pfam05110 494 SATPEPEPPSSNKWQLDNWLN 514
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 336-350 3.87e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 35.48  E-value: 3.87e-03
                          10
                  ....*....|....*
gi 530379851  336 LIVKIDLNLLTRIPG 350
Cdd:pfam18875   1 LVVKIDLSLLSRVPQ 15
 
Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 521-784 9.78e-157

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 456.05  E-value: 9.78e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  521 SKPRRTKLVFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIK 600
Cdd:pfam18876   1 SKPRRPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  601 YTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLKNSYNNSQAPSPGlGSKAVGMPSPVS 680
Cdd:pfam18876  81 YVMKLKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPC-VAKSTGTPSPLS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851  681 PKLSPGNSGNYSSGASSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNA 760
Cdd:pfam18876 160 PMPSPASSVSSQSGSSGSSGSSSSVSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNS 239

                         250       260
                  ....*....|....*....|....
gi 530379851  761 SiMTDLVRYTRQGLHWLRQDAKLI 784
Cdd:pfam18876 240 S-MTELVRYTRQGLHWLRLDAKLP 262
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 1-101 4.53e-17

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 85.18  E-value: 4.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379851    1 MLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQ 80
Cdd:pfam05110 414 MLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDSESSSESDSESESSSSDSEANEPPR 493

                          90       100
                  ....*....|....*....|.
gi 530379851   81 SASPEPEPPPTNKWQLDNWLN 101
Cdd:pfam05110 494 SATPEPEPPSSNKWQLDNWLN 514
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 336-350 3.87e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 35.48  E-value: 3.87e-03
                          10
                  ....*....|....*
gi 530379851  336 LIVKIDLNLLTRIPG 350
Cdd:pfam18875   1 LVVKIDLSLLSRVPQ 15
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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