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Conserved domains on  [gi|942161749|ref|XP_005999075|]
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PREDICTED: alpha-2,8-sialyltransferase 8F [Latimeria chalumnae]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 19234068)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 137-409 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


:

Pssm-ID: 467719  Cd Length: 273  Bit Score: 553.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 137 EEHEKFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSA 216
Cdd:cd23991    1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 217 CGTEIDQADFVFRCNLPPTLGNISIDVGSKTSLVTLNPSIITHRFGKLNEKRKPFVETVSHYGEAFLLLPAFSFRSNTAL 296
Cdd:cd23991   81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 297 SFKVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHY 376
Cdd:cd23991  161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 942161749 377 YDNQLPKPGIHSMPKEFYHFLKLHNKGIIKLQF 409
Cdd:cd23991  241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
 
Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 137-409 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 553.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 137 EEHEKFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSA 216
Cdd:cd23991    1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 217 CGTEIDQADFVFRCNLPPTLGNISIDVGSKTSLVTLNPSIITHRFGKLNEKRKPFVETVSHYGEAFLLLPAFSFRSNTAL 296
Cdd:cd23991   81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 297 SFKVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHY 376
Cdd:cd23991  161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 942161749 377 YDNQLPKPGIHSMPKEFYHFLKLHNKGIIKLQF 409
Cdd:cd23991  241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 157-404 2.83e-99

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 296.44  E-value: 2.83e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749  157 IVSQNNTPLGTNMSYEvENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTL 236
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749  237 GnISIDVGSKTSLVTLNP-SIITHRFGKLNEK--RKPFVETVSHY--GEAFLLLPAFSFRSNTALSFKVYHTLEAFR--- 308
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKipv 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749  309 GKQKTIFFHPKYLKSLALFW-RSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNegkNISHHYYDNQLPKPGI- 386
Cdd:pfam00777 159 DPDKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKGGf 235

                         250       260
                  ....*....|....*....|.
gi 942161749  387 ---HSMPKEFYHFLKLHNKGI 404
Cdd:pfam00777 236 ygvHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 137-409 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 553.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 137 EEHEKFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSA 216
Cdd:cd23991    1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 217 CGTEIDQADFVFRCNLPPTLGNISIDVGSKTSLVTLNPSIITHRFGKLNEKRKPFVETVSHYGEAFLLLPAFSFRSNTAL 296
Cdd:cd23991   81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 297 SFKVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHY 376
Cdd:cd23991  161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 942161749 377 YDNQLPKPGIHSMPKEFYHFLKLHNKGIIKLQF 409
Cdd:cd23991  241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 137-409 1.83e-163

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 459.80  E-value: 1.83e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 137 EEHEKFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSA 216
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 217 CGTEIDQADFVFRCNLPPTlgNISIDVGSKTSLVTLNPSIITHRFGKLNEKRKPFVETVSHYGEAFLLLPAFSFRSNTAL 296
Cdd:cd23971   81 CGREIDSADFVIRCNLPPL--NDSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 297 SFKVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHY 376
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                        250       260       270
                 ....*....|....*....|....*....|...
gi 942161749 377 YDNQLPKPGIHSMPKEFYHFLKLHNKGIIKLQF 409
Cdd:cd23971  239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 137-407 9.21e-112

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 328.72  E-value: 9.21e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 137 EEHEKFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSA 216
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 217 CGTEIDQADFVFRCNLPPTLGNISIDVGSKTSLVTLNPSIITHRFGKLNEKRKPFVETVSHYGEAFLLLPAFSFRSNTAL 296
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 297 SFKVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHY 376
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 942161749 377 YDNQLPKPGIHSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 140-408 1.10e-106

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 316.00  E-value: 1.10e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 140 EKFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAgYPYNQCAVVGNGGILKNSACGT 219
Cdd:cd23989    4 EAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 220 EIDQADFVFRCNLPPTLGNISIDVGSKTSLVTLNPSIITHRFGKLNEKRKPFVETVSHYGEAFLLLPAFSFRSNTALSFK 299
Cdd:cd23989   83 QIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 300 VYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHYYDN 379
Cdd:cd23989  163 VYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDN 242

                        250       260
                 ....*....|....*....|....*....
gi 942161749 380 QLPKPGIHSMPKEFYHFLKLHNKGIIKLQ 408
Cdd:cd23989  243 VLPDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 157-404 2.83e-99

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 296.44  E-value: 2.83e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749  157 IVSQNNTPLGTNMSYEvENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTL 236
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749  237 GnISIDVGSKTSLVTLNP-SIITHRFGKLNEK--RKPFVETVSHY--GEAFLLLPAFSFRSNTALSFKVYHTLEAFR--- 308
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKipv 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749  309 GKQKTIFFHPKYLKSLALFW-RSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNegkNISHHYYDNQLPKPGI- 386
Cdd:pfam00777 159 DPDKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKGGf 235

                         250       260
                  ....*....|....*....|.
gi 942161749  387 ---HSMPKEFYHFLKLHNKGI 404
Cdd:pfam00777 236 ygvHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 139-408 1.46e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 289.93  E-value: 1.46e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 139 HEKFRSELSVCCNAvRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSACG 218
Cdd:cd23963    3 LDKFRKELERLLNT-RKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 219 TEIDQADFVFRCNLPPTLGNISiDVGSKTSLVTLNPSIITHRFGKL--NEKRKPFVETVSHYGEAFLLLPAFSFRSNTAL 296
Cdd:cd23963   82 KEIDSHDFVIRCNLPPIKGFEK-DVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 297 SFKVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKvYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHY 376
Cdd:cd23963  161 LLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHY 239

                        250       260       270
                 ....*....|....*....|....*....|....
gi 942161749 377 YDNQLPKP--GIHSMPKEFYHFLKLHNKGIIKLQ 408
Cdd:cd23963  240 YDDLSPSTknKVHNMPEEFKLLRELHKKGVLKLH 273
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 151-408 1.16e-67

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 216.13  E-value: 1.16e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 151 NAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSACGTEIDQADFVFRC 230
Cdd:cd23969   15 DPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRC 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 231 NLPPTLGNISiDVGSKTSLVTLNPSIITHRFGKLNEK--RKPFVETVSHYGEAFLLLPAFSFRSNT-----ALSFKVYHT 303
Cdd:cd23969   95 NLAPVEGYEK-DVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFVSKGGEehvqwTNEIILKHK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 304 LEAfrgkqKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHYYDNQ--L 381
Cdd:cd23969  174 LNV-----KTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRkyL 248

                        250       260
                 ....*....|....*....|....*..
gi 942161749 382 PKPGIHSMPKEFYHFLKLHNKGIIKLQ 408
Cdd:cd23969  249 TTARPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 137-407 1.65e-66

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 213.41  E-value: 1.65e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 137 EEHEKFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGR-TFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNS 215
Cdd:cd23970    4 TALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKyVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 216 ACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIITHRFGKLNEK--RKPFVETVSHYGEAFLLLPAFSFR-S 292
Cdd:cd23970   84 QCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLTIqdRNNFFLSLKKLDGAILWIPAFFFHtS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 293 NTALSFKVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNI 372
Cdd:cd23970  163 ATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 942161749 373 SHHYYDNQLPKPGI-----HSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23970  243 PYHYYDKKGTKFTTkwqesHQLPAEFVLLYKMHGAGVLKL 282
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 151-407 7.30e-53

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 177.84  E-value: 7.30e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 151 NAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSACGTEIDQADFVFRC 230
Cdd:cd23988   15 DAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRC 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 231 NLPPTLGnISIDVGSKTSLVTLNPSIITHRFGKLNEK--RKPFVETVSHYGEAFLLLPAFSFRSNTALSFKVYHTLEAFR 308
Cdd:cd23988   95 NLAPVVE-FAADVGTKSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 309 GKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHYYDN----QLPKP 384
Cdd:cd23988  174 LKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDlkyrYFSNA 253

                        250       260
                 ....*....|....*....|...
gi 942161749 385 GIHSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23988  254 GPHRMPLEFKTLNVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 141-407 3.30e-46

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 160.49  E-value: 3.30e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 141 KFRSELSVCCNAVRNFIVSQNNTPLGTNMSYEVENGRTFLITQRIFKMFPQSQPFAGYPYNQCAVVGNGGILKNSACGTE 220
Cdd:cd23987    5 KIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGRE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 221 IDQADFVFRCNLPPtLGNISIDVGSKTSLVTLNPSIITHRFGKLNEK--RKPFVETVSHYGEAFLLLPAFSFRSNTALSF 298
Cdd:cd23987   85 IDSHDFVIRCNLAP-VEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNEtwKEKFLQRLQSLNGSILWIPAFMAKGGEERVE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 299 KVYHTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHYYD 378
Cdd:cd23987  164 WVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYD 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 942161749 379 N----QLPKPGIHSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23987  244 SlkygYTSQASPHTMPLEFKALKNLHQQGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 203-393 2.29e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 110.14  E-value: 2.29e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 203 CAVVGNGGILKNSACGTEIDQADFVFRCNLPPTlGNISIDVGSKTSLVTLNPSIithrFGKLNEKRKPFVETVSHYGEAF 282
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPLEEEVV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 283 LLLpafsfrSNTALSFKVYHTLEAFRGKQKTIFFHP------KYLKSLalfWRSKGIKVY----RLSSGFMIANAAIELC 352
Cdd:cd19952   76 LIL------SRAAAADFKRLKRRKKRHDNAVLLLTDpapdllSYVRKR---LEKLGLKSFfggnAPSSGLLAVLLALQLC 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 942161749 353 KEVRLYGFWPFSKNNegKNISHHYYDNQLP--KPGIHSMPKEF 393
Cdd:cd19952  147 DSVDLYGFGVDSGHA--PKVPYHYYDLVEAeeGTAVHSFDLEA 187
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 159-407 7.19e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 97.71  E-value: 7.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 159 SQNNTPLGT-NMSYEVENGrtfliTQRIFKMFPQSQPFAGYPYNQ----CAVVGNGGILKNSACGTEIDQADFVFRCNLP 233
Cdd:cd23964   41 SHYKLPFGWgGLNREVVER-----LLRNLNLTSSRYMFVLRGGRPrcirCAVVGNGGILNGSGKGKEIDAHDYVFRVNHA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 234 PTLGnISIDVGSKTSLVTLNPSIITHRFGKLNekrkPFVETVshygeAFLLLPAFSFRS---NTALSFKVYHTLEAFRGK 310
Cdd:cd23964  116 LTKG-FEKDVGTKTSFYTFFPESLHNSLLKHV----PQDKDT-----KYLFIPFKIRDYdylDAVLSGKPVPDGCDKGKR 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 311 QKTIF-----------FHPKYLKSLALFW-RSKgiKVYRLSSGFMIANAAIELCKEVRLYGFwpfsknneG--KNISHHY 376
Cdd:cd23964  186 PPPLFgpklnatnvrlLHPDFIRYLFNRWlNSS--TSYRPTTGALMLLTALHTCDQVSVYGF--------GydPRFSLHY 255

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 942161749 377 YDNQ----LPKPGIHSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23964  256 YDKTfvkfTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 183-407 1.34e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 88.11  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 183 QRIFKMFPQSQPFAGYPYNQC---AVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTslvtlnpsiiTH 259
Cdd:cd23966   57 EKLFQVVPGENPYRTRDPNRCrrcAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKT----------TH 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 260 RFgklnekrkPFVETVSHY--GEAFLLLP-----------AFSFRSNTALSFKVYHTLEAfrGKQKTIFFHPKYLKSLAL 326
Cdd:cd23966  126 HF--------MYPESAVDLdpGVHLVLVPfkvldlqwlisALTTGEITRTYTPVKRFIKA--DKDKVLVINPAFIKYVHD 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 327 FW-RSKGikvyRL-SSGFMIANAAIELCKEVRLYGFWPFSKNNegkniSHHYYDNQLP-----KPGIHSMPKEFYHFLKL 399
Cdd:cd23966  196 NWtEHHG----RYpSTGFLALIFALHICDEVSVFGFGADSKGN-----WHHYWEKNRSagafrKTGVHDADFESDIIKKL 266


                 ....*...
gi 942161749 400 HNKGIIKL 407
Cdd:cd23966  267 AKEGKIRV 274
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 203-407 3.63e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 87.50  E-value: 3.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 203 CAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIITHR---FGKLNEKRKPFVETVShyg 279
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKG-FEKDVGRRTSFYTFSTNTLMNSlraYAGVGFNGPPQSKETR--- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 280 eaFLLLPAFSfRSNTALSFKVYHTL-----------EAFRGK----QKTIFFHPKYLKSL--ALFW----RSKGIKVYRL 338
Cdd:cd23974  163 --YIFLPDHD-RDYLLVKAALTHTPidrgrdkskrpSKYFGKdvtaEKFKIYHPDFIRYLrnRFLWspilNTKQRDIYRP 239

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 942161749 339 SSGFMIANAAIELCKEVRLYGfwpFSKNNEGKnISHHYYDNQLPKPGI---HSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23974  240 STGAVMLLAALHTCDQVSAYG---FMTPDYGK-YSDHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKL 307
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 202-407 8.67e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 77.56  E-value: 8.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 202 QCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLV-----TLNPSIITHR-FGklnekrkpFVETV 275
Cdd:cd23972   84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKG-FEEDVGTKTSFYgftvnTMKNSLISYWnLG--------FTRTP 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 276 SHYGEAFLLLPA----FSFRSNTALSFKVYHTLEafRGKQKTIFF------------HPKYLKSLA-LFWRSKGIK---- 334
Cdd:cd23972  155 QGQDLQYIFIPSdirdYVMLRSAILGVPVPEGLD--KGDRPHKYFgpeasakkfkllHPDFISYLTdRFLKSKLLNthyg 232

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942161749 335 -VYRLSSGFMIANAAIELCKEVRLYGFwpFSKNNEgkNISHHYYDNQLpKPGI----HSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23972  233 hLYMPSTGALMLLTALHTCDQVSAYGF--ITSNYW--KFSDHYYERKK-KPLVfyanHDMLLEAALWRRLHKAGILQL 305
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 203-407 1.34e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 77.10  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 203 CAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSL-VTLNPSIITHR--FGKLNEKRKP--------- 270
Cdd:cd23973   86 CAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKG-YEEDVGTRTSFyVHTAHSITSSLmiLQKRGFKNIPqdkdikyil 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 271 FVETVSHYG--EAFLLlpafsfrsNTALSFKVYHTL---EAFRGK---QKTIFFHPKYLKSLA-LFWRSKGIK-----VY 336
Cdd:cd23973  165 FPEGPRDYQwlEALLK--------NKTIPSGAYYGRrprSYFSGDfteDKYLVLHPDFLRYVKnRFLRSKTLKgkywaIY 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 942161749 337 RLSSGFMIANAAIELCKEVRLYGFWpfsknNEG-KNISHHYYDNQLPKP---GIHSMPKEFYHFLKLHNKGIIKL 407
Cdd:cd23973  237 RPTTGAFLLLTALHLCDTVSAYGFI-----TEDyRKYPDHYYDKKKTKLvfyINHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 181-407 1.29e-13

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 70.67  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 181 ITQRIFKMFPQSQPFAGYPYNQC---AVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTslvtlnpsii 257
Cdd:cd23979   58 VLSKLFQIIPGENPYRSWDPSRCrrcAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVG-FEADVGSRT---------- 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 258 THRFgKLNEKRKPFVETVShygeaFLLLPafsFRS------NTALSFK----VYHTLEAFR--GKQKTIFFHPKYLKSLA 325
Cdd:cd23979  127 THHF-MYPESAKNLPANVS-----FVLVP---FKTldllwiTSALSTGqirfTYAPVKQFLrvDKDKVQIYNPAFFKYIH 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 326 LFWRSKGIKVyrLSSGFMIANAAIELCKEVRLYGFWPFSKNNegkniSHHYYDN-----QLPKPGIHSMPKEFYHFLKLH 400
Cdd:cd23979  198 DRWTEHHGRY--PSTGMLVLFFALHVCDEVNVYGFGADSRGN-----WHHYWENnryagEFRKTGVHDADFEAHIIDMLA 270


                 ....*..
gi 942161749 401 NKGIIKL 407
Cdd:cd23979  271 KAGKIKV 277
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 184-379 1.31e-13

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 70.38  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 184 RIFKMFPQSQPFAGyPYNQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIIThrfgk 263
Cdd:cd23968   30 LRYPFPESSLENTK-RYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKG-FEKDVGSKTTLRLINSQILS----- 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 264 lneKRKPFVETVSHYGEAFLLL--PAFSFRSNTALSFKV-YHTLEAF------RGKQKTIFFHPKYLKSLalfW----RS 330
Cdd:cd23968  103 ---KPEFNFLTDPLYRNVTLLVwdPSSYNVNLEKWYKKPdFDFFPNYikyrrrHPEEPFYLIDPRFLWRL---WdilqEY 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 942161749 331 KGIKVYRL--SSGFMIANAAIELCKEVRLYGFWPfsknNEGKNISHHYYDN 379
Cdd:cd23968  177 TPEKIKPNppSSGFIGIVLMLHLCDWVDVYEYVP----SVRQTDRCHYYDV 223
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 201-383 1.27e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 66.88  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 201 NQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTslvtlnpsiiTHRFgklnekrkpfvetVSHyge 280
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRT----------TIRV-------------VSH--- 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 281 aflllpafsfrSNTALSFKVYHTLEAFRGKQKTIFFH-----------PKYLKSLALFWRSKGIKVYR------------ 337
Cdd:cd23965   55 -----------SSLPRLLRNAILLLAGTRAPTVVVFWgpetkmnkdgaGKYNLLRSLSKKYPDVEFYSltpekmdyadel 123

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942161749 338 ---------------LSSGFMIANAAIELCKEVRLYGFWP--FSKNNEGKNISHHYYDNQLPK 383
Cdd:cd23965  124 feketgksriksgtwLSTGWFTMLLALDVCDEIKVYGMVPenYCREHPNSKVPYHYYEPGGLK 186
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 202-393 1.44e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 67.60  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 202 QCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTslvtlnpsiiTHRFgKLNEKRKPFVETVShygea 281
Cdd:cd23980   83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEG-FEADVGSKT----------THHF-VYPESFRELAQNVS----- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 282 FLLLP--------AFSFRSNTALSFKVYHTLEAFR-GKQKTIFFHPKYLKSLALFWRsKGIKVYRlSSGFMIANAAIELC 352
Cdd:cd23980  146 MILVPfktldlewVISATTTGTISHTYVPVPRKIKvKKEKILIYHPAFIKYVFDRWL-QGHGRYP-STGILSVIFSLHVC 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 942161749 353 KEVRLYGFWPFSKNNegkniSHHYYDNQ-----LPKPGIHSMPKEF 393
Cdd:cd23980  224 DEVDLYGFGADSKGN-----WHHYWENNpsagaFRKTGVHDGDFES 264
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 203-395 3.61e-12

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 65.01  E-value: 3.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 203 CAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIIThrfgklnekRKPfvetVSHYGEAF 282
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYPESAF---------RDP----EEYDSDWL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 283 LLLPAfsFRSNTalsfkvYHTLEAFRGKQK---TIFFHpkylKSLALFW--RSKGIKVY--------------------- 336
Cdd:cd23967   71 LVLVP--FKSMD------LLWLQAVIKGKKpngKGGFW----KKIATSVpkPPKKIRILnpyilqeaafdliglpmngkq 138

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942161749 337 ---RLSSGFMIANAAIELCKEVRLYGF-WPFSKnnegKNISHHYYDNQLPKPgihsMPKEFYH 395
Cdd:cd23967  139 gknVPTTGIIAIVMALHYCDEVDIAGFgYDPSD----PNAPLHYYDSLTMKA----IKRSWTH 193
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 203-378 3.51e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 59.88  E-value: 3.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 203 CAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIITHRFGKLNEkrkpfVETVSHyGEAF 282
Cdd:cd23976   18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRG-YGKDVGNKTSLRVIAHSSIQRILRNRNE-----LLNVSQ-GTVF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 283 LLLPAFSF--RSNTALSFKVYHTLEAFRGKQKT-IFFHPKYLKSLALFWRSKG----IKVYRLSSGFMIANAAIELCKEV 355
Cdd:cd23976   91 IFWGPSNYmrRDGKGLVYNNLQLMNQILPKLKVyTITRHKMLQFDELFKRETGkdrkISNTWLSTGWFTMIIALELCDRI 170

                        170       180
                 ....*....|....*....|....*
gi 942161749 356 RLYGFWP--FSKNNEGKNISHHYYD 378
Cdd:cd23976  171 NVYGMVPpdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 201-382 7.46e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 58.71  E-value: 7.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 201 NQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSL-VTLNPSIitHRFGKlneKRKPFVETVSHYG 279
Cdd:cd23978    2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSV--YRVLR---RPQEFLNRTPETT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 280 EAFLLLPAFSFRSNTALSFKVYHTLEAFRGKQKTIFFHPKYLKSL-ALFWRSKGIKVYR----LSSGFMIANAAIELCKE 354
Cdd:cd23978   76 LIFWGPPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFdDLFRGETGRDRKKshswLSTGWFTMVIAVELCDN 155

                        170       180       190
                 ....*....|....*....|....*....|.
gi 942161749 355 VRLYGFWPF---SKNNEGKNISHHYYDNQLP 382
Cdd:cd23978  156 VHVYGMVPPnycSKRPTPKKMPYHYYEPKGP 186
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 202-392 9.79e-10

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 58.14  E-value: 9.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 202 QCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIITHRFGKLNEKRKPFVETVSHYGEA 281
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLDF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 282 FLLLPAFSFRSNTALSF-----KVYHtleaFRGKQKTIfFHPKYLKSLALFWRS---KGIKVYRLSSGFMIANAAIELCK 353
Cdd:cd23982   83 YWLYEILSNEKRVRKGFwkqppRIWD----ANPKQIRI-LNPYYTYVAATKLLQvpgQRKKKQKPTTGLLAITLALHLCD 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 942161749 354 EVRLYGF-WPfskNNEGKNISHHYYDNQLPKP---GIHSMPKE 392
Cdd:cd23982  158 EVHIAGFgYP---DNGNSNQPIHYYNQITLKSmanSGHNLNAE 197
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 199-261 1.57e-09

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 58.18  E-value: 1.57e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 942161749 199 PYNQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIIT---HRF 261
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTTIRLINSQLVTtekHKF 108
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 183-378 2.07e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 57.92  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 183 QRIFKMFPQSQPFAgYPYNQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPSIIT---H 259
Cdd:cd23986   33 EKYVPKIPLSKLHL-RGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRG-YEKDVGNKTTIRIINSQILTnpnH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 260 RFGKlnekrkpfvetVSHYGEAFLLL--PAfSFRSNTALSFK-----VYHTLEAFRGK---QKTIFFHPKYLKSLalfWR 329
Cdd:cd23986  111 HFID-----------SSLYKDVILVAwdPA-PYSANLHKWYKkpdynLFTPYVQYRKRnpnQPFYILHPKFIWQL---WD 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 942161749 330 ------SKGIKVYRLSSGFMIANAAIELCKEVRLYGFWPFSKNNEGKNISHHYYD 378
Cdd:cd23986  176 iiqentQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYD 230
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 202-399 1.90e-08

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 54.36  E-value: 1.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 202 QCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLVTLNPsiithrfgklneKRKPFVETVSHYGEA 281
Cdd:cd23983    4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYP------------EGAPKSEQEYDPTSL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 282 F--LLLPAFSFR------SNTALSF------------KVYHTLEAFRgkqktiFFHPKYLKSLAL----------FWRSK 331
Cdd:cd23983   71 FvaVLFKSVDFAwlkamvKKEPLSFwsrlffwkevadSIPLKPSQFR------ILNPLIIKETALdilqypepqsRLWGW 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942161749 332 GIKVYRLssGFMIANAAIELCKEVRLYGFwpfsknneGKNISH-----HYYDNQ----LPKPGIHSMPKEFYHFLKL 399
Cdd:cd23983  145 DKNVPTL--GVTAVVLATHLCDEVSLAGF--------GYDLSQphaplHYYDSVcmaaMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 202-249 5.95e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 52.62  E-value: 5.95e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 942161749 202 QCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSL 249
Cdd:cd23981    4 RCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTL 50
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 199-259 7.23e-08

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 52.44  E-value: 7.23e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 942161749 199 PYNQCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGNISiDVGSKTSLVTLNP-SIITH 259
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYEN-DVGKRTTFRLCYPeSIFSD 61
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 202-378 5.46e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 50.25  E-value: 5.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 202 QCAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSLvtlnpSIITHRFGKLNEKRKPFVETVSHYGEA 281
Cdd:cd23977    3 RCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAG-YEADVGNRSSL-----RVVSHTSVPLLLRNQGYFFQQSRDTKY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 282 FLLLPAFSF-RSNTALSFKVY-HTLEAFRGKQKTIFFHPKYLKSLALFWRSKGIKVYR----LSSGFMIANAAIELCKEV 355
Cdd:cd23977   77 VIWGPERNMdRDGGGKTYRALlTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKsgsfLSTGWFTMILALELCEEI 156

                        170       180
                 ....*....|....*....|....*
gi 942161749 356 RLYGFW--PFSKNNEGKNISHHYYD 378
Cdd:cd23977  157 LVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 203-395 1.72e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 42.61  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 203 CAVVGNGGILKNSACGTEIDQADFVFRCNLPPTLGnISIDVGSKTSlvtlnpsiithrfgklnekrkpfVETVSHYGEAF 282
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKG-YEEDVGKRTT-----------------------IRVVSHTSVPL 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942161749 283 LLL-PAFSFRSNTALSFKVYHTLEAFRGKQKTIFFHpkYLKSLALFWRSKGIKVYR------------------------ 337
Cdd:cd23975   60 LLKnPDYFFKETNETIYVIWGPFRNMRKDGKGIVYN--MLKKAVESYPQAKIYVTTekrmsycdtvfkketgkdrvqsgs 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 942161749 338 -LSSGFMIANAAIELCKEVRLYGFW--PFSKNNEGKNISHHYYDnqlpkPGIHSMPKEFYH 395
Cdd:cd23975  138 yLSTGWFTLILAMDACYGIHVYGMIndTYCKTEGYRKVPYHYYE-----PGRDECDEYFLH 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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