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Conserved domains on  [gi|568954547|ref|XP_006509346|]
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toll-like receptor 3 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
756-901 9.39e-24

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 97.78  E-value: 9.39e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547   756 EYTAYIIHAHKDrdWVWEHFSPM-EEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCrRFKVH 834
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954547   835 HAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKShcILNWPvqKERINAFHHKLQVALGSR 901
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWP--EDEKEQFWKKALYAVPSK 140
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 70-543 1.30e-14

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  70 TNFTRYSQLAIldAGFNSISKLEPELCQiLPLLKVLNLQHNELS-QISDQTFVFCTNLTELDLMSNSIhkIKSNPFKNQK 148
Cdd:PLN00113  66 NNSSRVVSIDL--SGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNF--TGSIPRGSIP 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 149 NLIKLDLSHNGLSStklgtgvqlenlqelllaknKILAlrseELEFLgnSSLRKLDLSSNPLKEFSPGCFQTIGKLFALL 228
Cdd:PLN00113 141 NLETLDLSNNMLSG--------------------EIPN----DIGSF--SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLT 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 229 LNNAQLNPHLTEKLCwelSNTSIQNLSLANNQLLATSESTFSGLkwTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEY 308
Cdd:PLN00113 195 LASNQLVGQIPRELG---QMKSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 309 NNIQRLSPRSFYGLSNLryLSLKraFTKQSVSlashPNIDDFSFQwLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSL- 387
Cdd:PLN00113 270 NKLSGPIPPSIFSLQKL--ISLD--LSDNSLS----GEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLw 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 388 SKTFT------------------SLQTLTNETFVSLAHSPLLT-LNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKL 448
Cdd:PLN00113 341 SNKFSgeipknlgkhnnltvldlSTNNLTGEIPEGLCSSGNLFkLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 449 SgQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVA-------------LKNVDIS--------PSPFRPLR 507
Cdd:PLN00113 421 P-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavPRKLGSLS 499

                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 568954547 508 NLTILDLSNNNIANINEDLLEGLENLEILDFQHNNL 543
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 503-649 1.71e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 503 FRPLRNLTILDLSNNNIANIneDLLEGLENLEILDFQHNNLARLwkranpggpvNFLKGLSHLHILNLESN------GLD 576
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI----------ENLENLVNLKKLYLGGNrisvveGLE 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568954547 577 EIPvgvfkNLFELKsinLGLNNLNKLEPFIFDDQT------SLRSLNLQKNLITSVEKDVfgpPFQNLNSLDMRFNPFD 649
Cdd:cd21340   88 NLT-----NLEELH---IENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLA---PLRNLEQLDASNNQIS 155
LRRCT smart00082
Leucine rich repeat C-terminal domain;
646-698 5.93e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.34  E-value: 5.93e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568954547   646 NPFDCTCEsISWFVNWINQT-HTNISElstHYLCNTPHHYYGfPLKLFDTSS--CK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
Tlr3_TMD super family cl39400
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 9.89e-05

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


The actual alignment was detected with superfamily member pfam17968:

Pssm-ID: 465595  Cd Length: 33  Bit Score: 40.37  E-value: 9.89e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568954547  699 DSAPFELLFIISTSMLLVFILVVLLIHIEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
756-901 9.39e-24

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 97.78  E-value: 9.39e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547   756 EYTAYIIHAHKDrdWVWEHFSPM-EEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCrRFKVH 834
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954547   835 HAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKShcILNWPvqKERINAFHHKLQVALGSR 901
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWP--EDEKEQFWKKALYAVPSK 140
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-543 1.30e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  70 TNFTRYSQLAIldAGFNSISKLEPELCQiLPLLKVLNLQHNELS-QISDQTFVFCTNLTELDLMSNSIhkIKSNPFKNQK 148
Cdd:PLN00113  66 NNSSRVVSIDL--SGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNF--TGSIPRGSIP 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 149 NLIKLDLSHNGLSStklgtgvqlenlqelllaknKILAlrseELEFLgnSSLRKLDLSSNPLKEFSPGCFQTIGKLFALL 228
Cdd:PLN00113 141 NLETLDLSNNMLSG--------------------EIPN----DIGSF--SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLT 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 229 LNNAQLNPHLTEKLCwelSNTSIQNLSLANNQLLATSESTFSGLkwTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEY 308
Cdd:PLN00113 195 LASNQLVGQIPRELG---QMKSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 309 NNIQRLSPRSFYGLSNLryLSLKraFTKQSVSlashPNIDDFSFQwLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSL- 387
Cdd:PLN00113 270 NKLSGPIPPSIFSLQKL--ISLD--LSDNSLS----GEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLw 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 388 SKTFT------------------SLQTLTNETFVSLAHSPLLT-LNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKL 448
Cdd:PLN00113 341 SNKFSgeipknlgkhnnltvldlSTNNLTGEIPEGLCSSGNLFkLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 449 SgQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVA-------------LKNVDIS--------PSPFRPLR 507
Cdd:PLN00113 421 P-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavPRKLGSLS 499

                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 568954547 508 NLTILDLSNNNIANINEDLLEGLENLEILDFQHNNL 543
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-416 1.81e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 1.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  52 SNITVLNLTHNQlrrlpptNFTRYSQLAILDAGFNSISKLEPELCQiLPLLKVLNLQHNELSQISDQtFVFCTNLTELDL 131
Cdd:COG4886   96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 132 MSNSIHKIkSNPFKNQKNLIKLDLSHNGLSStklgtgvqlenlqelllaknkilalrsEELEFLGNSSLRKLDLSSNPLK 211
Cdd:COG4886  167 SNNQLTDL-PEELGNLTNLKELDLSNNQITD---------------------------LPEPLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 212 EFsPGCFQTIGKLFALLLNNAQLnphltEKLCWELSNTSIQNLSLANNQLLATSEStfsgLKWTNLTQLDLSYNNLHDVG 291
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL-----TDLPELGNLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTDLK 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 292 NGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPST 371
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 568954547 372 KSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLT 416
Cdd:COG4886  369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR_8 pfam13855
Leucine rich repeat;
275-330 3.92e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 3.92e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568954547  275 TNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSL 330
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 405-541 6.88e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 6.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 405 LAHSPLLT-LNLTKNHISKIANgtFSWLGQLRILDLGLNEIEqKLSGQEwrGLRNIFEIYLSYNKyLQLST-------SS 476
Cdd:cd21340   42 LEFLTNLThLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENQR-LPPGEkltfdprSL 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954547 477 FALVPSLQRLMLRRvalKNVDiSPSPFRPLRNLTILDLSNNNIANINE--DLLEGLENLEILDFQHN 541
Cdd:cd21340  116 AALSNSLRVLNISG---NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 763-881 1.34e-06

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 49.29  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  763 HAHKDRDWVWEHFSPmeEQDQ-SLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCrRFKVHHAVQQAI 841
Cdd:pfam01582   8 RGSDTREWFVSHLLK--ELKQkGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWC-LDELVKILECAL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568954547  842 EQNLdSIILIFLQNIPDYKLNHALCLRRGmFKSHC-------ILNWP 881
Cdd:pfam01582  85 DLGQ-KVIPIFYEVDPSDVRKQTGSFGKA-FKKHKkvlteekVLKWR 129
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 503-649 1.71e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 503 FRPLRNLTILDLSNNNIANIneDLLEGLENLEILDFQHNNLARLwkranpggpvNFLKGLSHLHILNLESN------GLD 576
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI----------ENLENLVNLKKLYLGGNrisvveGLE 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568954547 577 EIPvgvfkNLFELKsinLGLNNLNKLEPFIFDDQT------SLRSLNLQKNLITSVEKDVfgpPFQNLNSLDMRFNPFD 649
Cdd:cd21340   88 NLT-----NLEELH---IENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLA---PLRNLEQLDASNNQIS 155
LRRCT smart00082
Leucine rich repeat C-terminal domain;
646-698 5.93e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.34  E-value: 5.93e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568954547   646 NPFDCTCEsISWFVNWINQT-HTNISElstHYLCNTPHHYYGfPLKLFDTSS--CK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 9.89e-05

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 40.37  E-value: 9.89e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568954547  699 DSAPFELLFIISTSMLLVFILVVLLIHIEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
756-901 9.39e-24

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 97.78  E-value: 9.39e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547   756 EYTAYIIHAHKDrdWVWEHFSPM-EEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCrRFKVH 834
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954547   835 HAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKShcILNWPvqKERINAFHHKLQVALGSR 901
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWP--EDEKEQFWKKALYAVPSK 140
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-543 1.30e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  70 TNFTRYSQLAIldAGFNSISKLEPELCQiLPLLKVLNLQHNELS-QISDQTFVFCTNLTELDLMSNSIhkIKSNPFKNQK 148
Cdd:PLN00113  66 NNSSRVVSIDL--SGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNF--TGSIPRGSIP 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 149 NLIKLDLSHNGLSStklgtgvqlenlqelllaknKILAlrseELEFLgnSSLRKLDLSSNPLKEFSPGCFQTIGKLFALL 228
Cdd:PLN00113 141 NLETLDLSNNMLSG--------------------EIPN----DIGSF--SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLT 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 229 LNNAQLNPHLTEKLCwelSNTSIQNLSLANNQLLATSESTFSGLkwTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEY 308
Cdd:PLN00113 195 LASNQLVGQIPRELG---QMKSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQ 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 309 NNIQRLSPRSFYGLSNLryLSLKraFTKQSVSlashPNIDDFSFQwLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSL- 387
Cdd:PLN00113 270 NKLSGPIPPSIFSLQKL--ISLD--LSDNSLS----GEIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLw 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 388 SKTFT------------------SLQTLTNETFVSLAHSPLLT-LNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKL 448
Cdd:PLN00113 341 SNKFSgeipknlgkhnnltvldlSTNNLTGEIPEGLCSSGNLFkLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 449 SgQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVA-------------LKNVDIS--------PSPFRPLR 507
Cdd:PLN00113 421 P-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavPRKLGSLS 499

                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 568954547 508 NLTILDLSNNNIANINEDLLEGLENLEILDFQHNNL 543
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-416 1.81e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 1.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  52 SNITVLNLTHNQlrrlpptNFTRYSQLAILDAGFNSISKLEPELCQiLPLLKVLNLQHNELSQISDQtFVFCTNLTELDL 131
Cdd:COG4886   96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 132 MSNSIHKIkSNPFKNQKNLIKLDLSHNGLSStklgtgvqlenlqelllaknkilalrsEELEFLGNSSLRKLDLSSNPLK 211
Cdd:COG4886  167 SNNQLTDL-PEELGNLTNLKELDLSNNQITD---------------------------LPEPLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 212 EFsPGCFQTIGKLFALLLNNAQLnphltEKLCWELSNTSIQNLSLANNQLLATSEStfsgLKWTNLTQLDLSYNNLHDVG 291
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL-----TDLPELGNLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTDLK 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 292 NGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPST 371
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 568954547 372 KSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLT 416
Cdd:COG4886  369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-289 2.60e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 2.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  37 DCSHLKLTHIPDDLPS--NITVLNLTHNQLRRLPPtNFTRYSQLAILDAGFNSISKLEPELCQiLPLLKVLNLQHNELSQ 114
Cdd:COG4886  142 DLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 115 ISDQtFVFCTNLTELDLMSNSIHKIKSnpFKNQKNLIKLDLSHNGLSStkLGTGVQLENLQELLLAKNKILALRSEELEF 194
Cdd:COG4886  220 LPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 195 LGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKW 274
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250
                 ....*....|....*
gi 568954547 275 TNLTQLDLSYNNLHD 289
Cdd:COG4886  375 LEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-537 3.52e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 3.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  86 NSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKL 165
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 166 GTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPgcfqTIGKLfalllnnaqlnphlteklcwe 245
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE----ELANL--------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 246 lsnTSIQNLSLANNQlLATSESTFSGLkwTNLTQLDLSYNNLHDVGNgSFSYLPSLRYLSLEYNNIQRLsPRSFYGLSNL 325
Cdd:COG4886  136 ---TNLKELDLSNNQ-LTDLPEPLGNL--TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 326 RYLSLkraftkqsvslaSHPNIDDF--SFQWLKYLEYLNMDDNNIPSTKSntFTGLVSLKYLSLS----KTFTSLQTLTN 399
Cdd:COG4886  208 EELDL------------SGNQLTDLpePLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSnnqlTDLPPLANLTN 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 400 ETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFAL 479
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568954547 480 VPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILD 537
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR_8 pfam13855
Leucine rich repeat;
275-330 3.92e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 3.92e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568954547  275 TNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSL 330
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 405-541 6.88e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 6.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 405 LAHSPLLT-LNLTKNHISKIANgtFSWLGQLRILDLGLNEIEqKLSGQEwrGLRNIFEIYLSYNKyLQLST-------SS 476
Cdd:cd21340   42 LEFLTNLThLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENQR-LPPGEkltfdprSL 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954547 477 FALVPSLQRLMLRRvalKNVDiSPSPFRPLRNLTILDLSNNNIANINE--DLLEGLENLEILDFQHN 541
Cdd:cd21340  116 AALSNSLRVLNISG---NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-551 7.13e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 7.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 133 SNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKE 212
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 213 FSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLlatsestfsglkwTNLTQLDLSYNNLHDVGN 292
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-------------TNLKELDLSNNQLTDLPE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 293 gSFSYLPSLRYLSLEYNNIQRLsPRSFYGLSNLRYLSLkraftkqsvslaSHPNIDDF--SFQWLKYLEYLNMDDNNIpS 370
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL------------SNNQITDLpePLGNLTNLEELDLSGNQL-T 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 371 TKSNTFTGLVSLKYLSLS----KTFTSLQTLTNetfvslahspLLTLNLTKNHISKIanGTFSWLGQLRILDLGLNEIEq 446
Cdd:COG4886  219 DLPEPLANLTNLETLDLSnnqlTDLPELGNLTN----------LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLT- 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 447 KLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDL 526
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                        410       420
                 ....*....|....*....|....*
gi 568954547 527 LEGLENLEILDFQHNNLARLWKRAN 551
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLL 390
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
296-677 4.54e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 4.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 296 SYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNT 375
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 376 FTGLVSLKYLSLSKTfTSLQTLTNETFVSLAHSP-------------LLTLNLTKNHISKIANgTFSWLGQLRILDLGLN 442
Cdd:COG4886   92 LGDLTNLTELDLSGN-EELSNLTNLESLDLSGNQltdlpeelanltnLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 443 EIEQKlsGQEWRGLRNIFEIYLSYNKYLQLStSSFALVPSLQRLMLRRVALKNVdisPSPFRPLRNLTILDLSNNNIANI 522
Cdd:COG4886  170 QLTDL--PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL---PEPLANLTNLETLDLSNNQLTDL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 523 NEdlLEGLENLEILDFQHNNLARLwkranpggpvNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKL 602
Cdd:COG4886  244 PE--LGNLTNLEELDLSNNQLTDL----------PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568954547 603 EPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYL 677
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLL 386
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-623 2.76e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 2.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 180 AKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANN 259
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 260 QLLATSESTFSGLKWTNLTQLDLSYNNlhdvgngSFSYLPSLRYLSLEYNNIQRLsPRSFYGLSNLRYLSLkraftkqsv 339
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL--------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 340 slaSHPNIDDF--SFQWLKYLEYLNMDDNNIPStksntftglvslkylsLSKTFTSLQTLTnetfvslahspllTLNLTK 417
Cdd:COG4886  144 ---SNNQLTDLpePLGNLTNLKSLDLSNNQLTD----------------LPEELGNLTNLK-------------ELDLSN 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 418 NHISKIANgTFSWLGQLRILDLGLNEIEQkLSgQEWRGLRNIFEIYLSYNkylQLST-SSFALVPSLQRLMLRRVALKNV 496
Cdd:COG4886  192 NQITDLPE-PLGNLTNLEELDLSGNQLTD-LP-EPLANLTNLETLDLSNN---QLTDlPELGNLTNLEELDLSNNQLTDL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 497 dispSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLD 576
Cdd:COG4886  266 ----PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 568954547 577 EIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLI 623
Cdd:COG4886  342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
LRR_8 pfam13855
Leucine rich repeat;
249-311 8.99e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 8.99e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568954547  249 TSIQNLSLANNQLLATSESTFSGLKwtNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNI 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 100-319 4.51e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.82  E-value: 4.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 100 PLLKVLNLQHNELSQISDQT------FVFCTNLTELDLMSNSIHKIKSNPFKN---QKNLIKLDLSHNGLSSTKLgtgvq 170
Cdd:cd00116   51 PSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDGCGVLESllrSSSLQELKLNNNGLGDRGL----- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 171 lenlqelllaKNKILALRSEELeflgnsSLRKLDLSSNPLKEFS----PGCFQTIGKLFALLLNNAQLNPHLTEKLCWEL 246
Cdd:cd00116  126 ----------RLLAKGLKDLPP------ALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALAEGL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 247 -SNTSIQNLSLANNQLLATSESTFSGL--KWTNLTQLDLSYNNLHDVG-----NGSFSYLPSLRYLSLEYNNIQRLSPRS 318
Cdd:cd00116  190 kANCNLEVLDLNNNGLTDEGASALAETlaSLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDGAKD 269


                 .
gi 568954547 319 F 319
Cdd:cd00116  270 L 270
LRR_8 pfam13855
Leucine rich repeat;
481-543 1.71e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.71e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568954547  481 PSLQRLMLRRVALknVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNL 543
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-158 2.80e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 2.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  42 KLTHIPD-DLPSNITVLNLTHNQLRRLPptNFTRYSQLAILDAGFNSISKLE-----PEL------CQILPL-------- 101
Cdd:cd21340   35 KITKIENlEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEglenlTNLeelhieNQRLPPgekltfdp 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568954547 102 ---------LKVLNLQHNELSQISDqtFVFCTNLTELDLMSNSIHKIK--SNPFKNQKNLIKLDLSHN 158
Cdd:cd21340  113 rslaalsnsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
76-136 8.12e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 8.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568954547   76 SQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSI 136
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 763-881 1.34e-06

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 49.29  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  763 HAHKDRDWVWEHFSPmeEQDQ-SLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCrRFKVHHAVQQAI 841
Cdd:pfam01582   8 RGSDTREWFVSHLLK--ELKQkGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWC-LDELVKILECAL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568954547  842 EQNLdSIILIFLQNIPDYKLNHALCLRRGmFKSHC-------ILNWP 881
Cdd:pfam01582  85 DLGQ-KVIPIFYEVDPSDVRKQTGSFGKA-FKKHKkvlteekVLKWR 129
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 503-649 1.71e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 503 FRPLRNLTILDLSNNNIANIneDLLEGLENLEILDFQHNNLARLwkranpggpvNFLKGLSHLHILNLESN------GLD 576
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI----------ENLENLVNLKKLYLGGNrisvveGLE 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568954547 577 EIPvgvfkNLFELKsinLGLNNLNKLEPFIFDDQT------SLRSLNLQKNLITSVEKDVfgpPFQNLNSLDMRFNPFD 649
Cdd:cd21340   88 NLT-----NLEELH---IENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLA---PLRNLEQLDASNNQIS 155
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 102-315 1.73e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 102 LKVLNLQHNELSQISDqtFVFCTNLTELDLMSNSIHKIksNPFKNQKNLIKLDLSHNGLSstklgtgvqlenlqelllak 181
Cdd:cd21340   26 LKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRIS-------------------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 182 nkilalRSEELEFLgnSSLRKLDLSSNPLKE-----FSPGCFQTIGKlfalllnnaqlnphlteklcwelsntSIQNLSL 256
Cdd:cd21340   82 ------VVEGLENL--TNLEELHIENQRLPPgekltFDPRSLAALSN--------------------------SLRVLNI 127

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568954547 257 ANNQLlaTSESTFSGLKwtNLTQLDLSYNNLHDVGN--GSFSYLPSLRYLSLEYNNIQRLS 315
Cdd:cd21340  128 SGNNI--DSLEPLAPLR--NLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-319 3.51e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  41 LKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILpllkvlnlqhnELSQisdqtf 120
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEM-----------ELSI------ 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 121 vfcTNLTELdlmsnsihkiksnPFKNQKNLIKLDLSHNGLSS--TKLGTGVQLENLQelllaKNKILALrSEELEflgnS 198
Cdd:PRK15370 251 ---NRITEL-------------PERLPSALQSLDLFHNKISClpENLPEELRYLSVY-----DNSIRTL-PAHLP----S 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 199 SLRKLDLSSNPLKeFSPgcfQTIGKLFALLLNNAQLNPHLTEKLCWELsntsiQNLSLANNQLLATSEStfsgLKWTnLT 278
Cdd:PRK15370 305 GITHLNVQSNSLT-ALP---ETLPPGLKTLEAGENALTSLPASLPPEL-----QVLDVSKNQITVLPET----LPPT-IT 370

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568954547 279 QLDLSYNNLHDVGNGsfsyLP-SLRYLSLEYNNIQRLsPRSF 319
Cdd:PRK15370 371 TLDVSRNALTNLPEN----LPaALQIMQASRNNLVRL-PESL 407
LRR_8 pfam13855
Leucine rich repeat;
52-112 3.54e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568954547   52 SNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNEL 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
646-698 5.93e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.34  E-value: 5.93e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568954547   646 NPFDCTCEsISWFVNWINQT-HTNISElstHYLCNTPHHYYGfPLKLFDTSS--CK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
LRR_8 pfam13855
Leucine rich repeat;
100-160 8.23e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 8.23e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568954547  100 PLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGL 160
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-488 9.73e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 9.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  46 IPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHN--------ELSQISD 117
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNqlvgqiprELGQMKS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 118 QTFVF----------------CTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTklgtgvqlenlqelllAK 181
Cdd:PLN00113 214 LKWIYlgynnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP----------------IP 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 182 NKILALRseeleflgnsSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCwelSNTSIQNLSLANNQL 261
Cdd:PLN00113 278 PSIFSLQ----------KLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT---SLPRLQVLQLWSNKF 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 262 laTSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLkraftkQSVSL 341
Cdd:PLN00113 345 --SGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRL------QDNSF 416

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 342 ASHPNIDdfsFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKtftslQTLTNETFVSLAHSPLLTLNLTKNHIS 421
Cdd:PLN00113 417 SGELPSE---FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLAR-----NKFFGGLPDSFGSKRLENLDLSRNQFS 488

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568954547 422 KIANGTFSWLGQLRILDLGLNEIEQKLSgQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLML 488
Cdd:PLN00113 489 GAVPRKLGSLSELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDL 554
LRR_8 pfam13855
Leucine rich repeat;
412-468 1.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.01e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568954547  412 TLNLTKNHISKIANGTFSWLGQLRILDLGLNEIeQKLSGQEWRGLRNIFEIYLSYNK 468
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
299-368 1.84e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568954547  299 PSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLkraftkqsvslaSHPNIDDFS---FQWLKYLEYLNMDDNNI 368
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL------------SNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 217-582 6.70e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 6.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 217 CFQTIGKLFALLLNNAQLNPHLTEKLcweLS-NTSIQNLSlannQLLATSESTFSGLKWTNLT--------QLDLSYNNL 287
Cdd:PLN00113   9 CPYLIFMLFFLFLNFSMLHAEELELL---LSfKSSINDPL----KYLSNWNSSADVCLWQGITcnnssrvvSIDLSGKNI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 288 HDVGNGSFSYLPSLRYLSLEYNNIQRLSPRS-FYGLSNLRYLSLKRAFTKQSVSLASHPNiddfsfqwlkyLEYLNMDDN 366
Cdd:PLN00113  82 SGKISSAIFRLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGSIPN-----------LETLDLSNN 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 367 NIPSTKSNTFTGLVSLKYLSLSKTF------TSLQTLTNETFVSLAHSPLLtlnltknhiskiaNGTFSWLGQLRILD-- 438
Cdd:PLN00113 151 MLSGEIPNDIGSFSSLKVLDLGGNVlvgkipNSLTNLTSLEFLTLASNQLV-------------GQIPRELGQMKSLKwi 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 439 -LGLNeieqKLSGQ---EWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNvDISPSPFRpLRNLTILDL 514
Cdd:PLN00113 218 yLGYN----NLSGEipyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLISLDL 291

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568954547 515 SNNNIANINEDLLEGLENLEILdfqhnnlarlwkranpggpvnflkglshlhilNLESNGLD-EIPVGV 582
Cdd:PLN00113 292 SDNSLSGEIPELVIQLQNLEIL--------------------------------HLFSNNFTgKIPVAL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 247-388 9.36e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 9.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 247 SNTSIQNLSLANNQLlaTSESTFSGLKwtNLTQLDLSYNNLHDVGNgsFSYLPSLRYLSLEYNNIQR-----LSPRSFYG 321
Cdd:cd21340   44 FLTNLTHLYLQNNQI--EKIENLENLV--NLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekltFDPRSLAA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568954547 322 LSN-LRYLSLkraftkqsvslaSHPNIDDFS-FQWLKYLEYLNMDDNNIPSTK--SNTFTGLVSLKYLSLS 388
Cdd:cd21340  118 LSNsLRVLNI------------SGNNIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLT 176
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 9.89e-05

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 40.37  E-value: 9.89e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568954547  699 DSAPFELLFIISTSMLLVFILVVLLIHIEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-142 1.08e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  37 DCSHLKLTHIPDDLPSNITVLNLTHNQLRRLP---PTNFTRYS---------------QLAILDAGFNSISKLePElcQI 98
Cdd:PRK15370 268 DLFHNKISCLPENLPEELRYLSVYDNSIRTLPahlPSGITHLNvqsnsltalpetlppGLKTLEAGENALTSL-PA--SL 344

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568954547  99 LPLLKVLNLQHNELSQISDqtfVFCTNLTELDLMSNSIHKIKSN 142
Cdd:PRK15370 345 PPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPEN 385
LRR_8 pfam13855
Leucine rich repeat;
124-210 3.18e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  124 TNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSStklgtgvqlenlqelllaknkilalrSEELEFLGNSSLRKL 203
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------------------LSPGAFSGLPSLRYL 54


                  ....*..
gi 568954547  204 DLSSNPL 210
Cdd:pfam13855  55 DLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 46-113 4.99e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 4.99e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  46 IPDDLPS--NITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELS 113
Cdd:PLN03150 434 IPNDISKlrHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-161 6.15e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 6.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  49 DLPSnITVLNLTHNQLRRLPPTNFtRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTE 128
Cdd:PLN00113 450 DMPS-LQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVS 527

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568954547 129 LDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLS 161
Cdd:PLN00113 528 LDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 192-388 6.87e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 192 LEFLGNSS-LRKLDLSSNPLKEFSPGCFQTIgklfalllnnaqlnphlteklcweLSNTSIQNLSLANNQLLATSESTFS 270
Cdd:cd00116   74 LQGLTKGCgLQELDLSDNALGPDGCGVLESL------------------------LRSSSLQELKLNNNGLGDRGLRLLA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 271 -GLK--WTNLTQLDLSYNNLHDVG----NGSFSYLPSLRYLSLEYNNIQ----RLSPRSFYGLSNLRYLSLK-RAFTKQS 338
Cdd:cd00116  130 kGLKdlPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNnNGLTDEG 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568954547 339 VSLASHpniddfSFQWLKYLEYLNMDDNNIPST-----KSNTFTGLVSLKYLSLS 388
Cdd:cd00116  210 ASALAE------TLASLKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLS 258
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 760-853 1.08e-03

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 39.61  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547  760 YIIHAHKDRDWV-W--EHFspmeeQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRfkvhhA 836
Cdd:pfam13676   2 FISYAGEDRAWAeWlaDAL-----EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRA-----E 71

                          90
                  ....*....|....*..
gi 568954547  837 VQQAIEQNLDSIILIFL 853
Cdd:pfam13676  72 WEAALADPEGRKRLIPV 88
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 508-543 1.76e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568954547  508 NLTILDLSNNNIANIneDLLEGLENLEILDFQHNNL 543
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNK 35
LRR_8 pfam13855
Leucine rich repeat;
381-444 3.12e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 3.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568954547  381 SLKYLSLSktFTSLQTLTNETFVSLAHspLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEI 444
Cdd:pfam13855   2 NLRSLDLS--NNRLTSLDDGAFKGLSN--LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
457-519 6.86e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568954547  457 RNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKnvDISPSPFRPLRNLTILDLSNNNI 519
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 251-330 7.24e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 7.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954547 251 IQNLSLANNQLLATSESTFSGLKwtNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSL 330
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLR--HLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNL 497
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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