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Conserved domains on  [gi|568960835|ref|XP_006510919|]
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pyruvate kinase PKM isoform X6 [Mus musculus]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 68-515 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 737.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTGLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYK 147
Cdd:cd00288   42 YHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTGLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGAD-FLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVF 226
Cdd:cd00288  113 NLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 227 ASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:cd00288  193 ASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAG 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRL 386
Cdd:cd00288  273 KPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRL 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 387 APITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNa 466
Cdd:cd00288  353 TPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG- 431

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 467 WAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 515
Cdd:cd00288  432 WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 68-515 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 737.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTGLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYK 147
Cdd:cd00288   42 YHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTGLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGAD-FLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVF 226
Cdd:cd00288  113 NLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 227 ASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:cd00288  193 ASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAG 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRL 386
Cdd:cd00288  273 KPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRL 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 387 APITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNa 466
Cdd:cd00288  353 TPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG- 431

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 467 WAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 515
Cdd:cd00288  432 WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 68-512 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 666.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835   68 YHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTGLIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYK 147
Cdd:TIGR01064  41 EHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTGEIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  148 NICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFA 227
Cdd:TIGR01064 111 GLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAA 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  228 SFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:TIGR01064 191 SFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAG 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRL 386
Cdd:TIGR01064 271 KPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  387 APITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlna 466
Cdd:TIGR01064 351 DPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE----- 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 568960835  467 WAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTG-WRPGSGFTNTMRV 512
Cdd:TIGR01064 426 EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 68-515 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 576.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATEsfasdpILYRPVAVALDTKGPEIRTGLIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYK 147
Cdd:COG0469   43 EHRERIELIREAAK------ELGRPVAILLDLQGPKIRTGKFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFA 227
Cdd:COG0469  111 ELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIAL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 228 SFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGK 307
Cdd:COG0469  191 SFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGK 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 308 PVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLA 387
Cdd:COG0469  271 PVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEP 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 388 PITSDPTEAAAVGAVEASFKCCsgAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnaw 467
Cdd:COG0469  351 ERTITDAIARAAVELAEDLGAK--AIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDD------ 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 468 AEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVVPV 515
Cdd:COG0469  423 VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 68-380 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 555.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835   68 YHAETIKNVREATESFASDpilyrpVAVALDTKGPEIRTGLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYK 147
Cdd:pfam00224  42 YHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRTGNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYK 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  148 NICKVVEVGSKIYVDDGLISLQVKEKGADF-LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVF 226
Cdd:pfam00224 115 NIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIF 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  227 ASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:pfam00224 195 ASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAG 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568960835  307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 380
Cdd:pfam00224 275 KPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 68-499 4.57e-172

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 493.52  E-value: 4.57e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRTGLIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYK 147
Cdd:PRK05826  44 EHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVGKFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFA 227
Cdd:PRK05826 113 GLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 228 SFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:PRK05826 193 SFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAG 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAaiyHLQLFEELRRL 386
Cdd:PRK05826 273 KPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRL 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 387 APITSDPTEAAAVGAVEASFK-CCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLC-KDAVL 464
Cdd:PRK05826 350 DRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFdSAADT 429

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 568960835 465 NAWAEDvdlrvnlAMDVGKARGFFKKGDVVIVLTG 499
Cdd:PRK05826 430 DDAAEE-------ALRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 68-515 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 737.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTGLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYK 147
Cdd:cd00288   42 YHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTGLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGAD-FLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVF 226
Cdd:cd00288  113 NLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 227 ASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:cd00288  193 ASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAG 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRL 386
Cdd:cd00288  273 KPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRL 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 387 APITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNa 466
Cdd:cd00288  353 TPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG- 431

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 467 WAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 515
Cdd:cd00288  432 WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 68-512 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 666.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835   68 YHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTGLIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYK 147
Cdd:TIGR01064  41 EHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTGEIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  148 NICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFA 227
Cdd:TIGR01064 111 GLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAA 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  228 SFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:TIGR01064 191 SFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAG 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRL 386
Cdd:TIGR01064 271 KPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  387 APITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlna 466
Cdd:TIGR01064 351 DPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE----- 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 568960835  467 WAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTG-WRPGSGFTNTMRV 512
Cdd:TIGR01064 426 EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 68-515 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 576.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATEsfasdpILYRPVAVALDTKGPEIRTGLIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYK 147
Cdd:COG0469   43 EHRERIELIREAAK------ELGRPVAILLDLQGPKIRTGKFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFA 227
Cdd:COG0469  111 ELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIAL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 228 SFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGK 307
Cdd:COG0469  191 SFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGK 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 308 PVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLA 387
Cdd:COG0469  271 PVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEP 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 388 PITSDPTEAAAVGAVEASFKCCsgAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnaw 467
Cdd:COG0469  351 ERTITDAIARAAVELAEDLGAK--AIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDD------ 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 468 AEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVVPV 515
Cdd:COG0469  423 VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 68-380 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 555.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835   68 YHAETIKNVREATESFASDpilyrpVAVALDTKGPEIRTGLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYK 147
Cdd:pfam00224  42 YHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRTGNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYK 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  148 NICKVVEVGSKIYVDDGLISLQVKEKGADF-LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVF 226
Cdd:pfam00224 115 NIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIF 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  227 ASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:pfam00224 195 ASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAG 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568960835  307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 380
Cdd:pfam00224 275 KPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 68-499 4.57e-172

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 493.52  E-value: 4.57e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRTGLIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYK 147
Cdd:PRK05826  44 EHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVGKFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYK 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFA 227
Cdd:PRK05826 113 GLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 228 SFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:PRK05826 193 SFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAG 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAaiyHLQLFEELRRL 386
Cdd:PRK05826 273 KPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRL 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 387 APITSDPTEAAAVGAVEASFK-CCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLC-KDAVL 464
Cdd:PRK05826 350 DRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFdSAADT 429

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 568960835 465 NAWAEDvdlrvnlAMDVGKARGFFKKGDVVIVLTG 499
Cdd:PRK05826 430 DDAAEE-------ALRLLLEKGLVESGDLVVVTSG 457
PRK09206 PRK09206
pyruvate kinase PykF;
69-512 1.53e-162

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 469.54  E-value: 1.53e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  69 HAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTglIKGSGTAEVELKKGATLKITLDNAYMEkcDENILWLDYKN 148
Cdd:PRK09206  43 HGQRIKNLRNVMSKTG------KKAAILLDTKGPEIRT--MKLEGGNDVSLKAGQTFTFTTDKSVVG--NKERVAVTYEG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 149 ICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFAS 228
Cdd:PRK09206 113 FTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAAS 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 229 FIRKAADVHEVRKVLGE-KGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGK 307
Cdd:PRK09206 193 FIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARK 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 308 PVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAA----IYHLQLFEEL 383
Cdd:PRK09206 273 VVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVmnsrLESNNDNRKL 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 384 RrlapITSdpteaaavgaveasfKCCSGA-----------IIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYR 452
Cdd:PRK09206 353 R----ITE---------------AVCRGAvetaekldaplIVVATQGGKSARSVRKYFPDATILALTTNEKTARQLVLSK 413

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 453 GIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRV 512
Cdd:PRK09206 414 GVVPQLVKE------IASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTASV 467
PLN02461 PLN02461
Probable pyruvate kinase
 68-497 1.14e-161

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 468.69  E-value: 1.14e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATesfASDPILyrpVAVALDTKGPEIRTGLIKGSGTaeVELKKGATLKITLDnaYMEKCDENILWLDYK 147
Cdd:PLN02461  61 YHQETLDNLRQAM---ANTGIL---CAVMLDTKGPEIRTGFLKDGKP--VQLKQGQEITITTD--YSIKGDENMIAMSYK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQV----KEKGadfLVT-EVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQD 221
Cdd:PLN02461 131 KLAVDVKPGSVILCADGTITLTVlscdVEAG---TVRcRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNK 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 222 VDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 301
Cdd:PLN02461 208 IDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYK 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 302 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFE 381
Cdd:PLN02461 288 CNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEASLDYGALFK 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 382 ELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAV-------------TRNPQTARQA 448
Cdd:PLN02461 368 EIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPAVPILSVvvpeittdsfdwsCSDEAPARHS 447

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 449 HLYRGIFPVLCKDAVLNAWAEDVDLRVNLAMDVGKARGFFKKGDVVIVL 497
Cdd:PLN02461 448 LIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVVAL 496
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 68-515 2.67e-160

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 462.98  E-value: 2.67e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATESFASDpilyrpVAVALDTKGPEIRTGLIKGSGTAeveLKKGATLKITLDNAYMEKCDENILWLDYK 147
Cdd:PTZ00300  15 YHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGGEAV---MERGATCYVTTDPAFADKGTKDKFYIDYQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKEKGADF-LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVF 226
Cdd:PTZ00300  86 NLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQGVDMIF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 227 ASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAG 306
Cdd:PTZ00300 166 ASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 307 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRL 386
Cdd:PTZ00300 246 KPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVFFNSIKKL 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 387 APITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCkDAVLNA 466
Cdd:PTZ00300 326 QPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF-DAERLG 404

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 467 WAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 515
Cdd:PTZ00300 405 HDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PRK06354 PRK06354
pyruvate kinase; Provisional
 68-512 4.01e-149

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 439.36  E-value: 4.01e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATEsfasdpILYRPVAVALDTKGPEIRTGLIKGSGtaeVELKKGATLKITLDNAymeKCDENILWLDYK 147
Cdd:PRK06354  48 EHGARIKNIREASK------KLGKTVGILQDLQGPKIRLGRFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYD 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLISLQVKE--KGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV 225
Cdd:PRK06354 116 GLADEVPVGSRILLDDGLIELEVEEvdKADGELHCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWI 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 226 FASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNR 304
Cdd:PRK06354 196 ALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANR 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 305 AGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELR 384
Cdd:PRK06354 276 LGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRP 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 385 RLapiTSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavl 464
Cdd:PRK06354 356 EF---TTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLD--- 429

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 568960835 465 nawAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRV 512
Cdd:PRK06354 430 ---APSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGeSGSTDLMKV 475
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 69-516 8.18e-143

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 420.71  E-value: 8.18e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  69 HAETIKNVREATESfasdpilyRP---VAVALDTKGPEIRTGLIKGSgtAEVELKKGATLKITLDnaYMEKCDENILWLD 145
Cdd:PTZ00066  79 HKKTLNNVREAAKA--------RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTD--YTFLGDETCISCS 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 146 YKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDM 224
Cdd:PTZ00066 147 YKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDF 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 225 VFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNR 304
Cdd:PTZ00066 227 IALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNV 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 305 AGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELR 384
Cdd:PTZ00066 307 AGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIH 386

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 385 RLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIfpvlcKDAVL 464
Cdd:PTZ00066 387 LAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGV-----TTYVV 461

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568960835 465 NAWaEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVVPVP 516
Cdd:PTZ00066 462 NSF-QGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKIP 513
PRK06247 PRK06247
pyruvate kinase; Provisional
 69-512 1.83e-130

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 387.74  E-value: 1.83e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  69 HAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRTGLIKGSgtaEVELKKGATLKITLDNAymeKCDENILWLDYKN 148
Cdd:PRK06247  46 HRELYKRIREVEDE------TGRPIGILADLQGPKLRLGRFADG---KVQLANGQTFRLDVDDA---PGDHDRVSLPHPE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 149 ICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFAS 228
Cdd:PRK06247 114 IAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 229 FIRKAADVHEVRKVLGEKgknIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKP 308
Cdd:PRK06247 194 FVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKP 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 309 VICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEA-----AIYHLQLFEEL 383
Cdd:PRK06247 271 VVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEAVRTMARIIRQVERdptypPLIHAQRPQPE 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 384 -----------RRLAPITSDPteaaavgaveasfkccsgAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYR 452
Cdd:PRK06247 351 atkrdaisyaaRDIAERLDLA------------------ALVAYTSSGDTALRAARERPPLPILALTPNPETARRLALTW 412

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568960835 453 GIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRV 512
Cdd:PRK06247 413 GVHCVVVDD------ARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPGSTNMLRI 467
PLN02765 PLN02765
pyruvate kinase
 68-496 9.32e-94

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 295.04  E-value: 9.32e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRtglIKGSGTAEVELKKGATLKITLDNayMEKCDENILWLDYK 147
Cdd:PLN02765  68 YHQETLENLKIAVKN------TKKLCAVMLDTVGPELQ---VINKTEKPISLKAGNTVTLTPDQ--SKEASSEVLPINFP 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 148 NICKVVEVGSKIYVDDGLIS--------LQVKEKGADFLVTEVENGGSL-GSKKGVNLPGAAVDLPAVSEKDIQDLK-FG 217
Cdd:PLN02765 137 GLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCTVKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWG 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 218 VEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQK 296
Cdd:PLN02765 217 VPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQK 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 297 MMIGRCNRAGKPVIcATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYH 376
Cdd:PLN02765 297 AALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQ 375

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 377 LQLFeelRRLAPITSDPTEAA---AVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAV-----TRNP------ 442
Cdd:PLN02765 376 DLYF---KKTVKYVGEPMSHLesiASSAVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVviprlKTNQlkwsft 452

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568960835 443 --QTARQAHLYRGIFPVLCK---DAVLNAWAEDVDLRVnlAMDVGKARGFFKKGDVVIV 496
Cdd:PLN02765 453 gaFQARQCLIVRGLFPMLADprhSAESTSATNESVLKV--ALDHGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 4-502 2.84e-90

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 287.59  E-value: 2.84e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835   4 EAQTQRTKGLQEPCRSHTVKQGLPSFRPSSSMQPWLTPSWNTCAA-WTLTLPPSRPATL-------ASfvplyHAETIKN 75
Cdd:PLN02623  83 EDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMiWKLAEAGMNVARLnmshgdhAS-----HQKVIDL 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  76 VREATESFASDPIlyrpvAVALDTKGPEIRTGLIKgsgtAEVELKKGATLKITLDNAY-MEKCdeniLWLDYKNICKVVE 154
Cdd:PLN02623 158 VKEYNAQSKDNVI-----AIMLDTKGPEVRSGDLP----QPIMLEEGQEFTFTIKRGVsTEDC----VSVNYDDFVNDVE 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 155 VGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAA 234
Cdd:PLN02623 225 VGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQ 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 235 DVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQ 314
Cdd:PLN02623 305 VVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATN 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 315 MLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPT 394
Cdd:PLN02623 385 MLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEM 464

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 395 EAAAVGAVEASFkccSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKdavlnaWAEDVDLR 474
Cdd:PLN02623 465 FAFHATMMANTL---GTSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQ------FSDDAEET 535

                        490       500
                 ....*....|....*....|....*....
gi 568960835 475 VNLAMDVGKARGFFKKGD-VVIVLTGWRP 502
Cdd:PLN02623 536 FARALSLLLNKGMVKEGEeVALVQSGRQP 564
PRK06739 PRK06739
pyruvate kinase; Validated
 98-371 1.73e-82

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 260.26  E-value: 1.73e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  98 DTKGPEIRTGLIKGSgtaEVELKKGATLKITLDNAYMEKCDENIlwlDYKNICKVVEVGSKIYVDDGLISLQVKEKGADF 177
Cdd:PRK06739  61 DVQGPKIRLGEIKGE---QITLQAGDSFILHTQPVTGSSTEASV---DYEGIANDVKVGSRILMNDGEVELIVEKVSTDK 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 178 LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNI-KIISKI 256
Cdd:PRK06739 135 IETKVKTGGNISSHKGVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKI 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 257 ENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANA 336
Cdd:PRK06739 215 ETMEAIENFQDICKEADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQA 294

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568960835 337 VLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE 371
Cdd:PRK06739 295 VLDGTNAVMLSAESASGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 68-516 4.18e-67

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 224.62  E-value: 4.18e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  68 YHAETIKNVREATES--FAsdpilyrpVAVALDTKGPEIRTGLIKGSGTAEVElkKGATLKITLdNAYMEKCDENILWLD 145
Cdd:PLN02762  65 WHRDVIRRVRRLNEEkgFA--------VAVMMDTEGSEIHMGDLGGASSAKAE--DGEEWTFTV-RKFDGSRPEFTIQVN 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 146 YKNICKVVEVGSKIYVDDGLISLQVKEK-GADFLVTEVENG-------------GSLGSKKGVNLPgaavdlpAVSEKDI 211
Cdd:PLN02762 134 YDGFAEDVKVGDELVVDGGMVRFEVIEKiGPDVKCKCTDPGlllpranltfwrdGSLVRERNAMLP-------TISSKDW 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 212 QDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKN--IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAE 289
Cdd:PLN02762 207 LDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLE 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 290 KVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAV--------R 361
Cdd:PLN02762 287 QVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSGESAMGLYPEKALsvlrsvslR 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 362 MQHLIAREAEAAIYHLQlfeelrRLAPITSDPTeaaavgaveaSFKCCSG-----------AIIVLTKSGRSAHQVARYR 430
Cdd:PLN02762 367 MELWSREEKRHEALELP------QLSSSLSDRI----------SEEICNSaakmannlgvdAIFVYTKHGHMASLLSRNR 430

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 431 PRAPIIAVTRNPQTARQAHLYRGIFPVLCkdavlnAWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPgSGFTNTM 510
Cdd:PLN02762 431 PDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSDDMESNLNKTFSLLKARGMIKSGDLVIAVSDLTP-SSMLQSI 503


                 ....*.
gi 568960835 511 RVVPVP 516
Cdd:PLN02762 504 QVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 73-363 6.52e-45

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 164.80  E-value: 6.52e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  73 IKNVREATESFAsdpilyRPVAVALDTKGPEIRTGLIKGsGTAEVELKKGATLKITLDNAyMEKCDENILWLDykniCKV 152
Cdd:PRK08187 179 IGHLRQAERATG------RRCKILMDLAGPKIRTGAVAG-PLGKTRLYTGDRLALVAQGP-PRRIDEEHFQVT----CTL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 153 ------VEVGSKIYVDDGLISLQVKEKGADFLVTEV----ENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQdV 222
Cdd:PRK08187 247 peilarLAVGARVWIDDGKLGARVERVGPGGALLEVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARH-A 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 223 DMVFASFIRKAADVHEVRKVLGEKGKN----IKIISKIENHEGVRRFDEILEASDG-----IMVARGDLGIEIPAEKVFL 293
Cdd:PRK08187 326 DLVGYSFVQSPGDVEALQAALAARRPDdwrkLGLVLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAE 405

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960835 294 AQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAvlDGADCIMLSgetaKGDYPLEAV--------RMQ 363
Cdd:PRK08187 406 MQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--ARAECVMLN----KGPYLVEAVtflddllaRMD 477
PRK14725 PRK14725
pyruvate kinase; Provisional
 153-387 6.52e-42

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 158.19  E-value: 6.52e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 153 VEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSK----KGVNLPGAAVDLPAVSEKDIQDLKFGVEQdVDMVFAS 228
Cdd:PRK14725 373 ARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALS 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 229 FIRKAADVHEVRKVLGE-KGKNIKIISKIENHEGVRRFDEI-LEA----SDGIMVARGDLGIEIPAEKVFLAQKMMIGRC 302
Cdd:PRK14725 452 FVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRIlLEAmrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLC 531

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 303 NRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLdgADCIMLSgetaKGDYPLEAVRMQHLIAREAEAaiYHLQLFEE 382
Cdd:PRK14725 532 EAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE--HQRKKRSL 603


                 ....*
gi 568960835 383 LRRLA 387
Cdd:PRK14725 604 LRRLR 608
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
301-515 1.26e-40

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 148.89  E-value: 1.26e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 301 RCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 380
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835 381 EElRRLAPITSDPTeaaavgavEASFKCCS-------GAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRG 453
Cdd:COG3848   81 VP-RAKESSTTITD--------AISHAVATtaadlgaAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWG 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568960835 454 IFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVI----VLTGwrpGSGFTNTMRVVPV 515
Cdd:COG3848  152 VYPLLVEE------SASTDEMFAVAVALALEAGLVKDGDLVVitagVPVG---VSGTTNLLKVHVV 208
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 412-513 3.90e-37

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 132.60  E-value: 3.90e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960835  412 AIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKG 491
Cdd:pfam02887  18 AIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEMLRRAVKVAKEAGLVKKG 91

                          90       100
                  ....*....|....*....|...
gi 568960835  492 DVVIVLTGWRPG-SGFTNTMRVV 513
Cdd:pfam02887  92 DLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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