extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar proteins; LYPD2 is a lymphocyte antigen-6 family protein. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568993155  22 ALQCYTCANPVSASNCVTTTHCHINETMCKTTLYSLEIVFPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNSDLCN 100
Cdd:cd23620    1 ALRCYVCPEPTSASDCVTITTCHTNETMCKTTLYSREIVYPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNTDLCN 79

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar proteins; LYPD2 is a lymphocyte antigen-6 family protein. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568993155  22 ALQCYTCANPVSASNCVTTTHCHINETMCKTTLYSLEIVFPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNSDLCN 100
Cdd:cd23620    1 ALRCYVCPEPTSASDCVTITTCHTNETMCKTTLYSREIVYPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNTDLCN 79

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993155   25 CYTCANpVSASNCVTTTHCHINETMCKTTlySLEIVFPFLGDSTVTKSCA-SKCEPSDVDGIGQTRP---VSCCNSDLCN 100
Cdd:pfam00021   1 CYSCLG-VSNEDCLSEVTCPLSDGQCVTT--TLELPEGNLRGTVVSKGCArSSCPRLLSDFINGGIIsvsESCCQSDLCN 77

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar proteins; LYPD2 is a lymphocyte antigen-6 family protein. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568993155  22 ALQCYTCANPVSASNCVTTTHCHINETMCKTTLYSLEIVFPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNSDLCN 100
Cdd:cd23620    1 ALRCYVCPEPTSASDCVTITTCHTNETMCKTTLYSREIVYPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNTDLCN 79

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993155  22 ALQCYTCANPVSASNCVTTTHCHINETMCKTTLYSLEIVFPFLgdSTVTKSCASKCEPSDVDGIGQTRPVSCCNSDLCNV 101
Cdd:cd23575    2 SLKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSL--TTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNV 79

                 ....
gi 568993155 102 DGAP 105
Cdd:cd23575   80 SGAQ 83

extracellular domain (ECD) found in secreted Ly-6/uPAR-related protein 1 (SLURP-1) and similar proteins; SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. SLURP-1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568993155  23 LQCYTCANPVSASNCVTTTHCHINETMCKTTLYSLEIVFPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNSDLCN 100
Cdd:cd23619    1 LKCYTCKEPMTSASCRTITRCKPEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCN 78

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993155  17 GELAMALQCYTCanpVSASNCVTTTHCHINETMCKTTLYSleivfPFLGDSTVTKSCASKCepSDVDGIGQTRPVSCCNS 96
Cdd:cd23552    1 GSSAQALKCHEC---KGIEDCYNPTSCNNQSRYCLTTWYT-----PPGEKTTVTKSCAYTC--PDAPESLANSKASCCNT 70

                 ....
gi 568993155  97 DLCN 100
Cdd:cd23552   71 DLCN 74

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993155    23 LQCYTCANPvSASNCVTTTHCHINETMCKTTLYSLEIVFpflGDSTVTKSCA--SKCEPSDVDGIGQTR---PVSCCNSD 97
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVISDS---RGSVVYKGCAtsPICPGSHGYEINLTIaflKVSCCQTD 76

                   ....
gi 568993155    98 LCNV 101
Cdd:smart00134  77 LCNA 80

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993155  23 LQCYTC---ANPVSASNCVTTTHCHINETMCKTTLYSLEIvfpflGDSTVTKSCASKCEPSDVD-----GIGQTRPVSCC 94
Cdd:cd00117    1 LKCYQCnssNDPNCCNSSPTLVTCSSPETFCRKIVGKVGG-----GETLVIRGCATECECGCTEccsgtGTSGTTCTSCC 75

                 ....*.
gi 568993155  95 NSDLCN 100
Cdd:cd00117   76 DTDLCN 81

extracellular domain (ECD) found in Danio rerio lymphocyte antigen 6 family member PGE (Ly6PGE) and similar proteins; Ly6PGE is an uncharacterized Ly-6/uPAR family protein. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993155  23 LQCYTCANPVSASNCVTTTHCHINETMCKTTLYSLEivfpflGDSTVTKSCASK--CEPSDVDGIGQTRP---VSCCNSD 97
Cdd:cd23553    1 LKCYQCVGSEDDCNKQKSVVCPSSHDRCITVTGRNE------GKTTVTKSCSYKsfCDQASESCSLVKREgcnVSCCDSD 74

                 ...
gi 568993155  98 LCN 100
Cdd:cd23553   75 GCN 77

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993155  23 LQCYTCANPVSasNCVTTTHCHINETMCKTTLYSleivfpflgdSTVTKSC--ASKCepsDVDGIGQTRPVS-----CCN 95
Cdd:cd23554    1 LKCYNCPNPTS--NCNTNVTCSSNLDACLIVKAG----------NRIYRQCwkYSDC---NFDFISERFGESnfkyrCCQ 65

                 ....*
gi 568993155  96 SDLCN 100
Cdd:cd23554   66 KDLCN 70