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Conserved domains on  [gi|568957282|ref|XP_006531293|]
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sulfotransferase family 5A, member 1 isoform X1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-283 1.34e-95

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 282.31  E-value: 1.34e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282   36 DTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNLPT---WARVPWIEQISFD-------SLHSKRNTSWPRLFTSHLN 105
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDtyfdvaeGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  106 AKGLSPALMKSKAKVVYMARNPKDVLVSFFHFHRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKGWLSLQKDLTLFF 185
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  186 VTYEELHQEPRSTIRKLSEFLGRPLGPKEEDIILEHSSFSFMSQSNIVNYSLLSKEIidqseGKFFRKGVVGNWREYFTP 265
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 568957282  266 ELNEKFNAVYQSKMGDSG 283
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-283 1.34e-95

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 282.31  E-value: 1.34e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282   36 DTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNLPT---WARVPWIEQISFD-------SLHSKRNTSWPRLFTSHLN 105
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDtyfdvaeGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  106 AKGLSPALMKSKAKVVYMARNPKDVLVSFFHFHRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKGWLSLQKDLTLFF 185
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  186 VTYEELHQEPRSTIRKLSEFLGRPLGPKEEDIILEHSSFSFMSQSNIVNYSLLSKEIidqseGKFFRKGVVGNWREYFTP 265
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 568957282  266 ELNEKFNAVYQSKMGDSG 283
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 32-284 3.06e-27

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 108.47  E-value: 3.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  32 FQFQDTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNlPTWAR-----VPWIEqISF------DSLHSKRNTswprLF 100
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIE-IDFpffpsvDVLKDKGNT----LF 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282 101 TSHLNAKGLSPALMKSKAKVVYMARNPKDVLVSFFHF-HRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKG-WLSLQ 178
Cdd:PLN02164 149 STHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQ 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282 179 KDLT-LFFVTYEELHQEPRSTIRKLSEFLGRPLGPKEEDIILEHSSFSFMSQSNIVNYSLLSKEIIDQ------SEGKFF 251
Cdd:PLN02164 229 ENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEKGVVEKVVKLCSFETLKNLEANKGEKDREdrpavyANSAYF 308

                        250       260       270
                 ....*....|....*....|....*....|...
gi 568957282 252 RKGVVGNWREYFTPELNEKFNAVYQSKMGDSGL 284
Cdd:PLN02164 309 RKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
135-220 8.67e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 36.91  E-value: 8.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282 135 FHFHRIAGFLPNPSSFEDFVDEFLEGTGffgswfdhvkgwlslqkdLTLFFVTYEELHQEPRSTIRKLSEFLGRPLGPKE 214
Cdd:COG4424  146 YDAEEIARLLEALQDFEARWEAWFARTG------------------ITPLEITYEDLAADPVEVLNRVLDFLGVDPPLAP 207


                 ....*.
gi 568957282 215 EDIILE 220
Cdd:COG4424  208 LRPALK 213
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-283 1.34e-95

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 282.31  E-value: 1.34e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282   36 DTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNLPT---WARVPWIEQISFD-------SLHSKRNTSWPRLFTSHLN 105
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDtyfdvaeGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  106 AKGLSPALMKSKAKVVYMARNPKDVLVSFFHFHRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKGWLSLQKDLTLFF 185
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  186 VTYEELHQEPRSTIRKLSEFLGRPLGPKEEDIILEHSSFSFMSQSNIVNYSLLSKEIidqseGKFFRKGVVGNWREYFTP 265
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 568957282  266 ELNEKFNAVYQSKMGDSG 283
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 32-284 3.06e-27

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 108.47  E-value: 3.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  32 FQFQDTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNlPTWAR-----VPWIEqISF------DSLHSKRNTswprLF 100
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIE-IDFpffpsvDVLKDKGNT----LF 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282 101 TSHLNAKGLSPALMKSKAKVVYMARNPKDVLVSFFHF-HRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKG-WLSLQ 178
Cdd:PLN02164 149 STHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQ 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282 179 KDLT-LFFVTYEELHQEPRSTIRKLSEFLGRPLGPKEEDIILEHSSFSFMSQSNIVNYSLLSKEIIDQ------SEGKFF 251
Cdd:PLN02164 229 ENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEKGVVEKVVKLCSFETLKNLEANKGEKDREdrpavyANSAYF 308

                        250       260       270
                 ....*....|....*....|....*....|...
gi 568957282 252 RKGVVGNWREYFTPELNEKFNAVYQSKMGDSGL 284
Cdd:PLN02164 309 RKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
39-210 1.57e-10

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 58.84  E-value: 1.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282   39 ILLVTFPKSGTTWMQQVLSL---IFCEGHLWPIHnlptwARVPWIEQISFDSLHSKRNT-SWPRLFTSHL--NAKGLsPA 112
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAhpdVRPPEETWFVI-----PRILALLQAWGKSLEALARVpSYARWLCDKSpsHLFHL-DL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282  113 LMK--SKAKVVYMARNPKDVLV-SFFHFHRIAGflpnpssfEDFVDEFLEGTGFFGS-WFDHVKGWLSLQKDL---TLFF 185
Cdd:pfam13469  75 LLKafPDAKFIHLHRDPVDTVIsSYCSLFGFTL--------SSYSTAFLRDIGLALArWSRAYERLMAARARVppgRFLD 146

                         170       180
                  ....*....|....*....|....*
gi 568957282  186 VTYEELHQEPRSTIRKLSEFLGRPL 210
Cdd:pfam13469 147 VRYEDLVADPEGTLRRILEFLGLPW 171
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
135-220 8.67e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 36.91  E-value: 8.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957282 135 FHFHRIAGFLPNPSSFEDFVDEFLEGTGffgswfdhvkgwlslqkdLTLFFVTYEELHQEPRSTIRKLSEFLGRPLGPKE 214
Cdd:COG4424  146 YDAEEIARLLEALQDFEARWEAWFARTG------------------ITPLEITYEDLAADPVEVLNRVLDFLGVDPPLAP 207


                 ....*.
gi 568957282 215 EDIILE 220
Cdd:COG4424  208 LRPALK 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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