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Conserved domains on  [gi|568971338|ref|XP_006532135|]
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voltage-dependent T-type calcium channel subunit alpha-1G isoform X7 [Mus musculus]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 3.69e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 221.76  E-value: 3.69e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568971338   897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1276-1548 9.33e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.71  E-value: 9.33e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1276 HKMFDHVVLVIIFLNCITIAMERPKIDPHSAErIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1355
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1356 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1435
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1436 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1515
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 568971338  1516 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1548
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1600-1841 1.86e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.39  E-value: 1.86e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1600 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1677
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1678 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1757
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1758 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1837
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 568971338  1838 AVLM 1841
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 1.73e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 156.27  E-value: 1.73e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338    80 NPWFERVSMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   238 rnrcflpenFSLplsvdlepyyqtenedespficsqpreNGMrscrsvptlrgeggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 568971338   397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
2088-2367 4.23e-06

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2088 QLPKDAHYLLQPHGAPTWGA-----IPKLPPPGRSPLAQRPlRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSS 2162
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAAAcdrfePPTGPPPGPGTEAPAN-ESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPT 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2163 FWGGS--------SIQVQQRSGSQSKVSKHirlPAPCPGLEPSWAKDPQETRSSleldtelswiSGDLLPSSQEEPLSPR 2234
Cdd:PHA03307  121 PPPASpppspapdLSEMLRPVGSPGPPPAA---SPPAAGASPAAVASDAASSRQ----------AALPLSSPEETARAPS 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2235 DLKKCYSVEAQSCRRRPGSwldeQRRHSIAvscldsgSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGP 2314
Cdd:PHA03307  188 SPPAEPPPSTPPAAASPRP----PRRSSPI-------SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECP 256
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568971338 2315 RPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTD 2367
Cdd:PHA03307  257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAP 309
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 3.69e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 221.76  E-value: 3.69e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568971338   897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1276-1548 9.33e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.71  E-value: 9.33e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1276 HKMFDHVVLVIIFLNCITIAMERPKIDPHSAErIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1355
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1356 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1435
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1436 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1515
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 568971338  1516 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1548
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1600-1841 1.86e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.39  E-value: 1.86e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1600 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1677
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1678 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1757
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1758 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1837
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 568971338  1838 AVLM 1841
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 1.73e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 156.27  E-value: 1.73e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338    80 NPWFERVSMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   238 rnrcflpenFSLplsvdlepyyqtenedespficsqpreNGMrscrsvptlrgeggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 568971338   397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
2088-2367 4.23e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2088 QLPKDAHYLLQPHGAPTWGA-----IPKLPPPGRSPLAQRPlRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSS 2162
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAAAcdrfePPTGPPPGPGTEAPAN-ESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPT 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2163 FWGGS--------SIQVQQRSGSQSKVSKHirlPAPCPGLEPSWAKDPQETRSSleldtelswiSGDLLPSSQEEPLSPR 2234
Cdd:PHA03307  121 PPPASpppspapdLSEMLRPVGSPGPPPAA---SPPAAGASPAAVASDAASSRQ----------AALPLSSPEETARAPS 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2235 DLKKCYSVEAQSCRRRPGSwldeQRRHSIAvscldsgSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGP 2314
Cdd:PHA03307  188 SPPAEPPPSTPPAAASPRP----PRRSSPI-------SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECP 256
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568971338 2315 RPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTD 2367
Cdd:PHA03307  257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAP 309
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 3.69e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 221.76  E-value: 3.69e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568971338   897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1276-1548 9.33e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.71  E-value: 9.33e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1276 HKMFDHVVLVIIFLNCITIAMERPKIDPHSAErIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1355
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1356 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1435
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1436 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1515
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 568971338  1516 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1548
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1600-1841 1.86e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.39  E-value: 1.86e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1600 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1677
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1678 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1757
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1758 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1837
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 568971338  1838 AVLM 1841
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 1.73e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 156.27  E-value: 1.73e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338    80 NPWFERVSMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   238 rnrcflpenFSLplsvdlepyyqtenedespficsqpreNGMrscrsvptlrgeggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 568971338   397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1635-1846 1.46e-07

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 54.59  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1635 ICNYIFTVIFVLESVFKLVAFGfRRFFQDRWNQLDLAIVLLSIMGITL---EEIEVNA---SLPINP------------- 1695
Cdd:pfam08016   15 IVFVVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVLIVLniyRDFLADRlikSVEASPvtfidfdrvaqld 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338  1696 TIIRIMR----VLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGdlecdeTHpceglgr 1771
Cdd:pfam08016   94 NLYRIILaflvFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG------TQ------- 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568971338  1772 HATFRNFGMAFLTLFRVSTGD-NWNGIMKDtlrdcdqestcyNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEE 1846
Cdd:pfam08016  161 APNFSNFVKSILTLFRTILGDfGYNEIFSG------------NRVLGPLLFLTFVFLVIFILLNLFLAIINDSYVE 224
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
2088-2367 4.23e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2088 QLPKDAHYLLQPHGAPTWGA-----IPKLPPPGRSPLAQRPlRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSS 2162
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAAAcdrfePPTGPPPGPGTEAPAN-ESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPT 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2163 FWGGS--------SIQVQQRSGSQSKVSKHirlPAPCPGLEPSWAKDPQETRSSleldtelswiSGDLLPSSQEEPLSPR 2234
Cdd:PHA03307  121 PPPASpppspapdLSEMLRPVGSPGPPPAA---SPPAAGASPAAVASDAASSRQ----------AALPLSSPEETARAPS 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2235 DLKKCYSVEAQSCRRRPGSwldeQRRHSIAvscldsgSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGP 2314
Cdd:PHA03307  188 SPPAEPPPSTPPAAASPRP----PRRSSPI-------SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECP 256
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568971338 2315 RPPCSPGVCLRRRAPASDSKDPSASSPLDSTAASPSPKKDALSLSGLSSDPTD 2367
Cdd:PHA03307  257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAP 309
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1867-2370 1.80e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 1867 TLSPQPHSPL-GSPFLWPGVEGV---NSPDSPKPGAPHTTAHIGAASSGFSLEHPTDRQLFDTISLLIQgSLEGELKLMD 1942
Cdd:PHA03307   27 TPGDAADDLLsGSQGQLVSDSAElaaVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTL-APASPAREGS 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 1943 ELAGPGGQPSAFPSAPSPGDSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDS---LPDDTHTLLLSALESNMVPHTEEG 2019
Cdd:PHA03307  106 PTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASpaaVASDAASSRQAALPLSSPEETARA 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2020 PVPLGPDLlTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSIlSVHSQPADTscilqlpkdahyllqp 2099
Cdd:PHA03307  186 PSSPPAEP-PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD-SSSSESSGC---------------- 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2100 hgapTWGAIPKLPPPGRSPLAQRPLRRQAAIrtdsldvqglgsredllSEVSGPSCPLTRSSSFWGGSSiqvqqrsgsqs 2179
Cdd:PHA03307  248 ----GWGPENECPLPRPAPITLPTRIWEASG-----------------WNGPSSRPGPASSSSSPRERS----------- 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2180 kvskhirlPAPCPGLEPSWAKDPQETRSSleldtELSWISGDLLPSSQEEPLSPRDlkkCYSVEAQSCRRRPGSwldeqr 2259
Cdd:PHA03307  296 --------PSPSPSSPGSGPAPSSPRASS-----SSSSSRESSSSSTSSSSESSRG---AAVSPGPSPSRSPSP------ 353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2260 rhsiavsclDSGSQPRLCPSPSSlggqplggpgsRPKKKLSPPSISIDPPESQGPRppcspgvclRRRAPASDSKDPSAS 2339
Cdd:PHA03307  354 ---------SRPPPPADPSSPRK-----------RPRPSRAPSSPAASAGRPTRRR---------ARAAVAGRARRRDAT 404
                         490       500       510
                  ....*....|....*....|....*....|.
gi 568971338 2340 SPLDSTAASPSPKKDALSLSGLSSDPTDLDP 2370
Cdd:PHA03307  405 GRFPAGRPRPSPLDAGAASGAFYARYPLLTP 435
PHA03247 PHA03247
large tegument protein UL36; Provisional
1951-2366 2.05e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 1951 PSAFPSAPSPGDSDPQIPLAEMEALSLTSEIvsepscslaLTDDSLPDDTHTLLLS---ALESNMVPHTEEGPVPLGPDL 2027
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAI---------LPDEPVGEPVHPRMLTwirGLEELASDDAGDPPPPLPPAA 2559
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2028 LTVrksgvSRTHSLPNDSYMCRNGSTAERSLGHRgwglPkaqsgsilSVHSQPADTSCILQLPKDAHYLLQPHGAPTWGA 2107
Cdd:PHA03247 2560 PPA-----APDRSVPPPRPAPRPSEPAVTSRARR----P--------DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH 2622
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2108 IPKLPPPGRSPLAQRPLRRQ--AAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSqskVSKHI 2185
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPppTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS---LTSLA 2699
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2186 RLPAPCPGLEPSwakdPQETRSSLELDTELSWISGD--------LLPSSQEEPLSPRDLKKCYSVEAQSCRRRPGSWLDE 2257
Cdd:PHA03247 2700 DPPPPPPTPEPA----PHALVSATPLPPGPAAARQAspalpaapAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338 2258 ----QRRHSIAVSCLDSGSQPRLcPSPSS--------LGGQPLGGPGSRPKKKLSPPSISID--PPESQGPRPP------ 2317
Cdd:PHA03247 2776 aagpPRRLTRPAVASLSESRESL-PSPWDpadppaavLAPAAALPPAASPAGPLPPPTSAQPtaPPPPPGPPPPslplgg 2854
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568971338 2318 -CSPGVCLRRRAPASDSKDPSASSP------LDSTAASPSPKKDALSLSGLSSDPT 2366
Cdd:PHA03247 2855 sVAPGGDVRRRPPSRSPAAKPAAPArppvrrLARPAVSRSTESFALPPDQPERPPQ 2910
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
838-967 3.57e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.49  E-value: 3.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971338   838 LMRVLKLVRFlpalQRQLVVLMKTM----DNVATFCMLLMLFIFIFSILGMHLFGCKFAserdgdtlpdrkNFDSLLWAI 913
Cdd:pfam08016  108 WLKLFKVLRF----NKTMSLFTKTLsrawKDLAGFALMFVIFFFAYAQFGYLLFGTQAP------------NFSNFVKSI 171
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568971338   914 VTVFQILtqedWNKVLYNGMASTSSW-AALYFIALMTFGNYVLFNLLVAILVEGF 967
Cdd:pfam08016  172 LTLFRTI----LGDFGYNEIFSGNRVlGPLLFLTFVFLVIFILLNLFLAIINDSY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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