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Conserved domains on  [gi|568935108|ref|XP_006534748|]
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volume-regulated anion channel subunit LRRC8C isoform X1 [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 590.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108    1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAvISTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108   81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQSGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 568935108  313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 5.67e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 5.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568935108 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 6.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 6.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCVHNDgtKLVMLNNLKK 587
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568935108 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 590.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108    1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAvISTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108   81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQSGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 568935108  313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 5.67e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 5.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568935108 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 4.83e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 4.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELclhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 516
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 517 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCVHNDGTKLVMLNNLKKMTNLTE 593
Cdd:PLN00113 287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 594 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 648
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 649 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 726
Cdd:PLN00113 441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568935108 727 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 777
Cdd:PLN00113 521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 578-764 1.29e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 578 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 657
Cdd:cd21340   13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 658 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 737
Cdd:cd21340   88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 568935108 738 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 764
Cdd:cd21340  151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
589-649 1.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568935108  589 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 649
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 6.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 6.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCVHNDgtKLVMLNNLKK 587
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568935108 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-665 6.10e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 503
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  504 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 560
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  561 VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 638
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 568935108  639 LTVLKLWYNSIAYIPEHIKKLTSLERL 665
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 590.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108    1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAvISTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108   81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSGTIQSGPEGNLVRSQSLKSIPEKFVVD-KSAAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 568935108  313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 5.67e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 5.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568935108 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-779 1.74e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 1.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 515 NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTEL 594
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 595 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEV 674
Cdd:COG4886   81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 754
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 568935108 755 SYLDIKGNHFEVLpPELGDCRALKR 779
Cdd:COG4886  231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
510-771 2.28e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.72  E-value: 2.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 510 MYGLRNLEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKIPqavvdvsshlqkmcvhndgtklvmlNNLKKM 588
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDLP-------------------------EPLGNL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 589 TNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFS 668
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 669 HNKVEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKI 748
Cdd:COG4886  237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        250       260
                 ....*....|....*....|...
gi 568935108 749 GNLLFLSYLDIKGNHFEVLPPEL 771
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-758 7.27e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 7.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 356 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 435
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 436 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 515
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 516 LEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcvhndgtklvmlnnLKKMTNLTEL 594
Cdd:COG4886  161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWYNSIAYIPEhIKKLTSLERLFFSHNKVEV 674
Cdd:COG4886  211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 675 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 753
Cdd:COG4886  287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                 ....*
gi 568935108 754 LSYLD 758
Cdd:COG4886  367 LTLGL 371
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 4.83e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 4.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELclhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 516
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 517 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCVHNDGTKLVMLNNLKKMTNLTE 593
Cdd:PLN00113 287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 594 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 648
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 649 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 726
Cdd:PLN00113 441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568935108 727 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 777
Cdd:PLN00113 521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 543-795 8.60e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 8.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 543 SLKILSIKSNV--SKIPQAVVDVSShLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 619
Cdd:PLN00113 165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 620 KENNLksIEEI-VSFQHLRKLTVLKLWYNSIA-YIPEHIKKLTSLERLFFSHNKVE-VLPSHLFLCNKIRYLDLSYNDIR 696
Cdd:PLN00113 244 VYNNL--TGPIpSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 697 -FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDIKgnhfev 766
Cdd:PLN00113 322 gKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------ 395

                        250       260
                 ....*....|....*....|....*....
gi 568935108 767 LPPELGDCRALKRAGLvVEDALFETLPSD 795
Cdd:PLN00113 396 IPKSLGACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 578-764 1.29e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 578 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 657
Cdd:cd21340   13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 658 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 737
Cdd:cd21340   88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 568935108 738 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 764
Cdd:cd21340  151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
589-649 1.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568935108  589 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 649
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
581-801 4.58e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 581 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIeeivsfqhlrkltvlklwynsiayiPEHIKklT 660
Cdd:PRK15370 172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSL-------------------------PENLQ--G 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 661 SLERLFFSHNKVEVLPSHLflCNKIRYLDLSYNDIRFIPPEIGvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 740
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATL--PDTIQEMELSINRITELPERLP--SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568935108 741 LSVLSPKIGNllFLSYLDIKGNHFEVLPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 801
Cdd:PRK15370 295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 603-778 7.55e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 7.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 603 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIA-YIPEhiKKLTSLERLFFSHNKVE-VLPSHLF 680
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 681 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 757
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 568935108 758 DIKGNHFE-VLPPELGDCRALK 778
Cdd:PLN00113 242 DLVYNNLTgPIPSSLGNLKNLQ 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 513-687 2.25e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 513 LRNLEELYLvgslSH-DISKnvtLESLRDLKSLKILSIKSNvskipqavvdvsshlqkmcvhndgtKLVMLNNLKKMTNL 591
Cdd:cd21340   45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKLYLGGN-------------------------RISVVEGLENLTNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 592 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:cd21340   93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPS 169

                        170       180
                 ....*....|....*....|....*.
gi 568935108 662 LERLFFSHNKVevlpshlflCNKIRY 687
Cdd:cd21340  170 LRELDLTGNPV---------CKKPKY 186
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 582-743 4.17e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 4.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 582 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWYNSI-----AYIP 653
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 654 EHIKKLTSLERLFFSHNKVEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 717
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                        170       180
                 ....*....|....*....|....*.
gi 568935108 718 VESLPDELYFCKKLKTLKIGKNSLSV 743
Cdd:COG5238  337 AIALAKALQENTTLHSLDLSDNQIGD 362
LRR_8 pfam13855
Leucine rich repeat;
613-672 1.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568935108  613 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSIAYI-PEHIKKLTSLERLFFSHNKV 672
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
706-764 7.75e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 7.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568935108  706 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDIKGNHF 764
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 590-695 8.16e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 8.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 590 NLTELELVHCDL-----ERIPHAVFSLLSLQELDLKENNLKS--IEEI-VSFQHLRKLTVLKLWYNSI-----AYIPEHI 656
Cdd:cd00116  138 ALEKLVLGRNRLegascEALAKALRANRDLKELNLANNGIGDagIRALaEGLKANCNLEVLDLNNNGLtdegaSALAETL 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568935108 657 KKLTSLERLFFSHNKV------EVLPSHLFLCNKIRYLDLSYNDI 695
Cdd:cd00116  218 ASLKSLEVLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDI 262
PLN03150 PLN03150
hypothetical protein; Provisional
 604-670 8.69e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 8.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568935108 604 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWYNSI-AYIPEHIKKLTSLERLFFSHN 670
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGN 500
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 6.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 6.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCVHNDgtKLVMLNNLKK 587
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568935108 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-665 6.10e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 503
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  504 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 560
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935108  561 VDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 638
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 568935108  639 LTVLKLWYNSIAYIPEHIKKLTSLERL 665
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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