NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|751466140|ref|XP_011188089|]
View 

axin isoform X1 [Zeugodacus cucurbitae]

Protein Classification

Axin_b-cat_bind and DIX domain-containing protein( domain architecture ID 10246770)

protein containing domains RGS, Axin_b-cat_bind, and DIX

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 54-168 1.08e-43

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08707:

Pssm-ID: 470619  Cd Length: 117  Bit Score: 153.00  E-value: 1.08e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  54 LNHLLEDRDGVELFKKYVEDEAPGynDHLNFYFACEGLKQQTD-PEKIKQIIGAIYRFLRKSQLSIPEDLRRIIKAGLKN 132
Cdd:cd08707    1 LHSLLDDQDGIELFRTYLEQEGCA--DLLDFWFACNGFRKMSDsEEKRSKLAKAIYRRYIKDNGIVSRQLKPATKSFIKE 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 751466140 133 EV---PLNANIYDSMQQYVEATIRDNIYPSFLCSEMYIL 168
Cdd:cd08707   79 CIkkqQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 655-731 3.08e-33

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


:

Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 3.08e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751466140  655 TTTVVFSFCDEEYPYRTKI--PGSQPTLKQFKDYLPKKGNFRFFFKThcEDPESPVIQEEIVNDSDILPLFEGKVMGLV 731
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIKIhkPGGQITLGDFKELLPKKGNYRYFFKT--LDPEFGTVKEEITDDDDILPLWEGKIVAKV 77
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 484-519 1.85e-08

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


:

Pssm-ID: 462616  Cd Length: 35  Bit Score: 50.39  E-value: 1.85e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 751466140  484 DNDQDILDQHVSRVWKDqTPHRSPGTMSPCPPLPTR 519
Cdd:pfam08833   1 DNPQSILDEHVSRVWKT-PGCQSPGRHSPRSRSPDS 35
 
Name Accession Description Interval E-value
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
 54-168 1.08e-43

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


Pssm-ID: 188662  Cd Length: 117  Bit Score: 153.00  E-value: 1.08e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  54 LNHLLEDRDGVELFKKYVEDEAPGynDHLNFYFACEGLKQQTD-PEKIKQIIGAIYRFLRKSQLSIPEDLRRIIKAGLKN 132
Cdd:cd08707    1 LHSLLDDQDGIELFRTYLEQEGCA--DLLDFWFACNGFRKMSDsEEKRSKLAKAIYRRYIKDNGIVSRQLKPATKSFIKE 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 751466140 133 EV---PLNANIYDSMQQYVEATIRDNIYPSFLCSEMYIL 168
Cdd:cd08707   79 CIkkqQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 655-731 3.08e-33

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 3.08e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751466140  655 TTTVVFSFCDEEYPYRTKI--PGSQPTLKQFKDYLPKKGNFRFFFKThcEDPESPVIQEEIVNDSDILPLFEGKVMGLV 731
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIKIhkPGGQITLGDFKELLPKKGNYRYFFKT--LDPEFGTVKEEITDDDDILPLWEGKIVAKV 77
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 53-169 3.82e-20

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 86.55  E-value: 3.82e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140    53 TLNHLLEDRDGVELFKKYVEDEAPGynDHLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLRKS---QLSIPEDLRRIIKA 128
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSE--ENLEFWLAVEEFKKAEDDEERIAKAREIYdKFLSPNapkEVNLDSDLREKIEE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 751466140   129 GLKNEVPlNANIYDSMQQYVEATIRDNIYPSFLCSEMYILY 169
Cdd:smart00315  79 NLESEEP-PPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 54-166 2.99e-17

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 78.04  E-value: 2.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140   54 LNHLLEDRDGVELFKKYVEDEAPGynDHLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLR---KSQLSIPEDLRRIIKAG 129
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSE--ENLEFWLACEEFKKADPDEERLKKAKEIYnEFLApgsPKEINLDSDLREEIREN 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 751466140  130 LKNEVplNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:pfam00615  80 LEKEP--TRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
DAX smart00021
Domain present in Dishevelled and axin; Domain of unknown function.
 656-735 2.98e-15

Domain present in Dishevelled and axin; Domain of unknown function.


Pssm-ID: 197474  Cd Length: 83  Bit Score: 71.29  E-value: 2.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140   656 TTVVFSFCDEEYPYRTKIPG--SQPTLKQFKDYLPKKgNFRFFFKThcEDPESP-VIQEEIVNDSDILPLFEGKVMGLVK 732
Cdd:smart00021   4 TKVIYHLDDEETPYLVKVPVpaERVTLGDFKEVLTKK-NYKYYFKS--MDDDFGgVVKEEIRDDSARLPCFNGRVVSWLV 80


                   ...
gi 751466140   733 PSD 735
Cdd:smart00021  81 SVE 83
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 484-519 1.85e-08

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


Pssm-ID: 462616  Cd Length: 35  Bit Score: 50.39  E-value: 1.85e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 751466140  484 DNDQDILDQHVSRVWKDqTPHRSPGTMSPCPPLPTR 519
Cdd:pfam08833   1 DNPQSILDEHVSRVWKT-PGCQSPGRHSPRSRSPDS 35
 
Name Accession Description Interval E-value
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
 54-168 1.08e-43

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


Pssm-ID: 188662  Cd Length: 117  Bit Score: 153.00  E-value: 1.08e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  54 LNHLLEDRDGVELFKKYVEDEAPGynDHLNFYFACEGLKQQTD-PEKIKQIIGAIYRFLRKSQLSIPEDLRRIIKAGLKN 132
Cdd:cd08707    1 LHSLLDDQDGIELFRTYLEQEGCA--DLLDFWFACNGFRKMSDsEEKRSKLAKAIYRRYIKDNGIVSRQLKPATKSFIKE 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 751466140 133 EV---PLNANIYDSMQQYVEATIRDNIYPSFLCSEMYIL 168
Cdd:cd08707   79 CIkkqQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 655-731 3.08e-33

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 3.08e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751466140  655 TTTVVFSFCDEEYPYRTKI--PGSQPTLKQFKDYLPKKGNFRFFFKThcEDPESPVIQEEIVNDSDILPLFEGKVMGLV 731
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIKIhkPGGQITLGDFKELLPKKGNYRYFFKT--LDPEFGTVKEEITDDDDILPLWEGKIVAKV 77
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 53-169 3.82e-20

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 86.55  E-value: 3.82e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140    53 TLNHLLEDRDGVELFKKYVEDEAPGynDHLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLRKS---QLSIPEDLRRIIKA 128
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSE--ENLEFWLAVEEFKKAEDDEERIAKAREIYdKFLSPNapkEVNLDSDLREKIEE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 751466140   129 GLKNEVPlNANIYDSMQQYVEATIRDNIYPSFLCSEMYILY 169
Cdd:smart00315  79 NLESEEP-PPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 54-166 2.99e-17

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 78.04  E-value: 2.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140   54 LNHLLEDRDGVELFKKYVEDEAPGynDHLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLR---KSQLSIPEDLRRIIKAG 129
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSE--ENLEFWLACEEFKKADPDEERLKKAKEIYnEFLApgsPKEINLDSDLREEIREN 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 751466140  130 LKNEVplNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:pfam00615  80 LEKEP--TRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
DAX smart00021
Domain present in Dishevelled and axin; Domain of unknown function.
 656-735 2.98e-15

Domain present in Dishevelled and axin; Domain of unknown function.


Pssm-ID: 197474  Cd Length: 83  Bit Score: 71.29  E-value: 2.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140   656 TTVVFSFCDEEYPYRTKIPG--SQPTLKQFKDYLPKKgNFRFFFKThcEDPESP-VIQEEIVNDSDILPLFEGKVMGLVK 732
Cdd:smart00021   4 TKVIYHLDDEETPYLVKVPVpaERVTLGDFKEVLTKK-NYKYYFKS--MDDDFGgVVKEEIRDDSARLPCFNGRVVSWLV 80


                   ...
gi 751466140   733 PSD 735
Cdd:smart00021  81 SVE 83
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 58-166 1.86e-11

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 61.64  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  58 LEDRDGVELFKKYVEDEapgYNDH-LNFYFACEGLKQQT-DPEKIKQIIGAIYR-FLRKS---QLSIPEDLRRIIKAGLK 131
Cdd:cd07440    1 LRDPYGLEYFRQFLKSE---HCEEnLEFWLAVEKFKKTTsSDEELKSKAKEIYDkYISKDapkEINIPESIREEIEENLE 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 751466140 132 NEVPlNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd07440   78 EPYP-DPDCFDEAQEHILNLLEKDSYPRFLKSDLY 111
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 484-519 1.85e-08

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


Pssm-ID: 462616  Cd Length: 35  Bit Score: 50.39  E-value: 1.85e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 751466140  484 DNDQDILDQHVSRVWKDqTPHRSPGTMSPCPPLPTR 519
Cdd:pfam08833   1 DNPQSILDEHVSRVWKT-PGCQSPGRHSPRSRSPDS 35
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 54-166 3.21e-06

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 46.59  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  54 LNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLRKS---QLSIPEDLRRIIKAG 129
Cdd:cd08709    1 FDELLASKYGVAAFRAFLKSEFSEEN--IEFWLACEDFKKTKSPQKLTSKAKKIYtDFIEKEapkEINIDFQTKTLIAQN 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 751466140 130 LKNEvplNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08709   79 IQEA---TSGCFTAAQKRVYSLMENNSYPRFLESEFY 112
RGS_R7-like cd08705
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...
 50-166 4.78e-06

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.


Pssm-ID: 188660  Cd Length: 121  Bit Score: 46.08  E-value: 4.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  50 WARTLNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQtDPEKIKQIIGAIYR-FLRK---SQLSIPEDLRRI 125
Cdd:cd08705    5 WGFSFSELLKDPVGREQFLKFLEKEFSGEN--LRFWEACQDLKYG-PQSQVPEKVQEIYQeFLAPgapSWINIDSKTMEI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 751466140 126 IKAGLKNEvplNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08705   82 TLKNLKDP---HRYTFDAAQEHIYMLMKKDSYPRFLRSDIY 119
RGS_RGS19 cd08745
Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...
 50-166 5.31e-06

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .


Pssm-ID: 188699  Cd Length: 118  Bit Score: 46.20  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  50 WARTLNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTDPEKIKQIIGAIYR----FLRKSQLSIPEDLRRI 125
Cdd:cd08745    1 WAQSFDKLMKSPAGRNVFREFLRTEYSEEN--MLFWLACEELKAEANKHVIDEKARLIYEdyisILSPKEVSLDSRVREG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 751466140 126 IKAGLKNEvplNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08745   79 INRKMQEP---SSHTFDDAQLQIYTLMHRDSYPRFLNSPIY 116
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
 50-166 8.90e-06

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 45.53  E-value: 8.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  50 WARTLNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTDPEKIKQIIGAIYR----FLRKSQLSIPEDLRRI 125
Cdd:cd08718    1 WAQSFDKLMKSPAGRNVFREFLRTEYSEEN--MLFWLACEELKKEANKHVIEEKARLIYEdyisILSPKEVSLDSRVREV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 751466140 126 IKaglKNEVPLNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08718   79 IN---RNMLEPSPHTFDDAQLQIYTLMHRDSYPRFLNSAIY 116
RGS_RGS18 cd08712
Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator ...
 57-167 3.40e-05

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.


Pssm-ID: 188667  Cd Length: 114  Bit Score: 43.77  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  57 LLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLRKS---QLSIPEDLRRIIKAGLKN 132
Cdd:cd08712    4 LLSHKDGLEAFTRFLKTEFSEEN--IEFWIACEDYKKSKTPQQIHLKAKAIYeKFIQTDapkEVNLDFHTKEVTTNSIEQ 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 751466140 133 EVplnANIYDSMQQYVEATIRDNIYPSFLCSEMYI 167
Cdd:cd08712   82 PT---LTSFDAAQSRVYQLMEQDSYPRFLKSDIYL 113
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 54-166 5.72e-05

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 43.08  E-value: 5.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  54 LNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLrKSQLSIP---EDLRRIIKAG 129
Cdd:cd08706    1 FERLLQDPVGVKYFTEFLKKEFSEEN--ILFWQACEKFKKIPDKKQLVQEAREIYdTFL-SSKASSPvniDSQAQLAEEM 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 751466140 130 LKNEVPLnanIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08706   78 LEEPHPD---MFQKQQLQIFNLMKFDSYSRFLKSPLY 111
RGS_RGS5 cd08717
Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of ...
 54-166 7.74e-05

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.


Pssm-ID: 188672  Cd Length: 114  Bit Score: 42.67  E-value: 7.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  54 LNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTDPEKIKQIIGAIYRFLRKSQLSIPEDLRRIIKA-GLKN 132
Cdd:cd08717    1 LDKLLQNSYGLASFKSFLKSEFSEEN--IEFWEACEDYKKTKSPLKMATKAKKIYEEFIQTEAPKEVNIDHFTKDvTMKN 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 751466140 133 EVPLNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08717   79 LVEPSSSSFDLAQKRIFALMEKDSLPRFVRSEFY 112
RGS_RGS20 cd08746
Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...
 25-166 1.03e-04

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.


Pssm-ID: 188700 [Multi-domain]  Cd Length: 167  Bit Score: 43.44  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  25 EESRVKKM-----TEGVADSSRNSPPSYLN---WARTLNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTD 96
Cdd:cd08746   17 EDERNRRTsyefrAEGIPNCEESPKPTLEEvcaWGQSFDKLMLTPAGRNAFREFLRTEFSEEN--MLFWMACEELKKEAN 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 751466140  97 PEKIKQIIGAIYR----FLRKSQLSIPEDLRRIIKaglKNEVPLNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08746   95 KSVIEEKARIIYEdyisILSPKEVSLDSRVREVIN---RNMLEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIY 165
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 57-166 2.65e-04

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 41.20  E-value: 2.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  57 LLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQQTDPEKIKQIIGAIY-RFLrksQLSIPEDLRriIKAGLKNEVP 135
Cdd:cd08723    1 LLANQAGLDAFRTFLKSEFSEEN--VEFWLACEDFKKTKSSTEIALKAQMIYsEFI---QADAPKEIN--IDFHTRDLIS 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 751466140 136 LNA-----NIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08723   74 QNIseptlKCFDEAQSLIYCLMAKDSFPRFLKSEVY 109
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 46-117 4.24e-04

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 40.78  E-value: 4.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 751466140  46 SYLNWARTLNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQ--QTDPEKIKQIIGAIY-RFLRKSQLS 117
Cdd:cd08743    3 SVASWAVSFERLLQDPLGVEYFTEFLKKEFSAEN--VNFWKACERFQQipASDTQQLAQEARKIYnEFLSSSSQS 75
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
 57-166 7.83e-04

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 39.70  E-value: 7.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  57 LLEDRDGVELFKKYVEDEAPgyNDHLNFYFACEGLKQqTDPEKIKQIIGAI-YRFLRKSQLSIPED--LRRIIKAGL-KN 132
Cdd:cd08720    1 ILANVFGRKYLSQFLERMDS--QALIGFWEAVEELRS-ANKSEWHQLGAEIfYTFIVEPTAEIKVDksLRKRIEQFLlGD 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 751466140 133 EVPlnaNIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08720   78 KGP---EVFYEVQENVVETLEEKYYPSFVVSDQY 108
RGS_RGS11 cd08740
Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator ...
 50-166 2.05e-03

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS11 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS9, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS11 is expressed exclusively in retinal ON-bipolar neurons in which it forms complexes with G-beta-5 and R7AP (RGS7 anchor protein ) and plays crucial roles in processing the light responses of retinal neurons.


Pssm-ID: 188694  Cd Length: 126  Bit Score: 38.74  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751466140  50 WARTLNHLLEDRDGVELFKKYVEDEAPGYNdhLNFYFACEGLKQqTDPEKIKQIIGAIYR-FLRKSQ---LSIPEDLRRI 125
Cdd:cd08740    6 WGFSFRELLNDPVGRKEFLDFLEKEFSAEN--LSFWEACEELRY-GEQSKIPELVDSVYQqFLAPGAtrwVNIDSKTMER 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 751466140 126 IKAGLKNEvplNANIYDSMQQYVEATIRDNIYPSFLCSEMY 166
Cdd:cd08740   83 TLEGLKQP---HRYVLDDAQMHIYMLMKKDSYPRFLKSDLY 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH