|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
33-492 |
0e+00 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 626.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLNLCVCGALMRplspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqag 272
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 273 hrknmcalrilktvswltmrvrkgfedwysgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDV 352
Cdd:cd17429 179 -------------------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDK 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDL 432
Cdd:cd17429 222 FPLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYFSLMPVVTEDL 301
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 433 VGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQP 492
Cdd:cd17429 302 VGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLLKP 361
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
33-492 |
2.87e-113 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 339.53 E-value: 2.87e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLNLCVCGALMRplspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqag 272
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 273 hrknmcalrilktvswltmrvrkgfedwysgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQnDV 352
Cdd:cd17352 179 -------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDES-DA 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSG-YFSLMPVVTED 431
Cdd:cd17352 221 AFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGsYSSLTPVILAD 300
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917067 432 LVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQP 492
Cdd:cd17352 301 LVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
34-490 |
2.85e-65 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 215.45 E-value: 2.85e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAML 193
Cdd:cd17428 82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 194 IQGAVSLNLCVCGALMRplspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqagh 273
Cdd:cd17428 162 IVGALALNLLACGSLMR--------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 274 rknmcalrilktvswltmrvrkgfedwysgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVF 353
Cdd:cd17428 179 ------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALI 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 354 PLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDLV 433
Cdd:cd17428 223 PLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPYVTTKTV 302
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 767917067 434 GIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17428 303 GIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
24-490 |
3.90e-61 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 207.29 E-value: 3.90e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 24 PHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTA 103
Cdd:TIGR00892 8 EGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 104 IIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLC 183
Cdd:TIGR00892 88 IAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 184 AEYGWRNAMLIQGAVSLNLCVCGALMRPLSPGKNPNDPgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlQ 263
Cdd:TIGR00892 168 ESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKS-----------------------------------------K 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 264 AQECPDQAGHRKNMCALRILKTVswltmrvrKGFEDWysgyfgtaSLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNL 343
Cdd:TIGR00892 207 SKEGLPPDGSTKKLSKKSTAEKI--------NRFLDF--------SLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKD 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 344 YNLSEQNDVFpLTSIIAIVHIFGKVILGVIADLPCIS--VWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGY 421
Cdd:TIGR00892 271 KGVDEYEAAF-LLSIIGFVDIFARPSCGLIAGLKWIRphVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGS 349
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 422 F-SLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:TIGR00892 350 VgALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAI 419
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
34-492 |
2.17e-57 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 195.30 E-value: 2.17e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAML 193
Cdd:cd17423 82 FLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 194 IQGAVSLNLCVCGALMRPLSPGKNPNDPGEKdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqagh 273
Cdd:cd17423 162 LLSALSLHLVPCGALLRPLALPGDPPAPPRS------------------------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 274 rknmcalrilktvswltmrvrkgfedwYSGYFGTaSLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVF 353
Cdd:cd17423 193 ---------------------------LSAAFGL-SLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAF 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 354 pLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGyfSLMPV---VTE 430
Cdd:cd17423 245 -VVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAG--ALAPLvfsVLP 321
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767917067 431 DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQP 492
Cdd:cd17423 322 ELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILLTLP 383
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
34-488 |
5.58e-48 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 169.99 E-value: 5.58e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:cd17424 2 WMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAML 193
Cdd:cd17424 82 LILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 194 IQGAVSLNLCVCGALMRPLSpgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqeCPDqagh 273
Cdd:cd17424 162 ILGGFVLNLCVCGALMRFLL-----------------------------------------------------MPD---- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 274 rknmcalrilktvswltmrvrkgfedwysgyfgtaslftnrmFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVF 353
Cdd:cd17424 185 ------------------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAF 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 354 pLTSIIAIVHIFGKVILGVIADLPCISVWN--VFLLANFTLVLSIFILPLMHTYAGLAVICALIG-FSSGYFSLMPVVTE 430
Cdd:cd17424 223 -LMSILGVIDIIGNITFGWLTDRRCLKKYRyfCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGyFDGAYVALIPVVTS 301
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 767917067 431 DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFL 488
Cdd:cd17424 302 DVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
34-488 |
1.01e-43 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 158.37 E-value: 1.01e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAML 193
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 194 IQGAVSLNLCVCGALMrplspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqagh 273
Cdd:cd17422 162 VVGALQLNIVVCGALL---------------------------------------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 274 rknmcalRILKTVSwltmrvrkgfedwysgyfgtaslftnrmFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVF 353
Cdd:cd17422 178 -------RVLKEPG----------------------------FICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAY 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 354 PLtSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYF--SLMPVVTE- 430
Cdd:cd17422 223 ML-SAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVagTHIPLLAEd 301
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 767917067 431 DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFL 488
Cdd:cd17422 302 DVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFL 359
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
34-489 |
1.40e-43 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 158.73 E-value: 1.40e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAML 193
Cdd:cd17314 82 YTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 194 IQGAVSLNLCVCGALMRPLSPGKNPndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqagh 273
Cdd:cd17314 162 ILGILAAIVLSVVSLLGFKEPPDNQ------------------------------------------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 274 rknmcalrilktvswLTMRVRKGFEDWysgyfgtaslfTNRMFVAFIFWALF-AYSSFVIPF----IHLPEIVNLYNLSE 348
Cdd:cd17314 187 ---------------ARLHVQKKKTQT-----------MGEIFRDKVFWILFiAIFLVLIGGflfiANMASLVRSLQLDA 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 349 QNDVFPLTSIIAIVHIFGKVILGVIADL---PCISVWNVFLLAnfTLVLSIFILPLMHTYAGLAVICALIGFS-SGYFSL 424
Cdd:cd17314 241 PSFVTKLMSIYGLFNAFGRLLWGIVADFfggRLSTLSILLTIL--GLGLCAFLFLLKMTPVGLVLTGSLLGFSyGGLFTV 318
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767917067 425 MPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLL 489
Cdd:cd17314 319 YPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
33-490 |
1.23e-42 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 155.31 E-value: 1.23e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLNLCVCGALMRPlspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqag 272
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 273 hrknmcalrilktvswltmrvrkgfedwysgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDV 352
Cdd:cd17425 180 -------------------------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAA 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FpLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLV--LSIFILPLMHTYAGLAVICALIGFS-SGYFSLMPVVT 429
Cdd:cd17425 223 L-LLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLngLSNLICAISASFPVLLVYCLLYSISmSGIGSLIFQVL 301
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917067 430 EDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17425 302 MDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
33-492 |
5.55e-39 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 146.52 E-value: 5.55e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEF-----HQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGG 107
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 108 LVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYG 187
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 188 WRNAMLIQGAVSLNLCVCGALMRPLSPGKNPndpgekdvrglpahstesvkstgqqgrTEEKDGGlgneetlcdlqaqec 267
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPED---------------------------PKSKPGR--------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 268 pdQAGHRKNMCALRilktvSWLTMRVrkgfedwysgyfgtaslFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNlYNLS 347
Cdd:cd17420 199 --RTLHSRINLFLR-----KIFNVEI-----------------FKRKRYVIWALGIPLALFGYFVPYVHLMKFVK-EEFF 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 348 EQNDVFPLTSIIAIVHIFGKVILGVIADLPcISVWNVFL--LANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYF-SL 424
Cdd:cd17420 254 PGKDVNVPLMCIGITSGIGRLIFGVIADMP-PGVKKMYLqvLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFiSI 332
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767917067 425 MPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQP 492
Cdd:cd17420 333 MAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFIP 400
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
33-490 |
1.12e-38 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 144.87 E-value: 1.12e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLNLCVCGALMRPLspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcDLqaqecpdqag 272
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPL------------------------------------------------DF---------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 273 hrknmcalrilktvswltmrvrkgfedwysgyfgtaSLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDV 352
Cdd:cd17430 183 ------------------------------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAA 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FpLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLAnFTLV---LSIFILPLMHTYAGLAVICALIGFSSGYF-SLMPVV 428
Cdd:cd17430 227 F-LLSILGFIDIFARPACGVVAGLKWVRPRVVYLFS-FAMLfngLTDLCSATAADYGGLVVFCVFFGISYGMVgALQFEV 304
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767917067 429 TEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17430 305 LMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
33-495 |
1.28e-37 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 141.88 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFgTFLMTVLLKYLCAEYGWRNAM 192
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLNLCVCGALMRPLSpgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqag 272
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPID----------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 273 hrknmcalrilktvswltmrvrkgfedwysgyfgtASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDV 352
Cdd:cd17421 181 -----------------------------------FSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDAS 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FpLTSIIAIVHIFGKVILGVIADLPCISVWN----VFLLANFTLVLSifilPLMHTYAGLAV--ICALIgFSSGYFSLMP 426
Cdd:cd17421 226 F-IISVAGITETVAQLASGWIADQNWIKKYHyhkaYLILCGVTNLLA----PLATTYPLLMTyaVFFAI-FCGGYLALLL 299
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767917067 427 VVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQPCIR 495
Cdd:cd17421 300 PVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEPLAR 368
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
34-490 |
2.14e-34 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 133.01 E-value: 2.14e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAML 193
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 194 IQGAVSLNLCVCGALMRPLSPgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqagh 273
Cdd:cd17427 162 ILGGLLLNCCVAGSLMRPLGP----------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 274 rknmcalrilktvswltmrvrkgfedwysgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVF 353
Cdd:cd17427 183 ------------------------------------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAF 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 354 pLTSIIAIVHIFGKVILGVIADLPCI--SVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVT-E 430
Cdd:cd17427 227 -LLSILAFVDMFARPSMGLVANSKWIrpRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETlM 305
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 431 DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17427 306 DLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWLFI 365
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
34-492 |
1.61e-33 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 131.07 E-value: 1.61e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEF-----HQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGL 108
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgskddAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 109 VNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGW 188
Cdd:cd17464 82 VGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 189 RNAMLIQGAVSLNLCVCGALMRPLSPGKNPNDPGEKDVRGLPAHSTESVKstgqqgrteekdgglgneetlcdlqaqecp 268
Cdd:cd17464 162 FNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRKFKCPPLKKIFNFN------------------------------ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 269 dqaghrknmcalrILKTVSWltmrvrkgfedwysgyfgtaslftnRMFVAFIFWALFAYssfVIPFIHLPEIVNLYNLSE 348
Cdd:cd17464 212 -------------IWKSTGY-------------------------RIWAFGIPAALFGY---FVPYVHLMNHVKERFGED 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 349 QNDVFpLTSIIAIVHIFGKVILGVIAD-LPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYF-SLMP 426
Cdd:cd17464 251 VNKEV-LLMCIGITSGIGRLIFGRVADyIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFiSIMA 329
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767917067 427 VVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQP 492
Cdd:cd17464 330 PIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFIP 395
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
33-490 |
1.84e-32 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 128.07 E-value: 1.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNA 191
Cdd:COG2223 83 GLLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 192 MLIQGAVSLNLCVCGALMrplspgknpndpgekdVRGLPAHSTESVKSTGQQgrteekdgglgneetlcdlqaqecpdqa 271
Cdd:COG2223 162 FLILGILLLVVAVLAWLF----------------LRDPPAGAAAAAKASLRD---------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 272 ghrknmcALRILKTVSWLTMrvrkgfedwYSGYFGTaslftnrmfvafiFWALFAYSSFVIPFihlpeIVNLYNLSeQND 351
Cdd:COG2223 198 -------QLEALRDPRFWLL---------SLLYFGT-------------FGSFIGFSSWLPPY-----LVDQFGLS-AAT 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 352 VFPLTSIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALI--GFSSGYFSLMPVVT 429
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDR--IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLlgLALGGGNGAVFALV 320
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917067 430 EDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
33-490 |
5.28e-32 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 126.57 E-value: 5.28e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHiLIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17353 2 RWLVLLGAVLMH-LILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLNL-CVCGALMRplspgknpnDPGEKDVRGLPAHSTESVKSTGQQGRTEEkdgglgneetlcdlqaqecpdqa 271
Cdd:cd17353 161 LILGIIFLIIiVIGAFLIR---------DPPKGWVPPGVDPLANNAENSPRDYTPRE----------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 272 ghrknmcalrILKTVSWLTMRVrkgfedwysgyfgtaslftnrMFVAFIFWALFAYSSFViPFIHLPEIVNLYNLSEqnd 351
Cdd:cd17353 209 ----------MLRTPTFWLLWL---------------------MFFLNATAGLMLIGQAK-PIGQEFAGLDAGIAAL--- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 352 vfpLTSIIAIVHIFGKVILGVIADLpcISVWNVFLLAN-FTLVLSIFILPLMHTYAGLAVICALIGFSSG-YFSLMPVVT 429
Cdd:cd17353 254 ---AVSILSIFNGGGRPFWGWLSDK--IGRKNTLSIAFlIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGgGFALFPALT 328
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917067 430 EDLVGIEHLANAYGIIICANGISALLGPPFAGWiYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17353 329 ADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
65-490 |
1.88e-31 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 124.99 E-value: 1.88e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 65 FHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLP 144
Cdd:cd17426 33 FNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNP 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 145 AVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLSPgknpndpgek 224
Cdd:cd17426 113 ALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFLILGGLLLNCCVAGSLMRPIGP---------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 225 dvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqaghrknmcalrilktvswltmrvrKGFEDwysgy 304
Cdd:cd17426 183 ----------------------------------------------------------------------KPFLD----- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 305 fgtASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFpLTSIIAIVHIFGKVILGVIADLPCISVWNV 384
Cdd:cd17426 188 ---LTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAF-LLSILAFVDMVARPSMGIVANTKWVRPRIQ 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 385 FLLANFTLVLSI--FILPLMHTYAGLAVICALIGFSSGYFSLMPVVT-EDLVGIEHLANAYGIIICANGISALLGPPFAG 461
Cdd:cd17426 264 YFFAASVLYNGVchLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETlMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLG 343
|
410 420
....*....|....*....|....*....
gi 767917067 462 WIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17426 344 RLNDIYGDYKYTYWACGIVLIISSIYLFI 372
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
33-489 |
4.72e-26 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 109.67 E-value: 4.72e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMV-GRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNA 191
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 192 MLIQGAVSLNLCVCGALMRPLSPgknPNDPGEKDVRGLPAHSTESVKSTGQQGRTeekdgglgneetlcdlqaqecpdqa 271
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRP---ADLALRAYDDASPASPGSTLKEALRSASF------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 272 ghrknmcalrilktvsWLtmrvrkgfedwysgyfgtaslftnrMFVAFIFwALFAYSSFVipfIHLPEIVNLYNLSEQND 351
Cdd:cd17355 213 ----------------WL-------------------------LALAFFL-CGFAVVGLI---VHLVPYLADRGISPAAA 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 352 VFPLtSIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTLVLSIFILPLMH-TYAGLAVICALIGFSSG-YFSLMPVVT 429
Cdd:cd17355 248 AVAL-ALIGLFNIVGRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLPfPPLALLLFAALFGLGWGaTVPLTAALA 324
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 430 EDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLL 489
Cdd:cd17355 325 ARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-490 |
1.72e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 104.57 E-value: 1.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 30 GGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLV 109
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 110 NSLGWVLSAYAANVHYLFITFgVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGW 188
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 189 RNAMLIQGAVSLnlcVCGALMrplspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecp 268
Cdd:COG2271 164 RAAFLILGLPGL---LLALLR----------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 269 dqaghrknmcalrilktvSWLTMrvrkgfedwysgyfgtaslftnrMFVAFIFWALFAYSSFVIPFihlpeIVNLYNLSE 348
Cdd:COG2271 182 ------------------FWLLA-----------------------LAYFLVYFALYGFLTWLPTY-----LVEVRGLSL 215
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 349 QnDVFPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGF-SSGYFSLMPV 427
Cdd:COG2271 216 A-QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWA 294
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767917067 428 VTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQkYDFSFYICGLLYMIGILFLLI 490
Cdd:COG2271 295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-457 |
1.39e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.95 E-value: 1.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 41 FFVHILIMGSQMALGVLNVEWL-EEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAY 119
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 120 AANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYFQK-RRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAV 198
Cdd:pfam07690 82 ASSL-WLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 199 SLNLCVCGALMRPLSPGKNPNDPGEKDVRGLpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqaghrknmc 278
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLI------------------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 279 alrilktvswltmrvrkgfedwysgyFGTASLFTNRMFVAFIFWALFAySSFVIPFIHLPEIVNLYNLSEQNDVFPLtSI 358
Cdd:pfam07690 192 --------------------------VAWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLYQEVLGLSALLAGLLL-GL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 359 IAIVHIFGKVILGVIAD-LPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSG-YFSLMPVVTEDLVGIE 436
Cdd:pfam07690 244 GGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPALNALVSDLAPKE 323
|
410 420
....*....|....*....|.
gi 767917067 437 HLANAYGIIICANGISALLGP 457
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
34-492 |
2.74e-19 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 89.47 E-value: 2.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEF-----HQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGL 108
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQedqkdQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 109 VNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGW 188
Cdd:cd17465 82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 189 RNAMLIQGAVSLnlcvcgalmrplspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecp 268
Cdd:cd17465 162 AHTFQVLSLFMF-------------------------------------------------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 269 dqaghrknmcaLRILKTVSWLTMRvRKGFEDWysgYFGTASlftnrmfvafifwalfAYSSFVIPFIHLPEIVNlYNLSE 348
Cdd:cd17465 174 -----------IQIFLSLTYKVFR-RKTYRIW---AFGIAT----------------AVLGYFVPYVHLMKYVE-EEFKE 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 349 QNDVFPLTSIIAIVHIFGKVILGVIADLpCISVWNVFL-LANFTL--VLSIFIlPLMHTYAGLAVICALIGFSSGYF-SL 424
Cdd:cd17465 222 NKREWVLLVCIGASSGIGRLMSGKIGDL-IPGLKKIYLqVASFLLlgIMSMMI-PLCQVFEGVIVVCLFLGLCDGCFiTI 299
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767917067 425 MPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQP 492
Cdd:cd17465 300 MAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFVP 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
41-489 |
3.29e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.41 E-value: 3.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 41 FFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYA 120
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 121 ANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYL--CAEYGWRNAMLIQGA 197
Cdd:cd06174 82 PSF-WLLLLGRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 198 VSLNLCVCGALMRPLSPGKNPNDPGEKDvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqaghrknm 277
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEAS---------------------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 278 calriLKTVSWLTMRVRKgfedwysgyfgtaslftNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTS 357
Cdd:cd06174 189 -----SKSVLKLLKRVLK-----------------NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 358 IIAIVHIFGKVILGVIADLPcISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFS-SGYFSLMPVVTEDLVGIE 436
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDRL-IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFALIAELFPPE 325
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 767917067 437 HLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLL 489
Cdd:cd06174 326 IRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
33-490 |
3.01e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.47 E-value: 3.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:COG2807 96 GLLLRSLAPSV-ALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLNLCVCGALMRPLSPGKNPNDPGEKDVRGLpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqag 272
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSL------------------------------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 273 hrknmcaLRilktvSWLTMRVrkgfedwySGYFGTASlftnrmfvaFIFWALFAyssfvipfiHLPEIVNLYNLSEQNDV 352
Cdd:COG2807 212 -------WR-----SPLAWLL--------TLFFGLQS---------LLYYAVVA---------WLPPILRDAGLSAATAG 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FpLTSIIAIVHIFGKVILGVIAD-LPCISVWNVFLLAnfTLVLSIFILPLMHTyAGLAVICALIGFSSG-YFSLMPVVTE 430
Cdd:COG2807 254 L-LLSLFQLAGIPGSLLVPLLADrLGDRRPLLLLLGL--LGLAGLLGLLLAPG-SLPWLWAVLLGLGQGgLFPLALTLIG 329
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917067 431 DLVGI-EHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:COG2807 330 LRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLL 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
32-453 |
1.32e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.01 E-value: 1.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 32 WAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNS 111
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 112 LGWVLSAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRN 190
Cdd:COG2814 87 LGSLLCALAPSL-WLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 191 AMLIQGAVSLNLCVCGALMRPLSPGKNPNDPGEKdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdq 270
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAARARLRGS---------------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 271 aghrknmcalrilktvswltmrvrkgfedwysgyfgTASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIV-NLYNLSEQ 349
Cdd:COG2814 200 ------------------------------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSAS 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 350 nDVFPLTSIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSG-YFSLMPVV 428
Cdd:COG2814 244 -AAGLLLALFGLGGVLGALLAGRLADR--FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQAL 320
|
410 420
....*....|....*....|....*
gi 767917067 429 TEDLVGIEHLANAYGIIICANGISA 453
Cdd:COG2814 321 VAELAPPEARGRASGLYNSAFFLGG 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-211 |
1.54e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.42 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 32 WAWMMVLSSFFVHILIMGSQMALGVLNVEWL-EEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCG--CRQTAIIGGL 108
Cdd:COG2271 177 LALLRFWLLALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 109 VNSLGWVLSAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKR-RALAQGLSTTGTGFGTFLMTVLLKYLCAEYG 187
Cdd:COG2271 257 LAALALLLLALLPSP-ALAIALLFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
170 180
....*....|....*....|....
gi 767917067 188 WRNAMLIQGAVSLNLCVCGALMRP 211
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLLR 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
315-490 |
2.33e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.75 E-value: 2.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 315 MFVAFIFWALFAYSSFVIPFIhLPEIVNLYNLSEQnDVFPLTSIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTLVL 394
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPA-LPLIAADLGASPA-QAGLVVTAYLLGAALGAPLAGRLADR--FGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 395 SIFILPLMHTYAGLAVICALIGFSSG-YFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQkYDFS 473
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWV 166
|
170
....*....|....*..
gi 767917067 474 FYICGLLYMIGILFLLI 490
Cdd:COG2814 167 FLVNAVLALLALLLLLR 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
355-490 |
7.21e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.35 E-value: 7.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 355 LTSIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGF-SSGYFSLMPVVTEDLV 433
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLgAGALFPAALALIADWF 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 767917067 434 GIEHLANAYGIIICANGISALLGPPFAGWIYDITQkYDFSFYICGLLYMIGILFLLI 490
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLLAAVLLLL 170
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
355-490 |
1.48e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.35 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 355 LTSIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFslMPVVT---ED 431
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDR--FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAV--WPAAMaliAD 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 767917067 432 LVGIEHLANAYGIIICANGISALLGPPFAGWIYDITqKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALL 169
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
34-200 |
2.09e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYFQ-KRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:COG0477 93 SLLCGLAPSP-ELLIAARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
....*...
gi 767917067 193 LIQGAVSL 200
Cdd:COG0477 172 LINAPLGL 179
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-490 |
3.10e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.57 E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 113
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 114 WVLSAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 192
Cdd:cd17319 82 TALTGFATSL-TSLYVLRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 193 LIQGAVSLnlcvcgaLMRPLspgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcdlqaqecpdqag 272
Cdd:cd17319 161 IIEGLLGL-------LLAVL------------------------------------------------------------ 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 273 hrknmcALRILKTVSWLTMrvrkgfedwysGYFGTASLFTnrmfvAFIFWalfayssfvIPFIhlpeIVNLYNLSEQNdV 352
Cdd:cd17319 174 ------WWFYLRQVWGLAL-----------GYFGINYALY-----GLLTW---------LPTY----LKQARGFSLKQ-V 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FPLTSIIAIVHIFGKVILGVIAD--LPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVTE 430
Cdd:cd17319 218 GLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPA 297
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 431 DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17319 298 DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
305-490 |
3.29e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.58 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 305 FGTASLFTNRMFVAFIFWALFAYS---SFVIPFIHLpEIVNLYNLSEQnDVFPLTSIIAIVHIFGKVILGVIADLpcISV 381
Cdd:cd17325 189 RSGLRLLLRDRRLLALFLAIFVLAfafGALEPFLPL-YAAELGGLSPA-QIGLLFGAQGLASALSQPPAGKLSDR--IGR 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 382 WNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSG--YFSLMPVVTeDLVGIEHLANAYGIIICANGISALLGPPF 459
Cdd:cd17325 265 KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlvFPATLALLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
170 180 190
....*....|....*....|....*....|.
gi 767917067 460 AGWIYDiTQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17325 344 GGFLYD-AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
346-465 |
6.93e-07 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 51.48 E-value: 6.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 346 LSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCIS------VWNVFLLANFTLVLSIFILPLMHTYagLAVICALIGFSS 419
Cdd:cd17354 226 LTGPSNTSTLVSLFSIFSFLGRLLSGLLSDLFVRKfrlprpSRMVLLLLILSLGHLLQAFGLPSGA--LYVASALIGFGY 303
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767917067 420 GY-FSLMPVVTEDLVGIEHLANAYGIIICANGI-SALLGPPFAGWIYD 465
Cdd:cd17354 304 GGlFSIAPTIVSELFGLKNFGTNYGFLMLAPAIgSLIFSVIYAGVYYD 351
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
323-490 |
2.42e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.73 E-value: 2.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 323 ALFAYSSFVIPFIHLPEIVNLYNLSEQnDVFPLTSIIAIVHIFGKVILGVIADlpCISVWNVFLLANFTLVLSIFILPLM 402
Cdd:cd06174 5 FFLTGLARGLISPLLPALLQSFGLSAS-QLGLLFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 403 HTYAGLAVICALIGFSSG-YFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDItqkYDFSFYICGLLY 481
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS---LGFGWRAVFLIA 158
|
....*....
gi 767917067 482 MIGILFLLI 490
Cdd:cd06174 159 AALALLAAI 167
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
40-200 |
9.14e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.00 E-value: 9.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 40 SFFVHILIMGSQMALGVLNVEWLEEFHQSR---GLTAWVSSLSMGITLIvgpFIGLFINTCGCRQTAIIGGLVNSLgWVL 116
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLaqvGLLLSALNLGVAVSML---PAGWLLDRFGERRVLAVGLLLMGA-AAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 117 SAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKR-RALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQ 195
Cdd:cd17475 77 LMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVA 156
|
....*
gi 767917067 196 GAVSL 200
Cdd:cd17475 157 GLVSI 161
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
314-489 |
9.25e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.92 E-value: 9.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 314 RMFVAFIFWALFAYSSFVIPFIhlpeIVNLYNLSEQNDVFPLT-SIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTL 392
Cdd:cd17370 201 AFWLYLLAVALFALGNFSFAFL----ILRAQELGLSAALIPLLyALFNLVYALAAYPAGRLSDR--IGRKKLLILGYLSL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 393 VLSIFILPLMHTYAGLAVICALIGFSSGYF-SLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQkYD 471
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PS 353
|
170
....*....|....*...
gi 767917067 472 FSFYICGLLYMIGILFLL 489
Cdd:cd17370 354 AAFLFSAVLALIALLLLL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
34-200 |
1.08e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.65 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLsMGITLIVGPFI-GLFINTCGCRQTAIIGGLVNSL 112
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSA-FLIAYAVGKFIsGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNA 191
Cdd:cd17312 81 ANIFMGFSTSL-WFFAVLWGLNGLFQSMGWPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAA 159
|
....*....
gi 767917067 192 MLIQGAVSL 200
Cdd:cd17312 160 FLVPGIVGL 168
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
70-210 |
1.33e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.19 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 70 GLTAWVSSLSMG----ITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPA 145
Cdd:cd17504 213 GLGITEAGLLLLpgalVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASL 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767917067 146 VVMVGRYFQKRR-----ALAQGLSTTGTGFGTFLMTVLLK---------YLCAEYGWRNAMLIQGAVSLNLCVCGALMR 210
Cdd:cd17504 293 PNIVVESVPPDRtgiatGMNTVLRTIGSAIGPAIAGAILTtytvsitsgGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-200 |
6.20e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.26 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 13 EDGPKDKKTLKPHPNIDGGWAWMMVLSSFFVHILIMGSQMA-----LGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVG 87
Cdd:cd17325 173 EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFafgalEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 88 PFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFgVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTT 166
Cdd:cd17325 253 PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVpPEGRGTAMGLFNT 331
|
170 180 190
....*....|....*....|....*....|....
gi 767917067 167 GTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSL 200
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLL 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
355-489 |
6.70e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 355 LTSIIAIVHIFGKVILGVIADlpCISVWNVFLLANFTLVLSIFILPLMH-----TYAGLAVICALIGFSSGYF-----SL 424
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLAD--RFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFgparqAL 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767917067 425 MPvvteDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQkYDFSFYICGLLYMIGILFLL 489
Cdd:cd06173 117 LP----ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-PGGAFAINALSFLLSALLLL 176
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-200 |
8.81e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.84 E-value: 8.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSqmaLGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:COG0738 9 ALIAIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVhYLFITFGVAAGLGSGM---AYLPAVVMVGRYFQKRR-ALAQGLSTTGTGFGTFLMTVLLKyLCAEYGW 188
Cdd:COG0738 86 GLLLFALAPSY-PLLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLHAFFSLGALLGPLLGGLLIL-LGLSLSW 163
|
170
....*....|..
gi 767917067 189 RNAMLIQGAVSL 200
Cdd:COG0738 164 HLPYLILAVLLL 175
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
67-200 |
9.02e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 9.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 67 QSRGLTAW--VSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFItFGVAAGLGSGMAYlP 144
Cdd:cd17489 222 AERGISNAglFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVLYGLGFGLLF-P 299
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 767917067 145 A--VVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSL 200
Cdd:cd17489 300 AlqALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
63-232 |
9.61e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.46 E-value: 9.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 63 EEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAY 142
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 143 LpAVVMVGRYFQK-RRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAvsLNLCVCGALMRPLSPGKNPNDP 221
Cdd:cd17324 107 I-AAAYAADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV--LALLAALLLWRLLPSLPPKKPG 183
|
170
....*....|.
gi 767917067 222 GEKDVRGLPAH 232
Cdd:cd17324 184 SLGLLSSLLLL 194
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
74-200 |
2.84e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.11 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 74 WVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFItFGVAAGLGSGMAYLPAVVMVGRYF 153
Cdd:TIGR00895 56 FLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767917067 154 -QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSL 200
Cdd:TIGR00895 135 pKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPL 182
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-226 |
6.01e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 6.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 32 WAWMMVLSSFFVhilimgsQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNS 111
Cdd:cd17341 3 LSWLSFFLGFMV-------WFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 112 LGWVLSAYAANVHYLFITFGVAAGLGSGMaYLPAVVMVGRYFQKRR-----ALAQGLSTTGTGFGTFLMTVL---LKYLC 183
Cdd:cd17341 76 IPLLALALAVSSYWGLLVLGFLLGFAGAN-FASGQPWASFWFPKEKiggaaGGIAGAGNMGVAVSQLLAPLIagaIVFDG 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 767917067 184 AEYGWRNAMLIQGAVSLNLCVCGAL-MRPLSPGKNPNDPGEKDV 226
Cdd:cd17341 155 GFVGWRNAFFVPGILLAIAAVLVLLfGDDLPTGKASALEFLKVQ 198
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
38-214 |
6.12e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.23 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 38 LSSFFVHILIMGSQMALGVLNVEWLEEFHQSrGLTAWVSS-LSMGITlIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVL 116
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTaWSLAQA-VLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 117 SAYAANVHYL---FITFGVAAGLGSGMAYLPAVVMVGRYfqkrRALAQG----LSTTGTGFGTFLMTVLLKYLCAeyGWR 189
Cdd:cd06179 79 AGTAKSVNMLiggQALIGIGAGTQGLGAAVASELVPNKY----RGLVQGvvnlVASPGSALGPLIAGALVEANAA--GWR 152
|
170 180
....*....|....*....|....*.
gi 767917067 190 NAMLIQGAVS-LNLCVCGALMRPLSP 214
Cdd:cd06179 153 WIFYINAIFNaLALILLFFFYHPPPR 178
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-181 |
6.37e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSSFFVHILIMGSQMALGVLNVEWLeeFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVH-YLFITFGVAAGLGSGMAYLPAVVMVG--------RYFQKRRALAQGLST----TGTGFGTFLMTVLL 179
Cdd:COG2211 307 GLLLLFFLGPGNlWLLLVLAALAGIGLGAILVLPWAMLAdvvdydewKTGRRREGLYFGIFTfaikLGQALAGALAGLLL 386
|
..
gi 767917067 180 KY 181
Cdd:COG2211 387 AL 388
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
34-214 |
7.01e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.79 E-value: 7.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 34 WMMvlssFFVHILIMGSQMAL-GVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 112
Cdd:COG2223 208 WLL----SLLYFGTFGSFIGFsSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 113 GWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYG-WRN 190
Cdd:COG2223 284 GLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTA 363
|
170 180
....*....|....*....|....
gi 767917067 191 AMLIQGAVSLnLCVCGALMRPLSP 214
Cdd:COG2223 364 AFLVFAVLAL-VALVLTLLLYRRP 386
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
308-467 |
7.78e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 7.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 308 ASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLpcISVWNVFLL 387
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR--FGKKKAFII 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 388 ANFTLVLSIFILPLM--HTYAGLAVICALIGF-SSGYFSLMPVVTEDLVGIEHLAN-------AYGIIICANGISALLGP 457
Cdd:COG2211 300 GLLLAALGLLLLFFLgpGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAG 379
|
170
....*....|
gi 767917067 458 PFAGWIYDIT 467
Cdd:COG2211 380 ALAGLLLALF 389
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
103-230 |
7.97e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.91 E-value: 7.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 103 AIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQK-RRALAQGLSTTGTGFGTFLMTVLLKY 181
Cdd:cd06180 66 LIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAaGRGHLIGLLFAGVGLGIALSGLLVPA 145
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 767917067 182 LCAE-YGWRNAMLIQGAVSLNLCVCGALMRPLSPGKNPNDPGEKDVRGLP 230
Cdd:cd06180 146 GLGGgLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLN 195
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
37-490 |
1.75e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.77 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 37 VLSSFFVHILIMGSqmaLGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVL 116
Cdd:cd17333 1 LYISFFSNGLTDAL---LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 117 SAYAANVhYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCA-EYGWRNAMLIQ 195
Cdd:cd17333 78 IFATPSI-YLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLII 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 196 GAVSLNLCVCgaLMRPLSPgknpndpgekdvrglpahstesvkstgqqgrteekdgglgneetlcDLQAQECPDQAGHRK 275
Cdd:cd17333 157 GLIYLLLAIL--ILLTLFP----------------------------------------------ELPSARNPQQSVGAF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 276 NMCALRILKTVSWLtmrvrkgfedwysgyfgtaslftnrMFVAFIFW---ALFAYSSFVIPFihlpeivnlynLSEQNDV 352
Cdd:cd17333 189 SASASRLLRNPSII-------------------------LGALALFLyvgAETAFSSWVPSY-----------LVEKKHV 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 353 FPLTSIIAIVHIFGKVILGVIADLPCIS---VWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIG-FSSGYFSLMPVV 428
Cdd:cd17333 233 SDGLAGYLLSGFWVGITIGRLLGGPISRrikPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGlFMAALFPTILSL 312
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767917067 429 TEDLVGIEHlANAYGIIICANGISALLGPPFAGWIYDITQKYDFsFYICGLLYMIGILFLLI 490
Cdd:cd17333 313 GISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTA-MLLITILYAIIFVLALL 372
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
63-174 |
1.76e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 63 EEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANvHYLFITFGVAAGLGSGMAY 142
Cdd:cd17478 24 AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN-YWLLLLLVALAGIGSAAFH 102
|
90 100 110
....*....|....*....|....*....|..
gi 767917067 143 LPAVVMVGRYFQKRRALAQGLSTTGTGFGTFL 174
Cdd:cd17478 103 PEGARLASQAAGGRRGLAMSIFSVGGNLGFAL 134
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
33-209 |
2.00e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 33 AWMMVLSsFFVHILIMGSQMAlgvlnveWLEEFHQSRGLTA----WVSSLSMGITLIVGPFIGLFINTCGCRQ-TAIIGG 107
Cdd:COG2807 217 AWLLTLF-FGLQSLLYYAVVA-------WLPPILRDAGLSAatagLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLG 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 108 LVNSLGWVLSAYAAnvHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRR------ALAQGLSTTGTGFGTFLMTVLLKY 181
Cdd:COG2807 289 LLGLAGLLGLLLAP--GSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeaaalsGMAQSVGYLLAALGPLLVGALHDA 366
|
170 180
....*....|....*....|....*...
gi 767917067 182 LcaeYGWRNAMLIQGAVSLNLCVCGALM 209
Cdd:COG2807 367 T---GSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
36-179 |
2.74e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 36 MVLSSFFVHILIMGSQMALGVLNVEWLEEFHqsrGLTAWVSSLSM----GITLIVGPFIGLFINTCGCRQTAIIGGLVNS 111
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGVL---GYSPLQAGLALlplaLAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767917067 112 LG-WVLSAYAANVHYLFITFG-VAAGLGSGMAYLPA-VVMVGRYFQKRRALAQGLSTT----GTGFGTFLMTVLL 179
Cdd:cd17321 246 VGlLLLALLGADSSVWLLLPGlVLLGLGLGLFATPLtNAALSSVPKEKAGAASGILNTarqlGGALGVALLGALL 320
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
314-489 |
3.96e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 3.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 314 RMFVAFIFWALFAYSSFVIPFIhLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADlpcisVWNVFLLANFTLV 393
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTF-LPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD-----RIGRKKTLVIGLI 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 394 LSI------FILPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDIT 467
Cdd:cd17316 252 LSGilalplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
170 180
....*....|....*....|..
gi 767917067 468 QKYDFSFYICGLLYMIGILFLL 489
Cdd:cd17316 332 GGTGVPALILALLAIVALIVAL 353
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
355-489 |
5.22e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 5.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 355 LTSIIAIVHIFGKVILGVIADLpcISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFS-SGYFSLMPVVTEDLV 433
Cdd:cd17324 39 LVSAYALGYALGALLLGPLSDR--IERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAhGGFWAIAAAYAADLV 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 767917067 434 GIEHLANAYGIIICANGISALLGPPFAGWIYDITqKYDFSFYICGLLYMIGILFLL 489
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAFLAIAVLALLAALLLW 171
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
64-204 |
7.59e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 7.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 64 EFHQSRGLTAWV-SSLSMG--ITLIVGPFIGLFIntcGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFG-VAAGLGSG 139
Cdd:cd17318 50 EFDWSEKTQGIIlSSFFYGyiLTQIPGGYLAEKY---GAKRVLGYSILITALLTLLTPLAARGGYGALIVLrILQGLAQG 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917067 140 MAYlPAV-VMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCV 204
Cdd:cd17318 127 VTF-PAMhALWAKWApPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCL 192
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
384-490 |
8.90e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 8.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 384 VFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYF--SLMPVVTeDLVGIEHLANAYGIIICANGISALLGPPFAG 461
Cdd:cd17489 63 LLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFttAAATLVA-DIIPPSRRGEGIGYYGLATTLAMALGPALGL 141
|
90 100
....*....|....*....|....*....
gi 767917067 462 WIYDiTQKYDFSFYICGLLYMIGILFLLI 490
Cdd:cd17489 142 FLYQ-HLGFAVLFIVAAVLALLALLLVFL 169
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
72-194 |
9.24e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.44 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917067 72 TAWVSSLSMgITLIVGPFIGLFINTC----GCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAaGLGSGMAYLPAVV 147
Cdd:cd17371 33 EAEAGLLGT-VTLAGGAIGGILGGILadrfGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALA-GLGFGGEWAAGAA 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 767917067 148 MVG-----RYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLI 194
Cdd:cd17371 111 LMAeyvpaRHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLL 162
|
|
| |
