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Conserved domains on  [gi|767917512|ref|XP_011509239|]
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sushi, nidogen and EGF-like domain-containing protein 1 isoform X11 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
128-284 7.74e-55

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 186.86  E-value: 7.74e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917512   128 FWADVDNRRAGDVYYREATDPAMLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSF 207
Cdd:smart00539   2 FWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRTY 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512   208 TIFNYESIVWTtgthasSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQV 284
Cdd:smart00539  82 AIFLYPSLGWT------SDTTAGGDDGVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 335-371 9.73e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 9.73e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767917512 335 DVNECASQ-PCQNGGTCTHGINSFRCQCPAGFGGPTCE 371
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 817-851 1.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.29e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 817 DECR-AHPCRNGGSCRNLPGAYVCRCPAGFVGVHCE 851
Cdd:cd00054    3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 1.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.45e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 645 DSCASG-PCHNGGTCFHYIGKYKCDCPPGFSGRHCE 679
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 411-447 6.83e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 6.83e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767917512 411 DVDDC-SPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCE 447
Cdd:cd00054    1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 778-813 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.54e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767917512 778 IDECRSQ-PCLHGGSCQDRVAGYLCLCSTGYEGAHCE 813
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 722-775 8.53e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 8.53e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512 722 CGPPEEVKHATL--RFNGTRLGAVALYACDRGYSLSAPSRIRvCQPHGVWS-EPPQC 775
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTIT-CTENGGWSpPPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 455-488 2.22e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.22e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767917512 455 DACLSA-PCHNGGTCVDADQGYVCECPEGFMGLDC 488
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-601 1.03e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.03e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767917512 570 DSDPCFNGGSCDAHDDSYTCECPRGFHGKHCE 601
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 688-717 1.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.51e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 767917512 688 SPCVNGGTCEDRDTDFFCHCQAGYMGRRCQ 717
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 296-332 5.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 5.53e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767917512 296 CLALRPCLNGGKCIDdcvtGNPSYTCSCLSGFTGRRC 332
Cdd:cd00054    5 CASGNPCQNGGTCVN----TVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 609-640 6.10e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 6.10e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767917512 609 SSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCE 640
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
128-284 7.74e-55

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 186.86  E-value: 7.74e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917512   128 FWADVDNRRAGDVYYREATDPAMLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSF 207
Cdd:smart00539   2 FWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRTY 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512   208 TIFNYESIVWTtgthasSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQV 284
Cdd:smart00539  82 AIFLYPSLGWT------SDTTAGGDDGVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 192-281 1.41e-35

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 129.72  E-value: 1.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917512  192 VNTFQTVLITDGKLSFTIFNYES--IVWTTGThaSSGGNaTGLGGIAAQAGFNAGDG-QRYFSIPGSRTADMAEVETTTN 268
Cdd:pfam06119   1 TNTFQAVLATDGSGSFAIFNYPDggIQWTTGK--ASGGT-NGLGGTPAQAGFSAGDGdGRYYELPGSGTDSIRNLTETSN 77

                          90
                  ....*....|...
gi 767917512  269 VGVPGRWAFRIDD 281
Cdd:pfam06119  78 VGVPGRWVFRIDS 90
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 335-371 9.73e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 9.73e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767917512 335 DVNECASQ-PCQNGGTCTHGINSFRCQCPAGFGGPTCE 371
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 817-851 1.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.29e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 817 DECR-AHPCRNGGSCRNLPGAYVCRCPAGFVGVHCE 851
Cdd:cd00054    3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 1.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.45e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 645 DSCASG-PCHNGGTCFHYIGKYKCDCPPGFSGRHCE 679
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
335-371 2.24e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 2.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767917512   335 DVNECAS-QPCQNGGTCTHGINSFRCQCPAGF-GGPTCE 371
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 411-447 6.83e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 6.83e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767917512 411 DVDDC-SPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCE 447
Cdd:cd00054    1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
817-851 2.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 2.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767917512   817 DEC-RAHPCRNGGSCRNLPGAYVCRCPAGFV-GVHCE 851
Cdd:smart00179   3 DECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 778-813 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.54e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767917512 778 IDECRSQ-PCLHGGSCQDRVAGYLCLCSTGYEGAHCE 813
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 722-775 8.53e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 8.53e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512 722 CGPPEEVKHATL--RFNGTRLGAVALYACDRGYSLSAPSRIRvCQPHGVWS-EPPQC 775
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTIT-CTENGGWSpPPPTC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
645-679 1.30e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767917512   645 DSCAS-GPCHNGGTCFHYIGKYKCDCPPGFS-GRHCE 679
Cdd:smart00179   3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 647-677 1.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 1.88e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  647 CASGPCHNGGTCFHYIGKYKCDCPPGFSGRH 677
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Sushi pfam00084
Sushi repeat (SCR repeat);
722-775 2.06e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.87  E-value: 2.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512  722 CGPPEEVKHA--TLRFNGTRLGAVALYACDRGYSLSAPSRIrVCQPHGVWS-EPPQC 775
Cdd:pfam00084   1 CPPPPDIPNGkvSATKNEYNYGASVSYECDPGYRLVGSPTI-TCQEDGTWSpPFPEC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
411-447 2.17e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.17e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767917512   411 DVDDC-SPDPCLNGGSCVDLVGNYTCLCAEPFK-GLRCE 447
Cdd:smart00179   1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 455-488 2.22e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.22e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767917512 455 DACLSA-PCHNGGTCVDADQGYVCECPEGFMGLDC 488
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
777-813 3.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 3.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767917512   777 EIDECRS-QPCLHGGSCQDRVAGYLCLCSTGYE-GAHCE 813
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 722-775 5.85e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 5.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512   722 CGPPEEVKHATLRF--NGTRLGAVALYACDRGYSLSAPSRIRvCQPHGVWS-EPPQC 775
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTIT-CLENGTWSpPPPTC 56
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 415-445 9.96e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 9.96e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  415 CSPDPCLNGGSCVDLVGNYTCLCAEPFKGLR 445
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-601 1.03e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.03e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767917512 570 DSDPCFNGGSCDAHDDSYTCECPRGFHGKHCE 601
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 688-717 1.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.51e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 767917512 688 SPCVNGGTCEDRDTDFFCHCQAGYMGRRCQ 717
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 569-599 3.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 3.68e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  569 CDSDPCFNGGSCDAHDDSYTCECPRGFHGKH 599
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 339-369 3.98e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 3.98e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  339 CASQPCQNGGTCTHGINSFRCQCPAGFGGPT 369
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 296-332 5.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 5.53e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767917512 296 CLALRPCLNGGKCIDdcvtGNPSYTCSCLSGFTGRRC 332
Cdd:cd00054    5 CASGNPCQNGGTCVN----TVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 609-640 6.10e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 6.10e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767917512 609 SSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCE 640
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 457-483 6.83e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 6.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 767917512  457 CLSAPCHNGGTCVDADQGYVCECPEGF 483
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGY 27
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 819-849 1.61e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 1.61e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  819 CRAHPCRNGGSCRNLPGAYVCRCPAGFVGVH 849
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 608-638 2.71e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.71e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  608 CSSGPCRNGGTCKEAGGEYHCSCPYRFTGRH 638
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
455-488 3.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767917512   455 DACLSA-PCHNGGTCVDADQGYVCECPEGFM-GLDC 488
Cdd:smart00179   3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 781-811 3.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 3.74e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  781 CRSQPCLHGGSCQDRVAGYLCLCSTGYEGAH 811
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
688-717 6.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 6.59e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767917512   688 SPCVNGGTCEDRDTDFFCHCQAGYM-GRRCQ 717
Cdd:smart00179   9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-601 6.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 6.99e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767917512   570 DSDPCFNGGSCDAHDDSYTCECPRGFH-GKHCE 601
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
128-284 7.74e-55

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 186.86  E-value: 7.74e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917512   128 FWADVDNRRAGDVYYREATDPAMLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSF 207
Cdd:smart00539   2 FWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRTY 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512   208 TIFNYESIVWTtgthasSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQV 284
Cdd:smart00539  82 AIFLYPSLGWT------SDTTAGGDDGVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 192-281 1.41e-35

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 129.72  E-value: 1.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917512  192 VNTFQTVLITDGKLSFTIFNYES--IVWTTGThaSSGGNaTGLGGIAAQAGFNAGDG-QRYFSIPGSRTADMAEVETTTN 268
Cdd:pfam06119   1 TNTFQAVLATDGSGSFAIFNYPDggIQWTTGK--ASGGT-NGLGGTPAQAGFSAGDGdGRYYELPGSGTDSIRNLTETSN 77

                          90
                  ....*....|...
gi 767917512  269 VGVPGRWAFRIDD 281
Cdd:pfam06119  78 VGVPGRWVFRIDS 90
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 335-371 9.73e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 9.73e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767917512 335 DVNECASQ-PCQNGGTCTHGINSFRCQCPAGFGGPTCE 371
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 817-851 1.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.29e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 817 DECR-AHPCRNGGSCRNLPGAYVCRCPAGFVGVHCE 851
Cdd:cd00054    3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 1.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.45e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 645 DSCASG-PCHNGGTCFHYIGKYKCDCPPGFSGRHCE 679
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
335-371 2.24e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 2.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767917512   335 DVNECAS-QPCQNGGTCTHGINSFRCQCPAGF-GGPTCE 371
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 411-447 6.83e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 6.83e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767917512 411 DVDDC-SPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCE 447
Cdd:cd00054    1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
817-851 2.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 2.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767917512   817 DEC-RAHPCRNGGSCRNLPGAYVCRCPAGFV-GVHCE 851
Cdd:smart00179   3 DECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 778-813 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.54e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767917512 778 IDECRSQ-PCLHGGSCQDRVAGYLCLCSTGYEGAHCE 813
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 722-775 8.53e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 8.53e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512 722 CGPPEEVKHATL--RFNGTRLGAVALYACDRGYSLSAPSRIRvCQPHGVWS-EPPQC 775
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTIT-CTENGGWSpPPPTC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
645-679 1.30e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767917512   645 DSCAS-GPCHNGGTCFHYIGKYKCDCPPGFS-GRHCE 679
Cdd:smart00179   3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 647-677 1.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 1.88e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  647 CASGPCHNGGTCFHYIGKYKCDCPPGFSGRH 677
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Sushi pfam00084
Sushi repeat (SCR repeat);
722-775 2.06e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.87  E-value: 2.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512  722 CGPPEEVKHA--TLRFNGTRLGAVALYACDRGYSLSAPSRIrVCQPHGVWS-EPPQC 775
Cdd:pfam00084   1 CPPPPDIPNGkvSATKNEYNYGASVSYECDPGYRLVGSPTI-TCQEDGTWSpPFPEC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
411-447 2.17e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.17e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767917512   411 DVDDC-SPDPCLNGGSCVDLVGNYTCLCAEPFK-GLRCE 447
Cdd:smart00179   1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 455-488 2.22e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.22e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767917512 455 DACLSA-PCHNGGTCVDADQGYVCECPEGFMGLDC 488
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
777-813 3.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 3.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767917512   777 EIDECRS-QPCLHGGSCQDRVAGYLCLCSTGYE-GAHCE 813
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 722-775 5.85e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 5.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917512   722 CGPPEEVKHATLRF--NGTRLGAVALYACDRGYSLSAPSRIRvCQPHGVWS-EPPQC 775
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTIT-CLENGTWSpPPPTC 56
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 415-445 9.96e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 9.96e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  415 CSPDPCLNGGSCVDLVGNYTCLCAEPFKGLR 445
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-601 1.03e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.03e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767917512 570 DSDPCFNGGSCDAHDDSYTCECPRGFHGKHCE 601
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 688-717 1.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.51e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 767917512 688 SPCVNGGTCEDRDTDFFCHCQAGYMGRRCQ 717
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 648-679 2.30e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.38  E-value: 2.30e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767917512 648 ASGPCHNGGTCFHYIGKYKCDCPPGFSG-RHCE 679
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 569-599 3.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 3.68e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  569 CDSDPCFNGGSCDAHDDSYTCECPRGFHGKH 599
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 339-369 3.98e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 3.98e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  339 CASQPCQNGGTCTHGINSFRCQCPAGFGGPT 369
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 296-332 5.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 5.53e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767917512 296 CLALRPCLNGGKCIDdcvtGNPSYTCSCLSGFTGRRC 332
Cdd:cd00054    5 CASGNPCQNGGTCVN----TVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 609-640 6.10e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 6.10e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767917512 609 SSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCE 640
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 457-483 6.83e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 6.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 767917512  457 CLSAPCHNGGTCVDADQGYVCECPEGF 483
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGY 27
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 818-851 1.30e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.30e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 818 ECRA-HPCRNGGSCRNLPGAYVCRCPAGFVGV-HCE 851
Cdd:cd00053    1 ECAAsNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 338-371 1.60e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.60e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767917512 338 ECA-SQPCQNGGTCTHGINSFRCQCPAGFGGP-TCE 371
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 819-849 1.61e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 1.61e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  819 CRAHPCRNGGSCRNLPGAYVCRCPAGFVGVH 849
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 344-365 1.97e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.16  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|..
gi 767917512  344 CQNGGTCTHGINSFRCQCPAGF 365
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 608-638 2.71e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.71e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  608 CSSGPCRNGGTCKEAGGEYHCSCPYRFTGRH 638
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
455-488 3.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767917512   455 DACLSA-PCHNGGTCVDADQGYVCECPEGFM-GLDC 488
Cdd:smart00179   3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 458-485 3.41e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.41e-03
                         10        20
                 ....*....|....*....|....*...
gi 767917512 458 LSAPCHNGGTCVDADQGYVCECPEGFMG 485
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 781-811 3.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 3.74e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767917512  781 CRSQPCLHGGSCQDRVAGYLCLCSTGYEGAH 811
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
688-717 6.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 6.59e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767917512   688 SPCVNGGTCEDRDTDFFCHCQAGYM-GRRCQ 717
Cdd:smart00179   9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 462-483 6.66e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.00  E-value: 6.66e-03
                          10        20
                  ....*....|....*....|..
gi 767917512  462 CHNGGTCVDADQGYVCECPEGF 483
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-601 6.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 6.99e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767917512   570 DSDPCFNGGSCDAHDDSYTCECPRGFH-GKHCE 601
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 652-673 7.07e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 34.62  E-value: 7.07e-03
                          10        20
                  ....*....|....*....|..
gi 767917512  652 CHNGGTCFHYIGKYKCDCPPGF 673
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA pfam07645
Calcium-binding EGF domain;
335-364 7.18e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 7.18e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767917512  335 DVNECASQP--CQNGGTCTHGINSFRCQCPAG 364
Cdd:pfam07645   1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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