|
Name |
Accession |
Description |
Interval |
E-value |
| CNH |
smart00036 |
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2; |
1178-1474 |
1.20e-78 |
|
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
Pssm-ID: 214481 Cd Length: 302 Bit Score: 262.29 E-value: 1.20e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1178 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1250
Cdd:smart00036 2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1251 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1324
Cdd:smart00036 82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1325 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1400
Cdd:smart00036 161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770410 1401 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1474
Cdd:smart00036 233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
|
|
| CNH |
pfam00780 |
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ... |
1186-1438 |
3.63e-68 |
|
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.
Pssm-ID: 459938 Cd Length: 261 Bit Score: 230.60 E-value: 3.63e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1186 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1264
Cdd:pfam00780 1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1265 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1342
Cdd:pfam00780 77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1343 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1422
Cdd:pfam00780 157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226
|
250
....*....|....*.
gi 1039770410 1423 YLFVTHFNSLEVIEIQ 1438
Cdd:pfam00780 227 YLLAFHDNFIEIRDVE 242
|
|
| CRIK |
cd20814 |
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ... |
929-984 |
4.47e-38 |
|
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410364 Cd Length: 56 Bit Score: 136.22 E-value: 4.47e-38
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 929 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 984
Cdd:cd20814 1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
72-871 |
1.27e-23 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 109.38 E-value: 1.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 72 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:TIGR02168 197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 138 EEFKRKANECQHKLmkvvshpprgdsggtalddlhkmqghagltsakdqgkpevgeYSKLEKINAEQQlKIQELQEKLEK 217
Cdd:TIGR02168 277 SELEEEIEELQKEL------------------------------------------YALANEISRLEQ-QKQILRERLAN 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 218 AVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikkklVEAEELEEKHREAQVSAQHLEVHLKQKEQHYE----- 292
Cdd:TIGR02168 314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK------EELESLEAELEELEAELEELESRLEELEEQLEtlrsk 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 293 -----EKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK-----AMINAMDSKIRSLEQRIVELSEANKLAA 362
Cdd:TIGR02168 388 vaqleLQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElkelqAELEELEEELEELQEELERLEEALEELR 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 363 NSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKSRLLEL-------ETRLrEVSLEH 435
Cdd:TIGR02168 468 EELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGG 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 436 EEQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC 513
Cdd:TIGR02168 546 RLQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGV 625
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 514 TVITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL 585
Cdd:TIGR02168 626 LVVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAEL 703
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 586 KTTCTMLEEQvldLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavke 665
Cdd:TIGR02168 704 RKELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE-------- 768
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 666 hkaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 745
Cdd:TIGR02168 769 ---RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 746 GLQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPT 822
Cdd:TIGR02168 846 QIEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLA 925
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 823 QVPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 871
Cdd:TIGR02168 926 QLELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
202-772 |
4.28e-23 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 107.33 E-value: 4.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 202 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE 281
Cdd:COG1196 209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELEL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 282 VHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLA 361
Cdd:COG1196 284 EEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 362 ANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishQDHSDKSRLLELETRLREVSLEHEEQKLE 441
Cdd:COG1196 364 EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE----ALLERLERLEEELEELEEALAELEEEEEE 439
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 442 LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAhrDEIQRKFDALRNSCTVITDLEE 521
Cdd:COG1196 440 EEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL--LLEAEADYEGFLEGVKAALLLA 517
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 522 QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD------HLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 595
Cdd:COG1196 518 GLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVaaaaieYLKAAKAGRATFLPLDKIRARAALAAALARGAI 597
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 596 VLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQ 675
Cdd:COG1196 598 GAAVDLVASDLREADARYYVLGDTLLGRTLVAA-RLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLE 676
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 676 ALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRAD 755
Cdd:COG1196 677 AEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEEL 756
|
570
....*....|....*..
gi 1039770410 756 LLKTERSDLEYQLENIQ 772
Cdd:COG1196 757 PEPPDLEELERELERLE 773
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
193-765 |
2.38e-19 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 95.00 E-value: 2.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNRE--------DSSEGIKKKLVEAE 264
Cdd:COG1196 233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEyellaelaRLEQDIARLEERRR 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 265 ELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEkgkILSEQKAMINAMDSKI 344
Cdd:COG1196 313 ELEERLEELEEELAELE----EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLE---AEAELAEAEEELEELA 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 345 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdkSRLLEL 424
Cdd:COG1196 386 EELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE--------AELEEE 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 425 ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteLEETTAEAEEEIQALTAHRDEIQR 504
Cdd:COG1196 458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK--AALLLAGLRGLAGAVAVLIGVEAA 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 505 KFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQLRSEVDHLRREITEREMQLTSQKQTM 582
Cdd:COG1196 536 YEAALEAA-----LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDLRE 610
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 583 EALKTTCTM--LEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVE 660
Cdd:COG1196 611 ADARYYVLGdtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA-GGSLTGGSRRELLAALLEAEAELEELAERLA 689
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 661 LAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHI 740
Cdd:COG1196 690 EEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELEREL 769
|
570 580 590
....*....|....*....|....*....|....*....
gi 1039770410 741 FRLTQGLQE-------ALD-------RADLLKTERSDLE 765
Cdd:COG1196 770 ERLEREIEAlgpvnllAIEeyeeleeRYDFLSEQREDLE 808
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
57-696 |
2.11e-18 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 91.92 E-value: 2.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 57 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 136
Cdd:COG1196 204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 137 AEEFKRKANECQHKLMKVVShpprgdsggtalddlhkmqghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLE 216
Cdd:COG1196 276 LEELELELEEAQAEEYELLA------------------------------------ELARLEQDIARLEERRRELEERLE 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 217 KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIK 296
Cdd:COG1196 320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAE---AELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 297 VLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQE 376
Cdd:COG1196 397 ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 377 EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE------LKRQLTELQ 450
Cdd:COG1196 477 AALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEaalaaaLQNIVVEDD 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 451 LSLQERESQLTALQAARAA---LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLT 527
Cdd:COG1196 557 EVAAAAIEYLKAAKAGRATflpLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAAL 636
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 528 EDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAlkttctMLEEQVLDLEALNDELL 607
Cdd:COG1196 637 RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEEL------ELEEALLAEEEEERELA 710
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 608 EKERQWEAWRSVLGDEKSQFE-CRVRELQRMLDTEKQSRARADQRITE--SRQVVELAVKEHKAEI--------LALQQa 676
Cdd:COG1196 711 EAEEERLEEELEEEALEEQLEaEREELLEELLEEEELLEEEALEELPEppDLEELERELERLEREIealgpvnlLAIEE- 789
|
650 660
....*....|....*....|
gi 1039770410 677 LKEQKLKAESLSDKLNDLEK 696
Cdd:COG1196 790 YEELEERYDFLSEQREDLEE 809
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
287-855 |
3.13e-18 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 91.24 E-value: 3.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 287 KEQHYEEKIKVLDNQIKKDLADKESLEnmmqrheeeahekgKILSEQKAMINAMDSKIRSLEQRIVEL--------SEAN 358
Cdd:TIGR04523 34 EEKQLEKKLKTIKNELKNKEKELKNLD--------------KNLNKDEEKINNSNNKIKILEQQIKDLndklkknkDKIN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 359 KLAANSSLFT------QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREvs 432
Cdd:TIGR04523 100 KLNSDLSKINseikndKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNL-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 433 LEHEEQKLE-----LKRQLTELQLSL----------QERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQA 494
Cdd:TIGR04523 178 LEKEKLNIQknidkIKNKLLKLELLLsnlkkkiqknKSLESQISELKKQNNQLKDnieKKQQEINEKTTEISNTQTQLNQ 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 495 LTAHRDEIQRKFDA----LRNSCTVITDLEEQLNQLTEDNAELNNQnfylsKQLDEASGANDEIVQLRSEVDHLRREITE 570
Cdd:TIGR04523 258 LKDEQNKIKKQLSEkqkeLEQNNKKIKELEKQLNQLKSEISDLNNQ-----KEQDWNKELKSELKNQEKKLEEIQNQISQ 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 571 REMQLTSQKQTMEALKTTCTMLEeqvLDLEALNDELLEKERQWEAWRS---VLGDEKSQFECRVRELQRMLDTEKQSRAR 647
Cdd:TIGR04523 333 NNKIISQLNEQISQLKKELTNSE---SENSEKQRELEEKQNEIEKLKKenqSYKQEIKNLESQINDLESKIQNQEKLNQQ 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 648 ADQRITESRQVVELAVKEH---KAEILALQQALKE-------QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE-TER 716
Cdd:TIGR04523 410 KDEQIKKLQQEKELLEKEIerlKETIIKNNSEIKDltnqdsvKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEqKQK 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 717 ELKQRlLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQvlYSHEKVKMEGTISQQTKLIDFL 796
Cdd:TIGR04523 490 ELKSK-EKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE--DELNKDDFELKKENLEKEIDEK 566
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770410 797 QAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIE 855
Cdd:TIGR04523 567 NKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKE 625
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
10-808 |
6.00e-18 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 90.80 E-value: 6.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDI--REQS 87
Cdd:pfam02463 264 EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIeeLEKE 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 88 RKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVShpprgdsggtA 167
Cdd:pfam02463 344 LKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQ----------L 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 168 LDDLHKMQGHAgLTSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLH 247
Cdd:pfam02463 410 LLELARQLEDL-LKEEKKEELEILEE---EEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQ 485
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 248 NREDSSEgikKKLVEAEELEEKHREAqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKG 327
Cdd:pfam02463 486 LELLLSR---QKLEERSQKESKARSG------LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSAT 556
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 328 KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL 407
Cdd:pfam02463 557 ADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTK 636
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 408 EKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaarAALESQLRQAKTELEETTAE 487
Cdd:pfam02463 637 LKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESEL-------AKEEILRRQLEIKKKEQREK 709
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 488 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgandeiVQLRSEVDHLRRE 567
Cdd:pfam02463 710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSE--------LSLKEKELAEERE 781
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 568 ITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfECRVRELQRMLDTEKQSRAR 647
Cdd:pfam02463 782 KTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELAL-ELKEEQKLEKLAEEELERLE 860
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 648 ADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 727
Cdd:pfam02463 861 EEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEEL 940
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 728 KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKlIDFLQAKMDQPAKKK 807
Cdd:pfam02463 941 LLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEK-KKLIRAIIEETCQRL 1019
|
.
gi 1039770410 808 K 808
Cdd:pfam02463 1020 K 1020
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
5-765 |
7.24e-18 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 90.59 E-value: 7.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVElKASETQRSllEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIR 84
Cdd:PTZ00121 1112 EEARKAEEAKKKAEDARKAEEARKAEDAR-KAEEARKA--EDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVR 1188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 85 --EQSRKLQEIKEQEYQAQVEEMRlmmnQLEEdlvsARRrsdlYESELR-ESRLAAEEFKRKANECQHklmkvvSHPPRG 161
Cdd:PTZ00121 1189 kaEELRKAEDARKAEAARKAEEER----KAEE----ARK----AEDAKKaEAVKKAEEAKKDAEEAKK------AEEERN 1250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 162 DSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKI-------NAEQQLKIQELQEKLEKAVKASteatELLQNIRQ 234
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKkkadeakKAEEKKKADEAKKKAEEAKKAD----EAKKKAEE 1326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 235 AKERAERELEKLHNREDSSEGIKKklveaeELEEKHREAQVSAQHLEVHLKQKEqhyEEKIKVldNQIKKDLADKESLEN 314
Cdd:PTZ00121 1327 AKKKADAAKKKAEEAKKAAEAAKA------EAEAAADEAEAAEEKAEAAEKKKE---EAKKKA--DAAKKKAEEKKKADE 1395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 315 MMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISELRQQKfylETQAG 394
Cdd:PTZ00121 1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAD--EAKKKAEEAKKADEAKKKAEEAKKAEEAKKK---AEEAK 1470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 395 KLEAQNRKLEE--QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESqltalQAARAALEs 472
Cdd:PTZ00121 1471 KADEAKKKAEEakKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA-----DEAKKAEE- 1544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 473 qLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 552
Cdd:PTZ00121 1545 -KKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 553 EIVQLRSEvdHLRREITEREMQLTSQKQTMEALKTTCTML---EEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEC 629
Cdd:PTZ00121 1616 EEAKIKAE--ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEA 1693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 630 RVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAESLsdKLNDLEKK---HAMLEMNAR 706
Cdd:PTZ00121 1694 LKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAEEA--KKDEEEKKkiaHLKKEEEKK 1769
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770410 707 SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 765
Cdd:PTZ00121 1770 AEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEME 1828
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
193-571 |
9.44e-18 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 90.12 E-value: 9.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegiKKKLVEAEELEEKHRE 272
Cdd:TIGR02168 678 EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL----------RKDLARLEAEVEQLEE 747
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 352
Cdd:TIGR02168 748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLE 827
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 353 ELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVs 432
Cdd:TIGR02168 828 SLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL- 906
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 433 lehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRqakteleettAEAEEEIQALTAHRDEIQRKFDALRNS 512
Cdd:TIGR02168 907 ---ESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS----------EEYSLTLEEAEALENKIEDDEEEARRR 973
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 513 ctvITDLEEQLNQLTEDN-------AELNNQNFYLSKQLDEASGAndeIVQLRSEVDHLRREITER 571
Cdd:TIGR02168 974 ---LKRLENKIKELGPVNlaaieeyEELKERYDFLTAQKEDLTEA---KETLEEAIEEIDREARER 1033
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
193-720 |
3.53e-17 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 87.77 E-value: 3.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKEraerELEKlhnredssegiKKKLVEAEELEEKHRE 272
Cdd:TIGR04523 125 ELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE----ELEN-----------ELNLLEKEKLNIQKNI 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 AQVSAQHLEVHLK-QKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSE-QKAMINAMDSK---IRSL 347
Cdd:TIGR04523 190 DKIKNKLLKLELLlSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNtQTQLNQLKDEQnkiKKQL 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 348 EQRIVELSEANKLAANsslfTQRNMKAQEEMISELRQQKF-----YLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL 422
Cdd:TIGR04523 270 SEKQKELEQNNKKIKE----LEKQLNQLKSEISDLNNQKEqdwnkELKSELKNQEKKLEEIQNQISQNNKIISQLNEQIS 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 423 ELETRLREVSLEHEEQKLELKRQLTELQLSLQERES---QLTALQAARAALESQLRQAKteleETTAEAEEEIQALTAHR 499
Cdd:TIGR04523 346 QLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSykqEIKNLESQINDLESKIQNQE----KLNQQKDEQIKKLQQEK 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 500 DEIQRKFDALRNSctvITDLEEQLNQLTEDNAEL----NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:TIGR04523 422 ELLEKEIERLKET---IIKNNSEIKDLTNQDSVKeliiKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL 498
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 576 tsqkqtmEALKTTCTMLEEQVLDLEALNDELLEKERQWEAwrsvlgdEKSQFECRVRELQRMLDTEKQSRARA------- 648
Cdd:TIGR04523 499 -------KKLNEEKKELEEKVKDLTKKISSLKEKIEKLES-------EKKEKESKISDLEDELNKDDFELKKEnlekeid 564
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 649 --DQRITESRQV----------VELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-E 715
Cdd:TIGR04523 565 ekNKEIEELKQTqkslkkkqeeKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKlK 644
|
....*
gi 1039770410 716 RELKQ 720
Cdd:TIGR04523 645 QEVKQ 649
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2-714 |
4.05e-17 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 87.80 E-value: 4.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH 81
Cdd:TIGR02168 244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 82 DIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPP 159
Cdd:TIGR02168 324 QLEELESKLDELAEElaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIE 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 160 RGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYS-KLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKER 238
Cdd:TIGR02168 404 RLEARLERLEDRRERLQQEIEELLKKLEEAELKELQaELEELEEE----LEELQEELERLEEALEELREELEEAEQALDA 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 239 AERELEKLHNREDS-----------SEGIKKKLVEAEEL-------------EEKHREA-----QVSAQHLEV------- 282
Cdd:TIGR02168 480 AERELAQLQARLDSlerlqenlegfSEGVKALLKNQSGLsgilgvlselisvDEGYEAAieaalGGRLQAVVVenlnaak 559
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 283 ----HLKQKE----------QHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL- 347
Cdd:TIGR02168 560 kaiaFLKQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAk 639
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 348 ----EQRIVEL-----------SEANKLAANSSLFTQRN-------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 405
Cdd:TIGR02168 640 klrpGYRIVTLdgdlvrpggviTGGSAKTNSSILERRREieeleekIEELEEKIAELEKALAELRKELEELEEELEQLRK 719
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 406 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 482
Cdd:TIGR02168 720 ELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELK 799
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 483 ETTAEAEEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgandeiv 555
Cdd:TIGR02168 800 ALREALDELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDIESLAAEIEELEELIEE--------- 870
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 556 qLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ 635
Cdd:TIGR02168 871 -LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEY 949
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 636 RML--------DTEKQSRARADQRITESRQ------VVELAVKEHKAEILALQQALKEQKlkaESLSDKLNDLEKkhAML 701
Cdd:TIGR02168 950 SLTleeaealeNKIEDDEEEARRRLKRLENkikelgPVNLAAIEEYEELKERYDFLTAQK---EDLTEAKETLEE--AIE 1024
|
810
....*....|...
gi 1039770410 702 EMNARSLQQKLET 714
Cdd:TIGR02168 1025 EIDREARERFKDT 1037
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
22-868 |
1.18e-16 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 86.56 E-value: 1.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 22 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEyqaq 101
Cdd:pfam02463 143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQA---- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 102 veemrlmmnqleedlvsarrrsdlyESELRESRLAAEEFKRKANECQHKLMKVVshpprgdsgGTALDDLHKMQGHAGLT 181
Cdd:pfam02463 207 -------------------------KKALEYYQLKEKLELEEEYLLYLDYLKLN---------EERIDLLQELLRDEQEE 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 182 SAKDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 261
Cdd:pfam02463 253 IESSKQEIEKEE-EKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELK 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 262 ----EAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAmI 337
Cdd:pfam02463 332 kekeEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL-L 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 338 NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 417
Cdd:pfam02463 411 LELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLL 490
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 418 KSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER---------ESQLTALQAARAALESQLRQAKTELEETTAEA 488
Cdd:pfam02463 491 SRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGrlgdlgvavENYKVAISTAVIVEVSATADEVEERQKLVRAL 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 489 EEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSkqldEASGANDEIVQLRSEVDHLRREI 568
Cdd:pfam02463 571 TELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAK----VVEGILKDTELTKLKESAKAKES 646
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 569 TEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM------LDTEK 642
Cdd:pfam02463 647 GLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLkleaeeLLADR 726
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 643 QSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL---ETERELK 719
Cdd:pfam02463 727 VQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLkaqEEELRAL 806
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 720 QRLLEEQAKLQQQMDLQKNH---------------IFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK--- 781
Cdd:pfam02463 807 EEELKEEAELLEEEQLLIEQeekikeeeleelaleLKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKlkd 886
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 782 ----MEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 857
Cdd:pfam02463 887 elesKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLL 966
|
890
....*....|.
gi 1039770410 858 SAREEAAHRKA 868
Cdd:pfam02463 967 LAKEELGKVNL 977
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
215-783 |
4.76e-15 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 80.88 E-value: 4.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 215 LEKAVKASTEATELLQNIRQAKERAERELEklhnredSSEGIKKKLVEAE-ELEEKHREAQvsaqhlevHLKQKEQHYEE 293
Cdd:PRK03918 157 LDDYENAYKNLGEVIKEIKRRIERLEKFIK-------RTENIEELIKEKEkELEEVLREIN--------EISSELPELRE 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 294 KIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKI---LSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftqR 370
Cdd:PRK03918 222 ELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLeekIRELEERIEELKKEIEELEEKVKELKELKEKA--------E 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 371 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLREV-----SLEHEEQKLELKRQ 445
Cdd:PRK03918 294 EYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKELekrleELEERHELYEEAKA 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 446 LTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNS------CTVITDL 519
Cdd:PRK03918 370 KKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkgkcpvCGRELTE 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 520 EEQLNQLTEDNAELNNqnfyLSKQLDEASganDEIVQLRSEVDHLRREItEREMQLTSQKQTMEALKTTCTMLEEqvLDL 599
Cdd:PRK03918 448 EHRKELLEEYTAELKR----IEKELKEIE---EKERKLRKELRELEKVL-KKESELIKLKELAEQLKELEEKLKK--YNL 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 600 EALN------DELLEKERQWEAWRSVLGDE---KSQFECRVRELQRMLDTEKQSRARADQRITE----SRQVVELAVKEH 666
Cdd:PRK03918 518 EELEkkaeeyEKLKEKLIKLKGEIKSLKKElekLEELKKKLAELEKKLDELEEELAELLKELEElgfeSVEELEERLKEL 597
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 667 KA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQ-AKLQQQMDLQKNHIFR 742
Cdd:PRK03918 598 EPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEyEELREEYLELSRELAG 677
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 1039770410 743 LTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 783
Cdd:PRK03918 678 LRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
16-851 |
1.08e-14 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 80.11 E-value: 1.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 16 LHRRVSEVEAVLSQKEVElkASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 95
Cdd:TIGR02169 216 LLKEKREYEGYELLKEKE--ALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 96 QEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELREsrlaAEEFKRKANEcqhklmkvvshpprgdsggtaldDLHKMQ 175
Cdd:TIGR02169 287 EEQLRVKEKIG----ELEAEIASLERSIAEKERELED----AEERLAKLEA-----------------------EIDKLL 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 176 ghagltSAKDQGKPEVGEYSK-LEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSE 254
Cdd:TIGR02169 336 ------AEIEELEREIEEERKrRDKLTEE----YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELK 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 255 GIKKKLVeaEELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEahekgkiLSEQK 334
Cdd:TIGR02169 406 RELDRLQ--EELQRLSEELADLNAAIAG-IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQE-------LYDLK 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 335 AMINAMDSKIRSLEQRIVELsEANKLAANSslfTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE-----QLEK 409
Cdd:TIGR02169 476 EEYDRVEKELSKLQRELAEA-EAQARASEE---RVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEvaagnRLNN 551
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 410 ISHQDHSDKSRLLELETR----------LREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaaRAALESQLRQAKT 479
Cdd:TIGR02169 552 VVVEDDAVAKEAIELLKRrkagratflpLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY------EPAFKYVFGDTLV 625
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 480 ELEETTAEAEEEIQALTAHRDEIQRK-------FDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 552
Cdd:TIGR02169 626 VEDIEAARRLMGKYRMVTLEGELFEKsgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLD 705
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 553 EivqLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqvlDLEALNDELLEKERQWEAWRSVLGD---EKSQFEC 629
Cdd:TIGR02169 706 E---LSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEE---DLSSLEQEIENVKSELKELEARIEEleeDLHKLEE 779
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 630 RVRELQRMLDTEKQsraradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ 709
Cdd:TIGR02169 780 ALNDLEARLSHSRI------PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIE 853
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 710 QKLETERELKQRLLEEQAKLQQQmdlqknhifrltqgLQEALDRADLLKTERSDLEYQLENIQvlyshekvKMEGTISQQ 789
Cdd:TIGR02169 854 KEIENLNGKKEELEEELEELEAA--------------LRDLESRLGDLKKERDELEAQLRELE--------RKIEELEAQ 911
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 790 tklIDFLQAKMDQPAKKKKGLFSRRKE-DPALPTQVPlqYNELKLALEKEKARCAELEEALQK 851
Cdd:TIGR02169 912 ---IEKKRKRLSELKAKLEALEEELSEiEDPKGEDEE--IPEEELSLEDVQAELQRVEEEIRA 969
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
193-765 |
2.77e-14 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 78.47 E-value: 2.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKE--RAERELEKLHNREDSSEGIKKKLVEAEELEEKH 270
Cdd:TIGR00618 227 ELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEElrAQEAVLEETQERINRARKAAPLAAHIKAVTQIE 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 271 REAQVSAQHLEVHLKQKEQHYEEKIKVLDNQikKDLADKESLENMMQRHEEE---AHEKGKILSEQKAMINAMDSKIRSL 347
Cdd:TIGR00618 307 QQAQRIHTELQSKMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQTLHSQEIHirdAHEVATSIREISCQQHTLTQHIHTL 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 348 EQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETR 427
Cdd:TIGR00618 385 QQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQES 464
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 428 LRevSLEHEEQKLELKRQLTelqlslqERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFD 507
Cdd:TIGR00618 465 AQ--SLKEREQQLQTKEQIH-------LQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQ 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 508 ALRNSCTVITDLEEQLNQLTEDNAELNNQ------NFYLSKQLDEASGANDEIVQ------------LRSEVDHLRREIT 569
Cdd:TIGR00618 536 TYAQLETSEEDVYHQLTSERKQRASLKEQmqeiqqSFSILTQCDNRSKEDIPNLQnitvrlqdltekLSEAEDMLACEQH 615
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 570 EREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLE--KERQWEAWRSVLGDEKSQFECRVRELQRMldtekQSRAR 647
Cdd:TIGR00618 616 ALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTltQERVREHALSIRVLPKELLASRQLALQKM-----QSEKE 690
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 648 ADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 727
Cdd:TIGR00618 691 QLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEV 770
|
570 580 590
....*....|....*....|....*....|....*....
gi 1039770410 728 KLQQQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLE 765
Cdd:TIGR00618 771 TAALQTGAELSHLAAEIQFFNRLREeDTHLLKTLEAEIG 809
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
197-925 |
3.07e-14 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 78.62 E-value: 3.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 197 LEKINAEQQLKIQELQEKLekavkasTEATELLQN----IRQAKERAERELEKLHNREDSSEGIKKKlvEAEELEEKHRE 272
Cdd:pfam15921 76 IERVLEEYSHQVKDLQRRL-------NESNELHEKqkfyLRQSVIDLQTKLQEMQMERDAMADIRRR--ESQSQEDLRNQ 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 AQVSAQHLEVHLKQKEQHYEEKikvlDNQIkkdladkESLENMMQRHEEEAHE-----------KGKILSEQKAM----- 336
Cdd:pfam15921 147 LQNTVHELEAAKCLKEDMLEDS----NTQI-------EQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhf 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 337 ----------INAMDSKIRSLEQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 401
Cdd:pfam15921 216 rslgsaiskiLRELDTEISYLKGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQAN 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 402 KLEEQLEKISHQDHSDKS----RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 477
Cdd:pfam15921 296 SIQSQLEIIQEQARNQNSmymrQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNL 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 478 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDE 546
Cdd:pfam15921 376 DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAA 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 547 ASGANDEI-------VQLRSEVDHLRREITEremqLTSQKQTMEALKTTctmleeqVLDLEAlndELLEKERQWEAWRSV 619
Cdd:pfam15921 453 IQGKNESLekvssltAQLESTKEMLRKVVEE----LTAKKMTLESSERT-------VSDLTA---SLQEKERAIEATNAE 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 620 LGDEKSQFECRVRELQRMLDTEKQSR-------------ARADQRITESRQVVEL-------------AVKEHKA----E 669
Cdd:pfam15921 519 ITKLRSRVDLKLQELQHLKNEGDHLRnvqtecealklqmAEKDKVIEILRQQIENmtqlvgqhgrtagAMQVEKAqlekE 598
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 670 ILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSL----QQKLETERELKQrlleEQAKLQQQMDLQKNHIFRLTQ 745
Cdd:pfam15921 599 INDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLvnagSERLRAVKDIKQ----ERDQLLNEVKTSRNELNSLSE 674
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 746 GLqEALDR-----ADLLKTERSDLEYQLENIQ--------VLYSHE---------KVKMEGTISQQTKLIDFLQAK---- 799
Cdd:pfam15921 675 DY-EVLKRnfrnkSEEMETTTNKLKMQLKSAQseleqtrnTLKSMEgsdghamkvAMGMQKQITAKRGQIDALQSKiqfl 753
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 800 ---MDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALE-------KEKARCAELEEALQKT------------RIELR 857
Cdd:pfam15921 754 eeaMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEvlrsqerRLKEKVANMEVALDKAslqfaecqdiiqRQEQE 833
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 858 SAREEAAHR---KATDHP-HPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKE 925
Cdd:pfam15921 834 SVRLKLQHTldvKELQGPgYTSNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQ 906
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
201-772 |
3.11e-14 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 78.14 E-value: 3.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 201 NAEQQLK-IQELQEKLEKAVKASTEATELL-QNIRQAKERAERELEKLHN-REDSS----------EGIKKKLVEAEELE 267
Cdd:TIGR04523 51 NKEKELKnLDKNLNKDEEKINNSNNKIKILeQQIKDLNDKLKKNKDKINKlNSDLSkinseikndkEQKNKLEVELNKLE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 268 EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdladKESLENMMQRHEEEAHEKGKILSEQKAMINAMD---SKI 344
Cdd:TIGR04523 131 KQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQ----KEELENELNLLEKEKLNIQKNIDKIKNKLLKLElllSNL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 345 RSLEQRIVEL-SEANKL-AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL 422
Cdd:TIGR04523 207 KKKIQKNKSLeSQISELkKQNNQLKDNIEKKQQE--INEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIK 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 423 ELETRLREVSLE------------HEEQKLELK---RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 487
Cdd:TIGR04523 285 ELEKQLNQLKSEisdlnnqkeqdwNKELKSELKnqeKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRE 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 488 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ--NFYLSKQLDEASGAN--DEIVQLRSEVDH 563
Cdd:TIGR04523 365 LEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQikKLQQEKELLEKEIERlkETIIKNNSEIKD 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 564 LRREITEREMQLTSQKQTMEALKTTCTMLEEQV----LDLEALNDELLEKERQWEAwrsvLGDEKSQFECRVRELqrmld 639
Cdd:TIGR04523 445 LTNQDSVKELIIKNLDNTRESLETQLKVLSRSInkikQNLEQKQKELKSKEKELKK----LNEEKKELEEKVKDL----- 515
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 640 TEKQSraradqritesrqvvELAVKEHKAEILALQqalKEQKLKaeSLSDKLN--DLEKKHAMLEMNARSLQQKLETERE 717
Cdd:TIGR04523 516 TKKIS---------------SLKEKIEKLESEKKE---KESKIS--DLEDELNkdDFELKKENLEKEIDEKNKEIEELKQ 575
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 718 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL-------DRADLLKTERSDLEYQLENIQ 772
Cdd:TIGR04523 576 TQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEkkissleKELEKAKKENEKLSSIIKNIK 637
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
9-605 |
1.65e-13 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 75.87 E-value: 1.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdLATYITECSSLKRSLEQarmEVSQEDDKALQLLHDIREQSR 88
Cdd:PRK03918 198 KEKELEEVLREINEISSELPELREELEKLEKEVKELEE-LKEEIEELEKELESLEG---SKRKLEEKIRELEERIEELKK 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 89 KLQEIKEQEyqAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKlmkvvshpprgdsggtaL 168
Cdd:PRK03918 274 EIEELEEKV--KELKELK----EKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER-----------------I 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 169 DDLHKMQGHAG-LTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQE-KLEKAVKASTEATELLQNIRQAKERAERELEKL 246
Cdd:PRK03918 331 KELEEKEERLEeLKKKLKELEKRLEELEERHELYEEAKAKKEELERlKKRLTGLTPEKLEKELEELEKAKEEIEEEISKI 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 247 HNREDSSEGIKKKLVEA-EELEEKHREAQVSAQHLEvhlkqkEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHE 325
Cdd:PRK03918 411 TARIGELKKEIKELKKAiEELKKAKGKCPVCGRELT------EEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRE 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 326 KGKILSEQKAMI--NAMDSKIRSLEQRIVELsEANKLAANSSLFTqrnmKAQEEMIsELRQQKFYLETQAGKLEAQNRKL 403
Cdd:PRK03918 485 LEKVLKKESELIklKELAEQLKELEEKLKKY-NLEELEKKAEEYE----KLKEKLI-KLKGEIKSLKKELEKLEELKKKL 558
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 404 EEQLEKIshqdHSDKSRLLELETRLREVSLEHEEqklELKRQLTELQ------LSLQERESQLTALQAARAALESQLRQA 477
Cdd:PRK03918 559 AELEKKL----DELEEELAELLKELEELGFESVE---ELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEELDKA 631
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 478 ktelEETTAEAEEEIQALTAHRDEIQRKFDalrnsctvitdlEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQL 557
Cdd:PRK03918 632 ----FEELAETEKRLEELRKELEELEKKYS------------EEEYEELREEYLELSRELAGLRAELEELEKRREEIKKT 695
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 1039770410 558 RSEVDHLRREITEREMQLTSQKQTMEALkttcTMLEEQVLDLEALNDE 605
Cdd:PRK03918 696 LEKLKEELEEREKAKKELEKLEKALERV----EELREKVKKYKALLKE 739
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
202-868 |
4.08e-13 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 74.72 E-value: 4.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 202 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegikkklveaeeleEKHREaqvsaqhle 281
Cdd:TIGR02169 166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKA---------------------ERYQA--------- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 282 vhLKQKEQHYEEKIKVldNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEankla 361
Cdd:TIGR02169 216 --LLKEKREYEGYELL--KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE----- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 362 aNSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREVSLEHEEQKLE 441
Cdd:TIGR02169 287 -EEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKL-------LAEIEELEREIEEERKRRDKLTEE 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 442 LKRQLTELQLSLQERESQLTALQAARAALeSQLRQAkteleettaeaeeeIQALTAHRDEIQRKFDAlrnsctvitdLEE 521
Cdd:TIGR02169 359 YAELKEELEDLRAELEEVDKEFAETRDEL-KDYREK--------------LEKLKREINELKRELDR----------LQE 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 522 QLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLE- 600
Cdd:TIGR02169 414 ELQRLSEELADLNA----------AIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEk 483
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 601 ---ALNDELLEKERQWEAWRS----------VLGDEKSQFECRVREL-----QRMLDTEKQSRARADQRITESRQVVELA 662
Cdd:TIGR02169 484 elsKLQRELAEAEAQARASEErvrggraveeVLKASIQGVHGTVAQLgsvgeRYATAIEVAAGNRLNNVVVEDDAVAKEA 563
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 663 V---KEHK---AEILALQQALKEQKLKAESLSDKLND------------------------------------------- 693
Cdd:TIGR02169 564 IellKRRKagrATFLPLNKMRDERRDLSILSEDGVIGfavdlvefdpkyepafkyvfgdtlvvedieaarrlmgkyrmvt 643
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 694 -----LEKKHAM---------LEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-------LD 752
Cdd:TIGR02169 644 legelFEKSGAMtggsraprgGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAsrkigeiEK 723
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 753 RADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS-RRKEDPALPTQVPLQYNEL 831
Cdd:TIGR02169 724 EIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDlEARLSHSRIPEIQAELSKL 803
|
730 740 750
....*....|....*....|....*....|....*..
gi 1039770410 832 KLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 868
Cdd:TIGR02169 804 EEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
10-568 |
4.13e-13 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 74.59 E-value: 4.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:COG1196 252 EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 90 LQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKlmkvvshpprgdsggtA 167
Cdd:COG1196 332 LEELEEELEELEEELEEAEeeLEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA----------------A 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 168 LDDLHKMQGHAGLTSAKDQgkpevgeysKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLH 247
Cdd:COG1196 396 AELAAQLEELEEAEEALLE---------RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 248 NREDSSEGIKKKLVEAEELEEKhreaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLEnmmQRHEEEAHEKG 327
Cdd:COG1196 467 ELLEEAALLEAALAELLEELAE----AAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV---LIGVEAAYEAA 539
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 328 KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAN-SSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 406
Cdd:COG1196 540 LEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATfLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLG 619
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 407 LEK-----ISHQDHSDKSRLLELETRLREVSLEHEEQkleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 481
Cdd:COG1196 620 DTLlgrtlVAARLEAALRRAVTLAGRLREVTLEGEGG---SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELE 696
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 482 EETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAElnnqnfyLSKQLDEASGANDEIVQLRSEV 561
Cdd:COG1196 697 EALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEEL-------LEEEALEELPEPPDLEELEREL 769
|
....*..
gi 1039770410 562 DHLRREI 568
Cdd:COG1196 770 ERLEREI 776
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
6-719 |
4.40e-13 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 74.72 E-value: 4.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 6 EAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEddkalqllhdiRE 85
Cdd:TIGR02169 282 KDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEE-----------RK 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 86 QSRKLQEikeqEYQAQVEEMRLMMNQLEEDLVSARRRSDlyesELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGG 165
Cdd:TIGR02169 351 RRDKLTE----EYAELKEELEDLRAELEEVDKEFAETRD----ELKDYREKLEKLKREINELKRELDRLQEELQRLSEEL 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 166 TALddlhkmqgHAGLTSAKDQgkpevgeYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK 245
Cdd:TIGR02169 423 ADL--------NAAIAGIEAK-------INELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSK 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 246 LHNREDSSEGiKKKLVEAEELEEKHREAQVSAQHLEVH-----LKQKEQHYEEKIKV-----LDNQIKKDLADKESLENM 315
Cdd:TIGR02169 488 LQRELAEAEA-QARASEERVRGGRAVEEVLKASIQGVHgtvaqLGSVGERYATAIEVaagnrLNNVVVEDDAVAKEAIEL 566
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 316 MQRHE------------EEAHEKGKILSEQKAMINAMD--------------------------------SKIR--SLEQ 349
Cdd:TIGR02169 567 LKRRKagratflplnkmRDERRDLSILSEDGVIGFAVDlvefdpkyepafkyvfgdtlvvedieaarrlmGKYRmvTLEG 646
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 350 RIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLR 429
Cdd:TIGR02169 647 ELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIE 726
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 430 EVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaEAEEEIQALTAHR--DEIQR 504
Cdd:TIGR02169 727 QLEQEEEKLKerlEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLE--------EALNDLEARLSHSriPEIQA 798
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 505 KFDALRnscTVITDLEEQLNQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 584
Cdd:TIGR02169 799 ELSKLE---EEVSRIEARLREI---EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEE 872
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 585 LKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA-- 662
Cdd:TIGR02169 873 LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEEls 952
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770410 663 ---VKEHKAEILALQQALKEQKLKA----ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELK 719
Cdd:TIGR02169 953 ledVQAELQRVEEEIRALEPVNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
10-560 |
8.33e-13 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 73.54 E-value: 8.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRsllEQDLATyITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:PRK02224 198 EKEEKDLHERLNGLESELAELDEEIERYEEQR---EQARET-RDEADEVLEEHEERREELETLEAEIEDLRETIAETERE 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 90 LQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVvshpprgdsggtald 169
Cdd:PRK02224 274 REELAEE-----VRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC--------------- 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 170 dlhkmqgHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKA----VKASTEATELLQNIRQAKERAERELEK 245
Cdd:PRK02224 334 -------RVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAreavEDRREEIEELEEEIEELRERFGDAPVD 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 246 LHNREDSSEgikkklveaeELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADKESLENMMQR 318
Cdd:PRK02224 407 LGNAEDFLE----------ELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHVETIEEDRER 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 319 HEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELRQQKFYLETQ 392
Cdd:PRK02224 477 VEELEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELRERAAELEAE 552
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 393 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS--------LEHEEQKLE-LKRQLTELQLSLQERESQLTAL 463
Cdd:PRK02224 553 AEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLErirtllaaIADAEDEIErLREKREALAELNDERRERLAEK 632
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 464 QAARAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQLTEDNAELNN 535
Cdd:PRK02224 633 RERKRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEELRERREALEN 705
|
570 580
....*....|....*....|....*
gi 1039770410 536 QNFYLSKQLDEASGANDEIVQLRSE 560
Cdd:PRK02224 706 RVEALEALYDEAEELESMYGDLRAE 730
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
368-720 |
1.42e-12 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 73.17 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 368 TQRNMKAQEEMISELRQQKFYLETQAGKLEaQNRKLEEQLEKISH-----QDHSDKSRLLELETRLREVSLEHEEQKLEL 442
Cdd:TIGR02168 184 TRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELallvlRLEELREELEELQEELKEAEEELEELTAEL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 443 KR---QLTELQLSLQERESQLTALQAA-------RAALESQLRQAK---TELEETTAEAEEEIQALTAHRDEIQRKFDAL 509
Cdd:TIGR02168 263 QEleeKLEELRLEVSELEEEIEELQKElyalaneISRLEQQKQILRerlANLERQLEELEAQLEELESKLDELAEELAEL 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 510 RNsctVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKttc 589
Cdd:TIGR02168 343 EE---KLEELKEELESLEAELEELEAELEELESRLEEL---EEQLETLRSKVAQLELQIASLNNEIERLEARLERLE--- 413
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 590 TMLEEQVLDLEALNDELLEKERqwEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRITESRQVVELAVKEHkAE 669
Cdd:TIGR02168 414 DRRERLQQEIEELLKKLEEAEL--KELQAELEELEEELE----ELQEELERLEEALEELREELEEAEQALDAAEREL-AQ 486
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 670 ILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ 720
Cdd:TIGR02168 487 LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEA 537
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
198-823 |
1.56e-12 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 72.45 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 198 EKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--RQAKERAERELEKLHNRE---DSSEGIKKKLVEAEELEekhre 272
Cdd:pfam05483 130 EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaRSAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELR----- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 AQVSAQHLEVHLKQKEQHyeEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGK----ILSEQKAMINAMDSKIRSLE 348
Cdd:pfam05483 204 VQAENARLEMHFKLKEDH--EKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKdltfLLEESRDKANQLEEKTKLQD 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 349 QRIVELSEAN----------KLAANSSLFTQRNMKA---------------QEEMISELRQQKFY-------LETQAGKL 396
Cdd:pfam05483 282 ENLKELIEKKdhltkelediKMSLQRSMSTQKALEEdlqiatkticqlteeKEAQMEELNKAKAAhsfvvteFEATTCSL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 397 EAQNRKLEEQLEKISHQ------DHSDKSRLLELETRL---REVSLEH------EEQKL------------ELKRQLTEL 449
Cdd:pfam05483 362 EELLRTEQQRLEKNEDQlkiitmELQKKSSELEEMTKFknnKEVELEElkkilaEDEKLldekkqfekiaeELKGKEQEL 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 450 QLSLQERES-------QLTALQAARAALESQLRQAKTELEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQ 522
Cdd:pfam05483 442 IFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLE 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 523 LNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqltsqKQTMEALKTTCTMLEEQVLDLEAl 602
Cdd:pfam05483 515 LKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDELESVREEF----------IQKGDEVKCKLDKSEENARSIEY- 580
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 603 ndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMldtEKQSRARADQRITESRQvveLAVKEHKAEILALQQALKEQKL 682
Cdd:pfam05483 581 --EVLKKEKQMKILENKCNNLKKQIENKNKNIEEL---HQENKALKKKGSAENKQ---LNAYEIKVNKLELELASAKQKF 652
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 683 KaESLSDKLNDLEKKhamlemnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNH-IFRLTQGLQEALDRADLLKTER 761
Cdd:pfam05483 653 E-EIIDNYQKEIEDK--------KISEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHkIAEMVALMEKHKHQYDKIIEER 723
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 762 SDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 823
Cdd:pfam05483 724 DSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
403-863 |
1.90e-12 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 72.38 E-value: 1.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 403 LEEQLEKISHQDHSDksRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 479
Cdd:PRK02224 192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 480 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 551
Cdd:PRK02224 269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 552 DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRV 631
Cdd:PRK02224 349 EDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRERE 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 632 RELQRMLDTEKQSRARAD------------QRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN------D 693
Cdd:PRK02224 429 AELEATLRTARERVEEAEalleagkcpecgQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraedlvE 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 694 LEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 766
Cdd:PRK02224 507 AEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKE 586
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 767 QLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCAELE 846
Cdd:PRK02224 587 RIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKRELE 640
|
490
....*....|....*...
gi 1039770410 847 EALQKTRIE-LRSAREEA 863
Cdd:PRK02224 641 AEFDEARIEeAREDKERA 658
|
|
| C1_MgcRacGAP |
cd20821 |
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ... |
931-985 |
2.18e-12 |
|
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410371 Cd Length: 55 Bit Score: 63.19 E-value: 2.18e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1039770410 931 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 985
Cdd:cd20821 1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
515-864 |
3.69e-12 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 71.63 E-value: 3.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 515 VITDLEEQLNQLtEDNAELNNQNFYLSKQLDEAsgandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE 594
Cdd:TIGR02168 194 ILNELERQLKSL-ERQAEKAERYKELKAELREL-----ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEE 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 595 QvldLEALNDELLEKERQWEAWRSVLGD---EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavKEHKAEIL 671
Cdd:TIGR02168 268 K---LEELRLEVSELEEEIEELQKELYAlanEISRLEQQKQILRERLANLERQLEELEAQLEELESK-----LDELAEEL 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 672 A-LQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERElkqrlleEQAKLQQQMDLQKNHIFRLTQGLQEA 750
Cdd:TIGR02168 340 AeLEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRS-------KVAQLELQIASLNNEIERLEARLERL 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 751 LDRADLLKTERSDLEYQLENIQVLYSHEKVkmegtisqqtklidflqakmdqpAKKKKGLFSRRKEDPALPTQvplqyne 830
Cdd:TIGR02168 413 EDRRERLQQEIEELLKKLEEAELKELQAEL-----------------------EELEEELEELQEELERLEEA------- 462
|
330 340 350
....*....|....*....|....*....|....
gi 1039770410 831 lklaLEKEKARCAELEEALQKTRIELRSAREEAA 864
Cdd:TIGR02168 463 ----LEELREELEEAEQALDAAERELAQLQARLD 492
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
58-614 |
4.67e-12 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 71.25 E-value: 4.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 58 LKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:PRK03918 194 LIKEKEKELEEVLREINEISSELPELREELEKLEKEVKE-----LEELKEEIEELEKELESLEGSKRKLEEKIRELEERI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 138 EEFKRKANECQHKLMKVvshpprgdsggtalddlhkmqghagltsakDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEK 217
Cdd:PRK03918 269 EELKKEIEELEEKVKEL------------------------------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSR 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 218 avkasteATELLQNIrqakeraERELEKLHNREDSSEGIKKKLveaEELEEKHREaqvsaqhlevhLKQKEQHYEEKIKV 297
Cdd:PRK03918 319 -------LEEEINGI-------EERIKELEEKEERLEELKKKL---KELEKRLEE-----------LEERHELYEEAKAK 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 298 LDN--QIKKDLADK--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN- 371
Cdd:PRK03918 371 KEEleRLKKRLTGLtpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHr 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 372 ---MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSLEHEEQKLE----L 442
Cdd:PRK03918 451 kelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekL 530
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 443 KRQLTEL---QLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDA 508
Cdd:PRK03918 531 KEKLIKLkgeIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLE 606
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 509 LRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDH--LRREITEREMQLTSQKQTMEALK 586
Cdd:PRK03918 607 LKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYeeLREEYLELSRELAGLRAELEELE 686
|
570 580
....*....|....*....|....*...
gi 1039770410 587 TTCTMLEEQVLDLEALNDELLEKERQWE 614
Cdd:PRK03918 687 KRREEIKKTLEKLKEELEEREKAKKELE 714
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
81-772 |
1.29e-11 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 69.99 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 81 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQL---------EEDLVSARRRsdLYES-----ELRESRLAAEEF 140
Cdd:PRK04863 307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALrqqekieryQADLEELEER--LEEQnevveEADEQQEENEAR 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 141 KRKANECQHKLMKVVSHPPRgdsggtALDDLHKM-----QGHAGLTSAKDQ-GKPEVgEYSKLEKINAEQQLKIQELQEK 214
Cdd:PRK04863 385 AEAAEEEVDELKSQLADYQQ------ALDVQQTRaiqyqQAVQALERAKQLcGLPDL-TADNAEDWLEEFQAKEQEATEE 457
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 215 L----------EKAVKASTEATELLQNI----------RQAKErAERELEKLHNREDSSEGIKKKLVEAEELEEKHReaq 274
Cdd:PRK04863 458 LlsleqklsvaQAAHSQFEQAYQLVRKIagevsrseawDVARE-LLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQ--- 533
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 275 vSAQHLevhLKQKEQhyeekikvldnQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL 354
Cdd:PRK04863 534 -RAERL---LAEFCK-----------RLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRL 598
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 355 S--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKSRLLEL 424
Cdd:PRK04863 599 AarAPAWLAAQDALARLREQSGEEfedsQDVTEYMQQLLERERELtverDELAARKQALDEEIERLSQPGGSEDPRLNAL 678
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 425 ETRLREVSLE--HEEQKLE-----------------------LKRQLTELQ-----LSLQE------RESQLTALQAARA 468
Cdd:PRK04863 679 AERFGGVLLSeiYDDVSLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcpedLYLIEgdpdsfDDSVFSVEELEKA 758
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 469 AL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTednaelnNQNFYLSK 542
Cdd:PRK04863 759 VVvkiaDRQWRYSRFPEVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFI-------GSHLAVAF 831
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 543 QLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE-----QVLDLEALNDELLEKERQWEAWR 617
Cdd:PRK04863 832 EADP----EAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRllprlNLLADETLADRVEEIREQLDEAE 907
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 618 --------------------SVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILA-- 672
Cdd:PRK04863 908 eakrfvqqhgnalaqlepivSVLQSDPEQFE----QLKQDYQQAQQTQRDAKQQAfalTEVVQRRAHFSYEDAAEMLAkn 983
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 673 --LQQALKEQKLKAESLSDKLNDLEKKHA--MLEMNAR------SLQQKLETERELKQRL----------LEEQAKLQQQ 732
Cdd:PRK04863 984 sdLNEKLRQRLEQAEQERTRAREQLRQAQaqLAQYNQVlaslksSYDAKRQMLQELKQELqdlgvpadsgAEERARARRD 1063
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 1039770410 733 mdlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 772
Cdd:PRK04863 1064 ---------ELHARLSANRSRRNQLEKQLTFCEAEMDNLT 1094
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
195-871 |
1.46e-11 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 69.62 E-value: 1.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 195 SKLEKINAEQQLKIQELQEKLEKAVKASTEAT---ELLQNIRQAKERAERELEKLHNREdssegIKKKLVEAEELEEKHR 271
Cdd:pfam02463 156 LEIEEEAAGSRLKRKKKEALKKLIEETENLAEliiDLEELKLQELKLKEQAKKALEYYQ-----LKEKLELEEEYLLYLD 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 272 EAQVSAQHLevHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMD-SKIRSLEQR 350
Cdd:pfam02463 231 YLKLNEERI--DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELkSELLKLERR 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 351 IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLRE 430
Cdd:pfam02463 309 KVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSS 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 431 VSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAL-----ESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 505
Cdd:pfam02463 389 AAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEEleileEEEESIELKQGKLTEEKEELEKQELKLLKDELELK 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 506 FDALRNSCTVITDLEEQLN-QLTEDNAELNNQNFylskqldeaSGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 584
Cdd:pfam02463 469 KSEDLLKETQLVKLQEQLElLLSRQKLEERSQKE---------SKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVE 539
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 585 LKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS-----RARADQRITESRQVV 659
Cdd:pfam02463 540 NYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIdpilnLAQLDKATLEADEDD 619
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 660 ELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ-----KLETERELKQRLLEEQAKLQQQMD 734
Cdd:pfam02463 620 KRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSEltkelLEIQELQEKAESELAKEEILRRQL 699
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 735 LQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDF-LQAKMDQPAKKKKGLFSR 813
Cdd:pfam02463 700 EIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEeKEEEKSELSLKEKELAEE 779
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 814 RKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDH 871
Cdd:pfam02463 780 REKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEE 837
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
9-567 |
1.50e-11 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 69.58 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 88
Cdd:COG1196 279 LELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 89 KLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKvvshpprgdsggTAL 168
Cdd:COG1196 359 ELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL------------EEL 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 169 DDLHKmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHN 248
Cdd:COG1196 427 EEALA----ELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 249 REDSSEGIKKKLVE----------AEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQR 318
Cdd:COG1196 503 YEGFLEGVKAALLLaglrglagavAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKI 582
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 319 HEEEAHEKGKILSEQKAMINAMDSKIRSLE---QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGK 395
Cdd:COG1196 583 RARAALAAALARGAIGAAVDLVASDLREADaryYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSL 662
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 396 LEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 475
Cdd:COG1196 663 TGGSRRELLAALLEAEAEL----EELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELL 738
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 476 QAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctvITDLEEQLNQL-------TEDNAELNNQNFYLSKQLDEAS 548
Cdd:COG1196 739 EELLEEEELLEEEALEELPEPPDLEELERE----------LERLEREIEALgpvnllaIEEYEELEERYDFLSEQREDLE 808
|
570
....*....|....*....
gi 1039770410 549 GANDEIVQLRSEVDHLRRE 567
Cdd:COG1196 809 EARETLEEAIEEIDRETRE 827
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
203-784 |
1.58e-11 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 69.43 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 203 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSsegikkkLVEAEE----LEEKHREAQVSAQ 278
Cdd:pfam01576 6 EMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETEL-------CAEAEEmrarLAARKQELEEILH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 279 HLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESLENmmQRHEEEAhekgkilSEQKAMIN--AMDSKIRSLEQRIVELSE 356
Cdd:pfam01576 79 ELESRLEEEE----ERSQQLQNEKKKMQQHIQDLEE--QLDEEEA-------ARQKLQLEkvTTEAKIKKLEEDILLLED 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 357 ANklaansslftqrnmkaqeemiSELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLR---EVSL 433
Cdd:pfam01576 146 QN---------------------SKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKkeeKGRQ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 434 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTA---EAEEEIQALTAHRDEIQRKFDALR 510
Cdd:pfam01576 205 ELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAqknNALKKIRELEAQISELQEDLESER 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 511 NSCTVIT----DLEEQLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 586
Cdd:pfam01576 285 AARNKAEkqrrDLGEELEALKTE----------LEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKH 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 587 TTCtmleeqvldLEALNDELLEKER---QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQritesrQVVELAV 663
Cdd:pfam01576 355 TQA---------LEELTEQLEQAKRnkaNLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEG------QLQELQA 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 664 KEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRllEEQAKLQ-----QQMDLQ 736
Cdd:pfam01576 420 RLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQE--ETRQKLNlstrlRQLEDE 497
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 1039770410 737 KNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKVKMEG 784
Cdd:pfam01576 498 RN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKKKLEE 535
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
544-868 |
2.09e-11 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 69.20 E-value: 2.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 544 LDEASGandeIVQLRSevdhlRREITEREMQLTSQkqtmealkttctmleeqvlDLEALNDELLEKERQWEAwrsvLGDE 623
Cdd:COG1196 161 IEEAAG----ISKYKE-----RKEEAERKLEATEE-------------------NLERLEDILGELERQLEP----LERQ 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 624 KSQFEcRVRELQRMLDT-EKQSRARADQRITESRQVVELAVKEHKAEILALQQ-------ALKEQKLKAESLSDKLNDLE 695
Cdd:COG1196 209 AEKAE-RYRELKEELKElEAELLLLKLRELEAELEELEAELEELEAELEELEAelaeleaELEELRLELEELELELEEAQ 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 696 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLY 775
Cdd:COG1196 288 AEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 776 SHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptqvpLQYNELKLALEKEKARCAELEEALQKTRIE 855
Cdd:COG1196 368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE--------EALLERLERLEEELEELEEALAELEEEEEE 439
|
330
....*....|...
gi 1039770410 856 LRSAREEAAHRKA 868
Cdd:COG1196 440 EEEALEEAAEEEA 452
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
30-587 |
2.97e-11 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 68.39 E-value: 2.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 30 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 107
Cdd:PRK01156 172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 108 MMNQLEEdlvsarrrSDLYESELR--ESRLAAEEFKR-KANECQHKLMKVVSHPprgdsggtALDDLHKMQGHAGLtsak 184
Cdd:PRK01156 244 LSSLEDM--------KNRYESEIKtaESDLSMELEKNnYYKELEERHMKIINDP--------VYKNRNYINDYFKY---- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 185 dqgKPEVGEYSK-LEKINAEqqlkIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV-- 261
Cdd:PRK01156 304 ---KNDIENKKQiLSNIDAE----INKYHAIIKKL--------SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNsy 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 262 --EAEELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLDNQIKKDLADKES-LENMMQR------HEEEAHEKGKI 329
Cdd:PRK01156 369 lkSIESLKKKIEEYSKNIERMSAFISEILKIQEidpDAIKKELNEINVKLQDISSkVSSLNQRiralreNLDELSRNMEM 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 330 LSEQKAM----INAMDSKIRSLEQRIVElsEANKLAANSSlFTQRNMKAQEEMISELRQQKFYLET-QAGKLEAQNRKLE 404
Cdd:PRK01156 449 LNGQSVCpvcgTTLGEEKSNHIINHYNE--KKSRLEEKIR-EIEIEVKDIDEKIVDLKKRKEYLESeEINKSINEYNKIE 525
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 405 E---QLEKISHQDHSDKSRLL---ELETRLREVSLEHEEQKL-----------------------ELKRQLTELQLSLQE 455
Cdd:PRK01156 526 SaraDLEDIKIKINELKDKHDkyeEIKNRYKSLKLEDLDSKRtswlnalavislidietnrsrsnEIKKQLNDLESRLQE 605
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 456 RESQLTALQAAraaLESQLRQAKTELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNN 535
Cdd:PRK01156 606 IEIGFPDDKSY---IDKSIREIENEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIED 681
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 536 QNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKT 587
Cdd:PRK01156 682 NLKKSRKALDD---AKANRARLESTIEILRTRINELSDRINDINETLESMKK 730
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
18-575 |
3.44e-11 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 68.61 E-value: 3.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 18 RRVSEVEAVLSQKEVELKAS----ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEI 93
Cdd:pfam15921 317 RQLSDLESTVSQLRSELREAkrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 94 KEQeyqaqveEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAeEFKRKANECQHKLMKVVshpprgdsggtalddlhk 173
Cdd:pfam15921 397 KEQ-------NKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA-LLKAMKSECQGQMERQM------------------ 450
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 174 mqghagltsAKDQGKPEVGE-----YSKLEKINAEQQLKIQELQEK---LEKAVKASTEATELLQNIRQAKERAERELEK 245
Cdd:pfam15921 451 ---------AAIQGKNESLEkvsslTAQLESTKEMLRKVVEELTAKkmtLESSERTVSDLTASLQEKERAIEATNAEITK 521
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 246 LHNREDssegikKKLVEAEEL--EEKH-REAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIkkdladkeslENMMQ---RH 319
Cdd:pfam15921 522 LRSRVD------LKLQELQHLknEGDHlRNVQTECEALKLQMAEKDK----VIEILRQQI----------ENMTQlvgQH 581
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 320 --------------EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQ 384
Cdd:pfam15921 582 grtagamqvekaqlEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQ 653
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 385 QKFYLETQAGKLEAQNRKLEEQLEKishqdhsdksrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 464
Cdd:pfam15921 654 ERDQLLNEVKTSRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSME 719
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 465 AARA-ALESQLRQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQ 543
Cdd:pfam15921 720 GSDGhAMKVAMGMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQE 777
|
570 580 590
....*....|....*....|....*....|....*.
gi 1039770410 544 LD----EASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:pfam15921 778 LStvatEKNKMAGELEVLRSQERRLKEKVANMEVAL 813
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
57-806 |
6.00e-11 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 67.67 E-value: 6.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 57 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 134
Cdd:COG3096 289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 135 LAAEEFKRKANECQHKLMKVVSHPPRGDSG----GTALDDLHK-----MQGHAGLTSAKDQ-GKPE-----VGEYskLEK 199
Cdd:COG3096 368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQladyQQALDVQQTraiqyQQAVQALEKARALcGLPDltpenAEDY--LAA 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 200 INAEQQL---KIQELQEKLEKAVKASTE---ATELLQNIRQAKERAE---------RELEKLHNREDSSEGIKKKLVEAE 264
Cdd:COG3096 446 FRAKEQQateEVLELEQKLSVADAARRQfekAYELVCKIAGEVERSQawqtarellRRYRSQQALAQRLQQLRAQLAELE 525
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 265 ELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQikkdladKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 344
Cdd:COG3096 526 QRLRQQQNAERLLEEFCQRIGQQLDAAEE----LEEL-------LAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARI 594
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 345 RSLEQRivelsEANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHS 416
Cdd:COG3096 595 KELAAR-----APAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQPGGA 669
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 417 DKSRLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ESQL 460
Cdd:COG3096 670 EDPRLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfdDSVF 749
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 461 TALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtednaeln 534
Cdd:COG3096 750 DAEELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF-------- 821
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 535 nqnfyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTML---------------EEQVL 597
Cdd:COG3096 822 -----VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLnkllpqanlladetlADRLE 896
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 598 DLEALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVK 664
Cdd:COG3096 897 ELREELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSY 972
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 665 EHKAEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHi 740
Cdd:COG3096 973 EDAVGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADA- 1051
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 741 frltqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 806
Cdd:COG3096 1052 --------EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
|
|
| C1_ScPKC1-like_rpt2 |
cd20823 |
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ... |
929-986 |
7.32e-11 |
|
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410373 Cd Length: 59 Bit Score: 58.86 E-value: 7.32e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770410 929 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 986
Cdd:cd20823 1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
403-863 |
1.29e-10 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 66.33 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 403 LEEQLEKISHQDHSDKSRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 481
Cdd:COG4717 47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 482 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgANDEIVQLRSEV 561
Cdd:COG4717 126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA--TEEELQDLAEEL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 562 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNdELLEKERQWEAWRSVL-----GDEKSQFECRVRELQR 636
Cdd:COG4717 202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEE-RLKEARLLLLIAAALLallglGGSLLSLILTIAGVLF 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 637 MLdtekqSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE--MNARSLQQKLET 714
Cdd:COG4717 281 LV-----LGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLEllDRIEELQELLRE 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 715 ERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI-----QVLYSHEKVKMEG 784
Cdd:COG4717 356 AEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgeleELLEALDEEELEE 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 785 TISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE---ALQKTRIELRSARE 861
Cdd:COG4717 433 ELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewaALKLALELLEEARE 507
|
..
gi 1039770410 862 EA 863
Cdd:COG4717 508 EY 509
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
192-730 |
1.46e-10 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 66.22 E-value: 1.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 192 GEYSKLekINA---EQQ------LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK-----LHNREDSSEGIK 257
Cdd:PRK02224 138 GEVNKL--INAtpsDRQdmiddlLQLGKLEEYRERASDARLGVERVLSDQRGSLDQLKAQIEEkeekdLHERLNGLESEL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 258 KKL-VEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEkIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAM 336
Cdd:PRK02224 216 AELdEEIERYEEQREQARETRDEADEVLEEHEERREE-LETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEE 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 337 INAM-------DSKIRSLEQRIVELsEANKLAANSSLFTQR-NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLE 408
Cdd:PRK02224 295 RDDLlaeagldDADAEAVEARREEL-EDRDEELRDRLEECRvAAQAHNEEAESLREDADDLEERAEELREEAAELESELE 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 409 KISHQDHSDKSRLLELETRLREVSL-----------------EHEEQKLELKRQLTELQLSLQERESQLT---ALQAA-- 466
Cdd:PRK02224 374 EAREAVEDRREEIEELEEEIEELRErfgdapvdlgnaedfleELREERDELREREAELEATLRTARERVEeaeALLEAgk 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 467 -----------------------RAALESQLRQAKTELEETTAEAEEEiQALTAHRDEIQRKFDALRNSCTVITDLEEQL 523
Cdd:PRK02224 454 cpecgqpvegsphvetieedrerVEELEAELEDLEEEVEEVEERLERA-EDLVEAEDRIERLEERREDLEELIAERRETI 532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 524 NQLTEDNAELNNQNFYLSkqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqVLDLEALN 603
Cdd:PRK02224 533 EEKRERAEELRERAAELE---AEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAA-IADAEDEI 608
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 604 DELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkehkaeilalqqalkeqklk 683
Cdd:PRK02224 609 ERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEYL-------------------------- 662
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 1039770410 684 aESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ 730
Cdd:PRK02224 663 -EQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVE 708
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
321-772 |
1.57e-10 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 66.09 E-value: 1.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 321 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 397
Cdd:COG4913 238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 398 AQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 473
Cdd:COG4913 316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 474 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 532
Cdd:COG4913 396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 533 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREI-TEREMQLTSQKQTMEALKTTctmleeqvldle 600
Cdd:COG4913 476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLvYERVRTGLPDPERPRLDPDS------------ 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 601 aLNDELLEKERQWEAW-RSVLGDEKSqFEC--RVRELQR---------MLDTEKQSRARADQRITESRQV----VELAVK 664
Cdd:COG4913 536 -LAGKLDFKPHPFRAWlEAELGRRFD-YVCvdSPEELRRhpraitragQVKGNGTRHEKDDRRRIRSRYVlgfdNRAKLA 613
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 665 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEM---------NARSLQQKLETERELKQRLLEEQ---AKLQQQ 732
Cdd:COG4913 614 ALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAELEAELERLDASSddlAALEEQ 693
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1039770410 733 MDlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 772
Cdd:COG4913 694 LE-------ELEAELEELEEELDELKGEIGRLEKELEQAE 726
|
|
| C1 |
smart00109 |
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ... |
933-981 |
1.76e-10 |
|
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.
Pssm-ID: 197519 Cd Length: 50 Bit Score: 57.48 E-value: 1.76e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1039770410 933 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 981
Cdd:smart00109 1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
312-548 |
1.80e-10 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 65.81 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 312 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 391
Cdd:COG3206 162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 392 QAGKLEAQNRKLEEQLEKISHQ--DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 469
Cdd:COG3206 234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 470 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 548
Cdd:COG3206 303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
|
|
| C1 |
cd00029 |
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ... |
933-981 |
1.95e-10 |
|
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.
Pssm-ID: 410341 Cd Length: 50 Bit Score: 57.53 E-value: 1.95e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1039770410 933 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd00029 1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
5-472 |
2.36e-10 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 65.47 E-value: 2.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLE--QDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHD 82
Cdd:PRK03918 246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEING 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 83 IREQ-------SRKLQEIKEQEYQAQVEEMRL--------MMNQLEEDLVSARRRSDLYESELRESRLaaEEFKRKANEC 147
Cdd:PRK03918 326 IEERikeleekEERLEELKKKLKELEKRLEELeerhelyeEAKAKKEELERLKKRLTGLTPEKLEKEL--EELEKAKEEI 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 148 QHKLMKVVSHPPRGDSGG----TALDDLHKMQGHAGLTSAkdqgkpEVGEYSKLEkINAEQQLKIQELQEKLEKAVKAST 223
Cdd:PRK03918 404 EEEISKITARIGELKKEIkelkKAIEELKKAKGKCPVCGR------ELTEEHRKE-LLEEYTAELKRIEKELKEIEEKER 476
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 224 EATELLQNIRQAKERaERELEKLHNREDSSEGIKKKL--VEAEELEEKHREAQvsaqhlevHLKQKEQHYEEKIKVLdnq 301
Cdd:PRK03918 477 KLRKELRELEKVLKK-ESELIKLKELAEQLKELEEKLkkYNLEELEKKAEEYE--------KLKEKLIKLKGEIKSL--- 544
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 302 iKKDLADKESLENMMQRHEEEAHEKGKILSE-QKAMINAMDSKIRSLEQRIVELSEANK---LAANSSLFTQRNMKAQEE 377
Cdd:PRK03918 545 -KKELEKLEELKKKLAELEKKLDELEEELAElLKELEELGFESVEELEERLKELEPFYNeylELKDAEKELEREEKELKK 623
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 378 MISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS-RLLELETRLREVslehEEQKLELKRQLTELQLSLQER 456
Cdd:PRK03918 624 LEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELReEYLELSRELAGL----RAELEELEKRREEIKKTLEKL 699
|
490
....*....|....*.
gi 1039770410 457 ESQLTALQAARAALES 472
Cdd:PRK03918 700 KEELEEREKAKKELEK 715
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
193-746 |
3.35e-10 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 64.79 E-value: 3.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELeklhnredssegikkklveaEELEEKHRE 272
Cdd:COG4717 54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEEL--------------------EELEAELEE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 AQVSAQHLEvHLKQKEQHYEEKIKVldnqikkdladKESLENMMQRHEEeahekgkiLSEQKAMINAMDSKIRSLEQRIV 352
Cdd:COG4717 114 LREELEKLE-KLLQLLPLYQELEAL-----------EAELAELPERLEE--------LEERLEELRELEEELEELEAELA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 353 ELSEA-NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS--HQDHSDKSRLLELETRLR 429
Cdd:COG4717 174 ELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEneLEAAALEERLKEARLLLL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 430 EVSLEHEeqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdal 509
Cdd:COG4717 254 IAAALLA---------LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE---- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 510 rnsctvitdLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC 589
Cdd:COG4717 321 ---------LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAAL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 590 TMLEEQV---LDLEALNDELLEKERQWEAWRSVLGDEksqfecrvrELQRMLDTEKQSRARADQRITESRQvvELAVKEH 666
Cdd:COG4717 392 EQAEEYQelkEELEELEEQLEELLGELEELLEALDEE---------ELEEELEELEEELEELEEELEELRE--ELAELEA 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 667 KAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAklqqqmdlqkNHIF-RLTQ 745
Cdd:COG4717 461 ELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA----------SEYFsRLTD 530
|
.
gi 1039770410 746 G 746
Cdd:COG4717 531 G 531
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
192-883 |
4.46e-10 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 64.60 E-value: 4.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 192 GEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIR--QAKERAERELEKLHNREDSSEGIKKKLVEAEELEEK 269
Cdd:TIGR00618 152 GEFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHgkAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 270 hREAQVSAQHLEVHLKQKEQHYEEKIKvLDNQIKKDLADKESLENMMQRHEEE------AHEKGKILSEQKAMINaMDSK 343
Cdd:TIGR00618 232 -REALQQTQQSHAYLTQKREAQEEQLK-KQQLLKQLRARIEELRAQEAVLEETqerinrARKAAPLAAHIKAVTQ-IEQQ 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 344 IRSLEQRIVElseanKLAANSSLFTQRNMKAQEEmiSELRQQKFYLETqagkLEAQNRKLEEQLEK-ISHQDHSDKSRLL 422
Cdd:TIGR00618 309 AQRIHTELQS-----KMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQT----LHSQEIHIRDAHEVaTSIREISCQQHTL 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 423 ELETRLREVSLEHEEQKLELKRQLTElqlSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiQALTAHRDEI 502
Cdd:TIGR00618 378 TQHIHTLQQQKTTLTQKLQSLCKELD---ILQREQATIDTRTSAFRDLQGQLAHAKKQ------------QELQQRYAEL 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 503 QRKFdalrnsctvitdLEEQLNQLTEDNAELNNqnfylskqldeasgandeivqlrsevdhLRREITEREMQLTSQKQTM 582
Cdd:TIGR00618 443 CAAA------------ITCTAQCEKLEKIHLQE----------------------------SAQSLKEREQQLQTKEQIH 482
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 583 EALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVRELQRMLDTEKQSRARAD---QRITESRQVV 659
Cdd:TIGR00618 483 LQETRKKAVVLARLLELQEEPCPLCGSCIHPNPAR-QDIDNPGPLTRRMQRGEQTYAQLETSEEDVYhqlTSERKQRASL 561
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 660 ELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKnh 739
Cdd:TIGR00618 562 KEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD---LTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQ-- 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 740 ifrLTQGLQEALDRadlLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGL----FSRRK 815
Cdd:TIGR00618 637 ---CSQELALKLTA---LHALQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLaqcqTLLRE 708
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 816 EDPALPTQVPlQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 883
Cdd:TIGR00618 709 LETHIEEYDR-EFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
244-737 |
6.56e-10 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 64.15 E-value: 6.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 244 EKLHNREDSSEGIKKKLveaEELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKESLENMMQRHEEEA 323
Cdd:PRK01156 190 EKLKSSNLELENIKKQI---ADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESEI 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 324 HEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRKL 403
Cdd:PRK01156 259 KT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKKL 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 404 EEqLEKISHQDHSDKSRLLELETRLREVSLEH-----------------EEQKLELKRQLTELQLSLQERESQLTALQAA 466
Cdd:PRK01156 332 SV-LQKDYNDYIKKKSRYDDLNNQILELEGYEmdynsylksieslkkkiEEYSKNIERMSAFISEILKIQEIDPDAIKKE 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 467 RAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYLS 541
Cdd:PRK01156 411 LNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKIR 486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 542 KQLDEASGANDEIVQLRSEVDHLR-----------REITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKE 610
Cdd:PRK01156 487 EIEIEVKDIDEKIVDLKKRKEYLEseeinksineyNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSK 566
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 611 R-QW------------EAWRSVLGDEKSQF---ECRVRELQ--------------RMLDTE------KQSRARADQRITE 654
Cdd:PRK01156 567 RtSWlnalavislidiETNRSRSNEIKKQLndlESRLQEIEigfpddksyidksiREIENEannlnnKYNEIQENKILIE 646
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 655 SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQ 730
Cdd:PRK01156 647 KLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETLE 726
|
....*..
gi 1039770410 731 QQMDLQK 737
Cdd:PRK01156 727 SMKKIKK 733
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
229-773 |
7.57e-10 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 64.09 E-value: 7.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 229 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQ-HLEVHLKQKEQHYEEKI-------KVLDN 300
Cdd:pfam12128 236 IMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSaELNQLLRTLDDQWKEKRdelngelSAADA 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 301 QIKKDLADKESLENMMQRHEEEAHEKGKI-----------LSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLftQ 369
Cdd:pfam12128 316 AVAKDRSELEALEDQHGAFLDADIETAAAdqeqlpswqseLENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDI--A 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 370 RNMKAQEEMISELRQQKFYLETQAGKLEAQ-NRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEqklelKRQLTE 448
Cdd:pfam12128 394 GIKDKLAKIREARDRQLAVAEDDLQALESElREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPEL-----LLQLEN 468
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 449 LQLSLQERESQLTALQAARAALESQLRQAKTELEettaeaeeeiQALTAHRDEIQRkfdalrnsctvitdLEEQLNQLTE 528
Cdd:pfam12128 469 FDERIERAREEQEAANAEVERLQSELRQARKRRD----------QASEALRQASRR--------------LEERQSALDE 524
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 529 DNAELNNQNFYLSKQL-DEASGANDEIVQLRSEvDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELL 607
Cdd:pfam12128 525 LELQLFPQAGTLLHFLrKEAPDWEQSIGKVISP-ELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELR 603
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 608 EKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKA 684
Cdd:pfam12128 604 ERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSA 680
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 685 E----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRaD 755
Cdd:pfam12128 681 NerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALETWYKR-D 759
|
570 580 590
....*....|....*....|....*....|
gi 1039770410 756 L------------LKTERSDLEYQLENIQV 773
Cdd:pfam12128 760 LaslgvdpdviakLKREIRTLERKIERIAV 789
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
181-870 |
8.72e-10 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 64.01 E-value: 8.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 181 TSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKAsteatellQNIRQAKErAERELEKLHNREDSSEGIKKKL 260
Cdd:PTZ00121 1090 DEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKA--------EEARKAED-ARKAEEARKAEDAKRVEIARKA 1160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 261 VEAEELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQ--RHEEEAHEKGKILSEQKAMIN 338
Cdd:PTZ00121 1161 EDARKAEEARKAED--AKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEeaRKAEDAKKAEAVKKAEEAKKD 1238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 339 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM-ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 417
Cdd:PTZ00121 1239 AEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARkADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAD 1318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 418 KSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 497
Cdd:PTZ00121 1319 EAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK 1398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 498 HRDEIQRKFDALRNSCTVITDLEEQLNQLTE-DNAELNNQNFYLSKQLDEASGANDEivqlRSEVDHLRREITEREMQLT 576
Cdd:PTZ00121 1399 KAEEDKKKADELKKAAAAKKKADEAKKKAEEkKKADEAKKKAEEAKKADEAKKKAEE----AKKAEEAKKKAEEAKKADE 1474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 577 SQKQTMEALKTtctmlEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR 656
Cdd:PTZ00121 1475 AKKKAEEAKKA-----DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKAD 1549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 657 QVVELAVKEHKAEILALQQALKEQKLKAESL--SDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 734
Cdd:PTZ00121 1550 ELKKAEELKKAEEKKKAEEAKKAEEDKNMALrkAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAE 1629
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 735 LQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgtisqqtklidflQAKMDQPAKKKKGLFSRR 814
Cdd:PTZ00121 1630 EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAE-------------EAKKAEEDEKKAAEALKK 1696
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 815 KEDPALPTQvplqynELKLALEKEKARCAEL--EEALQKTRIELRSAREEAAHRKATD 870
Cdd:PTZ00121 1697 EAEEAKKAE------ELKKKEAEEKKKAEELkkAEEENKIKAEEAKKEAEEDKKKAEE 1748
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
203-657 |
1.69e-09 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 63.01 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 203 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAE--ELEEKHREAQVSAQHL 280
Cdd:COG4913 285 FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREieRLERELEERERRRARL 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 281 EVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeANKL 360
Cdd:COG4913 365 EALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIP-ARLL 443
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 361 AANSSLFTQRNMKAQE--------EMISE-----------LRQQKF--------------------------YLETQAGK 395
Cdd:COG4913 444 ALRDALAEALGLDEAElpfvgeliEVRPEeerwrgaiervLGGFALtllvppehyaaalrwvnrlhlrgrlvYERVRTGL 523
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 396 LEAQNRKLEEQ--LEKISHQDHSDKSRLL-ELETRLREVSLEHEEQKLELKRQLT-ELQLSL------------------ 453
Cdd:COG4913 524 PDPERPRLDPDslAGKLDFKPHPFRAWLEaELGRRFDYVCVDSPEELRRHPRAITrAGQVKGngtrhekddrrrirsryv 603
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 454 --QERESQLTALQAARAALESQLRQAKteleettaeaeEEIQALTAHRDEIQRKFDALRNsctvITDLEEQLNQLTEDNA 531
Cdd:COG4913 604 lgFDNRAKLAALEAELAELEEELAEAE-----------ERLEALEAELDALQERREALQR----LAEYSWDEIDVASAER 668
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 532 ELNNqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKER 611
Cdd:COG4913 669 EIAE----LEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR 744
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 612 QW------EAWRSVLGDEKSQfecRVRE-LQRMLDTEKQSRARADQRITESRQ 657
Cdd:COG4913 745 LElralleERFAAALGDAVER---ELREnLEERIDALRARLNRAEEELERAMR 794
|
|
| ROM1 |
COG5422 |
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ... |
1186-1437 |
1.72e-09 |
|
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];
Pssm-ID: 227709 [Multi-domain] Cd Length: 1175 Bit Score: 62.99 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1186 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1257
Cdd:COG5422 868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1258 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1326
Cdd:COG5422 944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1327 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1405
Cdd:COG5422 1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091
|
250 260 270
....*....|....*....|....*....|...
gi 1039770410 1406 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1437
Cdd:COG5422 1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
13-747 |
2.22e-09 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 62.68 E-value: 2.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 13 MTRLHRRVSEVEAVLSQKEVELkasETQrsLLEQDLATYITECSSLKRSLEQARMEVSQE---DDKALQLLHDIREQSRK 89
Cdd:TIGR00618 184 MEFAKKKSLHGKAELLTLRSQL---LTL--CTPCMPDTYHERKQVLEKELKHLREALQQTqqsHAYLTQKREAQEEQLKK 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 90 LQEIKE---QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPrgdsggT 166
Cdd:TIGR00618 259 QQLLKQlraRIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRA------A 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 167 ALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 246
Cdd:TIGR00618 333 HVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATI 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 247 HNREDSSEGIKKKLVEAE---ELEEKHREA-QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdLADKEsleNMMQRHEEE 322
Cdd:TIGR00618 413 DTRTSAFRDLQGQLAHAKkqqELQQRYAELcAAAITCTAQCEKLEKIHLQESAQSLKEREQQ-LQTKE---QIHLQETRK 488
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 323 AHEKGKILSEQKaminamdSKIRSLEQRIVELSEANKLAANSSLFTQRnmkaqeemISELRQQKFYLETQAGKLEAQNRK 402
Cdd:TIGR00618 489 KAVVLARLLELQ-------EEPCPLCGSCIHPNPARQDIDNPGPLTRR--------MQRGEQTYAQLETSEEDVYHQLTS 553
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 403 LEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 482
Cdd:TIGR00618 554 ERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLH 633
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 483 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEdNAELNNQNFY--LSKQLDEASGANDEIVQLRSE 560
Cdd:TIGR00618 634 LQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLASRQ-LALQKMQSEKeqLTYWKEMLAQCQTLLRELETH 712
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 561 VDHLRREITEREMQLTSQKQTMEALKTTCTML--EEQVLDLEALNDELLEKERQWEAWRSVL--GDEKSQFECRVRELQR 636
Cdd:TIGR00618 713 IEEYDREFNEIENASSSLGSDLAAREDALNQSlkELMHQARTVLKARTEAHFNNNEEVTAALqtGAELSHLAAEIQFFNR 792
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 637 MLDTEKQSRARADQRITESRQVVELAVKehkAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 716
Cdd:TIGR00618 793 LREEDTHLLKTLEAEIGQEIPSDEDILN---LQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQA 869
|
730 740 750
....*....|....*....|....*....|.
gi 1039770410 717 ELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 747
Cdd:TIGR00618 870 KIIQLSDKLNGINQIKIQFDGDALIKFLHEI 900
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
291-862 |
2.69e-09 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 62.00 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 291 YEEKIKVLDNQIKKDLADKESLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 370
Cdd:PRK03918 160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 371 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREV-SLEHEEQK-LELKRQLTE 448
Cdd:PRK03918 232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 449 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 528
Cdd:PRK03918 305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 529 DNAELNNQNF-YLSKQLDEASGANDEIvqlRSEVDHLRREITEREMQLTSQKQTMEALKT------TC----------TM 591
Cdd:PRK03918 377 LKKRLTGLTPeKLEKELEELEKAKEEI---EEEISKITARIGELKKEIKELKKAIEELKKakgkcpVCgrelteehrkEL 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 592 LEEQVLDLEALNDELLEkerqweawrsvLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEil 671
Cdd:PRK03918 454 LEEYTAELKRIEKELKE-----------IEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLE-- 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 672 alqqALKEQKLKAESLSDKLNDLEKKhamlemnARSLQQKLETERELKQRLLEEQAKLQQqmdlqknhifrltqglqeal 751
Cdd:PRK03918 519 ----ELEKKAEEYEKLKEKLIKLKGE-------IKSLKKELEKLEELKKKLAELEKKLDE-------------------- 567
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 752 dradlLKTERSDLEYQLENIQVLYSHEkvkMEGTISQQTKLID-FLQAKmdqPAKKKKglfsRRKEDpalptqvplqyne 830
Cdd:PRK03918 568 -----LEEELAELLKELEELGFESVEE---LEERLKELEPFYNeYLELK---DAEKEL----EREEK------------- 619
|
570 580 590
....*....|....*....|....*....|..
gi 1039770410 831 lklALEKEKARCAELEEALQKTRIELRSAREE 862
Cdd:PRK03918 620 ---ELKKLEEELDKAFEELAETEKRLEELRKE 648
|
|
| Crescentin |
pfam19220 |
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ... |
396-763 |
2.69e-09 |
|
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 61.24 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 396 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQLR 475
Cdd:pfam19220 25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYG----KLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 476 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 555
Cdd:pfam19220 101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 556 QLRSEVDHLRREITEREMQLTSQKQTMEALkttctmLEEQVLDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQ 635
Cdd:pfam19220 153 KALQRAEGELATARERLALLEQENRRLQAL------SEEQAAELAELTRRLAELETQLDATRA-----------RLRALE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 636 RMLDTEKQSRARADQRItesrqvvELAVKEHKAEILALqqalkeqKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETE 715
Cdd:pfam19220 216 GQLAAEQAERERAEAQL-------EEAVEAHRAERASL-------RMKLEALTARAAATEQ---LLAEARNQLRDRDEAI 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 716 RELKQRLLE---EQAKLQQQMDLQKNHIFRLTQGLQEaLDRADLLKTERSD 763
Cdd:pfam19220 279 RAAERRLKEasiERDTLERRLAGLEADLERRTQQFQE-MQRARAELEERAE 328
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
10-767 |
3.23e-09 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 61.99 E-value: 3.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQdlatyITECSSLKRSLEQARMEVSQEDDkALQLLHDIREQ 86
Cdd:TIGR00606 318 ERELVDCQRELEKLNKerrLLNQEKTELLVEQGRLQLQAD-----RHQEHIRARDSLIQSLATRLELD-GFERGPFSERQ 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 87 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGG- 165
Cdd:TIGR00606 392 IKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSd 471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 166 ----------TALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQEL---QEKLEKAVKASTEATELLQNI 232
Cdd:TIGR00606 472 rileldqelrKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLnhhTTTRTQMEMLTKDKMDKDEQI 551
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 233 RQAKERAERELEKL----HNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKK---- 304
Cdd:TIGR00606 552 RKIKSRHSDELTSLlgyfPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLE----QNKNHINNELESKEEQLSSyedk 627
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 305 --DLADKESLENMMQRHEEEAHEKGKilseQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISEL 382
Cdd:TIGR00606 628 lfDVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDL 700
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 383 RQQKFYLETQAGKLEAQNRKLEEQLEKI--------SHQDHSDKsRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 454
Cdd:TIGR00606 701 QSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrqSIIDLKEK-EIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMP 779
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 455 ERES------QLTALQAARAALESQLRQ-AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC----TVITDLEEQL 523
Cdd:TIGR00606 780 EEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIelnrKLIQDQQEQI 859
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 524 NQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEalkttctmleeqvlDLEALN 603
Cdd:TIGR00606 860 QHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLE--------------KDQQEK 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 604 DELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRqvvELAVKEHKAEILALQQALKEQKLK 683
Cdd:TIGR00606 926 EELISSKET----------SNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGK---DDYLKQKETELNTVNAQLEECEKH 992
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 684 AESLSDKLNDLEKKHAMLEMNARSLQQKL----------ETERELKQRLLE-----------EQAKLQQQMDLQKNHIFR 742
Cdd:TIGR00606 993 QEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEELKQHLKEmgqmqvlqmkqEHQKLEENIDLIKRNHVL 1072
|
810 820
....*....|....*....|....*
gi 1039770410 743 LTQGLQEALDRADLLKTERSDLEYQ 767
Cdd:TIGR00606 1073 ALGRQKGYEKEIKHFKKELREPQFR 1097
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
186-650 |
6.44e-09 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 60.55 E-value: 6.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 186 QGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegikkKLVEAEE 265
Cdd:COG4717 126 QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQL------------SLATEEE 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 266 LEEKHREAQvsaqhlevHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKI 344
Cdd:COG4717 194 LQDLAEELE--------ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLG 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 345 RSLEQRIVELSEANKL-AANSSLFTQRNMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLE 423
Cdd:COG4717 266 GSLLSLILTIAGVLFLvLGLLALLFLLLAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLE 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 424 LETRLREV-----SLEHEEQKLELKRQLTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEt 484
Cdd:COG4717 342 LLDRIEELqellrEAEELEEELQLEELEQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE- 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 485 taeaeeeiQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHL 564
Cdd:COG4717 421 --------LLEALDEEELEEELEELEEE---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEEL 481
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 565 RREITEREMQLTSQKQTMEALKTTCTMLEEQVLdlealnDELLEKERQW------EAWRSVLGDEKSQFECRvRELQRML 638
Cdd:COG4717 482 KAELRELAEEWAALKLALELLEEAREEYREERL------PPVLERASEYfsrltdGRYRLIRIDEDLSLKVD-TEDGRTR 554
|
490
....*....|..
gi 1039770410 639 DTEKQSRARADQ 650
Cdd:COG4717 555 PVEELSRGTREQ 566
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
9-558 |
8.47e-09 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 60.75 E-value: 8.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 85
Cdd:TIGR00618 384 LQQQKTTLTQKLQSLCKELDILQREQATIDTRtsaFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQE 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 86 QSRKLQEIKEQEYQAQVeemrlmmnqleedlvsarrrsdlyeSELRESRLAAEEFKR----KANECQHKLMKVVSHPPRG 161
Cdd:TIGR00618 464 SAQSLKEREQQLQTKEQ-------------------------IHLQETRKKAVVLARllelQEEPCPLCGSCIHPNPARQ 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 162 DSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER 241
Cdd:TIGR00618 519 DIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD 598
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 242 ELEKLHNREDssegikkKLVEAEELEEKHREAQVSAQHLEVHLKQKEQhyeekikvldNQIKKDLADKESLENMMQRHEE 321
Cdd:TIGR00618 599 LTEKLSEAED-------MLACEQHALLRKLQPEQDLQDVRLHLQQCSQ----------ELALKLTALHALQLTLTQERVR 661
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 322 EAHEKGKILSEQKAMIN-----AMDSKIRSLEQRIVELSEANKLaansslftqrnMKAQEEMISELR----QQKFYLETQ 392
Cdd:TIGR00618 662 EHALSIRVLPKELLASRqlalqKMQSEKEQLTYWKEMLAQCQTL-----------LRELETHIEEYDrefnEIENASSSL 730
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 393 AGKLEAQNRKLEEQLEKISHQdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 472
Cdd:TIGR00618 731 GSDLAAREDALNQSLKELMHQ----ARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEA 806
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 473 QLRQAKTELEETTAEAEEEIQaltAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 552
Cdd:TIGR00618 807 EIGQEIPSDEDILNLQCETLV---QEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQ 883
|
....*.
gi 1039770410 553 EIVQLR 558
Cdd:TIGR00618 884 IKIQFD 889
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
370-765 |
1.23e-08 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 59.78 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 370 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSlEHEEQKLELKRQLT 447
Cdd:COG4717 71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 448 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 527
Cdd:COG4717 150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 528 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQTM 582
Cdd:COG4717 227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 583 EALKTTCTMLEEQV---------LDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 647
Cdd:COG4717 307 LQALPALEELEEEEleellaalgLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 648 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 727
Cdd:COG4717 387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456
|
410 420 430
....*....|....*....|....*....|....*...
gi 1039770410 728 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 765
Cdd:COG4717 457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
|
|
| C1_KSR |
cd20812 |
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ... |
931-982 |
2.20e-08 |
|
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410362 Cd Length: 48 Bit Score: 51.56 E-value: 2.20e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 931 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 982
Cdd:cd20812 1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
360-612 |
2.57e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 57.85 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 360 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhsdkSRLLELETRLREVslehEEQK 439
Cdd:COG4942 10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE-------RRIAALARRIRAL----EQEL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 440 LELKRQLTELQLSLQERESQLTALqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDL 519
Cdd:COG4942 79 AALEAELAELEKEIAELRAELEAQ---KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPAR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 520 EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDL 599
Cdd:COG4942 149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAA---LEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
|
250
....*....|...
gi 1039770410 600 EALNDELLEKERQ 612
Cdd:COG4942 226 EALIARLEAEAAA 238
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
204-410 |
2.96e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 57.85 E-value: 2.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 204 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR-EDSSEGIKKKLVEAEELEEKHREAQVSAQHLEV 282
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiAALARRIRALEQELAALEAELAELEKEIAELRA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 283 HLKQKEQHYEEKIKVLDNQIKKDL-------ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS 355
Cdd:COG4942 98 ELEAQKEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1039770410 356 EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI 410
Cdd:COG4942 178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
500-779 |
4.50e-08 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 58.39 E-value: 4.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 500 DEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLtsQK 579
Cdd:COG4913 228 DALVEHFDDLERAHEALEDAREQIELLEP-----------IRELAERYAAARERLAELEYLRAALRLWFAQRRLEL--LE 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 580 QTMEALKTTCTMLEEQVLDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQV 658
Cdd:COG4913 295 AELEELRAELARLEAELERLEARLDALREELDELEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AA 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 659 VELAVKEHKAEILALQQALKEQKLKAESLSDKlndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKN 738
Cdd:COG4913 371 LGLPLPASAEEFAALRAEAAALLEALEEELEA-----------------LEEALAEAEAALRDLRRELRELEAEIASLER 433
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1039770410 739 HIFRLTQGLQEALDR-ADLLKTERSDLEYQLENIQVLYSHEK 779
Cdd:COG4913 434 RKSNIPARLLALRDAlAEALGLDEAELPFVGELIEVRPEEER 475
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
502-734 |
4.75e-08 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 57.72 E-value: 4.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 502 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:COG3206 166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 576 TSQKQTMEALKTTCTMLEEQVLdLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITES 655
Cdd:COG3206 243 AALRAQLGSGPDALPELLQSPV-IQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQQEAQRILAS 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 656 RQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE--EQAKLQQQM 733
Cdd:COG3206 318 LEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrlEEARLAEAL 383
|
.
gi 1039770410 734 D 734
Cdd:COG3206 384 T 384
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
427-753 |
4.87e-08 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 58.04 E-value: 4.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 427 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettAEAEEEIQALTAHRDEIQRKF 506
Cdd:COG3096 282 ELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAA--------SDHLNLVQTALRQQEKIERYQ 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 507 DALrnsctviTDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 586
Cdd:COG3096 354 EDL-------EELTERLEEQEEVVEEAAEQ---LAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALE 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 587 TTCTMLEEQVLDLEALNDELLE-KERQWEAWRSVLGDE---------KSQFECRVRELQRMLDTEKQSRA--RADQRITE 654
Cdd:COG3096 424 KARALCGLPDLTPENAEDYLAAfRAKEQQATEEVLELEqklsvadaaRRQFEKAYELVCKIAGEVERSQAwqTARELLRR 503
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 655 SRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHA-------MLEMNARSLQQKLETERELKQRLLEE 725
Cdd:COG3096 504 YRSQQALAQRLQqlRAQLAELEQRLRQQQ-NAERL---LEEFCQRIGqqldaaeELEELLAELEAQLEELEEQAAEAVEQ 579
|
330 340 350
....*....|....*....|....*....|....
gi 1039770410 726 QAKLQQQMDLQKNHIFRLTQ------GLQEALDR 753
Cdd:COG3096 580 RSELRQQLEQLRARIKELAArapawlAAQDALER 613
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
284-478 |
5.10e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 57.08 E-value: 5.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 284 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS---EANKL 360
Cdd:COG4942 25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRaelEAQKE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 361 AANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGKLEAQNRKLEEQLEKIshqdHSDKSRLLELETRLREVSLEHEEQK 439
Cdd:COG4942 105 ELAELLRALYRLGRQPPLALLLSPEDFLdAVRRLQYLKYLAPARREQAEEL----RADLAELAALRAELEAERAELEALL 180
|
170 180 190
....*....|....*....|....*....|....*....
gi 1039770410 440 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:COG4942 181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219
|
|
| PH |
pfam00169 |
PH domain; PH stands for pleckstrin homology. |
1014-1133 |
5.49e-08 |
|
PH domain; PH stands for pleckstrin homology.
Pssm-ID: 459697 [Multi-domain] Cd Length: 105 Bit Score: 52.56 E-value: 5.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1014 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1093
Cdd:pfam00169 1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1039770410 1094 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1133
Cdd:pfam00169 69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
653-864 |
6.08e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 56.70 E-value: 6.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 653 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 732
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 733 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 794
Cdd:COG4942 99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 795 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 864
Cdd:COG4942 175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
201-858 |
6.08e-08 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 57.52 E-value: 6.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 201 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHL 280
Cdd:pfam10174 69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 281 EVHLKQKEQHYEEKikvlDNQIKKDLADKESlENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKl 360
Cdd:pfam10174 143 ELRIETQKQTLGAR----DESIKKLLEMLQS-KGLPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREELH- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 361 aansslftQRNMKAQE-EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ-DHSDKSRllELETRLREVSLEHEEQ 438
Cdd:pfam10174 217 --------RRNQLQPDpAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNgLLHTEDR--EEEIKQMEVYKSHSKF 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 439 kleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC-- 513
Cdd:pfam10174 287 ---MKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLee 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 514 --TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 591
Cdd:pfam10174 357 keSFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSN 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 592 LEEQVLDLEalnDELLEKERQWEAWRsvlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHk 667
Cdd:pfam10174 434 TDTALTTLE---EALSEKERIIERLK-----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH- 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 668 AEILALQQALKEQKLKA---------ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDl 735
Cdd:pfam10174 505 ASSLASSGLKKDSKLKSleiaveqkkEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE- 582
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 736 qknhifRLTQGLQEAldradllKTERSDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRK 815
Cdd:pfam10174 583 ------RLLGILREV-------ENEKNDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QL 637
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 1039770410 816 EDPALPTQVPLQYNELKLALEkekarcaELEEALQKTRIELRS 858
Cdd:pfam10174 638 LEEARRREDNLADNSQQLQLE-------ELMGALEKTRQELDA 673
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
22-734 |
6.13e-08 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 57.88 E-value: 6.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 22 EVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR-------KLQ 91
Cdd:pfam01576 300 ELEALKTELEDTLDTTAAQqelRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKrnkanleKAK 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 92 EIKEQEYQAQVEEMRLMMNQLEEdlvSARRRSDLyESELRESRLAAEEFKRKANECQHKLMKVVSHPprgDSGGTALDDL 171
Cdd:pfam01576 380 QALESENAELQAELRTLQQAKQD---SEHKRKKL-EGQLQELQARLSESERQRAELAEKLSKLQSEL---ESVSSLLNEA 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 172 ----HKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQE-----LQEKLEKAVKASTEATELLQNIRQAKERAERE 242
Cdd:pfam01576 453 egknIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEdernsLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKK 532
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 243 LEKLHNREDSSEGIKKKLV-EAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQ-------------IKKDLAD 308
Cdd:pfam01576 533 LEEDAGTLEALEEGKKRLQrELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQrqlvsnlekkqkkFDQMLAE 612
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 309 KESLENMMQ----RHEEEAHEK-GKILSEQKAMINAMDSKirsleqriVELSEANKLaansslftqrnMKAQ-EEMIS-- 380
Cdd:pfam01576 613 EKAISARYAeerdRAEAEAREKeTRALSLARALEEALEAK--------EELERTNKQ-----------LRAEmEDLVSsk 673
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 381 --------ELRQQKFYLETQAGKLEAQNRKLEEQLekishQDHSDKSRLLELETRLREVSLEH---------EEQKLELK 443
Cdd:pfam01576 674 ddvgknvhELERSKRALEQQVEEMKTQLEELEDEL-----QATEDAKLRLEVNMQALKAQFERdlqardeqgEEKRRQLV 748
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 444 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQAL---TAHRDEIQRKFDALRNSCTVI---- 516
Cdd:pfam01576 749 KQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLkklQAQMKDLQRELEEARASRDEIlaqs 828
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 517 -------TDLEEQLNQLTEDNA------------------ELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREI--- 568
Cdd:pfam01576 829 kesekklKNLEAELLQLQEDLAaserarrqaqqerdeladEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTell 908
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 569 TEREMQLTSQKQTME----ALKTTCTMLEEQVLDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQ 643
Cdd:pfam01576 909 NDRLRKSTLQVEQLTtelaAERSTSQKSESARQQLERQNKELKAKLQEMEgTVKSKFKSSIAALEAKIAQLEEQLEQESR 988
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 644 SRARADQRITEsrqvvelavKEHKAEILALQqaLKEQKLKAESLSDKLndlEKKHAMLemnaRSLQQKLETERELKQRLL 723
Cdd:pfam01576 989 ERQAANKLVRR---------TEKKLKEVLLQ--VEDERRHADQYKDQA---EKGNSRM----KQLKRQLEEAEEEASRAN 1050
|
810
....*....|.
gi 1039770410 724 EEQAKLQQQMD 734
Cdd:pfam01576 1051 AARRKLQRELD 1061
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
9-559 |
6.95e-08 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 57.49 E-value: 6.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 9 MEQEMTRLHRRVSEVEAvlSQKEVELKASETQRSLleQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 88
Cdd:pfam01576 494 LEDERNSLQEQLEEEEE--AKRNVERQLSTLQAQL--SDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYD 569
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 89 KLQEIKEQeYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA----AEEFKRKANECQHKLMKVVSHPPRGDSG 164
Cdd:pfam01576 570 KLEKTKNR-LQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAIsaryAEERDRAEAEAREKETRALSLARALEEA 648
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 165 GTALDDLHKMQGH-----AGLTSAKDQGKPEVGEYSKlEKINAEQQLKIQELQ-EKLEKAVKASTEATELLQ-NIRQAKE 237
Cdd:pfam01576 649 LEAKEELERTNKQlraemEDLVSSKDDVGKNVHELER-SKRALEQQVEEMKTQlEELEDELQATEDAKLRLEvNMQALKA 727
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 238 RAERELeklHNREDSSEGIKKKLV------EAEELEEKHREAQVSA--QHLEVHLKQKEQHYEEKIKVLDNQIKKdLADK 309
Cdd:pfam01576 728 QFERDL---QARDEQGEEKRRQLVkqvrelEAELEDERKQRAQAVAakKKLELDLKELEAQIDAANKGREEAVKQ-LKKL 803
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 310 ESLENMMQRHEEEAHekgkiLSEQKAMINAMDS--KIRSLEQRIVELSEanKLAANSSLFTQRNM---KAQEEMI----- 379
Cdd:pfam01576 804 QAQMKDLQRELEEAR-----ASRDEILAQSKESekKLKNLEAELLQLQE--DLAASERARRQAQQerdELADEIAsgasg 876
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 380 -SELRQQKFYLETQAGKLEAQNRklEEQLEKISHQDHSDKSRLL--ELETRL---REVSLEHEEQKLELKRQLTELQLSL 453
Cdd:pfam01576 877 kSALQDEKRRLEARIAQLEEELE--EEQSNTELLNDRLRKSTLQveQLTTELaaeRSTSQKSESARQQLERQNKELKAKL 954
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 454 QERESQ--------LTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEIQRKfDALRNSCTVIT 517
Cdd:pfam01576 955 QEMEGTvkskfkssIAALEAKIAQLEEQLEQesrerqaaNKLVRRTEKKLKEVLLQVEDERRHADQYK-DQAEKGNSRMK 1033
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 1039770410 518 DLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND----EIVQLRS 559
Cdd:pfam01576 1034 QLKRQLEEAEEEASRANAARRKLQRELDDATESNEsmnrEVSTLKS 1079
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
301-770 |
8.84e-08 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 57.06 E-value: 8.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 301 QIKKDLADKEsLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 378
Cdd:pfam05557 13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 379 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 455
Cdd:pfam05557 75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 456 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 530
Cdd:pfam05557 151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 531 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM---EALKTTCTMLEEQVLDLEALNDELL 607
Cdd:pfam05557 224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLrspEDLSRRIEQLQQREIVLKEENSSLT 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 608 EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALKEQKLKA 684
Cdd:pfam05557 304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSPQLLERI 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 685 ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDRADLLKT 759
Cdd:pfam05557 383 EEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELERQRLRE 462
|
490
....*....|.
gi 1039770410 760 ERSDLEYQLEN 770
Cdd:pfam05557 463 QKNELEMELER 473
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
2-769 |
9.27e-08 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 57.11 E-value: 9.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKA-------SETQRSLLEQDLATYITECSSLKRSLEQARM------- 67
Cdd:pfam01576 213 LEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAalarleeETAQKNNALKKIRELEAQISELQEDLESERAarnkaek 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 68 ----------------EVSQEDDKALQLLHDIREQS----RKLQEIKEQEYQAQVEEMRLMMNQ----LEEDLVSARR-R 122
Cdd:pfam01576 293 qrrdlgeelealktelEDTLDTTAAQQELRSKREQEvtelKKALEEETRSHEAQLQEMRQKHTQaleeLTEQLEQAKRnK 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 123 SDLYES----ELRESRLAAE-----------EFKRKANECQ-HKLMKVVSHPPRGDSggTALDDLHKMQGH-----AGLT 181
Cdd:pfam01576 373 ANLEKAkqalESENAELQAElrtlqqakqdsEHKRKKLEGQlQELQARLSESERQRA--ELAEKLSKLQSElesvsSLLN 450
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 182 SAKDQGKPEVGEYSKLE-KINAEQQLKIQELQEKLEKA--VKASTEATELLQNIRQAKERAERELEK-LHNREDSSEGIK 257
Cdd:pfam01576 451 EAEGKNIKLSKDVSSLEsQLQDTQELLQEETRQKLNLStrLRQLEDERNSLQEQLEEEEEAKRNVERqLSTLQAQLSDMK 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 258 KKLVE----AEELEEKHREAQVSAQHLEVHLKQKEQHYE--EKIKV-LDNQIKKDLADKESLENMMQRHEEEAHEKGKIL 330
Cdd:pfam01576 531 KKLEEdagtLEALEEGKKRLQRELEALTQQLEEKAAAYDklEKTKNrLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQML 610
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 331 SEQKAMINAM-------DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ----EEMIS----------ELRQQKFYL 389
Cdd:pfam01576 611 AEEKAISARYaeerdraEAEAREKETRALSLARALEEALEAKEELERTNKQLraemEDLVSskddvgknvhELERSKRAL 690
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 390 ETQAGKLEAQNRKLEEQLekishQDHSDKSRLLELETRLREVSLEH---------EEQKLELKRQLTELQLSLQERESQL 460
Cdd:pfam01576 691 EQQVEEMKTQLEELEDEL-----QATEDAKLRLEVNMQALKAQFERdlqardeqgEEKRRQLVKQVRELEAELEDERKQR 765
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 461 TALQAARAALESQLRQAKTELEETTAEAEEEIQAL---TAHRDEIQRKFDALRNSctvitdLEEQLNQLTEDNAELNNQN 537
Cdd:pfam01576 766 AQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLkklQAQMKDLQRELEEARAS------RDEILAQSKESEKKLKNLE 839
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 538 FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQvLDLEALNDELLeKERQweawr 617
Cdd:pfam01576 840 AELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEE-LEEEQSNTELL-NDRL----- 912
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 618 svlgdEKSQFECrvrelqRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALK-EQKLKAESLSDKLNDLEK 696
Cdd:pfam01576 913 -----RKSTLQV------EQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVKsKFKSSIAALEAKIAQLEE 981
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 697 KhamLEMNARSLQQ--KL--ETERELKQRLL---EEQAKLQQ---QMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 766
Cdd:pfam01576 982 Q---LEQESRERQAanKLvrRTEKKLKEVLLqveDERRHADQykdQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQR 1058
|
...
gi 1039770410 767 QLE 769
Cdd:pfam01576 1059 ELD 1061
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
494-863 |
1.03e-07 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 56.97 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 494 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 573
Cdd:PRK02224 188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 574 QLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS--------- 644
Cdd:PRK02224 266 TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAaqahneeae 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 645 --RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRL 722
Cdd:PRK02224 346 slREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDEL 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 723 LEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshEKVKMEGTIS 787
Cdd:PRK02224 425 REREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----EVEEVEERLE 499
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 788 QQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEA 863
Cdd:PRK02224 500 RAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEA 567
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
56-478 |
1.18e-07 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 56.70 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 56 SSLKRSLEQARMEVSQEDDKALQL-LHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--E 132
Cdd:COG4717 45 AMLLERLEKEADELFKPQGRKPELnLKELKELEEELKEAEEKE--EEYAELQEELEELEEELEELEAELEELREELEklE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 133 SRLAAEEFKRKANECQHKLmkvvshpprgDSGGTALDDL-HKMQGHAGLTSAKDQGKPEVGEYSklEKINAEQQLKIQEL 211
Cdd:COG4717 123 KLLQLLPLYQELEALEAEL----------AELPERLEELeERLEELRELEEELEELEAELAELQ--EELEELLEQLSLAT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 212 QEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHR-------------------- 271
Cdd:COG4717 191 EEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLllliaaallallglggslls 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 272 -----------EAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKEsLENMMQRHEEEAHEKGKILSEQKAMINAM 340
Cdd:COG4717 271 liltiagvlflVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEEL 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 341 DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyletqagkleaQNRKLEEQLEKISHQdhsdksr 420
Cdd:COG4717 350 QELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAE------------EYQELKEELEELEEQ------- 410
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 421 lLELETRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:COG4717 411 -LEELLGELEELLEALDEE-ELEEELEELEEELEELEEELEELREELAELEAELEQLE 466
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
547-809 |
1.42e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 55.54 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 547 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTtctmleeqvlDLEALNDELLEKERQweawrsvlgdeksq 626
Cdd:COG4942 15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK----------QLAALERRIAALARR-------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 627 fecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 706
Cdd:COG4942 71 ----IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 707 SLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTI 786
Cdd:COG4942 147 ARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA 222
|
250 260
....*....|....*....|...
gi 1039770410 787 SQQTKLIDFLQAKMDQPAKKKKG 809
Cdd:COG4942 223 EELEALIARLEAEAAAAAERTPA 245
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
11-669 |
1.86e-07 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 56.08 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 11 QEMTRLHRRVSEVEAVLSQkeVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS-RK 89
Cdd:COG4913 262 ERYAAARERLAELEYLRAA--LRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGgDR 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 90 LQEIKEQeyqaqveemrlmMNQLEEDLVSARRRSDLYESELRESRLA----AEEFKRKANECQHKLmkvvshpprgdsgg 165
Cdd:COG4913 340 LEQLERE------------IERLERELEERERRRARLEALLAALGLPlpasAEEFAALRAEAAALL-------------- 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 166 TALDDLHKmQGHAGLTSAKDQGKPEVGEYSKLEK-INAEQQLK------IQELQEKLEKAVKASTE----ATELLQnIRQ 234
Cdd:COG4913 394 EALEEELE-ALEEALAEAEAALRDLRRELRELEAeIASLERRKsniparLLALRDALAEALGLDEAelpfVGELIE-VRP 471
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 235 AKERAERELEK-LHNR------EDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLKQ-KEQHYEEKIKVLDNQ----I 302
Cdd:COG4913 472 EEERWRGAIERvLGGFaltllvPPEHYAAALRWVNRLHLRGRLVYERVRTGLPDPERPRlDPDSLAGKLDFKPHPfrawL 551
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 303 KKDLADK------ESLENM-----------MQRHEEEAHEKG---KILSEQ------KAMINAMDSKIRSLEQRIVELSE 356
Cdd:COG4913 552 EAELGRRfdyvcvDSPEELrrhpraitragQVKGNGTRHEKDdrrRIRSRYvlgfdnRAKLAALEAELAELEEELAEAEE 631
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 357 ANKLAANSslftQRNMKAQEEMISELRQQKFYlETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLREVSLEH- 435
Cdd:COG4913 632 RLEALEAE----LDALQERREALQRLAEYSWD-EIDVASAEREIAELEAELERLD----ASSDDLAALEEQLEELEAELe 702
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 436 --EEQKLELKRQLTELQLSLQERESQLTALQAA------------RAALESQLRQAKTELEETTAEAEEEiQALTAHRDE 501
Cdd:COG4913 703 elEEELDELKGEIGRLEKELEQAEEELDELQDRleaaedlarlelRALLEERFAAALGDAVERELRENLE-ERIDALRAR 781
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 502 IQRKFDALRN------------SCTVITDLE------EQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDH 563
Cdd:COG4913 782 LNRAEEELERamrafnrewpaeTADLDADLEslpeylALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRR 857
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 564 LRREITER-----------------EMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKerqweawrsvlgdeksQ 626
Cdd:COG4913 858 AIREIKERidplndslkripfgpgrYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEA----------------R 921
|
730 740 750 760
....*....|....*....|....*....|....*....|....
gi 1039770410 627 FEcRVREL-QRMLDTEKQSRARADQRITESRQVVELAVKEHKAE 669
Cdd:COG4913 922 FA-ALKRLiERLRSEEEESDRRWRARVLDVRNHLEFDAEEIDRE 964
|
|
| PH |
smart00233 |
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ... |
1014-1133 |
1.99e-07 |
|
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.
Pssm-ID: 214574 [Multi-domain] Cd Length: 102 Bit Score: 50.62 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1014 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1093
Cdd:smart00233 1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1039770410 1094 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1133
Cdd:smart00233 69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
58-733 |
2.73e-07 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 55.61 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 58 LKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDlYESELRESRLAA 137
Cdd:pfam12128 214 PKSRLNRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNT-----LESAELRLSHLHFGYKSDETLIA-SRQEERQETSAE 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 138 EEFKRKANECQhklMKVVSHPPRGDSGgTALDDLHKMQGHagLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEK 217
Cdd:pfam12128 288 LNQLLRTLDDQ---WKEKRDELNGELS-AADAAVAKDRSE--LEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEE 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 218 AVKASTEA----TELLQNIRQA-KERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHY- 291
Cdd:pfam12128 362 RLKALTGKhqdvTAKYNRRRSKiKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYr 441
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 292 -EEKIKVLDNQIKKDLADKESLENMMQRHEEeahekgkilseqkamINAMDSKIrsleqrivELSEANKLAANSSLFTQR 370
Cdd:pfam12128 442 lKSRLGELKLRLNQATATPELLLQLENFDER---------------IERAREEQ--------EAANAEVERLQSELRQAR 498
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 371 nmKAQEEMISELRQQKFYLETQAGKLEAqnrkLEEQLEKISH-------------QDHSDK--SRLLELETRLREVSLEH 435
Cdd:pfam12128 499 --KRRDQASEALRQASRRLEERQSALDE----LELQLFPQAGtllhflrkeapdwEQSIGKviSPELLHRTDLDPEVWDG 572
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 436 EEQ--------KLELKR----QLTELQLSLQERESQL-TALQAAR---AALESQLRQAKTELEETTAEAEEEIQALTAHR 499
Cdd:pfam12128 573 SVGgelnlygvKLDLKRidvpEWAASEEELRERLDKAeEALQSARekqAAAEEQLVQANGELEKASREETFARTALKNAR 652
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 500 DEIQRKFDALRNSCTVITD--------LEEQLNQL-TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVdhlrreITE 570
Cdd:pfam12128 653 LDLRRLFDEKQSEKDKKNKalaerkdsANERLNSLeAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVV------EGA 726
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 571 REMQLTSQKQTMEALKTTctmLEEQVLDLEALNDELLEKerqweawRSVLGDEKSQFECRVRELQRMLDTEKQSRaradQ 650
Cdd:pfam12128 727 LDAQLALLKAAIAARRSG---AKAELKALETWYKRDLAS-------LGVDPDVIAKLKREIRTLERKIERIAVRR----Q 792
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 651 RITESRQVVELAVKEHKaeilalqQALKEQKLKAESlsdKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQ 726
Cdd:pfam12128 793 EVLRYFDWYQETWLQRR-------PRLATQLSNIER---AISELQQQLARLIADTKLRRAKLEMERkaseKQQVRLSENL 862
|
....*..
gi 1039770410 727 AKLQQQM 733
Cdd:pfam12128 863 RGLRCEM 869
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
193-478 |
3.33e-07 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 54.96 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEqqLKIQELQEKLEKAVKASTEATELLQNIRQAKERAeRELEKLHNREDSSEGIKKKLVEAEEleekhre 272
Cdd:COG5185 254 KLEKLVEQNTD--LRLEKLGENAESSKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEA------- 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 aqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKdlaDKESLENMMQRHEEEAHEKGKI--LSEQKAMINAMDSKIRSLEQR 350
Cdd:COG5185 324 --------EQELEESKRETETGIQNLTAEIEQ---GQESLTENLEAIKEEIENIVGEveLSKSSEELDSFKDTIESTKES 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 351 IVELSEANKLAANSSLFT-QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQdhSDKSRLLELETRLR 429
Cdd:COG5185 393 LDEIPQNQRGYAQEILATlEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMRE--ADEESQSRLEEAYD 470
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1039770410 430 EVSLEHEEQKLELKRQLTELQLSLQEresQLTALQAARAALESQLRQAK 478
Cdd:COG5185 471 EINRSVRSKKEDLNEELTQIESRVST---LKATLEKLRAKLERQLEGVR 516
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
210-717 |
3.51e-07 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 55.31 E-value: 3.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 210 ELQEKLEKAvkasTEATELLQNIRQAKERAERELEKLHNREDSSEGIK-----KKLVEAEELEEKHREAQVSAQHLEVHL 284
Cdd:COG4913 239 RAHEALEDA----REQIELLEPIRELAERYAAARERLAELEYLRAALRlwfaqRRLELLEAELEELRAELARLEAELERL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 285 KQKEQHYEEKIKVLDNQIKK-DLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAN 363
Cdd:COG4913 315 EARLDALREELDELEAQIRGnGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLE 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 364 SSlftqrnmkaqEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREvSLEHEEQKL--- 440
Cdd:COG4913 395 AL----------EEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAE-ALGLDEAELpfv 463
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 441 -ELkrqlteLQLSLQERESQLTA-----------------LQAARAALES-QLRQAKTELEETTAEAEEEIQALTAH--- 498
Cdd:COG4913 464 gEL------IEVRPEEERWRGAIervlggfaltllvppehYAAALRWVNRlHLRGRLVYERVRTGLPDPERPRLDPDsla 537
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 499 --------------RDEIQRKFD--------ALRNSCTVIT----------------------------DLEEQLNQLTE 528
Cdd:COG4913 538 gkldfkphpfrawlEAELGRRFDyvcvdspeELRRHPRAITragqvkgngtrhekddrrrirsryvlgfDNRAKLAALEA 617
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 529 DNAELNnqnfylskqlDEASGANDEIVQLRSEVDHL--RREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDEL 606
Cdd:COG4913 618 ELAELE----------EELAEAEERLEALEAELDALqeRREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDL 687
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 607 LEKERQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 686
Cdd:COG4913 688 AALEEQLEELEA----ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAV 763
|
570 580 590
....*....|....*....|....*....|.
gi 1039770410 687 LSDKLNDLEKKHAMLEMNARSLQQKLETERE 717
Cdd:COG4913 764 ERELRENLEERIDALRARLNRAEEELERAMR 794
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
2-735 |
4.11e-07 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 55.18 E-value: 4.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSL---KRSLEQARMEVSQEddkalq 78
Cdd:pfam01576 94 LQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLskeRKLLEERISEFTSN------ 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 79 lLHDIREQSRKLQEIKEQeYQAQVEEMRLMMNQLE---EDLVSARRRSDLYESELRES----RLAAEEFK----RKANEC 147
Cdd:pfam01576 168 -LAEEEEKAKSLSKLKNK-HEAMISDLEERLKKEEkgrQELEKAKRKLEGESTDLQEQiaelQAQIAELRaqlaKKEEEL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 148 QHKLMKVvshPPRGDSGGTALDDLHKMQGHagLTSAKDQGKPEVGEYSKLEK----------------------INAEQQ 205
Cdd:pfam01576 246 QAALARL---EEETAQKNNALKKIRELEAQ--ISELQEDLESERAARNKAEKqrrdlgeelealkteledtldtTAAQQE 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 206 LKIQELQE--KLEKAVKASTEATEL-LQNIRQAKERAEREL-EKLHNREDSSEGIKK-KLVEAEELEEKHREAQVsaqhl 280
Cdd:pfam01576 321 LRSKREQEvtELKKALEEETRSHEAqLQEMRQKHTQALEELtEQLEQAKRNKANLEKaKQALESENAELQAELRT----- 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 281 evhLKQKEQHYEEKIKVLDNQikkdLADKESLENMMQRHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEankl 360
Cdd:pfam01576 396 ---LQQAKQDSEHKRKKLEGQ----LQELQARLSESERQRAELAEK---LSKLQSELESVSSLLNEAEGKNIKLSK---- 461
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 361 aANSSLFTQrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK-------ISHQDHSDKSRLLELETRLREVSL 433
Cdd:pfam01576 462 -DVSSLESQ--LQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEeeeakrnVERQLSTLQAQLSDMKKKLEEDAG 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 434 ---EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETtaeaeeeiQALTAHRDEIQRKFD-AL 509
Cdd:pfam01576 539 tleALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQ--------RQLVSNLEKKQKKFDqML 610
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 510 RNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI----VQLRSEVDHL-------RREITEREMQLTSQ 578
Cdd:pfam01576 611 AEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELertnKQLRAEMEDLvsskddvGKNVHELERSKRAL 690
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 579 KQTMEALKTTCTMLEEQvldLEALNDELLEKERQWEAW----------RSVLGDEK-SQFECRVRELQRMLDTEKQSRAR 647
Cdd:pfam01576 691 EQQVEEMKTQLEELEDE---LQATEDAKLRLEVNMQALkaqferdlqaRDEQGEEKrRQLVKQVRELEAELEDERKQRAQ 767
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 648 AdqriTESRQVVELAVKEHKAEILALQQ----ALKEQKLKAESLSDKLNDLEKKHAMLEmnaRSLQQKLETERELKQRll 723
Cdd:pfam01576 768 A----VAAKKKLELDLKELEAQIDAANKgreeAVKQLKKLQAQMKDLQRELEEARASRD---EILAQSKESEKKLKNL-- 838
|
810
....*....|..
gi 1039770410 724 eEQAKLQQQMDL 735
Cdd:pfam01576 839 -EAELLQLQEDL 849
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
307-532 |
5.48e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 53.61 E-value: 5.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 307 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQK 386
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA-------LEQELAALEAELAELEKEI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 387 FYLETQagkLEAQNRKLEEQL---EKISHQDH-------SDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER 456
Cdd:COG4942 93 AELRAE---LEAQKEELAELLralYRLGRQPPlalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 457 ESQLTALQAARAALESQlrqaKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 532
Cdd:COG4942 170 EAERAELEALLAELEEE----RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
516-738 |
5.72e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 53.61 E-value: 5.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 516 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 595
Cdd:COG4942 22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 596 vldLEALNDELleKERQWEAWRS---------VLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVKEH 666
Cdd:COG4942 99 ---LEAQKEEL--AELLRALYRLgrqpplallLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRAEL 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 667 KAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 738
Cdd:COG4942 170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
493-713 |
5.92e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 53.61 E-value: 5.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 493 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREI 568
Cdd:COG4942 16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALarriRALEQELAALEAELAELEKEI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 569 TEREMQLTSQKQTM-EALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRar 647
Cdd:COG4942 93 AELRAELEAQKEELaELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAALR-- 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 648 adQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 713
Cdd:COG4942 167 --AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
318-746 |
6.06e-07 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 54.57 E-value: 6.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 318 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 392
Cdd:COG3096 275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 393 AGKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 472
Cdd:COG3096 353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 473 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 549
Cdd:COG3096 424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 550 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEkerqWEAWRSV 619
Cdd:COG3096 493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAE----LEAQLEE 568
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 620 LGDEKSQFECRVRELQRmldTEKQSRARADqritesrqvvELAVKEhkAEILALQQALkeqklkaESLSDKLND-LEKKH 698
Cdd:COG3096 569 LEEQAAEAVEQRSELRQ---QLEQLRARIK----------ELAARA--PAWLAAQDAL-------ERLREQSGEaLADSQ 626
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 699 AMleMNARslQQKLETERELKQ---RLLEEQAKLQQQmdlqknhIFRLTQG 746
Cdd:COG3096 627 EV--TAAM--QQLLEREREATVerdELAARKQALESQ-------IERLSQP 666
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
233-635 |
6.47e-07 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 54.58 E-value: 6.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 233 RQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQ---HLEVHLKQKEQHYEEKIKVL--DNQIKKDLA 307
Cdd:PRK04863 276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEaesDLEQDYQAASDHLNLVQTALrqQEKIERYQA 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 308 DKESLENMMqrheEEAHEKGKILSEQKAMINAmdsKIRSLEQRIVELseANKLAAnsslfTQRNMKAQEEMISELRQQKF 387
Cdd:PRK04863 356 DLEELEERL----EEQNEVVEEADEQQEENEA---RAEAAEEEVDEL--KSQLAD-----YQQALDVQQTRAIQYQQAVQ 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 388 YLE-----TQAGKLEAQNrkLEEQLEKISHQDHSDKSRLLELETRLR--EVSLEHEEQKLELKRQLT-ELqlslqEREsq 459
Cdd:PRK04863 422 ALErakqlCGLPDLTADN--AEDWLEEFQAKEQEATEELLSLEQKLSvaQAAHSQFEQAYQLVRKIAgEV-----SRS-- 492
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 460 lTALQAARAALEsQLRQAKTELEETtaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 539
Cdd:PRK04863 493 -EAWDVARELLR-RLREQRHLAEQL--------QQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEE 562
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 540 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV-------LDLEALNDELLEKERQ 612
Cdd:PRK04863 563 LEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSgeefedsQDVTEYMQQLLERERE 642
|
410 420
....*....|....*....|...
gi 1039770410 613 WEAWRSVLGDEKSQFECRVRELQ 635
Cdd:PRK04863 643 LTVERDELAARKQALDEEIERLS 665
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
437-699 |
8.19e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 53.23 E-value: 8.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 437 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 516
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 517 tDLEEQLNQLTEDNAELNNQnfylskqldeasgandeIVQLRSEVDHLRREITE--REMQLTSQKQTMEALKTTCTMLE- 593
Cdd:COG4942 73 -ALEQELAALEAELAELEKE-----------------IAELRAELEAQKEELAEllRALYRLGRQPPLALLLSPEDFLDa 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 594 -EQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelaVKEHKAEILA 672
Cdd:COG4942 135 vRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKL----LARLEKELAE 210
|
250 260
....*....|....*....|....*..
gi 1039770410 673 LQQALKEQKLKAESLSDKLNDLEKKHA 699
Cdd:COG4942 211 LAAELAELQQEAEELEALIARLEAEAA 237
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
214-774 |
1.05e-06 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 53.90 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 214 KLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEE 293
Cdd:TIGR00606 180 SATRYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEH 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 294 ---KIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQ-KAMINAMDSKIRSLEQRIVELseanklaansslftQ 369
Cdd:TIGR00606 260 nlsKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQlNDLYHNHQRTVREKERELVDC--------------Q 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 370 RNMKAQEEMISELRQQKFYLETQAGKLeaqnrkleeQLEKISHQDHSDK--SRLLELETRLREVSLEHEEQKLELKRQLT 447
Cdd:TIGR00606 326 RELEKLNKERRLLNQEKTELLVEQGRL---------QLQADRHQEHIRArdSLIQSLATRLELDGFERGPFSERQIKNFH 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 448 ELQLSLQERESQLTA-----LQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQ 522
Cdd:TIGR00606 397 TLVIERQEDEAKTAAqlcadLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILEL 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 523 LNQLTEDNAELN--NQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQtMEALKTTCTMLEEQVLDLE 600
Cdd:TIGR00606 477 DQELRKAERELSkaEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQ-MEMLTKDKMDKDEQIRKIK 555
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 601 ALNDELL-------EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItESRQVVELAVKEHKAEILAL 673
Cdd:TIGR00606 556 SRHSDELtsllgyfPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNEL-ESKEEQLSSYEDKLFDVCGS 634
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 674 QqalkEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE-------LKQRLLEEQAKLQQqmdlqknHIFRLTQG 746
Cdd:TIGR00606 635 Q----DEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDenqsccpVCQRVFQTEAELQE-------FISDLQSK 703
|
570 580
....*....|....*....|....*...
gi 1039770410 747 LQEALDRADLLKTERSDLEYQLENIQVL 774
Cdd:TIGR00606 704 LRLAPDKLKSTESELKKKEKRRDEMLGL 731
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
369-584 |
1.22e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 52.84 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 369 QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTE 448
Cdd:COG4942 33 QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 449 LQLSLQERE-----SQLTALQAARAA--LESQLRQAKTELEETTaeaeEEIQALTAHRDEIQRKFDALRnscTVITDLEE 521
Cdd:COG4942 113 LYRLGRQPPlalllSPEDFLDAVRRLqyLKYLAPARREQAEELR----ADLAELAALRAELEAERAELE---ALLAELEE 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 522 QLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 584
Cdd:COG4942 186 ERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
644-921 |
1.69e-06 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 52.14 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 644 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 721
Cdd:COG3883 10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 722 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 798
Cdd:COG3883 86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 799 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 878
Cdd:COG3883 141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1039770410 879 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 921
Cdd:COG3883 221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
|
|
| C1_1 |
pfam00130 |
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ... |
928-983 |
1.91e-06 |
|
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.
Pssm-ID: 395079 Cd Length: 53 Bit Score: 46.28 E-value: 1.91e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770410 928 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 983
Cdd:pfam00130 1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
2-325 |
2.03e-06 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 52.76 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKR---SLEQARMEVSQEDDKALQ 78
Cdd:TIGR02169 686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEdlsSLEQEIENVKSELKELEA 765
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 79 LLHDIREQSRKLQE----IKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELrESRLAAEEFKRKanECQHKLMKV 154
Cdd:TIGR02169 766 RIEELEEDLHKLEEalndLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-NRLTLEKEYLEK--EIQELQEQR 842
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 155 VSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPE--VGEYSKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNI 232
Cdd:TIGR02169 843 IDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRdlESRLGDLKKERDELEAQLRELERKIEEL-EAQIEKKRKRLSE 921
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 233 RQAK-ERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNQIKKD--LAD 308
Cdd:TIGR02169 922 LKAKlEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEpVNMLAIQEYEEVLKRLDELKEKRAklEEE 1001
|
330
....*....|....*..
gi 1039770410 309 KESLENMMQRHEEEAHE 325
Cdd:TIGR02169 1002 RKAILERIEEYEKKKRE 1018
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
560-866 |
2.26e-06 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 52.53 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 560 EVDHLRREITEREmQLTSQKQTMEALKTTctMLEEQVLDLEALNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLD 639
Cdd:pfam12128 229 DIQAIAGIMKIRP-EFTKLQQEFNTLESA--ELRLSHLHFGYKSDETLIASRQ-EERQETSAELNQLLRTLDDQWKEKRD 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 640 TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETEREL- 718
Cdd:pfam12128 305 ELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKi 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 719 KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQA 798
Cdd:pfam12128 385 KEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA 458
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 799 kmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQKTRIELRSAREEAAHR 866
Cdd:pfam12128 459 ------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQSELRQARKRRDQASEA 507
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
246-862 |
2.81e-06 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 52.35 E-value: 2.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 246 LHNREDSSEGIKKklvEAEELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHE 325
Cdd:PRK02224 182 LSDQRGSLDQLKA---QIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 326 kgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrkLEE 405
Cdd:PRK02224 253 ------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE----------RDD 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 406 QLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 485
Cdd:PRK02224 298 LLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELE 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 486 aeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSEVDH 563
Cdd:PRK02224 370 --------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREERDE 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 564 LRreitEREMQLTSQKQTMEalkttcTMLEEqvldlealNDELLEKERQWEAWRSVLG----DEKSQFECRVRELQRMLD 639
Cdd:PRK02224 424 LR----EREAELEATLRTAR------ERVEE--------AEALLEAGKCPECGQPVEGsphvETIEEDRERVEELEAELE 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 640 TEKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE 715
Cdd:PRK02224 486 DLEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEA 563
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 716 RELKQRLLEEQAKLQQQMDLQKNHIfrltqglqEALDRADLLKTERSDLEYQLENIQvlyshEKVKMEGTISQQTKliDF 795
Cdd:PRK02224 564 EEEAEEAREEVAELNSKLAELKERI--------ESLERIRTLLAAIADAEDEIERLR-----EKREALAELNDERR--ER 628
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770410 796 LQAKMDqpakKKKGLFSRRKEDpalptqvplqynelklALEKEKARCAELEEALQKTRIELRSAREE 862
Cdd:PRK02224 629 LAEKRE----RKRELEAEFDEA----------------RIEEAREDKERAEEYLEQVEEKLDELREE 675
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
45-771 |
3.23e-06 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 52.10 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 45 EQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQeiKEQEYQAQVEEMRLMMnqleedlvsARRRSD 124
Cdd:pfam01576 4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQ--AETELCAEAEEMRARL---------AARKQE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 125 LYE--SELrESRLAAEEfkrkanECQHKLMkvvshpprgdsggtalDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINA 202
Cdd:pfam01576 73 LEEilHEL-ESRLEEEE------ERSQQLQ----------------NEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTT 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 203 EQQLK--------IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSegikkklveAEELEEKHREAQ 274
Cdd:pfam01576 130 EAKIKkleedillLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAM---------ISDLEERLKKEE 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 275 VSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL 354
Cdd:pfam01576 201 KGRQELEKAKRKLEGESTD----LQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISEL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 355 SEanklaansSLFTQRNMKAQEEmiselrQQKFYLETQagkLEAQNRKLEEQLEKISHQDHSDKSR---LLELETRLREV 431
Cdd:pfam01576 277 QE--------DLESERAARNKAE------KQRRDLGEE---LEALKTELEDTLDTTAAQQELRSKReqeVTELKKALEEE 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 432 SLEHEEQKLELKR----QLTELQLSLQERESQLTALQAARAALESQ----------LRQAKTELEETTAEAEEEIQALTA 497
Cdd:pfam01576 340 TRSHEAQLQEMRQkhtqALEELTEQLEQAKRNKANLEKAKQALESEnaelqaelrtLQQAKQDSEHKRKKLEGQLQELQA 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 498 HRDEIQRkfdalrnsctVITDLEEQLNQLTednAELNNQNFYLSKQLDEASGANDEIVQLRSE---VDHLRREITEREMQ 574
Cdd:pfam01576 420 RLSESER----------QRAELAEKLSKLQ---SELESVSSLLNEAEGKNIKLSKDVSSLESQlqdTQELLQEETRQKLN 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 575 LTSQKQTMEALKTTctmLEEQVldlealnDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITE 654
Cdd:pfam01576 487 LSTRLRQLEDERNS---LQEQL-------EEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEA 556
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 655 SRQvvELAVKEHKAEILA-----LQQALKEQKLKAESLSDKLNDLEKKHamlemnaRSLQQKLETERELKQRLLEEQAKL 729
Cdd:pfam01576 557 LTQ--QLEEKAAAYDKLEktknrLQQELDDLLVDLDHQRQLVSNLEKKQ-------KKFDQMLAEEKAISARYAEERDRA 627
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 1039770410 730 QQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 771
Cdd:pfam01576 628 EAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDL 669
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
5-459 |
4.26e-06 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 51.66 E-value: 4.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQARMEVSQEDD--KAL---- 77
Cdd:pfam15921 364 ERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRNMEVQRLEAllKAMksec 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 78 -----QLLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLVSA--------------------------------- 119
Cdd:pfam15921 443 qgqmeRQMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTAKkmtlessertvsdltaslqekeraieatnaeit 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 120 --RRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSA-----KDQGKPEVG 192
Cdd:pfam15921 521 klRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGamqveKAQLEKEIN 600
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 ----EYSKLEKINAEQQLKIQELQEK-----LEKaVKASTEATELLQNIRQAKERAERELEKLHN-REDSSEGIKKKLVE 262
Cdd:pfam15921 601 drrlELQEFKILKDKKDAKIRELEARvsdleLEK-VKLVNAGSERLRAVKDIKQERDQLLNEVKTsRNELNSLSEDYEVL 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 263 AEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLdnqikkdladkESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 342
Cdd:pfam15921 680 KRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTL-----------KSMEGSDGHAMKVAMGMQKQITAKRGQIDALQS 748
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 343 KIRSLEQrivELSEANKlaANSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRKLEEqlekishqdhsdksRLL 422
Cdd:pfam15921 749 KIQFLEE---AMTNANK--EKHFLKEEKNKLSQE--LSTVATEKNKMAGELEVLRSQERRLKE--------------KVA 807
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1039770410 423 ELETRLREVSLEHEEQKLELKRQLTE-----LQLSLQERESQ 459
Cdd:pfam15921 808 NMEVALDKASLQFAECQDIIQRQEQEsvrlkLQHTLDVKELQ 849
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
476-745 |
4.65e-06 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 50.58 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 476 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND--- 552
Cdd:pfam15905 66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNEllk 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 553 -----------------EIVQLRSEVDHLRREITEREMQLTSQkqtmeaLKTTCTMLEEQVLDLEALNDELLEKERQWEa 615
Cdd:pfam15905 143 akfsedgtqkkmsslsmELMKLRNKLEAKMKEVMAKQEGMEGK------LQVTQKNLEHSKGKVAQLEEKLVSTEKEKI- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 616 wrsvlgDEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKLNDLE 695
Cdd:pfam15905 216 ------EEKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQIKDLN 281
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1039770410 696 KKHAMLEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 745
Cdd:pfam15905 282 EKCKLLE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
|
|
| COG5281 |
COG5281 |
Phage-related minor tail protein [Mobilome: prophages, transposons]; |
327-754 |
5.10e-06 |
|
Phage-related minor tail protein [Mobilome: prophages, transposons];
Pssm-ID: 444092 [Multi-domain] Cd Length: 603 Bit Score: 51.15 E-value: 5.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 327 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 406
Cdd:COG5281 3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 407 LEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 486
Cdd:COG5281 83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 487 EAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 566
Cdd:COG5281 160 AAAAAAAAAAAAAAAAAAALAAASAAAAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQAALAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 567 EITE--REMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRMLDTEKQS 644
Cdd:COG5281 240 ASAAaqALAALAAAAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAAAAQLAAA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 645 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLE 724
Cdd:COG5281 317 AAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAGAKAALAE 391
|
410 420 430
....*....|....*....|....*....|
gi 1039770410 725 EQAKLQQQMDLQKNHIFRLTQGLQEALDRA 754
Cdd:COG5281 392 YADSATNVAAQVAQAATSAFSGLTDALAGA 421
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
75-806 |
9.49e-06 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 50.82 E-value: 9.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 75 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQ 148
Cdd:TIGR00606 186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 149 HKLMKVVShpprgdsggtaLDDlhkmqghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 228
Cdd:TIGR00606 259 HNLSKIMK-----------LDN----------------------EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLND 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 229 LQNIRQAKERaerelEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVhlkQKEQHYEEKIK----VLDNQIKK 304
Cdd:TIGR00606 306 LYHNHQRTVR-----EKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQL---QADRHQEHIRArdslIQSLATRL 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 305 DLaDKESLENMMQRHEEEAHEKGKILSEQKA-----MINAMDSKIRSLEQRIVELSEANKLAANSslfTQRNMKAQEEMI 379
Cdd:TIGR00606 378 EL-DGFERGPFSERQIKNFHTLVIERQEDEAktaaqLCADLQSKERLKQEQADEIRDEKKGLGRT---IELKKEILEKKQ 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 380 SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREVSLEHEeqKLELKRQLTELQLSLQERE-- 457
Cdd:TIGR00606 454 EELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETL-KKEVKSLQNE--KADLDRKLRKLDQEMEQLNhh 530
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 458 ----SQLTALQAARAALESQLRQAKTELEETTAEAEEEI-------QALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 526
Cdd:TIGR00606 531 tttrTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFpnkkqleDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHI 610
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 527 TEDNAELNNQNFYLSKQLDEASGANDEivqlRSEVDHLRREITEREMQLT------------------------------ 576
Cdd:TIGR00606 611 NNELESKEEQLSSYEDKLFDVCGSQDE----ESDLERLKEEIEKSSKQRAmlagatavysqfitqltdenqsccpvcqrv 686
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 577 --SQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRIT 653
Cdd:TIGR00606 687 fqTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKND 766
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 654 ESRQVVELAV---KEHKAEIL--------ALQQALKEQKLKAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERE 717
Cdd:TIGR00606 767 IEEQETLLGTimpEEESAKVCltdvtimeRFQMELKDVERKIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIE 846
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 718 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQ 797
Cdd:TIGR00606 847 LNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQ 923
|
....*....
gi 1039770410 798 AKMDQPAKK 806
Cdd:TIGR00606 924 EKEELISSK 932
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
17-444 |
9.79e-06 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 50.67 E-value: 9.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 17 HRRVSEVEAVLSQKEVELKASETQRSLLEqDLATYITECSSLKRSLEQARMEVsQEDDKALQLLHDIREQSRKLQEIKEQ 96
Cdd:PRK01156 328 IKKLSVLQKDYNDYIKKKSRYDDLNNQIL-ELEGYEMDYNSYLKSIESLKKKI-EEYSKNIERMSAFISEILKIQEIDPD 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 97 EYQAQVEEMRLMMNQLEEDLVSARRRSDlyesELRESRlaaEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDlHKMQG 176
Cdd:PRK01156 406 AIKKELNEINVKLQDISSKVSSLNQRIR----ALRENL---DELSRNMEMLNGQSVCPVCGTTLGEEKSNHIIN-HYNEK 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 177 HAGLTSAKDQGKPEVgeysklEKINaEQQLKIQELQEKLEKAvkastEATELLQNIRQAKErAERELEKLHNREDSsegI 256
Cdd:PRK01156 478 KSRLEEKIREIEIEV------KDID-EKIVDLKKRKEYLESE-----EINKSINEYNKIES-ARADLEDIKIKINE---L 541
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 257 KKKLVEAEELEEKHReaqvsAQHLEVhLKQKEQHYEEKIKVLD-----------NQIKKDLADKESlenmmqRHEEEAHE 325
Cdd:PRK01156 542 KDKHDKYEEIKNRYK-----SLKLED-LDSKRTSWLNALAVISlidietnrsrsNEIKKQLNDLES------RLQEIEIG 609
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 326 KGKILSEQKAMINAMDSKIRSLEQRIVELsEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 405
Cdd:PRK01156 610 FPDDKSYIDKSIREIENEANNLNNKYNEI-QENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRK 688
|
410 420 430
....*....|....*....|....*....|....*....
gi 1039770410 406 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 444
Cdd:PRK01156 689 ALDDAKANRARLESTIEILRTRINELSDRINDINETLES 727
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
354-581 |
1.15e-05 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 50.01 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 354 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKSrllELETRLREVSL 433
Cdd:PHA02562 165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 434 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE------------ETTAEAEEEIQALTAHRDE 501
Cdd:PHA02562 231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcptctQQISEGPDRITKIKDKLKE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 502 IQRKFDALRNSctvITDLEEQLNQ-------LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 574
Cdd:PHA02562 311 LQHSLEKLDTA---IDELEEIMDEfneqskkLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDE 387
|
....*..
gi 1039770410 575 LTSQKQT 581
Cdd:PHA02562 388 LDKIVKT 394
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1490-1581 |
1.22e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 50.07 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1490 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1553
Cdd:PTZ00449 527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606
|
90 100 110
....*....|....*....|....*....|
gi 1039770410 1554 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1581
Cdd:PTZ00449 607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
333-536 |
1.40e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 49.38 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 333 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 412
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 413 QDHSDKSRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 485
Cdd:COG4942 98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 486 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 536
Cdd:COG4942 178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
|
|
| Tropomyosin |
pfam00261 |
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ... |
207-455 |
1.50e-05 |
|
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.
Pssm-ID: 459736 [Multi-domain] Cd Length: 235 Bit Score: 48.10 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 207 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEA-EELEEKHREAQVSAQHLE 281
Cdd:pfam00261 2 KMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRiqllEEELERTEERLAEAlEKLEEAEKAADESERGRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 282 VhLKQKEQHYEEKIKVLDNQIKKdladkeslenmMQRHEEEAHEKGKILSEQKAMINA----MDSKIRSLEQRIVELSEA 357
Cdd:pfam00261 82 V-LENRALKDEEKMEILEAQLKE-----------AKEIAEEADRKYEEVARKLVVVEGdlerAEERAELAESKIVELEEE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 358 NKLAANSSlftqRNMKAQEEMISElRQQKFyletqagklEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEE 437
Cdd:pfam00261 150 LKVVGNNL----KSLEASEEKASE-REDKY---------EEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEA 215
|
250
....*....|....*...
gi 1039770410 438 QKLELKRQLTELQLSLQE 455
Cdd:pfam00261 216 EKEKYKAISEELDQTLAE 233
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
194-572 |
1.79e-05 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 49.96 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 194 YSKLEKINAEQQLKIqELQEKLEKAVKASTEateLLQNIRQAKER------AERELEKLHNREDSSEGIKKKLVEAEELE 267
Cdd:PRK04863 296 YTSRRQLAAEQYRLV-EMARELAELNEAESD---LEQDYQAASDHlnlvqtALRQQEKIERYQADLEELEERLEEQNEVV 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 268 EkhrEAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL 347
Cdd:PRK04863 372 E---EADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQALERAKQLCGLPDLTADNA 440
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 348 EQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEEQLEKISHQDhsdkSRLL 422
Cdd:PRK04863 441 EDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLRRLREQRHLA----EQLQ 516
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 423 ELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 499
Cdd:PRK04863 517 QLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARI 595
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 500 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITERE 572
Cdd:PRK04863 596 QRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDEEIERLSQPG 668
|
|
| C1_SpBZZ1-like |
cd20824 |
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ... |
932-982 |
1.97e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410374 Cd Length: 53 Bit Score: 43.46 E-value: 1.97e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 932 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 982
Cdd:cd20824 1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
10-269 |
2.08e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.61 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:COG4942 26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 90 LQE-IKEQEYQAQVEEMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKANEcqhklmkvvshpprgdsggtal 168
Cdd:COG4942 106 LAElLRALYRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE---------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 169 ddlhkmqghagLTSAKDQgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHN 248
Cdd:COG4942 162 -----------LAALRAE----------LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQ 220
|
250 260
....*....|....*....|.
gi 1039770410 249 REDSSEGIKKKLVEAEELEEK 269
Cdd:COG4942 221 EAEELEALIARLEAEAAAAAE 241
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
196-448 |
2.19e-05 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 49.66 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 196 KLEKINA--EQQLKIQELQEKLEKAVKASTEATELLQNIRQAK---ERAERELEKLHNREDSSEgIKKKLVEAE------ 264
Cdd:TIGR01612 1471 KIKKDNAtnDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKelfEQYKKDVTELLNKYSALA-IKNKFAKTKkdseii 1549
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 265 --ELEEKHREAQVSAQHLEVHLKQKEQhyeEKIKVLDNQIKKDLADKESLEnmMQRHEEEAHEKGKILSEQKAMINAMDS 342
Cdd:TIGR01612 1550 ikEIKDAHKKFILEAEKSEQKIKEIKK---EKFRIEDDAAKNDKSNKAAID--IQLSLENFENKFLKISDIKKKINDCLK 1624
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 343 KIRSLEQRIVELS---EANKLAANSSlftqrNMKAQEEMISELRQQKFYLETQAGKLEaqnrKLEEQLEKISHQ-DHSDK 418
Cdd:TIGR01612 1625 ETESIEKKISSFSidsQDTELKENGD-----NLNSLQEFLESLKDQKKNIEDKKKELD----ELDSEIEKIEIDvDQHKK 1695
|
250 260 270
....*....|....*....|....*....|
gi 1039770410 419 SRLLELETRLREVSLEHEEqKLELKRQLTE 448
Cdd:TIGR01612 1696 NYEIGIIEKIKEIAIANKE-EIESIKELIE 1724
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
284-477 |
2.20e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 48.67 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 284 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMIN----AMDSKIRSLEQRIVELSEANK 359
Cdd:COG3883 28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEerreELGERARALYRSGGSVSYLDV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 360 LAANSSL--FTQRN------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREV 431
Cdd:COG3883 108 LLGSESFsdFLDRLsalskiADADADLLEELKADKAELEAKKAELEAKLAELEALKA--------------ELEAAKAEL 173
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1039770410 432 slehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 477
Cdd:COG3883 174 ----EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
273-497 |
2.64e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 48.29 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 352
Cdd:COG3883 3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 353 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKSRLLELETR 427
Cdd:COG3883 83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 428 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 497
Cdd:COG3883 152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
437-728 |
2.65e-05 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 47.98 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 437 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDeiqrKFDALRNSctvI 516
Cdd:COG1340 1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELRE----KRDELNEK---V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 517 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqV 596
Cdd:COG1340 74 KELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKELEKELEK-A 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 597 LDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvelavKEHKAEILALQQA 676
Cdd:COG1340 153 KKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA-------DELHKEIVEAQEK 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 677 LKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 728
Cdd:COG1340 225 ADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
545-734 |
2.76e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 48.29 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 545 DEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQvldLEALNDELLEKERQWEAWRSVLGDek 624
Cdd:COG3883 16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE---IDKLQAEIAEAEAEIEERREELGE-- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 625 sqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKLNDLE 695
Cdd:COG3883 91 -----RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKLAELE 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 1039770410 696 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 734
Cdd:COG3883 161 ALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
194-767 |
3.26e-05 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 48.58 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 194 YSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEE-LEEKHRE 272
Cdd:pfam05557 6 ESKARLSQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEaLREQAEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 273 AQVSAQHLEVHLKQKEQHY--EEKIKVLDNQIKKDLAD-KESLENMMQRHEEEAHEKGKI---LSEQKAMINAMDSKIRS 346
Cdd:pfam05557 78 NRLKKKYLEALNKKLNEKEsqLADAREVISCLKNELSElRRQIQRAELELQSTNSELEELqerLDLLKAKASEAEQLRQN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 347 L----------EQRIVELSEANKLAANSSLFTqRNMKAQEEMISElrqqkfyLETQAGKLEAQNRKLEEQLEKIS---HQ 413
Cdd:pfam05557 158 LekqqsslaeaEQRIKELEFEIQSQEQDSEIV-KNSKSELARIPE-------LEKELERLREHNKHLNENIENKLllkEE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 414 DHSDKSRLLELE-TRLREVSLEHEEQKLELKrqLTELQLSLQERESQLTALQAARAALEsQLRQAKTELEETTAEAEEEI 492
Cdd:pfam05557 230 VEDLKRKLEREEkYREEAATLELEKEKLEQE--LQSWVKLAQDTGLNLRSPEDLSRRIE-QLQQREIVLKEENSSLTSSA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 493 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQLRSEVDHLRREITERE 572
Cdd:pfam05557 307 RQLEKARRELEQELAQYLKK---IEDLNKKLKRHKALVRRLQRRVLLLTKERD----------GYRAILESYDKELTMSN 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 573 mqlTSQKQTMEALKttctmLEEQVLDLEALNDELlekerqweawrsvlgdeksqfECRVRELQRMLDTEKQSRARADQRI 652
Cdd:pfam05557 374 ---YSPQLLERIEE-----AEDMTQKMQAHNEEM---------------------EAQLSVAEEELGGYKQQAQTLEREL 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 653 TESRQVVELA-VKEHKAEILALQQALKEQKLKAESLSDKLNDLEkkhamLEMNARSLQQKLETER------------ELK 719
Cdd:pfam05557 425 QALRQQESLAdPSYSKEEVDSLRRKLETLELERQRLREQKNELE-----MELERRCLQGDYDPKKtkvlhlsmnpaaEAY 499
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 1039770410 720 QRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQ 767
Cdd:pfam05557 500 QQRKNQLEKLQAEIERLK----RLLKKLEDDLEQVLRLPETTSTMNFK 543
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
339-508 |
3.35e-05 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 47.23 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 339 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 418
Cdd:COG1579 14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 419 SRLLELETRLREVS-------LEHEEQKLELKRQLTE-LQLSLQER----ESQLTALQAARAALESQLRQAKTELEETTA 486
Cdd:COG1579 73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEdEILELMERieelEEELAELEAELAELEAELEEKKAELDEELA 152
|
170 180
....*....|....*....|..
gi 1039770410 487 EAEEEIQALTAHRDEIQRKFDA 508
Cdd:COG1579 153 ELEAELEELEAEREELAAKIPP 174
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
11-384 |
3.44e-05 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 48.61 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 11 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATY--ITECSSLKRSLEQARMEVSQEDDKALQL---LHDIRE 85
Cdd:COG4717 81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekLLQLLPLYQELEALEAELAELPERLEELeerLEELRE 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 86 QSRKLQEIKEQEYQAQVEEMRLM----------MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMK-- 153
Cdd:COG4717 161 LEEELEELEAELAELQEELEELLeqlslateeeLQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAaa 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 154 -----------------VVSHPPRGDSGGTALDDLHKMQ---------GHAGLTSAKDQGKPEVGEYSKLEKINAEQQLK 207
Cdd:COG4717 241 leerlkearlllliaaaLLALLGLGGSLLSLILTIAGVLflvlgllalLFLLLAREKASLGKEAEELQALPALEELEEEE 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 208 IQELQEKLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHL 280
Cdd:COG4717 321 LEELLAALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQEL 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 281 EVHLKQKEQHYEEKIKVLDNQIkkDLADKESLENMMQRHEEEahekgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKL 360
Cdd:COG4717 401 KEELEELEEQLEELLGELEELL--EALDEEELEEELEELEEE-------LEELEEELEELREELAELEAELEQLEEDGEL 471
|
410 420
....*....|....*....|....
gi 1039770410 361 AansslftqRNMKAQEEMISELRQ 384
Cdd:COG4717 472 A--------ELLQELEELKAELRE 487
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
428-745 |
4.02e-05 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 48.37 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 428 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 504
Cdd:PRK11281 48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 505 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQKQT 581
Cdd:PRK11281 116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLKG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 582 MEALKTTCTMLEEQVLDLE-ALNDELLEKERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrARADQRITESRQVV- 659
Cdd:PRK11281 182 GKVGGKALRPSQRVLLQAEqALLNAQNDLQRKSLEGNTQLQD--------LLQKQRDYLTARI--QRLEHQLQLLQEAIn 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 660 --ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQ--QMDL 735
Cdd:PRK11281 252 skRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLLKATEKLNTltQQNL 309
|
330
....*....|.
gi 1039770410 736 Q-KNHIFRLTQ 745
Cdd:PRK11281 310 RvKNWLDRLTQ 320
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
380-857 |
4.68e-05 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 48.18 E-value: 4.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 380 SELRQQKFYLETQAGKLEAQNRKLEE---QLEKISH------QDHSDKSR-----------LLELETRLREVSLEHEEQK 439
Cdd:pfam05483 99 AELKQKENKLQENRKIIEAQRKAIQElqfENEKVSLkleeeiQENKDLIKennatrhlcnlLKETCARSAEKTKKYEYER 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 440 LELKRQLTELQLSLqerESQLTALQAARAalesQLRQAKTELEETTAEAEEEIQALtahRDEIQRKFDALRNSCTVItdl 519
Cdd:pfam05483 179 EETRQVYMDLNNNI---EKMILAFEELRV----QAENARLEMHFKLKEDHEKIQHL---EEEYKKEINDKEKQVSLL--- 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 520 eeqLNQLTEDNAELNNQNFYLSK------QLDEASGANDE-IVQLRSEVDHLRREITEREMQLTSQKQTMEAL------- 585
Cdd:pfam05483 246 ---LIQITEKENKMKDLTFLLEEsrdkanQLEEKTKLQDEnLKELIEKKDHLTKELEDIKMSLQRSMSTQKALeedlqia 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 586 -KTTCTMLEEQVLDLEALNDE-------LLEKERQWEAWRSVLGDEKSQFECRVRELqRMLDTEKQSRARADQRITESRQ 657
Cdd:pfam05483 323 tKTICQLTEEKEAQMEELNKAkaahsfvVTEFEATTCSLEELLRTEQQRLEKNEDQL-KIITMELQKKSSELEEMTKFKN 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 658 VVELAVKEHKaEILALQQALKEQKLKAESLSDKLNDLEKKHAML----EMNARSLQQKLETERELKQRLLEEQAKLQQQM 733
Cdd:pfam05483 402 NKEVELEELK-KILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKTEL 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 734 DLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtklIDFLQAKMDQpakkkkglfsR 813
Cdd:pfam05483 481 EKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQ----IENLEEKEMN----------L 546
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1039770410 814 RKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 857
Cdd:pfam05483 547 RDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMK 590
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
333-622 |
5.19e-05 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 48.13 E-value: 5.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 333 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 410
Cdd:PRK10929 43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 411 SHQdHSDKSRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTAL-QAARAAL--ESQLRQAKTELEE 483
Cdd:PRK10929 115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLaQAQLTALqaESAALKALVDELE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 484 TTAEAEEEIQALTAHRDEI-QRKFDALRNSctvITDLEEQLNQLTEDNAElnnQNFYLSKQLDEASG--ANDEIVQLRse 560
Cdd:PRK10929 194 LAQLSANNRQELARLRSELaKKRSQQLDAY---LQALRNQLNSQRQREAE---RALESTELLAEQSGdlPKSIVAQFK-- 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 561 vdhLRREITereMQLTSQKQTMEALKTTCTMLEEQVLDL-EALNDelLEKERQWEAWRSVLGD 622
Cdd:PRK10929 266 ---INRELS---QALNQQAQRMDLIASQQRQAASQTLQVrQALNT--LREQSQWLGVSNALGE 320
|
|
| Filament |
pfam00038 |
Intermediate filament protein; |
343-639 |
5.38e-05 |
|
Intermediate filament protein;
Pssm-ID: 459643 [Multi-domain] Cd Length: 313 Bit Score: 47.22 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 343 KIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRL 421
Cdd:pfam00038 19 KVRFLEQQNKLLeTKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAEDF-------RQKY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 422 lELETRLREvslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALE-------SQLRQAKTELEETTAEAEEEIQA 494
Cdd:pfam00038 92 -EDELNLRT---SAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKknheeevRELQAQVSDTQVNVEMDAARKLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 495 LTAHRDEIQRKFDALRNSCTviTDLEEQLNQLTEdnaELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQ 574
Cdd:pfam00038 168 LTSALAEIRAQYEEIAAKNR--EEAEEWYQSKLE---ELQ----------QAAARNGDALRSAKEEITELRRTIQSLEIE 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 575 LTSQKQTMEALKTTCTMLEEQ-VLDLEALNDELLEKERQweawrsvLGDEKSQFECRVRELQRMLD 639
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERyELQLADYQELISELEAE-------LQETRQEMARQLREYQELLN 291
|
|
| PH_ROCK |
cd01242 |
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ... |
1015-1060 |
5.80e-05 |
|
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Pssm-ID: 269948 Cd Length: 110 Bit Score: 43.88 E-value: 5.80e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1039770410 1015 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1060
Cdd:cd01242 2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
|
|
| C1_CeDKF1-like_rpt2 |
cd20798 |
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ... |
932-983 |
5.85e-05 |
|
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410348 Cd Length: 54 Bit Score: 42.10 E-value: 5.85e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1039770410 932 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 983
Cdd:cd20798 1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
6-478 |
6.45e-05 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 47.91 E-value: 6.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 6 EAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQD-----------LATYITECSSLKRSL------------ 62
Cdd:pfam12128 296 DDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDAdietaaadqeqLPSWQSELENLEERLkaltgkhqdvta 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 63 --EQARMEVSQEDDKALQLLHD----IREQSRKLQEIKEQEYQAQVEEMRLMMNQ------------------------- 111
Cdd:pfam12128 376 kyNRRRSKIKEQNNRDIAGIKDklakIREARDRQLAVAEDDLQALESELREQLEAgklefneeeyrlksrlgelklrlnq 455
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 112 ----------------------------------LEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMkvvsh 157
Cdd:pfam12128 456 atatpelllqlenfderierareeqeaanaeverLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLF----- 530
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 158 PPRG--------------DSGGTALDD--LHKMQGHAGLTSAKDQGKPEVGEYS-KLEKINAEQQLKI-QELQEKLEKAV 219
Cdd:pfam12128 531 PQAGtllhflrkeapdweQSIGKVISPelLHRTDLDPEVWDGSVGGELNLYGVKlDLKRIDVPEWAASeEELRERLDKAE 610
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 220 KASTEATELLQNIRQAKERAERELEKLHNRE-DSSEGIKKKLVEAEELEEKHREAQVSAQH-LEVHLKQKEQH---YEEK 294
Cdd:pfam12128 611 EALQSAREKQAAAEEQLVQANGELEKASREEtFARTALKNARLDLRRLFDEKQSEKDKKNKaLAERKDSANERlnsLEAQ 690
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 295 IKVLDNQIKKDLA--DKESLENMMQRHEeeahekgkilsEQKAMINAMDSKIRSLEQRIVELSEANKlAANSSLFTQ--R 370
Cdd:pfam12128 691 LKQLDKKHQAWLEeqKEQKREARTEKQA-----------YWQVVEGALDAQLALLKAAIAARRSGAK-AELKALETWykR 758
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 371 NMKAQ---EEMISELRQQKFYLETqagKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLT 447
Cdd:pfam12128 759 DLASLgvdPDVIAKLKREIRTLER---KIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIA 835
|
570 580 590
....*....|....*....|....*....|.
gi 1039770410 448 ELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:pfam12128 836 DTKLRRAKLEMERKASEKQQVRLSENLRGLR 866
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
230-476 |
7.03e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 47.70 E-value: 7.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 230 QNIRQAKERAERELEKLhnrEDSSEGIKKKLVEAEELEEKHREaqvsaQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADK 309
Cdd:COG3206 164 QNLELRREEARKALEFL---EEQLPELRKELEEAEAALEEFRQ-----KNGLVDLSEEAKLLLQQLSELESQLAEARAEL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 310 ESLENMMQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkf 387
Cdd:COG3206 236 AEAEARLAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ-- 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 388 yletqagkLEAQNRKLEEQLEkishqdhsdkSRLLELETRLREVSLEHEEQKLELKRqltelqlsLQERESQLTALQAAR 467
Cdd:COG3206 307 --------LQQEAQRILASLE----------AELEALQAREASLQAQLAQLEARLAE--------LPELEAELRRLEREV 360
|
....*....
gi 1039770410 468 AALESQLRQ 476
Cdd:COG3206 361 EVARELYES 369
|
|
| PH_MRCK |
cd01243 |
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ... |
1017-1132 |
7.54e-05 |
|
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Pssm-ID: 269949 Cd Length: 135 Bit Score: 44.21 E-value: 7.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 1017 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1093
Cdd:cd01243 15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1039770410 1094 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1132
Cdd:cd01243 91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
|
|
| C1_aPKC |
cd20794 |
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ... |
934-982 |
7.56e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410344 Cd Length: 55 Bit Score: 41.87 E-value: 7.56e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1039770410 934 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 982
Cdd:cd20794 9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
631-885 |
7.65e-05 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 47.60 E-value: 7.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 631 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 702
Cdd:COG4913 213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 703 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 781
Cdd:COG4913 290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 782 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 861
Cdd:COG4913 358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426
|
250 260
....*....|....*....|....
gi 1039770410 862 EAAHRKATDHPHPSTPATARQQIA 885
Cdd:COG4913 427 EIASLERRKSNIPARLLALRDALA 450
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
185-328 |
7.85e-05 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 47.08 E-value: 7.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 185 DQGKPEVGEYSKLEKINAEQqlKIQELQEKLEKAVKAST-EATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEA 263
Cdd:PRK12704 45 EEAKKEAEAIKKEALLEAKE--EIHKLRNEFEKELRERRnELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKELEQK 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 264 EE-LEEKHREAQVSAQHLEVHLKQ-----KEQHYEEKIKVLDNQIKKDLAdkesleNMMQRHEEEAHEKGK 328
Cdd:PRK12704 123 QQeLEKKEEELEELIEEQLQELERisgltAEEAKEILLEKVEEEARHEAA------VLIKEIEEEAKEEAD 187
|
|
| C1_Munc13-1 |
cd20858 |
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ... |
931-981 |
8.25e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410408 Cd Length: 60 Bit Score: 42.00 E-value: 8.25e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 931 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20858 6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
|
|
| Crescentin |
pfam19220 |
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ... |
205-529 |
8.34e-05 |
|
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 46.98 E-value: 8.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 205 QLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSE-GIKKKLVEAEEL--EEKHREAQVSAqhLE 281
Cdd:pfam19220 47 KSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEaALREAEAAKEELriELRDKTAQAEA--LE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 282 VHLKQ---KEQHYEEKIKVLDNQIK---KDLADKES-LENMMQRH---EEEAHEKGKILSEQKAMINAMDSKIRSLEQRI 351
Cdd:pfam19220 125 RQLAAeteQNRALEEENKALREEAQaaeKALQRAEGeLATARERLallEQENRRLQALSEEQAAELAELTRRLAELETQL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 352 ------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishqdhsdksrLLE 423
Cdd:pfam19220 205 datrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL-------------LAE 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 424 LETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRdeiq 503
Cdd:pfam19220 267 ARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTKALAAKD---- 338
|
330 340
....*....|....*....|....*.
gi 1039770410 504 rkfDALRNSCTVITDLEEQLNQLTED 529
Cdd:pfam19220 339 ---AALERAEERIASLSDRIAELTKR 361
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
649-806 |
8.57e-05 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 45.69 E-value: 8.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 649 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 724
Cdd:COG1579 16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 725 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 803
Cdd:COG1579 89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
|
...
gi 1039770410 804 AKK 806
Cdd:COG1579 169 AAK 171
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
449-768 |
8.86e-05 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 47.20 E-value: 8.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 449 LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdALRNSCTVITDLEEQLNQLTE 528
Cdd:pfam07888 32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE---ELRQSREKHEELEEKYKELSA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 529 DNAELNNQNFYLSKQLDEASGandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLE 608
Cdd:pfam07888 109 SSEELSEEKDALLAQRAAHEA---RIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 609 KERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEILALQQALKEQKLKAESLS 688
Cdd:pfam07888 186 ELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELRSLQERLNASERKVEGLG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 689 DKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 757
Cdd:pfam07888 258 EELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEE 337
|
330
....*....|.
gi 1039770410 758 KTERSDLEYQL 768
Cdd:pfam07888 338 RMEREKLEVEL 348
|
|
| PRK10246 |
PRK10246 |
exonuclease subunit SbcC; Provisional |
234-735 |
8.97e-05 |
|
exonuclease subunit SbcC; Provisional
Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 47.49 E-value: 8.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 234 QAKERAERE-LEKLHNRedssegIKKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKESL 312
Cdd:PRK10246 418 HAEQRPLRQrLVALHGQ------IVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTI 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 313 EnmmqrheeEAHEKGKILSEQKAMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLE 390
Cdd:PRK10246 484 C--------EQEARIKDLEAQRAQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 391 tqaGKLEAqnrkLEEQLekisHQDHSDKSRLLELETRLRE----------VSL-------------EHEEQKLELKRQLT 447
Cdd:PRK10246 551 ---GQLDA----LTKQL----QRDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRH 619
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 448 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLT 527
Cdd:PRK10246 620 ELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQS----WQQRQNELTALQNRIQQLT 695
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 528 EDNAELnnqnfylsKQLDEASgANDEIVQLrsevDHLrREITEREMQLTSQKQTMEALkttctmleeqvldlealndELL 607
Cdd:PRK10246 696 PLLETL--------PQSDDLP-HSEETVAL----DNW-RQVHEQCLSLHSQLQTLQQQ-------------------DVL 742
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 608 EKERQWEA---WRSVLgdEKSQFECRVRELQRMLDTEkqsrarADQRITESRQVVELAVKEHKAEILALQQALKEQKLKA 684
Cdd:PRK10246 743 EAQRLQKAqaqFDTAL--QASVFDDQQAFLAALLDEE------TLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHR 814
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 685 ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 735
Cdd:PRK10246 815 PDGLDLTVTVEQIQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQAL 865
|
|
| HOOK |
pfam05622 |
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ... |
448-807 |
9.72e-05 |
|
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 46.99 E-value: 9.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 448 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 523
Cdd:pfam05622 11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 524 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQTMEA- 584
Cdd:pfam05622 69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKKKLEDl 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 585 --LKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSRA----- 646
Cdd:pfam05622 148 gdLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLEEkleal 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 647 -RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMNAR---- 706
Cdd:pfam05622 224 qKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLGQEgsyr 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 707 ----SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKvkm 782
Cdd:pfam05622 304 erltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEAQSE--- 378
|
410 420
....*....|....*....|....*
gi 1039770410 783 egtISQQTKLIDFLQAKMDQPAKKK 807
Cdd:pfam05622 379 ---LQKKKEQIEELEPKQDSNLAQK 400
|
|
| C1_nPKC_theta-like_rpt2 |
cd20837 |
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ... |
933-981 |
1.18e-04 |
|
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410387 Cd Length: 50 Bit Score: 41.27 E-value: 1.18e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 933 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20837 1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
427-754 |
1.21e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 46.87 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 427 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 506
Cdd:PRK04863 283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 507 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEV-DHLRR--EITEREMQLTSQKQTME 583
Cdd:PRK04863 355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAA---EEEVDELKSQLaDYQQAldVQQTRAIQYQQAVQALE 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 584 ALKTTC-----------TMLEEQVLDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--ADQ 650
Cdd:PRK04863 425 RAKQLCglpdltadnaeDWLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvARE 500
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 651 RITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 728
Cdd:PRK04863 501 LLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSE 576
|
330 340
....*....|....*....|....*.
gi 1039770410 729 LQQQMDLQKNHIFRLTQGLQEALDRA 754
Cdd:PRK04863 577 ARERRMALRQQLEQLQARIQRLAARA 602
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
241-814 |
1.30e-04 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 46.76 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 241 RELEKL----HNREDSSEGIKKKLVE-AEELEEKHREAQVSAQHLEVHLK--------QKEQHYEEKIKVLDNQIKKDLA 307
Cdd:pfam12128 179 RHIDKIakamHSKEGKFRDVKSMIVAiLEDDGVVPPKSRLNRQQVEHWIRdiqaiagiMKIRPEFTKLQQEFNTLESAEL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 308 DKESLENMMQRHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEAnklaANSSLFTQRnmkaqeEMISELRQQKF 387
Cdd:pfam12128 259 RLSHLHFGYKSDETLIASR---QEERQETSAELNQLLRTLDDQWKEKRDE----LNGELSAAD------AAVAKDRSELE 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 388 YLETQAGKLE---AQNRKLE-EQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLT--------ELQLSLQE 455
Cdd:pfam12128 326 ALEDQHGAFLdadIETAAADqEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNrdiagikdKLAKIREA 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 456 RESQLTALQAARAALESQLRQAKTeleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDL---EEQLNQLTEDNAE 532
Cdd:pfam12128 406 RDRQLAVAEDDLQALESELREQLE-------------AGKLEFNEEEYRLKSRLGELKLRLNQAtatPELLLQLENFDER 472
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 533 LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK--------TTCTMLEEQVLDLE---- 600
Cdd:pfam12128 473 IERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELElqlfpqagTLLHFLRKEAPDWEqsig 552
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 601 -ALNDELLEK-ERQWEAWRSVLGDEKSQFECRVReLQRM-----LDTEKQSRARADQritesrqvvelaVKEhkaeilAL 673
Cdd:pfam12128 553 kVISPELLHRtDLDPEVWDGSVGGELNLYGVKLD-LKRIdvpewAASEEELRERLDK------------AEE------AL 613
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 674 QQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQmdlqknhifrLTQGLQEALDR 753
Cdd:pfam12128 614 QSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKA----------LAERKDSANER 683
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 754 ADLLKTERSDLEYQLEniQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRR 814
Cdd:pfam12128 684 LNSLEAQLKQLDKKHQ--AWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARR 742
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
211-475 |
1.31e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 46.55 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 211 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegikkklveaeeleekhreaqvSAQHLEVHLKQKEQH 290
Cdd:COG3206 166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEF-----------------------------RQKNGLVDLSEEAKL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 291 YEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQR 370
Cdd:COG3206 217 LLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPN 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 371 N--MKAQEEMISELRQQkfyLETQAGKLEAQnrkLEEQLEKISHQDHSDKSRLLELETRLREVSlEHEEQKLELKRQLTE 448
Cdd:COG3206 290 HpdVIALRAQIAALRAQ---LQQEAQRILAS---LEAELEALQAREASLQAQLAQLEARLAELP-ELEAELRRLEREVEV 362
|
250 260
....*....|....*....|....*..
gi 1039770410 449 LQLSLQERESQLTALQAARAALESQLR 475
Cdd:COG3206 363 ARELYESLLQRLEEARLAEALTVGNVR 389
|
|
| C1_aPKC_iota |
cd21094 |
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ... |
933-984 |
1.35e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410447 Cd Length: 55 Bit Score: 41.14 E-value: 1.35e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 933 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 984
Cdd:cd21094 3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
436-650 |
1.50e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.98 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 436 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRN---- 511
Cdd:COG3883 15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErara 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 512 ---SCTVITDLEEQLNQltEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 588
Cdd:COG3883 95 lyrSGGSVSYLDVLLGS--ESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 589 ctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 650
Cdd:COG3883 173 ---LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
514-733 |
1.66e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.98 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 514 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL---- 585
Cdd:COG3883 16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaral 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 586 ---KTTCTMLEeQVLDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELA 662
Cdd:COG3883 96 yrsGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELEAA 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 663 VKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 733
Cdd:COG3883 170 KAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
238-561 |
1.69e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 46.49 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 238 RAERE--LEKLHN-REDSSEGIKKKLVEAEELEEKHREA-QVSAQHLEVHLkqkEQHYEEKIKVLD---NQIKKDLADKE 310
Cdd:PRK04863 781 RAAREkrIEQLRAeREELAERYATLSFDVQKLQRLHQAFsRFIGSHLAVAF---EADPEAELRQLNrrrVELERALADHE 857
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 311 SLEnmmQRHEEEAhekgKILSEQKAMINAMDSKIR-----SLEQRIVELSEANKLAANSSLFTQRNMKA----------- 374
Cdd:PRK04863 858 SQE---QQQRSQL----EQAKEGLSALNRLLPRLNlladeTLADRVEEIREQLDEAEEAKRFVQQHGNAlaqlepivsvl 930
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 375 --QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL----ELETRLREVSLEHEEQKLELKRQLTE 448
Cdd:PRK04863 931 qsDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQ 1010
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 449 LQLSLQERESQLTALQAARAALESQLRQAKTELEET-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLT 527
Cdd:PRK04863 1011 AQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDLgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFC 1086
|
330 340 350
....*....|....*....|....*....|....
gi 1039770410 528 EdnAELNNQNfylsKQLDEasgANDEIVQLRSEV 561
Cdd:PRK04863 1087 E--AEMDNLT----KKLRK---LERDYHEMREQV 1111
|
|
| C1_MTMR-like |
cd20828 |
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ... |
929-982 |
1.92e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410378 Cd Length: 57 Bit Score: 40.89 E-value: 1.92e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1039770410 929 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 982
Cdd:cd20828 2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
501-801 |
2.15e-04 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 46.10 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 501 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITERE---- 572
Cdd:COG5185 233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTksid 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 573 -----MQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 645
Cdd:COG5185 307 ikkatESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 646 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 725
Cdd:COG5185 387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 726 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 801
Cdd:COG5185 458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
68-609 |
2.25e-04 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 46.20 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 68 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVsarrrsDLYESELRESRLAAEEFKRKANEC 147
Cdd:TIGR01612 1230 KIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETF------NISHDDDKDHHIISKKHDENISDI 1303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 148 QHKLMKVVshppRGDSGGTALDDLHKMQGHAGLTSAKDQGkpEVGEYskLEKI-NAEQQLKIQELQEKLEKAVKASTEAT 226
Cdd:TIGR01612 1304 REKSLKII----EDFSEESDINDIKKELQKNLLDAQKHNS--DINLY--LNEIaNIYNILKLNKIKKIIDEVKEYTKEIE 1375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 227 ELLQNIRQAKERAERELEKLhnREDSS-EGIKKKL---VEAEELEEKHREAQVSAQHL-------EVHLKQKEQHYE--- 292
Cdd:TIGR01612 1376 ENNKNIKDELDKSEKLIKKI--KDDINlEECKSKIestLDDKDIDECIKKIKELKNHIlseesniDTYFKNADENNEnvl 1453
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 293 ---EKIKVLDNQ------IKKDLADKESLENMMQRHE---------EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL 354
Cdd:TIGR01612 1454 llfKNIEMADNKsqhilkIKKDNATNDHDFNINELKEhidkskgckDEADKNAKAIEKNKELFEQYKKDVTELLNKYSAL 1533
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 355 SEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlEKISHQD---HSDKSrlleletrlrev 431
Cdd:TIGR01612 1534 AIKNKFA--------KTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKK--EKFRIEDdaaKNDKS------------ 1591
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 432 sleheeqklelKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqaltahrDEIQRKFDALR- 510
Cdd:TIGR01612 1592 -----------NKAAIDIQLSLENFENKFLKISDIKKKINDCLKET----------------------ESIEKKISSFSi 1638
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 511 -NSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE----ITEREMQLT-SQKQTMEA 584
Cdd:TIGR01612 1639 dSQDTELKENGDNLNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEIDVDQHKKNyeigIIEKIKEIAiANKEEIES 1718
|
570 580 590
....*....|....*....|....*....|..
gi 1039770410 585 LKTTCTMLEEQVL------DLEALN-DELLEK 609
Cdd:TIGR01612 1719 IKELIEPTIENLIssfntnDLEGIDpNEKLEE 1750
|
|
| C1_PKD2_rpt2 |
cd20843 |
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ... |
931-981 |
2.79e-04 |
|
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410393 Cd Length: 79 Bit Score: 41.11 E-value: 2.79e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 931 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20843 10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
171-464 |
3.09e-04 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 45.50 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 171 LHKMQGHAGLTSAKDQGKPEVGEYSKLEKiNAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA----ERELEKL 246
Cdd:pfam17380 275 LHIVQHQKAVSERQQQEKFEKMEQERLRQ-EKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMamerERELERI 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 247 hnredssegikkklveaeELEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKESLENMMQRHEEEAHE 325
Cdd:pfam17380 354 ------------------RQEERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAAR 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 326 KGKILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEE 405
Cdd:pfam17380 403 KVKILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQ 460
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770410 406 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 464
Cdd:pfam17380 461 QVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
192-313 |
3.41e-04 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 44.15 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 192 GEYSKLEKINAEQQLKIQELQEKLEKAvkasteaTELLQNIRQAKE--RAERELEKLHNR-EDSSEGIKKKLVEAEELEE 268
Cdd:COG1579 52 TELEDLEKEIKRLELEIEEVEARIKKY-------EEQLGNVRNNKEyeALQKEIESLKRRiSDLEDEILELMERIEELEE 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1039770410 269 KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 313
Cdd:COG1579 125 ELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELA 169
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
208-343 |
3.44e-04 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 45.20 E-value: 3.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 208 IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS-----EGIKKKLVEA-EELEEKHREAQVSAQhlE 281
Cdd:PRK00409 522 IASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLleeaeKEAQQAIKEAkKEADEIIKELRQLQK--G 599
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 282 VHLKQKEQHYEEKIKVLDNQIKKdlADKESLENMMQRHEEEAHEKGKILS-EQKAMINAMDSK 343
Cdd:PRK00409 600 GYASVKAHELIEARKRLNKANEK--KEKKKKKQKEKQEELKVGDEVKYLSlGQKGEVLSIPDD 660
|
|
| C1_Munc13-2-like |
cd20859 |
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ... |
927-981 |
4.18e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410409 Cd Length: 82 Bit Score: 40.82 E-value: 4.18e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 927 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20859 14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
418-781 |
4.35e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.51 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 418 KSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 497
Cdd:COG4372 5 GEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 498 HRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTS 577
Cdd:COG4372 85 LNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ---LEAQIAELQSEIAEREEELKELEEQLES 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 578 QKQTMEALKTTCTMLEEQVLDlEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 657
Cdd:COG4372 162 LQEELAALEQELQALSEAEAE-QALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 658 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 737
Cdd:COG4372 241 ALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALEL-EALEEAALELKLLALLLNLAALSLIGALEDALLA 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1039770410 738 NHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK 781
Cdd:COG4372 320 ALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGA 363
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
445-662 |
4.36e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 44.44 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 445 QLTELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQRKFDALRNSctvITDLEEQLN 524
Cdd:COG3883 17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEE-----------YNELQAELEALQAEIDKLQAE---IAEAEAEIE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 525 QLTEDNAELNNQNF---YLSKQLDEASGANDeIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEA 601
Cdd:COG3883 83 ERREELGERARALYrsgGSVSYLDVLLGSES-FSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 602 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 662
Cdd:COG3883 162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAA 222
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
10-476 |
4.68e-04 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 45.03 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRslEQARMEVSQEDDKAlqllhDIREQSRK 89
Cdd:PRK02224 313 EARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELRE--EAAELESELEEARE-----AVEDRREE 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 90 LQEIKEQ---------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKR-----KANECQHklmkvv 155
Cdd:PRK02224 386 IEELEEEieelrerfgDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEAlleagKCPECGQ------ 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 156 shpPRGDSGgtalddlhkmqgHAGLTSAKDQGKPEVGEysKLEKInAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA 235
Cdd:PRK02224 460 ---PVEGSP------------HVETIEEDRERVEELEA--ELEDL-EEEVEEVEERLERAEDLVEAEDRIERLEERREDL 521
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 236 KERAERELEKLHNREDSSEGIKKklvEAEELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKESLENm 315
Cdd:PRK02224 522 EELIAERRETIEEKRERAEELRE---RAAELEAEAEEKREAAAEAE----EEAEEAREEVAELNSKLAELKERIESLER- 593
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 316 mqrheeeahekgkiLSEQKAMINAMDSKIRSLEQRIVELSEAN-----KLAANSSLFTQRNMKAQEEMISELRQQKFYLE 390
Cdd:PRK02224 594 --------------IRTLLAAIADAEDEIERLREKREALAELNderreRLAEKRERKRELEAEFDEARIEEAREDKERAE 659
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 391 TQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREvslEHEEqklelkrqltelqlsLQERESQLTA-------L 463
Cdd:PRK02224 660 EYLEQVEEKLDELREERDDLQAEIGAVENELEELE-ELRE---RREA---------------LENRVEALEAlydeaeeL 720
|
490
....*....|...
gi 1039770410 464 QAARAALESQLRQ 476
Cdd:PRK02224 721 ESMYGDLRAELRQ 733
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
208-776 |
4.80e-04 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 45.07 E-value: 4.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 208 IQELQEKLEKavkasteatELLQNIRQAKERAERELEkLHNREDSSEGIKKK----------LVEAEELEEKHREAQV-- 275
Cdd:COG5022 819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEV-LIQKFGRSLKAKKRfsllkketiyLQSAQRVELAERQLQElk 888
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 276 ----SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH--EEEAHEKGKILSEQKAMINAMDSKIRSLEQ 349
Cdd:COG5022 889 idvkSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARLKKLlnNIDLEEGPSIEYVKLPELNKLHEVESKLKE 968
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 350 RIVELSEANKlaANSSLFTQRNmKAQEEM------ISELRQQKFYLETQAGKLEAQNRKLEE--QLEKISHQDHSDKSRL 421
Cdd:COG5022 969 TSEEYEDLLK--KSTILVREGN-KANSELknfkkeLAELSKQYGALQESTKQLKELPVEVAElqSASKIISSESTELSIL 1045
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 422 LELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAKTELEETTAEAEEEIQALTahrde 501
Cdd:COG5022 1046 KPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLESTENLLKTINVKDLEVTN----- 1105
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 502 iqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQT 581
Cdd:COG5022 1106 --RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRL 1182
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 582 ME--ALKTTCTMLEEQVLDLEalnDELLEKERQ-WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRAR--ADQRITESR 656
Cdd:COG5022 1183 YQsaLYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKkfDTPASMSNE 1259
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 657 QVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----LEMNARSLQQKLETERELKQRLLEEQAKLQQ 731
Cdd:COG5022 1260 KLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaLRTKASSLRWKSATEVNYNSEELDDWCREFE 1331
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 1039770410 732 QMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 776
Cdd:COG5022 1332 ISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
|
|
| HOOK |
pfam05622 |
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ... |
197-531 |
4.85e-04 |
|
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 44.68 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 197 LEKINAEQQLKIQELQeklekavKASTEATELLQNIRQAKERAEReLEKLhnrEDSSEGIKKKL---------VEAEE-- 265
Cdd:pfam05622 92 LEKEVLELQHRNEELT-------SLAEEAQALKDEMDILRESSDK-VKKL---EATVETYKKKLedlgdlrrqVKLLEer 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 266 ----------LEEKHREAQVSAQHLEVHLKQ-KEQHyeekiKVLDNQIKKdlADKESLE--NMMQRHEEEAHEKGKILSE 332
Cdd:pfam05622 161 naeymqrtlqLEEELKKANALRGQLETYKRQvQELH-----GKLSEESKK--ADKLEFEykKLEEKLEALQKEKERLIIE 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 333 QKAMINAMDS-KIRSLEQRivELSEANKLAANSSLfTQRNMkAQEEMISELRQQKFYLETQAGKL-EAQNRKLEEQLEKI 410
Cdd:pfam05622 234 RDTLRETNEElRCAQLQQA--ELSQADALLSPSSD-PGDNL-AAEIMPAEIREKLIRLQHENKMLrLGQEGSYRERLTEL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 411 SHQDHSDKSRLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaEAEE 490
Cdd:pfam05622 310 QQLLEDANRRKNELETQNR----LANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLEKLH--------EAQS 377
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1039770410 491 EIQALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNA 531
Cdd:pfam05622 378 ELQKKKEQIEELEPKQDS--NLAQKIDELQEALRKKDEDMK 416
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
227-523 |
5.13e-04 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 44.50 E-value: 5.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 227 ELLQNIRQAKERAERELEKLHNREDSSEGIKKK----LVEAEELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLD 299
Cdd:pfam07888 84 ELKEELRQSREKHEELEEKYKELSASSEELSEEkdalLAQRAAHEARIRELEEDIKTLTQRVLERETELErmkERAKKAG 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 300 NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeaNKLAAnsslfTQRNMKAQEEMI 379
Cdd:pfam07888 164 AQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT--QKLTT-----AHRKEAENEALL 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 380 SELRQQKFYLETQAGKLEAQNRKLEEQlekISHQDHS----DKSRL--LELETRLREVSLEHEEQKLELKRQLTELQLSL 453
Cdd:pfam07888 237 EELRSLQERLNASERKVEGLGEELSSM---AAQRDRTqaelHQARLqaAQLTLQLADASLALREGRARWAQERETLQQSA 313
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 454 QERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 523
Cdd:pfam07888 314 EADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQL 383
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
539-774 |
5.23e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 44.62 E-value: 5.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 539 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS--QKQTMEALKTTCTMLEEQVLDLE----ALNDELLEKER 611
Cdd:COG3206 161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLLQQLSELEsqlaEARAELAEAEA 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 612 QWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQKLKAe 685
Cdd:COG3206 241 RLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEAQRI- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 686 slsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTERSdle 765
Cdd:COG3206 315 -----LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAEA--- 382
|
....*....
gi 1039770410 766 YQLENIQVL 774
Cdd:COG3206 383 LTVGNVRVI 391
|
|
| PRK09039 |
PRK09039 |
peptidoglycan -binding protein; |
559-692 |
5.48e-04 |
|
peptidoglycan -binding protein;
Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 44.19 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 559 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELlekerqwEAWRSVLGDEKSQFECRVRELQRML 638
Cdd:PRK09039 53 SALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRL-------QALLAELAGAGAAAEGRAGELAQEL 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 639 DTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 692
Cdd:PRK09039 126 DSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
10-816 |
5.52e-04 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 45.04 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQarmEVSQEDDKALQLLHDIREQsrk 89
Cdd:TIGR01612 806 DEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNCKE---KIDSEHEQFAELTNKIKAE--- 879
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 90 LQEIKEQEYQAQVEEMRLMMNQ----LEEDL--VSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDS 163
Cdd:TIGR01612 880 ISDDKLNDYEKKFNDSKSLINEinksIEEEYqnINTLKKVDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNL 959
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 164 ggtaLDDLHKMQGHAGLTSAKDQGKPEVGEYS--KLEKINAEQQLKIQELQEKLEKAvKAST------EATELLQNIRQA 235
Cdd:TIGR01612 960 ----IEKSYKDKFDNTLIDKINELDKAFKDASlnDYEAKNNELIKYFNDLKANLGKN-KENMlyhqfdEKEKATNDIEQK 1034
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 236 KERAERELEKLH-----NREDSSEGIKKKLVEAEELEEKH--REAQVSAQHLEvHLKQKEQHY-------EEKIKVLD-- 299
Cdd:TIGR01612 1035 IEDANKNIPNIEiaihtSIYNIIDEIEKEIGKNIELLNKEilEEAEINITNFN-EIKEKLKHYnfddfgkEENIKYADei 1113
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 300 NQIKKDLadkeslENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQrivelsEANKLAANSSLftQRNMKAQEEMI 379
Cdd:TIGR01612 1114 NKIKDDI------KNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLED------VADKAISNDDP--EEIEKKIENIV 1179
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 380 SELRQQKfYLETQAGKLEAQNRKLEE---QLEKISHQDHSDKSRLLEL-------ETRLREVSLEHEEQKLElkrQLTEL 449
Cdd:TIGR01612 1180 TKIDKKK-NIYDEIKKLLNEIAEIEKdktSLEEVKGINLSYGKNLGKLflekideEKKKSEHMIKAMEAYIE---DLDEI 1255
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 450 QLSLQERESQLTALQAARAALESqlrqakteleettaeaeeeiqaLTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTED 529
Cdd:TIGR01612 1256 KEKSPEIENEMGIEMDIKAEMET----------------------FNISHDDDKDHHIISKKHDENISDIREKSLKIIED 1313
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 530 NAELNNQNFY---LSKQLDEASGANDEIVQLRSEVDHL-------------------RREITEREMQLTSQKQTMEAL-K 586
Cdd:TIGR01612 1314 FSEESDINDIkkeLQKNLLDAQKHNSDINLYLNEIANIynilklnkikkiidevkeyTKEIEENNKNIKDELDKSEKLiK 1393
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 587 T--------TC--------------------TMLEEQVLDLEALNDELLEKERQWEAWRSVL------GDEKSQFECRVR 632
Cdd:TIGR01612 1394 KikddinleECkskiestlddkdidecikkiKELKNHILSEESNIDTYFKNADENNENVLLLfkniemADNKSQHILKIK 1473
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 633 -------------ELQRMLDTEKQSRARADQRITESRQVVELaVKEHKAEILALQQALKEQKLK---AESLSDK---LND 693
Cdd:TIGR01612 1474 kdnatndhdfninELKEHIDKSKGCKDEADKNAKAIEKNKEL-FEQYKKDVTELLNKYSALAIKnkfAKTKKDSeiiIKE 1552
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 694 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ----MDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLE 769
Cdd:TIGR01612 1553 IKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSnkaaIDIQLS-----LENFENKFLKISDIKKKINDCLKETE 1627
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 770 NIQvlyshEKVKMEGTISQQTKL------IDFLQAKMDQPAKKKKGLFSRRKE 816
Cdd:TIGR01612 1628 SIE-----KKISSFSIDSQDTELkengdnLNSLQEFLESLKDQKKNIEDKKKE 1675
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
195-508 |
5.60e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.12 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 195 SKLEKINAEQQL---KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNredssegikkklvEAEELEEKHR 271
Cdd:COG4372 66 EELEQARSELEQleeELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQK-------------ERQDLEQQRK 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 272 EAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI 351
Cdd:COG4372 133 QLEAQIAELQSEIAERE----EELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 352 VELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREV 431
Cdd:COG4372 209 IESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEAL 288
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770410 432 SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 508
Cdd:COG4372 289 EEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
232-401 |
5.67e-04 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 44.38 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 232 IRQAKERAERELEklhNREDSSEGIKK-KLVEA--------EELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvldnqi 302
Cdd:PRK12704 33 IKEAEEEAKRILE---EAKKEAEAIKKeALLEAkeeihklrNEFEKELRERRNELQKLEKRLLQKEENLDR--------- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 303 KKDLADKEslENMMQRHEEEAHEKGKILSEQKAMInamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISEL 382
Cdd:PRK12704 101 KLELLEKR--EEELEKKEKELEQKQQELEKKEEEL---EELIEEQLQELERISGLTAEEAKEILLEKVEEEARHEAAVLI 175
|
170
....*....|....*....
gi 1039770410 383 RQqkfyLETQAgKLEAQNR 401
Cdd:PRK12704 176 KE----IEEEA-KEEADKK 189
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
5-277 |
5.81e-04 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 44.67 E-value: 5.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyitECSSLKRSLEQARMEVSQEDDKALQLLHDIR 84
Cdd:TIGR02169 778 EEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-----NRLTLEKEYLEKEIQELQEQRIDLKEQIKSI 852
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 85 EQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKvvshppRGDSG 164
Cdd:TIGR02169 853 EKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSE------LKAKL 926
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 165 GTALDDLhkmqghAGLTSAKDQGKPEVGEYSKLEKInaeqQLKIQELQEKLEKAVKASTEAtellqnIRQAKERAER--E 242
Cdd:TIGR02169 927 EALEEEL------SEIEDPKGEDEEIPEEELSLEDV----QAELQRVEEEIRALEPVNMLA------IQEYEEVLKRldE 990
|
250 260 270
....*....|....*....|....*....|....*.
gi 1039770410 243 LEKLHNR-EDSSEGIKKKLveaEELEEKHREAQVSA 277
Cdd:TIGR02169 991 LKEKRAKlEEERKAILERI---EEYEKKKREVFMEA 1023
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
33-478 |
5.96e-04 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 44.71 E-value: 5.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 33 ELKASETQRSLLEQDLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqL 112
Cdd:pfam05483 339 ELNKAKAAHSFVVTEFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------L 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 113 EE-DLVSARRRSDLYESELRESrlAAEEFKRKANECQHKLMkvvshpprgdsggTALDDLHKMQGHAGLTSAKDQgkpev 191
Cdd:pfam05483 408 EElKKILAEDEKLLDEKKQFEK--IAEELKGKEQELIFLLQ-------------AREKEIHDLEIQLTAIKTSEE----- 467
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 192 gEYSKlekinaeqqlKIQELQEKLEKAVKASTEATE-----LLQNIRQAKERAERELEKLHNREDSSEGIKKK---LVEA 263
Cdd:pfam05483 468 -HYLK----------EVEDLKTELEKEKLKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQEermLKQI 536
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 264 EELEEKhreaqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKEslENmMQRHEEEAHEKGKILSEQKAMINAMDSK 343
Cdd:pfam05483 537 ENLEEK-----------EMNLRDELESVREEFIQKGDEVKCKLDKSE--EN-ARSIEYEVLKKEKQMKILENKCNNLKKQ 602
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 344 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELR------QQKFYLETQAGKLEAQNRKLEEQ--LEKISH-QD 414
Cdd:pfam05483 603 IENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLElelasaKQKFEEIIDNYQKEIEDKKISEEklLEEVEKaKA 682
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 415 HSDKSRLLELETRLR------EVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:pfam05483 683 IADEAVKLQKEIDKRcqhkiaEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIK 752
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
639-798 |
6.02e-04 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 44.23 E-value: 6.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 639 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 709
Cdd:PHA02562 202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 710 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 779
Cdd:PHA02562 282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356
|
170
....*....|....*....
gi 1039770410 780 vkmEGTISQQTKLIDFLQA 798
Cdd:PHA02562 357 ---VDKAKKVKAAIEELQA 372
|
|
| C1_dGM13116p-like |
cd20831 |
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ... |
944-981 |
6.75e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410381 Cd Length: 58 Bit Score: 39.25 E-value: 6.75e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1039770410 944 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20831 17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
|
|
| ATG17_like |
pfam04108 |
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ... |
215-478 |
7.12e-04 |
|
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.
Pssm-ID: 427715 [Multi-domain] Cd Length: 360 Bit Score: 43.92 E-value: 7.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 215 LEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVE-AEELEEKHREAQVSAQHLEVHLKQKEQHYEE 293
Cdd:pfam04108 2 LSSAQDLCRWANELLTDARSLLEELVVLLAKIAFLRRGLSVQLANLEKvREGLEKVLNELKKDFKQLLKDLDAALERLEE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 294 KIKVLDNQI------------KK--DLADKESLENM---MQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSE 356
Cdd:pfam04108 82 TLDKLRNTPvepalppgeekqKTllDFIDEDSVEILrdaLKELIDELQAAQESLDSD---LKRFDDDLRDLQKELESLSS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 357 ANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHE 436
Cdd:pfam04108 159 PSESISLIPTLLKELESLEEEMASLLESLTNHYDQCVTAVKLTEGGRAEMLEVLENDARELDDVVPELQDRLDEMENNYE 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1039770410 437 ------EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:pfam04108 239 rlqkllEQKNSLIDELLSALQLIAEIQSRLPEYLAALKEFEERWEEEK 286
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
6-299 |
7.75e-04 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 44.12 E-value: 7.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 6 EAMMEQEmTRLHRRVSEVEAVLSQKevelKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 85
Cdd:pfam07888 143 QRVLERE-TELERMKERAKKAGAQR----KEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITT 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 86 QSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaaeefkrkanecqhklmkvvshpprgdsgg 165
Cdd:pfam07888 218 LTQKLTTAHRKE--AENEALLEELRSLQERLNASERKVEGLGEELSS--------------------------------- 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 166 talddlhkmqghagLTSAKDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNIRQAKERAER---E 242
Cdd:pfam07888 263 --------------MAAQRDRTQAELHQ-ARLQAAQLTLQLADASLALREGRA-RWAQERETLQQSAEADKDRIEKlsaE 326
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 243 LEKLHNR--EDSSEGIKKKLVEAEE-------LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 299
Cdd:pfam07888 327 LQRLEERlqEERMEREKLEVELGREkdcnrvqLSESRRELQELKASLRVAQKEKEQLQAEKQELLE 392
|
|
| CCDC22 |
pfam05667 |
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ... |
516-696 |
8.55e-04 |
|
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.
Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 43.86 E-value: 8.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 516 ITDLEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 595
Cdd:pfam05667 337 LEELQEQLEDLESSIQELE----------KEIKKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDLLPDAEENIAKL 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 596 VLDLEALNDELLEKERQWEAWRSVLGDEksqfecrVRELqrmldtekqsRARADQRITESRQVVElAVKEHKAEIlalQQ 675
Cdd:pfam05667 407 QALVDASAQRLVELAGQWEKHRVPLIEE-------YRAL----------KEAKSNKEDESQRKLE-EIKELREKI---KE 465
|
170 180
....*....|....*....|.
gi 1039770410 676 ALKEQKLKAESLSDKLNDLEK 696
Cdd:pfam05667 466 VAEEAKQKEELYKQLVAEYER 486
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
182-409 |
8.86e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.67 E-value: 8.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 182 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikkklv 261
Cdd:COG3883 13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERR------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 262 eaEELEEKHREAQVS---AQHLEVhlkqkeqhyeekikVLDNQIKKDLADKESLENMMQRHEeeahekGKILSEQKAMIN 338
Cdd:COG3883 86 --EELGERARALYRSggsVSYLDV--------------LLGSESFSDFLDRLSALSKIADAD------ADLLEELKADKA 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 339 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 409
Cdd:COG3883 144 ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
318-731 |
1.36e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 43.79 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 318 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 393
Cdd:PRK04863 276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 394 GKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESq 473
Cdd:PRK04863 355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALER- 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 474 LRQAKTELEETTAEAEEEIQALTAHRDEIQrkfDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQL-------DE 546
Cdd:PRK04863 426 AKQLCGLPDLTADNAEDWLEEFQAKEQEAT---EELL-------SLEQKLS-VAQAAHSQFEQAYQLVRKIagevsrsEA 494
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 547 ASGANDEIVQLRSEVDH------LRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAwrsvL 620
Cdd:PRK04863 495 WDVARELLRRLREQRHLaeqlqqLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLES----L 570
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 621 GDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVElavkehkaeilALQQaLKEQKLKAESLSDKLNDLEKKHAM 700
Cdd:PRK04863 571 SESVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQD-----------ALAR-LREQSGEEFEDSQDVTEYMQQLLE 638
|
410 420 430
....*....|....*....|....*....|.
gi 1039770410 701 LEmnaRSLQQKLETERELKQRLLEEQAKLQQ 731
Cdd:PRK04863 639 RE---RELTVERDELAARKQALDEEIERLSQ 666
|
|
| C1_MRCKalpha |
cd20864 |
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ... |
933-986 |
1.37e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410414 Cd Length: 60 Bit Score: 38.46 E-value: 1.37e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1039770410 933 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 986
Cdd:cd20864 3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
|
|
| C1_MRCK |
cd20809 |
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ... |
933-984 |
1.42e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410359 Cd Length: 53 Bit Score: 38.02 E-value: 1.42e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1039770410 933 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 984
Cdd:cd20809 1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
497-697 |
1.42e-03 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 43.08 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 497 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEASGA----NDEIVQLRSEVDHLRREITERE 572
Cdd:PHA02562 213 ENIARKQNKYDELVEE---AKTIKAEIEELTDELLNLV-------MDIEDPSAAlnklNTAAAKIKSKIEQFQKVIKMYE 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 573 ---------MQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQRMLDTEKQ 643
Cdd:PHA02562 283 kggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSK-----------KLLELKNKISTNKQ 351
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770410 644 SRARADQRITESRQVVELAVKE---HKAEILALQQALKEqklkaesLSDKLNDLEKK 697
Cdd:PHA02562 352 SLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDK-------IVKTKSELVKE 401
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
444-866 |
1.44e-03 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 43.50 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 444 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 518
Cdd:PRK10929 2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 519 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTsQKQTmEALKt 587
Cdd:PRK10929 82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLP-QQQT-EARR- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 588 tctMLEEQVLDLEALNDELLEKErqwEAWRSVLGDEKSQFECRVRELQrmldtekQSRARADQRITESRQVVELAVKEHk 667
Cdd:PRK10929 152 ---QLNEIERRLQTLGTPNTPLA---QAQLTALQAESAALKALVDELE-------LAQLSANNRQELARLRSELAKKRS- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 668 AEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrLLEEQAklqQQMDL 735
Cdd:PRK10929 218 QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-ALNQQA---QRMDL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 736 ----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKL 792
Cdd:PRK10929 284 iasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPQL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 793 IDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTRielrsareEAAHR 866
Cdd:PRK10929 363 RQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN--------EATHR 429
|
|
| C1_TNS1_v |
cd20888 |
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ... |
933-980 |
1.52e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410438 Cd Length: 57 Bit Score: 38.31 E-value: 1.52e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 933 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 980
Cdd:cd20888 6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
|
|
| C1_ScPKC1-like_rpt1 |
cd20822 |
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ... |
928-981 |
1.77e-03 |
|
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410372 Cd Length: 52 Bit Score: 38.04 E-value: 1.77e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1039770410 928 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20822 3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
202-464 |
1.98e-03 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 42.11 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 202 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLHNREDSSEGIKKKLVEAeeLEEKhREAQVSAQHL 280
Cdd:pfam15905 52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAA--VREK-TSLSASVASL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 281 EVHLKQKEQHYE-EKIKVLDNQIKKDLaDKESLENMMQRHEEEAHEKG----------------KILSEQKAMINAMDSK 343
Cdd:pfam15905 128 EKQLLELTRVNElLKAKFSEDGTQKKM-SSLSMELMKLRNKLEAKMKEvmakqegmegklqvtqKNLEHSKGKVAQLEEK 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 344 IRSLEQ-RIVELSEANKLAAnsslFTQRNMKAQEEMIS---ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS 419
Cdd:pfam15905 207 LVSTEKeKIEEKSETEKLLE----YITELSCVSEQVEKyklDIAQLEELLKEKNDEIESLKQSLEEKEQELSKQIKDLNE 282
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1039770410 420 RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 464
Cdd:pfam15905 283 KCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
193-313 |
2.05e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 41.45 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS------------------- 253
Cdd:COG1579 18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYeeqlgnvrnnkeyealqke 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770410 254 -EGIKKKLVEAE----ELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 313
Cdd:COG1579 98 iESLKRRISDLEdeilELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
648-784 |
2.19e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 42.46 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 648 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 727
Cdd:PRK12704 62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770410 728 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 784
Cdd:PRK12704 139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
|
|
| PRK04778 |
PRK04778 |
septation ring formation regulator EzrA; Provisional |
195-478 |
2.68e-03 |
|
septation ring formation regulator EzrA; Provisional
Pssm-ID: 179877 [Multi-domain] Cd Length: 569 Bit Score: 42.13 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 195 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAereLEKLHNREDSSEGIKKKLVEAEELEEKHREAQ 274
Cdd:PRK04778 112 SLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKSL---LANRFSFGPALDELEKQLENLEEEFSQFVELT 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 275 VSAQHLEVH---LKQKE-----QHYEEKIKVLDNQIKKDLADK-ESLENMMQRHEEEAH--EKGKILSEqkamINAMDSK 343
Cdd:PRK04778 189 ESGDYVEAReilDQLEEelaalEQIMEEIPELLKELQTELPDQlQELKAGYRELVEEGYhlDHLDIEKE----IQDLKEQ 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 344 IRSLEQRIVEL-----SEANKLAANS-----SLFtQRNMKAQEEMISELRQQKFYLEtqagKLEAQNRKLEEQLEKISHQ 413
Cdd:PRK04778 265 IDENLALLEELdldeaEEKNEEIQERidqlyDIL-EREVKARKYVEKNSDTLPDFLE----HAKEQNKELKEEIDRVKQS 339
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 414 ---DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:PRK04778 340 ytlNESELESVRQLEKQLES-----------LEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIE 396
|
|
| Filament |
pfam00038 |
Intermediate filament protein; |
417-734 |
3.35e-03 |
|
Intermediate filament protein;
Pssm-ID: 459643 [Multi-domain] Cd Length: 313 Bit Score: 41.44 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 417 DKSRLLELETRLREVSL-EHEEQKLELKRQLTEL-QLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqa 494
Cdd:pfam00038 18 DKVRFLEQQNKLLETKIsELRQKKGAEPSRLYSLyEKEIEDLRRQLDTLTVERARLQLELDNL----------------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 495 ltahRDEIQRkfdaLRNSctvitdLEEQLNQLTEDNAELNNqnfyLSKQLDEASGANDE----IVQLRSEVDHLRR---- 566
Cdd:pfam00038 81 ----RLAAED----FRQK------YEDELNLRTSAENDLVG----LRKDLDEATLARVDleakIESLKEELAFLKKnhee 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 567 EITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQweawrsvlgDEKSQFECRVRELQRMLDTEKQSRA 646
Cdd:pfam00038 143 EVRELQAQVSDTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNRE---------EAEEWYQSKLEELQQAAARNGDALR 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 647 RADQRITESRQVVElavkehkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE-RELKQRLLEE 725
Cdd:pfam00038 214 SAKEEITELRRTIQ-----------SLEIELQSLKKQKASLERQLAETEERYELQLADYQELISELEAElQETRQEMARQ 282
|
....*....
gi 1039770410 726 QAKLQQQMD 734
Cdd:pfam00038 283 LREYQELLN 291
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
558-876 |
3.60e-03 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 42.03 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 558 RSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawRSVLGDEKSQFE--------- 628
Cdd:pfam17380 295 KMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELE--RIRQEERKRELErirqeeiam 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 629 --CRVRELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNAR 706
Cdd:pfam17380 373 eiSRMRELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEAR 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 707 SLQ-QKLETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKVK 781
Cdd:pfam17380 434 QREvRRLEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEER 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 782 MEGTISQQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIELR 857
Cdd:pfam17380 505 KQAMIEEERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMMR 579
|
330
....*....|....*....
gi 1039770410 858 SAREEAAHRKATDHPHPST 876
Cdd:pfam17380 580 QIVESEKARAEYEATTPIT 598
|
|
| pepcterm_ChnLen |
TIGR03007 |
polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this ... |
557-736 |
3.61e-03 |
|
polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this protein family belong to the family of polysaccharide chain length determinant proteins (pfam02706). All are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria, and are found near the epsH homolog that is the putative exosortase gene. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 274386 [Multi-domain] Cd Length: 498 Bit Score: 41.96 E-value: 3.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 557 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE-----EQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRV 631
Cdd:TIGR03007 202 YYSEISEAQEELEAARLELNEAIAQRDALKRQLGGEEpvllaGSSVANSELDGRIEALEKQLDALRLRYTDKHPDVI-AT 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 632 RELQRMLDTEKQSRARADQRITESR-------QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmn 704
Cdd:TIGR03007 281 KREIAQLEEQKEEEGSAKNGGPERGeianpvyQQLQIELAEAEAEIASLEARVAELTARIERLESLLRTIPEVEAELT-- 358
|
170 180 190
....*....|....*....|....*....|....
gi 1039770410 705 arSLQQKLETERELKQRLLE--EQAKLQQQMDLQ 736
Cdd:TIGR03007 359 --QLNRDYEVNKSNYEQLLTrrESAEVSKQMEVQ 390
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
5-476 |
3.67e-03 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 42.34 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDL------ATYITECSSLKRSLEQARMEVSQEDDKAL- 77
Cdd:TIGR00606 585 EINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQRAMLAGATAv 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 78 --QLLHDIREQSRKLQEIKEQEYQAQvEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFkrkanecqhklmkvv 155
Cdd:TIGR00606 665 ysQFITQLTDENQSCCPVCQRVFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEM--------------- 728
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 156 shpprgdsggtalddLHKMQGHAGLTSAKDQGKPEVGEysKLEKINAEQQLKIQEL--QEKLEKAVKASTEATE------ 227
Cdd:TIGR00606 729 ---------------LGLAPGRQSIIDLKEKEIPELRN--KLQKVNRDIQRLKNDIeeQETLLGTIMPEEESAKvcltdv 791
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 228 -LLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLK--QKEQHYEEKIKVLDNQIKK 304
Cdd:TIGR00606 792 tIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKliQDQQEQIQHLKSKTNELKS 871
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 305 DLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSlfTQRNMKAQEE---MISE 381
Cdd:TIGR00606 872 EKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK--ETSNKKAQDKvndIKEK 949
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 382 LRQQKFYLET-----QAGKlEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKleLKRQLTELQLSLQER 456
Cdd:TIGR00606 950 VKNIHGYMKDienkiQDGK-DDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQK--IQERWLQDNLTLRKR 1026
|
490 500
....*....|....*....|
gi 1039770410 457 ESQLTALQAARAALESQLRQ 476
Cdd:TIGR00606 1027 ENELKEVEEELKQHLKEMGQ 1046
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
58-326 |
3.87e-03 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 41.05 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 58 LKRSLEQARMEVSQEDDKalqlLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEdlvsarRRSDLYEsELRESRLAA 137
Cdd:COG1340 13 LEEKIEELREEIEELKEK----RDELNEELKELAE-KRDELNAQVKELREEAQELRE------KRDELNE-KVKELKEER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 138 EEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKmqghagltsakdqgkpevgEYSKLEK--------INAEQQL--K 207
Cdd:COG1340 81 DELNEKLNELREELDELRKELAELNKAGGSIDKLRK-------------------EIERLEWrqqtevlsPEEEKELveK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 208 IQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV-----------EAEELEEKHREA 273
Cdd:COG1340 142 IKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIelykeadelrkEADELHKEIVEA 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1039770410 274 QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE-NMMQRHEEEAHEK 326
Cdd:COG1340 222 QEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEkEELEEKAEEIFEK 275
|
|
| C1_PKD_rpt2 |
cd20796 |
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ... |
932-981 |
4.02e-03 |
|
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410346 Cd Length: 54 Bit Score: 36.88 E-value: 4.02e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 932 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20796 1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
|
|
| HCR |
pfam07111 |
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ... |
193-749 |
4.09e-03 |
|
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 42.05 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTE--------ATELLQNIRQAKERAERELEKLHNREDSS----------- 253
Cdd:pfam07111 87 ETSLQQKMRLEAQAMELDALAVAEKAGQAEAEglraalagAEMVRKNLEEGSQRELEEIQRLHQEQLSSltqaheealss 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 254 -----EGIKKKLV--------EAEELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNqIKKDLADKESLENMMQRHE 320
Cdd:pfam07111 167 ltskaEGLEKSLNsletkragEAKQLAEAQKEAEL----LRKQLSKTQEELEAQVTLVES-LRKYVGEQVPPEVHSQTWE 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 321 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISELRQQKFYLETQAGKleaqn 400
Cdd:pfam07111 242 LERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRKIQPSDSLEPEFPK----- 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 401 rkleeqleKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTE--------------LQLSLQERESQLTALQAA 466
Cdd:pfam07111 303 --------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAElqeqvtsqsqeqaiLQRALQDKAAEVEVERMS 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 467 RAALESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDE 546
Cdd:pfam07111 375 AKGLQMELSRAQEARRRQQ-------QQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSYAVRKVHT 447
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 547 ASG---ANDEIVQLRSEVDHLRREITEREMQLTSQkqtMEALKTTCTMLEEQV-LDLEALNDELLEKERQWEAWRSVLGD 622
Cdd:pfam07111 448 IKGlmaRKVALAQLRQESCPPPPPAPPVDADLSLE---LEQLREERNRLDAELqLSAHLIQQEVGRAREQGEAERQQLSE 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 623 EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES-----LSD---KLNDL 694
Cdd:pfam07111 525 VAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVETrlreqLSDtkrRLNEA 604
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 695 EKKHAMLEMNARSLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhifRLTQGLQE 749
Cdd:pfam07111 605 RREQAKAVVSLRQIQHRATQEKERNQelrRLQDEARKEEGQ---------RLARRVQE 653
|
|
| C1_TNS2 |
cd20887 |
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ... |
932-984 |
4.29e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410437 Cd Length: 53 Bit Score: 37.07 E-value: 4.29e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 932 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 984
Cdd:cd20887 2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
664-791 |
4.33e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 41.69 E-value: 4.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 664 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 740
Cdd:PRK12704 32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1039770410 741 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 791
Cdd:PRK12704 103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
78-278 |
4.34e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 41.29 E-value: 4.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 78 QLLHDIREQSRKLQEIKEQE--YQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVV 155
Cdd:COG4942 31 QLQQEIAELEKELAALKKEEkaLLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 156 ---------SHPPRGDSGGTALDDLHKMQGHAGLTSA-KDQGKpevgeysKLEKINAEQQLKIQELQEKLEKAVKASTEA 225
Cdd:COG4942 111 ralyrlgrqPPLALLLSPEDFLDAVRRLQYLKYLAPArREQAE-------ELRADLAELAALRAELEAERAELEALLAEL 183
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1039770410 226 TELLQNIRQAKERAERELEKLHNREDSSEG-IKKKLVEAEELEEKHREAQVSAQ 278
Cdd:COG4942 184 EEERAALEALKAERQKLLARLEKELAELAAeLAELQQEAEELEALIARLEAEAA 237
|
|
| Lebercilin |
pfam15619 |
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ... |
368-575 |
4.42e-03 |
|
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.
Pssm-ID: 464776 [Multi-domain] Cd Length: 193 Bit Score: 40.27 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 368 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 444
Cdd:pfam15619 2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 445 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 524
Cdd:pfam15619 82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1039770410 525 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:pfam15619 141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
426-858 |
5.30e-03 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 41.70 E-value: 5.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 426 TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLrQAKTELEETTAEAEEEIQALTAHRDEIQRK 505
Cdd:pfam01576 1 TRQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQL-QAETELCAEAEEMRARLAARKQELEEILHE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 506 FDALrnsctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA------------------NDEIVQLRSEVDHLRRE 567
Cdd:pfam01576 80 LESR------LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAArqklqlekvtteakikklEEDILLLEDQNSKLSKE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 568 -------ITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEalnDELLEKERQW---EAWRSVLGDEKSQFECRVRELQRM 637
Cdd:pfam01576 154 rklleerISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLE---ERLKKEEKGRqelEKAKRKLEGESTDLQEQIAELQAQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 638 LDTEKQSRARADQRI----------TESRQVVELAVKEHKAEILALQQALKEQKL---KAESLSDKLN-DLEKKHAMLE- 702
Cdd:pfam01576 231 IAELRAQLAKKEEELqaalarleeeTAQKNNALKKIRELEAQISELQEDLESERAarnKAEKQRRDLGeELEALKTELEd 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 703 -MNARSLQQKLETERE-----LKQRLLEEQAKLQQQM-DLQKNHifrlTQGLQEALDRADLLKTERSDLEyqlENIQVLY 775
Cdd:pfam01576 311 tLDTTAAQQELRSKREqevteLKKALEEETRSHEAQLqEMRQKH----TQALEELTEQLEQAKRNKANLE---KAKQALE 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 776 SHEKvkmegtiSQQTKLIDFLQAKMDQPAKKKKglfsrrkedpalptqVPLQYNELKLAL-EKEKARcAELEEALQKTRI 854
Cdd:pfam01576 384 SENA-------ELQAELRTLQQAKQDSEHKRKK---------------LEGQLQELQARLsESERQR-AELAEKLSKLQS 440
|
....
gi 1039770410 855 ELRS 858
Cdd:pfam01576 441 ELES 444
|
|
| EzrA |
pfam06160 |
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ... |
224-610 |
5.50e-03 |
|
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.
Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 41.38 E-value: 5.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 224 EATELLQ--NIRQAKeRAERELEK-LHNREDSSEGIKKKLVEAEELEEKHREAqvsAQHLEVH-------LKQKEQHYEE 293
Cdd:pfam06160 71 EAEELNDkyRFKKAK-KALDEIEElLDDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktLLANRFSYGP 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 294 KIKVLDNQIKKDLADKESLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftQRNM 372
Cdd:pfam06160 147 AIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------------KTEL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 373 KAQ----EEMISELRQQKFYLETQagkleaqnrKLEEQLEKISHQDHSDKSRLLELEtrlrevsLEHEEQKLE-LKRQLT 447
Cdd:pfam06160 210 PDQleelKEGYREMEEEGYALEHL---------NVDKEIQQLEEQLEENLALLENLE-------LDEAEEALEeIEERID 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 448 ELQLSLqEREsqltalqaaraalesqlrqakteleettaeaeeeIQAltahRDEIQRKFDALRNSctvITDLEEQLNQLT 527
Cdd:pfam06160 274 QLYDLL-EKE----------------------------------VDA----KKYVEKNLPEIEDY---LEHAEEQNKELK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 528 EDNAELnNQNFYLS-KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDL-EALNDe 605
Cdd:pfam06160 312 EELERV-QQSYTLNeNELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQEEFkESLQS- 389
|
....*
gi 1039770410 606 lLEKE 610
Cdd:pfam06160 390 -LRKD 393
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
437-652 |
5.51e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 40.29 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 437 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 516
Cdd:COG1579 3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALE--------------ARLEAAKTELE------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 517 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGaNDEIVQLRSEVDHLRREITEREMQLtsqKQTMEAlkttctmleeqv 596
Cdd:COG1579 56 -DLEKEIKRLELEIEEVEARIKKYEEQLGNVRN-NKEYEALQKEIESLKRRISDLEDEI---LELMER------------ 118
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770410 597 ldLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI 652
Cdd:COG1579 119 --IEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKI 172
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
257-771 |
5.61e-03 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 41.35 E-value: 5.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 257 KKKLVEAEELEEKHREAQVSAQHLEVHLKQK---------EQHYE-------EKIKVLDNQIKKDLADKESLENMMQR-- 318
Cdd:pfam10174 174 KKSGEEDWERTRRIAEAEMQLGHLEVLLDQKekenihlreELHRRnqlqpdpAKTKALQTVIEMKDTKISSLERNIRDle 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 319 ------------HEEEAHEKGKILSEQKAMINAMDSKIRSLEQrivELS--EANKLAANSSLFTQRNM------------ 372
Cdd:pfam10174 254 devqmlktngllHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQ---ELSkkESELLALQTKLETLTNQnsdckqhievlk 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 373 -----KAQEEMI--SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDH--SDKSRLLELETR-----------LREVS 432
Cdd:pfam10174 331 esltaKEQRAAIlqTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGeiRDLKDMLDVKERkinvlqkkienLQEQL 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 433 LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqlrqakteleettaeaeEEIQALTAHRD-EIQRKFDALRN 511
Cdd:pfam10174 411 RDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKE------------------RIIERLKEQRErEDRERLEELES 472
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 512 SCTVITDLEEQLNQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREI---TEREMQLTSQKQTMEALKTT 588
Cdd:pfam10174 473 LKKENKDLKEKVSAL---QPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVeqkKEECSKLENQLKKAHNAEEA 549
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 589 CTMLEEQVLDLealndELLEKERQWEAWRSvlgdEKSQFEC-RVRELQRMLDTEKQSRaraDQRITEsrqvvelavkehk 667
Cdd:pfam10174 550 VRTNPEINDRI-----RLLEQEVARYKEES----GKAQAEVeRLLGILREVENEKNDK---DKKIAE------------- 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 668 AEILALQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ--RLLEEQAKLQQQMDLQKNHIFRLTQ 745
Cdd:pfam10174 605 LESLTLRQ-MKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQleELMGALEKTRQELDATKARLSSTQQ 683
|
570 580
....*....|....*....|....*.
gi 1039770410 746 GLQEaldRADLLKTERSDLEYQLENI 771
Cdd:pfam10174 684 SLAE---KDGHLTNLRAERRKQLEEI 706
|
|
| C1_Munc13 |
cd20807 |
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ... |
933-981 |
6.15e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410357 Cd Length: 53 Bit Score: 36.30 E-value: 6.15e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1039770410 933 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 981
Cdd:cd20807 1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
372-734 |
6.37e-03 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 41.03 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 372 MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREVSLEHEeqklELKRQLTELQL 451
Cdd:pfam07888 47 LQAQEAANRQREKEKERYKRDREQWERQRRELESRVA--------------ELKEELRQSREKHE----ELEEKYKELSA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 452 SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNA 531
Cdd:pfam07888 109 SSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELR 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 532 ELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDEL----- 606
Cdd:pfam07888 189 SLSKEFQELRNSLAQRD---TQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELssmaa 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 607 LEKERQWEAWRSVLgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE-----QK 681
Cdd:pfam07888 266 QRDRTQAELHQARL--QAAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEermerEK 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770410 682 LKAESLSDKLNDL----EKKHAMLEMNA--RSLQQKLETERELKQRLLEEQAKLQQQMD 734
Cdd:pfam07888 344 LEVELGREKDCNRvqlsESRRELQELKAslRVAQKEKEQLQAEKQELLEYIRQLEQRLE 402
|
|
| ATG16 |
pfam08614 |
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ... |
453-609 |
7.04e-03 |
|
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.
Pssm-ID: 462536 [Multi-domain] Cd Length: 176 Bit Score: 39.14 E-value: 7.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 453 LQERESQLTALQAA-RAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTvitDLEEQLNQLTEDNA 531
Cdd:pfam08614 12 LLDRTALLEAENAKlQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRG---ELAQRLVDLNEELQ 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 532 ELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEK 609
Cdd:pfam08614 89 ELEKKLREDERRLAALE---AERAQLEEKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENRELVER 163
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
244-465 |
7.10e-03 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 41.04 E-value: 7.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 244 EKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKEslenmmqrheeea 323
Cdd:PLN02939 94 DDDHNRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLE-DLVGMIQNAEKNILLLNQARLQALEDLE------------- 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 324 hekgKILSEQKAMinamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAqnrkL 403
Cdd:PLN02939 160 ----KILTEKEAL----QGKINILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIR---GATEGLCVHS----L 224
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770410 404 EEQLEKISHQDHSDKSRLLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQA 465
Cdd:PLN02939 225 SKELDVLKEENMLLKDDIQFLKAELIEVA-ETEERVFKLEKERSLLDASLRELESKFIVAQE 285
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
10-246 |
7.15e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.05 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ---------DLATYITECSS-----------------LKRSLE 63
Cdd:COG4913 616 EAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAEleaelerldassddlaaLEEQLE 695
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 64 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRS---DLYESELRE---SRL 135
Cdd:COG4913 696 ELEAELEELEEELDELKGEIGRLEKELEQAEEEldELQDRLEAAEDLARLELRALLEERFAAalgDAVERELREnleERI 775
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 136 AAEefKRKANECQHKLMKVVSH-----PPRGDSGGTALDDLHKMQGHagltsakdqgkpevgeYSKLEKINAEqqlkiqE 210
Cdd:COG4913 776 DAL--RARLNRAEEELERAMRAfnrewPAETADLDADLESLPEYLAL----------------LDRLEEDGLP------E 831
|
250 260 270
....*....|....*....|....*....|....*...
gi 1039770410 211 LQEKLEKAVKASTEA--TELLQNIRQAKERAERELEKL 246
Cdd:COG4913 832 YEERFKELLNENSIEfvADLLSKLRRAIREIKERIDPL 869
|
|
| PTZ00440 |
PTZ00440 |
reticulocyte binding protein 2-like protein; Provisional |
207-666 |
8.14e-03 |
|
reticulocyte binding protein 2-like protein; Provisional
Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 40.97 E-value: 8.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 207 KIQELQEKLEKAVKAS--------TEATELLQN---IRQAKERAERELEKL--HNREDSSEGIKKKLVEAEELEEKHREA 273
Cdd:PTZ00440 2224 KLQEIENSSEKYNDISklfnnvveTQKKKLLDNknkINNIKDKINDKEKELinVDSSFTLESIKTFNEIYDDIKSNIGDL 2303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 274 QVSAQHLEVHLKqKEQHYEEKIKVLDNQIkkdladkESLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVE 353
Cdd:PTZ00440 2304 YKLEDTNNDELK-KVKLYIENITHLLNRI-------NTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINN 2371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 354 LSEANKLaansslfTQRNMKAQEEMISELRQQKFYLETqAGKLEAQNRKLEEQLEkishqdhsdksrlleletrLREVSL 433
Cdd:PTZ00440 2372 LKEEFSK-------LLKNIKRNNTLCNNNNIKDFISNI-GKSVETIKQRFSSNLP-------------------EKEKLH 2424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 434 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DAL 509
Cdd:PTZ00440 2425 QIEENLNEIKNIMNETKRISNVDAFTNKILQDIDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDAL 2498
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 510 RNSCTVITDLEEQLNQLTEDNAELNNQ-NFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSqkqtmealktt 588
Cdd:PTZ00440 2499 RRVKEKKDEMNKLFNSLTENNNNNNNSaKNIVDNSTYIINELESHVSKLNELLSYIDNEIKELENEKLK----------- 2567
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 589 ctMLEEQVLDLEALNDELLEKERQweawrsvlGDEKSQFECRVRELQRMLDTEKQsRARADQRITESRQVVELAVKEH 666
Cdd:PTZ00440 2568 --LLEKAKIEESRKERERIESETQ--------EDNTDEEQINRQQQERLQKEEEQ-KAYSQERLNREVSGTDDTNKNH 2634
|
|
| GBP_C |
pfam02841 |
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ... |
648-765 |
8.21e-03 |
|
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.
Pssm-ID: 460721 [Multi-domain] Cd Length: 297 Bit Score: 40.35 E-value: 8.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 648 ADQRITESrqvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHamlEMNARSLQQKLETERELKQRllEEQA 727
Cdd:pfam02841 195 TDQALTAK----EKAIEAERAKAEAAEAEQELLREKQKEEEQMMEAQERSY---QEHVKQLIEKMEAEREQLLA--EQER 265
|
90 100 110
....*....|....*....|....*....|....*...
gi 1039770410 728 KLQQQMDLQKNhifRLTQGLQEaldRADLLKTERSDLE 765
Cdd:pfam02841 266 MLEHKLQEQEE---LLKEGFKT---EAESLQKEIQDLK 297
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
73-278 |
8.39e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 40.58 E-value: 8.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 73 DDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQHK 150
Cdd:COG3883 15 DPQIQAKQKELSELQAELEAAQAEldALQAELEELNEEYNELQAELEALQAEIDKLQAEI-------AEAEAEIEERREE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 151 LMKVVSHPPRGDSGGTAL----------DDLHKMQghaGLTSAKDQGKPEVGEYSKLEKINAEQQlkiQELQEKLEKAVK 220
Cdd:COG3883 88 LGERARALYRSGGSVSYLdvllgsesfsDFLDRLS---ALSKIADADADLLEELKADKAELEAKK---AELEAKLAELEA 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770410 221 ASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQ 278
Cdd:COG3883 162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
|
|
| CCCAP |
pfam15964 |
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ... |
217-612 |
8.40e-03 |
|
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.
Pssm-ID: 435040 [Multi-domain] Cd Length: 703 Bit Score: 40.66 E-value: 8.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 217 KAVKASTEATELLQNI-RQAKERAE---------RELEKLHNREDSS-EGIKKKLVEAEELEEKHREAQVSAQHLEVHLK 285
Cdd:pfam15964 287 EAVLAQTHTNVHMQTIeRLTKERDDlmsalvsvrSSLAEAQQRESSAyEQVKQAVQMTEEANFEKTKALIQCEQLKSELE 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 286 QKEQHYEekiKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSleqriVELSEANKLAANSS 365
Cdd:pfam15964 367 RQKERLE---KELASQQEKRAQEKEALRKEMKKEREELGATMLALSQNVAQLEAQVEKVTR-----EKNSLVSQLEEAQK 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 366 LFTQRNMKAQE---EMISELRQQKFYLETQAGKLEAQNRKLEEQLEkISHQdhsdKSRLLELETRLREVSLEHEEQKLEL 442
Cdd:pfam15964 439 QLASQEMDVTKvcgEMRYQLNQTKMKKDEAEKEHREYRTKTGRQLE-IKDQ----EIEKLGLELSESKQRLEQAQQDAAR 513
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 443 KRQ----LTELqLSLQERESQLTALQ--AARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNS---- 512
Cdd:pfam15964 514 AREeclkLTEL-LGESEHQLHLTRLEkeSIQQSFSNEAKAQALQAQQREQELTQKMQQMEAQHDKTVNEQYSLLTSqntf 592
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 513 --------CTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQlrSEVDHLRREITeremqltsQKQTMEA 584
Cdd:pfam15964 593 iaklkeecCTLAKKLEEITQKSRSEVEQLSQEKEYLQDRLEKLQKRNEELEE--QCVQHGRMHER--------MKQRLRQ 662
|
410 420
....*....|....*....|....*...
gi 1039770410 585 LKTTCTMLEEQVLDLEALNDELLeKERQ 612
Cdd:pfam15964 663 LDKHCQATAQQLVQLLSKQNQLF-KERQ 689
|
|
| fliH |
PRK06669 |
flagellar assembly protein H; Validated |
194-355 |
9.75e-03 |
|
flagellar assembly protein H; Validated
Pssm-ID: 235850 [Multi-domain] Cd Length: 281 Bit Score: 40.00 E-value: 9.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 194 YSKLEKINAEQ--QLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLH--NREDSSEGIKKKLVEA-EELEE 268
Cdd:PRK06669 6 FKRSNVINKEKlkTHEIQKYRFKVLSIKEKERLREEEEEQVEQLREEANDEAKEIIeeAEEDAFEIVEAAEEEAkEELLK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770410 269 KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADK---ESLENMMQRHEEEAHEKGKILSEqkaMINAMDSKIR 345
Cdd:PRK06669 86 KTDEASSIIEKLQMQIEREQEEWEEELERLIEEAKAEGYEEgyeKGREEGLEEVRELIEQLNKIIEK---LIKKREEILE 162
|
170
....*....|
gi 1039770410 346 SLEQRIVELS 355
Cdd:PRK06669 163 SSEEEIVELA 172
|
|
| |
