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Conserved domains on  [gi|1207189879|ref|XP_021328030|]
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reticulon-4 receptor-like 1 isoform X2 [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-299 8.66e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 8.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 124 MLWLYSNNISYIQPstFMGFTRLEELDLGDNKhLRSLaSDTFQGLTRLHALHLYHCGLITLPAGLFEgLHNLQYLYLQSN 203
Cdd:COG4886    95 LTNLTELDLSGNEE--LSNLTNLESLDLSGNQ-LTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNN 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 204 QLEFLeDDMFIDLLNLSHLFLHGNRLWSLHqNTFRGLGALDRLLLHQNRLQWVhKQAFHDLRRLTTLYLFNNSLPELPae 283
Cdd:COG4886   170 QLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP-- 244

                         170
                  ....*....|....*.
gi 1207189879 284 SLSQLPALEYLRLNDN 299
Cdd:COG4886   245 ELGNLTNLEELDLSNN 260
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 272-337 2.16e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 2.16e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879  272 LFNNSLPELPAESLSQLPALEYLRLNDNPWECDCKAVPLWDWLR----RFRGSTSALiCTAPPELVGKDL 337
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgvKVRQPEAAL-CAGPGALAGQPL 70
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-299 8.66e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 8.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 124 MLWLYSNNISYIQPstFMGFTRLEELDLGDNKhLRSLaSDTFQGLTRLHALHLYHCGLITLPAGLFEgLHNLQYLYLQSN 203
Cdd:COG4886    95 LTNLTELDLSGNEE--LSNLTNLESLDLSGNQ-LTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNN 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 204 QLEFLeDDMFIDLLNLSHLFLHGNRLWSLHqNTFRGLGALDRLLLHQNRLQWVhKQAFHDLRRLTTLYLFNNSLPELPae 283
Cdd:COG4886   170 QLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP-- 244

                         170
                  ....*....|....*.
gi 1207189879 284 SLSQLPALEYLRLNDN 299
Cdd:COG4886   245 ELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
218-277 1.77e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.77e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 218 NLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRLQWVHKQAFHDLRRLTTLYLFNNSL 277
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-300 8.73e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 8.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 103 VFLQNNKIQRLLQGHFSPTTVMLWLYSNNISYIQPSTFmgFTRLEELDLGDNKhLRSLasDTFQGLTRLHALHLYHcGLI 182
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQ-IEKI--ENLENLVNLKKLYLGG-NRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 183 TLPAGLfEGLHNLQYLYLQSNQL----EFLEDDMFIDLL--NLSHLFLHGNRLWSLHQntFRGLGALDRLLLHQNRLQwv 256
Cdd:cd21340    81 SVVEGL-ENLTNLEELHIENQRLppgeKLTFDPRSLAALsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS-- 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207189879 257 hkqAFHDLrrlttlylfnnslpelpAESLSQLPALEYLRLNDNP 300
Cdd:cd21340   156 ---DLEEL-----------------LDLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-299 2.51e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 105 LQNNKIQRLLQGHFSPTTVMLWLYSNNISYIQPSTFMGFTRLEELDLGDNKhLRSLASDTFQGLTRLHALHLYHCGLI-T 183
Cdd:PLN00113  125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-LVGKIPNSLTNLTSLEFLTLASNQLVgQ 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 184 LPAGLFEgLHNLQYLYLQSNQLEFLEDDMFIDLLNLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRLQWVHKQAFHD 263
Cdd:PLN00113  204 IPRELGQ-MKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1207189879 264 LRRLTTLYLFNNSLP-ELPaESLSQLPALEYLRLNDN 299
Cdd:PLN00113  283 LQKLISLDLSDNSLSgEIP-ELVIQLQNLEILHLFSN 318
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 272-337 2.16e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 2.16e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879  272 LFNNSLPELPAESLSQLPALEYLRLNDNPWECDCKAVPLWDWLR----RFRGSTSALiCTAPPELVGKDL 337
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgvKVRQPEAAL-CAGPGALAGQPL 70
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-299 8.66e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 8.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 124 MLWLYSNNISYIQPstFMGFTRLEELDLGDNKhLRSLaSDTFQGLTRLHALHLYHCGLITLPAGLFEgLHNLQYLYLQSN 203
Cdd:COG4886    95 LTNLTELDLSGNEE--LSNLTNLESLDLSGNQ-LTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNN 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 204 QLEFLeDDMFIDLLNLSHLFLHGNRLWSLHqNTFRGLGALDRLLLHQNRLQWVhKQAFHDLRRLTTLYLFNNSLPELPae 283
Cdd:COG4886   170 QLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP-- 244

                         170
                  ....*....|....*.
gi 1207189879 284 SLSQLPALEYLRLNDN 299
Cdd:COG4886   245 ELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-299 1.01e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 101 ERVFLQNNKIQRLLQGHFSPTTV-MLWLYSNNISYIqPSTFMGFTRLEELDLGDNKhLRSLaSDTFQGLTRLHALHLYHC 179
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNLkELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ-LTDL-PEELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 180 GLITLPAGLfEGLHNLQYLYLQSNQLEFLEDDmFIDLLNLSHLFLHGNRLWSLHQntFRGLGALDRLLLHQNRLQWVHKQ 259
Cdd:COG4886   193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1207189879 260 AfhDLRRLTTLYLFNNSLPELPAESLSQLPALEYLRLNDN 299
Cdd:COG4886   269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
218-277 1.77e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.77e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 218 NLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRLQWVHKQAFHDLRRLTTLYLFNNSL 277
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
194-253 3.41e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.41e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 194 NLQYLYLQSNQLEFLEDDMFIDLLNLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRL 253
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
169-229 4.94e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 4.94e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207189879 169 TRLHALHLYHCGLITLPAGLFEGLHNLQYLYLQSNQLEFLEDDMFIDLLNLSHLFLHGNRL 229
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-300 8.73e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 8.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 103 VFLQNNKIQRLLQGHFSPTTVMLWLYSNNISYIQPSTFmgFTRLEELDLGDNKhLRSLasDTFQGLTRLHALHLYHcGLI 182
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQ-IEKI--ENLENLVNLKKLYLGG-NRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 183 TLPAGLfEGLHNLQYLYLQSNQL----EFLEDDMFIDLL--NLSHLFLHGNRLWSLHQntFRGLGALDRLLLHQNRLQwv 256
Cdd:cd21340    81 SVVEGL-ENLTNLEELHIENQRLppgeKLTFDPRSLAALsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS-- 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207189879 257 hkqAFHDLrrlttlylfnnslpelpAESLSQLPALEYLRLNDNP 300
Cdd:cd21340   156 ---DLEEL-----------------LDLLSSWPSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
144-302 1.18e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 144 TRLEELDLGDNKHLRSLASDTFQGLTRLHALHLYHCGLItlpaglfEGLHNLQYLYLQSNQLEFLEDDMFiDLLNLSHLF 223
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL-------SNLTNLESLDLSGNQLTDLPEELA-NLTNLKELD 142

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207189879 224 LHGNRLWSLHQntfrglgaldrlllhqnrlqwvhkqAFHDLRRLTTLYLFNNSLPELPaESLSQLPALEYLRLNDNPWE 302
Cdd:COG4886   143 LSNNQLTDLPE-------------------------PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
243-300 4.48e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 4.48e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207189879 243 LDRLLLHQNRLQWVHKQAFHDLRRLTTLYLFNNSLPELPAESLSQLPALEYLRLNDNP 300
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
125-300 6.99e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 6.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 125 LWLYSNNISYIqPSTFMGFTRLEELDLGDNKhLRSLASdtFQGLTRLHALHLYHCGLITLPAGLfeGLHNLQYLYLQSNQ 204
Cdd:COG4886   210 LDLSGNQLTDL-PEPLANLTNLETLDLSNNQ-LTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 205 -----LEFLEDDMFIDLLNLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRLQWVHKQAFHDLRRLTTLYLFNNSLPE 279
Cdd:COG4886   284 ltdlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                         170       180
                  ....*....|....*....|.
gi 1207189879 280 LPAESLSQLPALEYLRLNDNP 300
Cdd:COG4886   364 TLLLTLGLLGLLEATLLTLAL 384
LRR_8 pfam13855
Leucine rich repeat;
144-205 8.23e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 8.23e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207189879 144 TRLEELDLGDNkHLRSLASDTFQGLTRLHALHLYHCGLITLPAGLFEGLHNLQYLYLQSNQL 205
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-299 2.51e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 105 LQNNKIQRLLQGHFSPTTVMLWLYSNNISYIQPSTFMGFTRLEELDLGDNKhLRSLASDTFQGLTRLHALHLYHCGLI-T 183
Cdd:PLN00113  125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-LVGKIPNSLTNLTSLEFLTLASNQLVgQ 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 184 LPAGLFEgLHNLQYLYLQSNQLEFLEDDMFIDLLNLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRLQWVHKQAFHD 263
Cdd:PLN00113  204 IPRELGQ-MKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1207189879 264 LRRLTTLYLFNNSLP-ELPaESLSQLPALEYLRLNDN 299
Cdd:PLN00113  283 LQKLISLDLSDNSLSgEIP-ELVIQLQNLEILHLFSN 318
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 126-299 2.97e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 126 WLY--SNNISYIQPSTFMGFTRLEELDLGDNKHLRSLASdTFQGLTRLHALHLYHCGLI-TLPAGLFeGLHNLQYLYLQS 202
Cdd:PLN00113  216 WIYlgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSD 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 203 NQLEFLEDDMFIDLLNLSHLFLHGN-------------------RLWSlhqNTFRG-----LGA---LDRLLLHQNRLQW 255
Cdd:PLN00113  294 NSLSGEIPELVIQLQNLEILHLFSNnftgkipvaltslprlqvlQLWS---NKFSGeipknLGKhnnLTVLDLSTNNLTG 370

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207189879 256 VHKQAFHDLRRLTTLYLFNNSLPELPAESLSQLPALEYLRLNDN 299
Cdd:PLN00113  371 EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 105-303 9.22e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 45.25  E-value: 9.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879  105 LQNNKIQRLLQGHFSPT---TVMLWlYSNNISYIqPSTFMGfTRLEELDLGDNKHLRSLASdTFQGLTRLHALHLYHC-G 180
Cdd:PLN03210   618 MQGSKLEKLWDGVHSLTglrNIDLR-GSKNLKEI-PDLSMA-TNLETLKLSDCSSLVELPS-SIQYLNKLEDLDMSRCeN 693

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879  181 LITLPAGLfeglhNLQYLY-LQSNQLEFLEddMFIDL-LNLSHLFLHGNRLWSLHQNTfrGLGALDRLLLHQNRLQ--WV 256
Cdd:PLN03210   694 LEILPTGI-----NLKSLYrLNLSGCSRLK--SFPDIsTNISWLDLDETAIEEFPSNL--RLENLDELILCEMKSEklWE 764

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207189879  257 HKQAFHDLRR-----LTTLYLFNN-SLPELPAeSLSQLPALEYLRLndnpWEC 303
Cdd:PLN03210   765 RVQPLTPLMTmlspsLTRLFLSDIpSLVELPS-SIQNLHKLEHLEI----ENC 812
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 146-300 1.61e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 146 LEELDLGDNKHLRSLAS-----DTFQGLTRLHALHLYHCGLITLPAGLFEGLH---NLQYLYLQSNQLEFLEDDMFIDLL 217
Cdd:cd00116    53 LKELCLSLNETGRIPRGlqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 218 -----NLSHLFLHGNRL-------WSlhqNTFRGLGALDRLLLHQNRLQW----VHKQAFHDLRRLTTLYLFNNSLPELP 281
Cdd:cd00116   133 kdlppALEKLVLGRNRLegasceaLA---KALRANRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTDEG 209

                         170       180
                  ....*....|....*....|...
gi 1207189879 282 ----AESLSQLPALEYLRLNDNP 300
Cdd:cd00116   210 asalAETLASLKSLEVLNLGDNN 232
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 125-299 1.85e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 125 LWLYSNNISYIQPSTFMGFTRLEELDLGDNKhLRSLASDTFQGLTRLHALHLYHCGLI-TLPAGLfEGLHNLQYLYLQSN 203
Cdd:PLN00113  265 LFLYQNKLSGPIPPSIFSLQKLISLDLSDNS-LSGEIPELVIQLQNLEILHLFSNNFTgKIPVAL-TSLPRLQVLQLWSN 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 204 QLEfleDDMFIDL---LNLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRLQWVHKQAFHDLRRLTTLYLFNNSLP-E 279
Cdd:PLN00113  343 KFS---GEIPKNLgkhNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgE 419

                         170       180
                  ....*....|....*....|
gi 1207189879 280 LPAEsLSQLPALEYLRLNDN 299
Cdd:PLN00113  420 LPSE-FTKLPLVYFLDISNN 438
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 129-239 2.31e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 40.99  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 129 SNNISYIQPSTFMGFTRLEELDLGDNkhLRSLASDTFqgltrlhalhlYHCGL--ITLPAGL-------FEGLHNLQYLY 199
Cdd:pfam13306  19 PSSLTSIGEYAFSNCTSLKSITLPSS--LTSIGSYAF-----------YNCSLtsITIPSSLtsigeyaFSNCSNLKSIT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1207189879 200 LQSNqLEFLEDDMFIDlLNLSHLFLHGNrLWSLHQNTFRG 239
Cdd:pfam13306  86 LPSN-LTSIGSYAFSN-CSLKSITIPSS-VTTIGSYAFSN 122
LRR_8 pfam13855
Leucine rich repeat;
101-155 3.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207189879 101 ERVFLQNNKIQRLLQGHFS--PTTVMLWLYSNNISYIQPSTFMGFTRLEELDLGDNK 155
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 89-290 9.01e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 9.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879  89 FQVVPEGIPAQSERVFLQNNKIQ-----RLLQGHFSPTTV-MLWLYSNNI----SYIQPSTFMGFTRLEELDLGDNK--- 155
Cdd:COG5238   171 ISMAKALQNNSVETVYLGCNQIGdegieELAEALTQNTTVtTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQigd 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 156 -HLRSLAsDTFQGLTRLHALHLYH-----CGLITLpAGLFEGLHNLQYLYLQSNQL---------EFLEDDMFIDLLNLS 220
Cdd:COG5238   251 eGVIALA-EALKNNTTVETLYLSGnqigaEGAIAL-AKALQGNTTLTSLDLSVNRIgdegaialaEGLQGNKTLHTLNLA 328

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 221 HlflhgnrlwslhqNTFRGLGAldRLLLhqnrlqwvhkQAFHDLRRLTTLYLFNNSLPELPAESLSQLPA 290
Cdd:COG5238   329 Y-------------NGIGAQGA--IALA----------KALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
194-300 1.03e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879 194 NLQYLYLQSNQLEFLEDDMFIDLLNLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHQNRLQWVHKQAFHDLRRLTTLYLF 273
Cdd:COG4886    42 LLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLS 121

                          90       100
                  ....*....|....*....|....*..
gi 1207189879 274 NNSLPELPAEsLSQLPALEYLRLNDNP 300
Cdd:COG4886   122 GNQLTDLPEE-LANLTNLKELDLSNNQ 147
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 272-337 2.16e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 2.16e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189879  272 LFNNSLPELPAESLSQLPALEYLRLNDNPWECDCKAVPLWDWLR----RFRGSTSALiCTAPPELVGKDL 337
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgvKVRQPEAAL-CAGPGALAGQPL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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