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Conserved domains on  [gi|1419145613|ref|XP_025485511|]
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hypothetical protein BO82DRAFT_43380, partial [Aspergillus uvarum CBS 121591]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 76-272 2.35e-28

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


:

Pssm-ID: 462583  Cd Length: 178  Bit Score: 108.10  E-value: 2.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613  76 AVPVLLTRLYSVLLDLA-----ASVEIRYHDTIYNDVMQWASQVPALRDARKSIAGTKNNfvSPWEKDEPKTGwqelske 150
Cdd:pfam08740   3 ALLAALRRGLRSLWSLLrrrflSTVEIRSDDESYDWVLAWLSQQPFWRRSRSLSAETRTN--SRSDDDDDDDG------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 151 elqqfdddprdfwvkirqlKRYLPIRYTPAPaGFHFFFHRGYLLGFRRQPYKDAGSPWTDH-REKLYL--YAWRQSVLRD 227
Cdd:pfam08740  74 -------------------SKKKPLRYTPGF-GTHYFWYKGRWFAVSRERESSSSDLATGSpRETLTLscLGRSPEPLKE 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1419145613 228 LLDEIQGIAEKRNDDLIRVNQALKDGMVPQWAGLPSKRPRPLSTV 272
Cdd:pfam08740 134 LLEEARELYLKKDEGKTVIYRAWRDGYGGSWRRVGSRPKRPLSTV 178
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 282-328 1.30e-15

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19510:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 153  Bit Score: 72.77  E-value: 1.30e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1419145613 282 IIADLTDFLqpRTRSWYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:cd19510     1 IIDDLKDFI--KNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAG 45
 
Name Accession Description Interval E-value
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 76-272 2.35e-28

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 108.10  E-value: 2.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613  76 AVPVLLTRLYSVLLDLA-----ASVEIRYHDTIYNDVMQWASQVPALRDARKSIAGTKNNfvSPWEKDEPKTGwqelske 150
Cdd:pfam08740   3 ALLAALRRGLRSLWSLLrrrflSTVEIRSDDESYDWVLAWLSQQPFWRRSRSLSAETRTN--SRSDDDDDDDG------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 151 elqqfdddprdfwvkirqlKRYLPIRYTPAPaGFHFFFHRGYLLGFRRQPYKDAGSPWTDH-REKLYL--YAWRQSVLRD 227
Cdd:pfam08740  74 -------------------SKKKPLRYTPGF-GTHYFWYKGRWFAVSRERESSSSDLATGSpRETLTLscLGRSPEPLKE 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1419145613 228 LLDEIQGIAEKRNDDLIRVNQALKDGMVPQWAGLPSKRPRPLSTV 272
Cdd:pfam08740 134 LLEEARELYLKKDEGKTVIYRAWRDGYGGSWRRVGSRPKRPLSTV 178
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 282-328 1.30e-15

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 72.77  E-value: 1.30e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1419145613 282 IIADLTDFLqpRTRSWYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:cd19510     1 IIDDLKDFI--KNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAG 45
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 76-272 1.98e-09

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 56.08  E-value: 1.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613   76 AVPVLLTRLYSVLLDLA-----ASVEIRYHDTIYNDVMQWASQVPALRDARKSIAGTKNnfvspwekdepktgWQELSKE 150
Cdd:smart01024   5 AAGAFLRRGISVAASLIrrrflVTLEVPSKDESYAWLLEWLSQQPFRQRSRHLSVETSY--------------TQHDNGK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613  151 ElqqfdddprdfwvkirqlkrYLPIRYTPAPaGFHFFFHRGYLLGFRRQPYKDA-----GSPWtdhrEKLYL--YAWRQS 223
Cdd:smart01024  71 S--------------------STSFSFVPGP-GTHWFWYKGRWIWVTREREKTMadmrtGSPF----ETLTLttLGRDRD 125

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1419145613  224 VLRDLLDEIQGIAEKRNDDLIRVNQAlkdgMVPQWAGLPSKRPRPLSTV 272
Cdd:smart01024 126 VFKELLEEARELALKRTEGKTVIYTA----DGPEWRRFAPRRKRPLSSV 170
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 114-328 4.03e-07

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 51.07  E-value: 4.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 114 VPALRDARKSIAGTKNNFVSPWEKDEPKTGWQELSKEELQQFDDDPRDFWVKIRQLKRYLPIRYTPAPAGFHFFFHRGYL 193
Cdd:COG0464     1 LAELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 194 LGFRRQPYKDAGSPWTDHREKLYLYAWRQSVLRDLLDEIQGIAEKRNDDLIRVNQALKDGMVPQWAGLPSKRPRPLSTVI 273
Cdd:COG0464    81 LLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1419145613 274 VEPDIKRAIIADLTDFLQPRTRswYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:COG0464   161 GLEEVKEELRELVALPLKRPEL--REEYGLPPPRGLLLYGPPGTGKTLLARALAG 213
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
269-328 8.51e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 43.33  E-value: 8.51e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 269 LSTVIVEPDIKRAIiADLTDFLqpRTRSWYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:COG1223     1 LDDVVGQEEAKKKL-KLIIKEL--RRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAG 57
PRK04195 PRK04195
replication factor C large subunit; Provisional
 265-328 8.02e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.06  E-value: 8.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1419145613 265 RPRPLSTVIVEPDIKRAIIADLtdflqprtRSWyhERGIPyRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:PRK04195    9 RPKTLSDVVGNEKAKEQLREWI--------ESW--LKGKP-KKALLLYGPPGVGKTSLAHALAN 61
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 309-328 1.90e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 37.96  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|
gi 1419145613 309 YLFQGPPGTGKSSLCLAIAG 328
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAK 20
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 306-328 8.29e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 8.29e-03
                           10        20
                   ....*....|....*....|...
gi 1419145613  306 RRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALAR 24
 
Name Accession Description Interval E-value
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 76-272 2.35e-28

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 108.10  E-value: 2.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613  76 AVPVLLTRLYSVLLDLA-----ASVEIRYHDTIYNDVMQWASQVPALRDARKSIAGTKNNfvSPWEKDEPKTGwqelske 150
Cdd:pfam08740   3 ALLAALRRGLRSLWSLLrrrflSTVEIRSDDESYDWVLAWLSQQPFWRRSRSLSAETRTN--SRSDDDDDDDG------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 151 elqqfdddprdfwvkirqlKRYLPIRYTPAPaGFHFFFHRGYLLGFRRQPYKDAGSPWTDH-REKLYL--YAWRQSVLRD 227
Cdd:pfam08740  74 -------------------SKKKPLRYTPGF-GTHYFWYKGRWFAVSRERESSSSDLATGSpRETLTLscLGRSPEPLKE 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1419145613 228 LLDEIQGIAEKRNDDLIRVNQALKDGMVPQWAGLPSKRPRPLSTV 272
Cdd:pfam08740 134 LLEEARELYLKKDEGKTVIYRAWRDGYGGSWRRVGSRPKRPLSTV 178
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 282-328 1.30e-15

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 72.77  E-value: 1.30e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1419145613 282 IIADLTDFLqpRTRSWYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:cd19510     1 IIDDLKDFI--KNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAG 45
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 76-272 1.98e-09

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 56.08  E-value: 1.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613   76 AVPVLLTRLYSVLLDLA-----ASVEIRYHDTIYNDVMQWASQVPALRDARKSIAGTKNnfvspwekdepktgWQELSKE 150
Cdd:smart01024   5 AAGAFLRRGISVAASLIrrrflVTLEVPSKDESYAWLLEWLSQQPFRQRSRHLSVETSY--------------TQHDNGK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613  151 ElqqfdddprdfwvkirqlkrYLPIRYTPAPaGFHFFFHRGYLLGFRRQPYKDA-----GSPWtdhrEKLYL--YAWRQS 223
Cdd:smart01024  71 S--------------------STSFSFVPGP-GTHWFWYKGRWIWVTREREKTMadmrtGSPF----ETLTLttLGRDRD 125

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1419145613  224 VLRDLLDEIQGIAEKRNDDLIRVNQAlkdgMVPQWAGLPSKRPRPLSTV 272
Cdd:smart01024 126 VFKELLEEARELALKRTEGKTVIYTA----DGPEWRRFAPRRKRPLSSV 170
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 277-328 3.15e-07

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 49.20  E-value: 3.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1419145613 277 DIKRAIIAdltdflqPRTRSWYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:cd19481     4 SLREAVEA-------PRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAG 48
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 114-328 4.03e-07

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 51.07  E-value: 4.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 114 VPALRDARKSIAGTKNNFVSPWEKDEPKTGWQELSKEELQQFDDDPRDFWVKIRQLKRYLPIRYTPAPAGFHFFFHRGYL 193
Cdd:COG0464     1 LAELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 194 LGFRRQPYKDAGSPWTDHREKLYLYAWRQSVLRDLLDEIQGIAEKRNDDLIRVNQALKDGMVPQWAGLPSKRPRPLSTVI 273
Cdd:COG0464    81 LLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1419145613 274 VEPDIKRAIIADLTDFLQPRTRswYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:COG0464   161 GLEEVKEELRELVALPLKRPEL--REEYGLPPPRGLLLYGPPGTGKTLLARALAG 213
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
269-328 8.51e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 43.33  E-value: 8.51e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 269 LSTVIVEPDIKRAIiADLTDFLqpRTRSWYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:COG1223     1 LDDVVGQEEAKKKL-KLIIKEL--RRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAG 57
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 218-328 1.22e-04

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 43.07  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419145613 218 YAWRQSVLRDLLDEIQGIAEKRNDDLIRvNQALKDGMVPQWAglPSKRPRPLSTVIVEPDIKRAIIADLTDFLQPRTRsw 297
Cdd:COG1222    29 LALLLQPVKALELLEEAPALLLNDANLT-QKRLGTPRGTAVP--AESPDVTFDDIGGLDEQIEEIREAVELPLKNPEL-- 103

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1419145613 298 YHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:COG1222   104 FRKYGIEPPKGVLLYGPPGTGKTLLAKAVAG 134
PRK04195 PRK04195
replication factor C large subunit; Provisional
 265-328 8.02e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.06  E-value: 8.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1419145613 265 RPRPLSTVIVEPDIKRAIIADLtdflqprtRSWyhERGIPyRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:PRK04195    9 RPKTLSDVVGNEKAKEQLREWI--------ESW--LKGKP-KKALLLYGPPGVGKTSLAHALAN 61
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 304-327 1.27e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 38.67  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....
gi 1419145613 304 PYRRGYLFQGPPGTGKSSLCLAIA 327
Cdd:cd00009    17 PPPKNLLLYGPPGTGKTTLARAIA 40
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 289-327 1.30e-03

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 38.81  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1419145613 289 FLQPRTrswYHERGIPYRRGYLFQGPPGTGKSSLCLAIA 327
Cdd:cd19503    20 LKYPEL---FRALGLKPPRGVLLHGPPGTGKTLLARAVA 55
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 286-328 1.32e-03

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 38.89  E-value: 1.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1419145613 286 LTDFLQPRTRSWYHER---GIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:cd19507     8 LKDWLKKRKAAFSKQAsayGLPTPKGLLLVGIQGTGKSLTAKAIAG 53
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 309-328 1.90e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 37.96  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|
gi 1419145613 309 YLFQGPPGTGKSSLCLAIAG 328
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAK 20
rfc PRK00440
replication factor C small subunit; Reviewed
 265-327 2.22e-03

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 39.47  E-value: 2.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1419145613 265 RPRPLSTVIVEPDIKRaiiadltdflqpRTRSWYHERGIPYrrgYLFQGPPGTGKSSLCLAIA 327
Cdd:PRK00440   12 RPRTLDEIVGQEEIVE------------RLKSYVKEKNMPH---LLFAGPPGTGKTTAALALA 59
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 298-327 3.26e-03

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 37.87  E-value: 3.26e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1419145613 298 YHERGIPYRRGYLFQGPPGTGKSSLCLAIA 327
Cdd:cd19528    19 FLKFGMTPSKGVLFYGPPGCGKTLLAKAIA 48
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 283-328 3.51e-03

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 37.60  E-value: 3.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1419145613 283 IADLTDFLQPRTRswYHERGIPYRRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:cd19501    16 LKEVVEFLKNPEK--FTKLGAKIPKGVLLVGPPGTGKTLLAKAVAG 59
ftsH CHL00176
cell division protein; Validated
 303-328 3.90e-03

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 38.88  E-value: 3.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 1419145613 303 IPyrRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:CHL00176  215 IP--KGVLLVGPPGTGKTLLAKAIAG 238
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
307-327 4.36e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 38.80  E-value: 4.36e-03
                          10        20
                  ....*....|....*....|.
gi 1419145613 307 RGYLFQGPPGTGKSSLCLAIA 327
Cdd:COG1224    65 KGILIVGPPGTGKTALAVAIA 85
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
295-327 6.31e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 37.65  E-value: 6.31e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1419145613 295 RSWYHERGIPyrRGYLFQGPPGTGKSSLCLAIA 327
Cdd:COG0470     9 LAAAESGRLP--HALLLHGPPGIGKTTLALALA 39
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 307-328 7.17e-03

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 36.61  E-value: 7.17e-03
                          10        20
                  ....*....|....*....|..
gi 1419145613 307 RGYLFQGPPGTGKSSLCLAIAG 328
Cdd:cd19518    35 RGVLLHGPPGCGKTMLANAIAG 56
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 306-328 8.29e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 8.29e-03
                           10        20
                   ....*....|....*....|...
gi 1419145613  306 RRGYLFQGPPGTGKSSLCLAIAG 328
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALAR 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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