integrin beta-1-binding protein 2 isoform X1 [Mus musculus]
cysteine and histidine-rich domain-containing protein( domain architecture ID 10523071)
cysteine and histidine-rich domain (CHORD)-containing protein is a zinc-binding protein
List of domain hits
Name | Accession | Description | Interval | E-value | ||
CHORD | pfam04968 | CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene ... |
3-64 | 1.04e-35 | ||
CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of the wild-type gene in nematode development. : Pssm-ID: 461502 Cd Length: 62 Bit Score: 122.63 E-value: 1.04e-35
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CHORD | pfam04968 | CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene ... |
149-209 | 8.05e-30 | ||
CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of the wild-type gene in nematode development. : Pssm-ID: 461502 Cd Length: 62 Bit Score: 107.22 E-value: 8.05e-30
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alpha-crystallin-Hsps_p23-like super family | cl00175 | alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a ... |
219-252 | 1.03e-13 | ||
alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.; The alpha-crystallin-Hsps_p23-like superfamily includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12-43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this superfamily is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). The actual alignment was detected with superfamily member cd06488: Pssm-ID: 469641 Cd Length: 87 Bit Score: 65.40 E-value: 1.03e-13
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Name | Accession | Description | Interval | E-value | ||
CHORD | pfam04968 | CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene ... |
3-64 | 1.04e-35 | ||
CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of the wild-type gene in nematode development. Pssm-ID: 461502 Cd Length: 62 Bit Score: 122.63 E-value: 1.04e-35
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CHORD | pfam04968 | CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene ... |
149-209 | 8.05e-30 | ||
CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of the wild-type gene in nematode development. Pssm-ID: 461502 Cd Length: 62 Bit Score: 107.22 E-value: 8.05e-30
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p23_melusin_like | cd06488 | p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related ... |
219-252 | 1.03e-13 | ||
p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta subunits. Melusin is a muscle-specific protein expressed in skeletal and cardiac muscles but not in smooth muscle or other tissues. It is needed for heart hypertrophy following mechanical overload. The integrin-binding portion of this domain appears to be sequestered in the full length melusin protein, Ca2+ may modulate the protein's conformation exposing this binding site. This group includes Chordc1, also known as Chp-1, which is conserved from vertebrates to humans. Mammalian Chordc1 interacts with the heat shock protein (HSP) Hsp90 and is implicated in circadian and/or homeostatic mechanisms in the brain. The N-terminal portions of proteins belonging to this group contain two cysteine and histidine rich domain (CHORD) domains. Pssm-ID: 107238 Cd Length: 87 Bit Score: 65.40 E-value: 1.03e-13
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Name | Accession | Description | Interval | E-value | ||
CHORD | pfam04968 | CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene ... |
3-64 | 1.04e-35 | ||
CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of the wild-type gene in nematode development. Pssm-ID: 461502 Cd Length: 62 Bit Score: 122.63 E-value: 1.04e-35
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CHORD | pfam04968 | CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene ... |
149-209 | 8.05e-30 | ||
CHORD; CHORD represents a Zn binding domain. Silencing of the C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of the wild-type gene in nematode development. Pssm-ID: 461502 Cd Length: 62 Bit Score: 107.22 E-value: 8.05e-30
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p23_melusin_like | cd06488 | p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related ... |
219-252 | 1.03e-13 | ||
p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta subunits. Melusin is a muscle-specific protein expressed in skeletal and cardiac muscles but not in smooth muscle or other tissues. It is needed for heart hypertrophy following mechanical overload. The integrin-binding portion of this domain appears to be sequestered in the full length melusin protein, Ca2+ may modulate the protein's conformation exposing this binding site. This group includes Chordc1, also known as Chp-1, which is conserved from vertebrates to humans. Mammalian Chordc1 interacts with the heat shock protein (HSP) Hsp90 and is implicated in circadian and/or homeostatic mechanisms in the brain. The N-terminal portions of proteins belonging to this group contain two cysteine and histidine rich domain (CHORD) domains. Pssm-ID: 107238 Cd Length: 87 Bit Score: 65.40 E-value: 1.03e-13
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Blast search parameters | ||||
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