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Conserved domains on  [gi|1720399496|ref|XP_030107587|]
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MAX gene-associated protein isoform X7 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLHzip_MGA cd18911
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and ...
 908-972 8.03e-33

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins; MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites.


:

Pssm-ID: 381481  Cd Length: 65  Bit Score: 121.82  E-value: 8.03e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLS 972
Cdd:cd18911      1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLTDQADRLIGQKTLLT 65
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 6-267 8.02e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 8.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496    6 PATNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVRTpqpltgpqkfSIRPSPVMVVTPVVSSEQVQ 85
Cdd:pfam17823  150 CRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAA----------SSAPATLTPARGISTAATAT 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   86 V---CSTVAAAVTTSPQVfLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQS---TATVNLTKT 159
Cdd:pfam17823  220 GhpaAGTALAAVGNSSPA-AGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMpsdTMARNPAAP 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  160 TGITTS-PVASVSFAKPLVAS---PTITlPVASTASTSIVMVTTAASSSVVTTPTS-----SLSSVPIilsgingsPPVS 230
Cdd:pfam17823  299 MGAQAQgPIIQVSTDQPVHNTagePTPS-PSNTTLEPNTPKSVASTNLAVVTTTKAqakepSASPVPV--------LHTS 369

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1720399496  231 QRPENAPQIPVTTPQISSNNVKRTGPRLLLIPVQQGS 267
Cdd:pfam17823  370 MIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVAT 406
 
Name Accession Description Interval E-value
bHLHzip_MGA cd18911
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and ...
 908-972 8.03e-33

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins; MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites.


Pssm-ID: 381481  Cd Length: 65  Bit Score: 121.82  E-value: 8.03e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLS 972
Cdd:cd18911      1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLTDQADRLIGQKTLLT 65
HLH pfam00010
Helix-loop-helix DNA-binding domain;
907-958 4.00e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 53.62  E-value: 4.00e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720399496  907 YRRTHTANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLT 958
Cdd:pfam00010    1 RREAHNERERRRRDRINDAFDELRELLpTLPPDKKLSKAEILRLAIEYIKHLQ 53
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 6-267 8.02e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 8.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496    6 PATNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVRTpqpltgpqkfSIRPSPVMVVTPVVSSEQVQ 85
Cdd:pfam17823  150 CRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAA----------SSAPATLTPARGISTAATAT 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   86 V---CSTVAAAVTTSPQVfLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQS---TATVNLTKT 159
Cdd:pfam17823  220 GhpaAGTALAAVGNSSPA-AGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMpsdTMARNPAAP 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  160 TGITTS-PVASVSFAKPLVAS---PTITlPVASTASTSIVMVTTAASSSVVTTPTS-----SLSSVPIilsgingsPPVS 230
Cdd:pfam17823  299 MGAQAQgPIIQVSTDQPVHNTagePTPS-PSNTTLEPNTPKSVASTNLAVVTTTKAqakepSASPVPV--------LHTS 369

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1720399496  231 QRPENAPQIPVTTPQISSNNVKRTGPRLLLIPVQQGS 267
Cdd:pfam17823  370 MIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVAT 406
HLH smart00353
helix loop helix domain;
912-963 6.35e-06

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 44.90  E-value: 6.35e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1720399496   912 TANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLTDQADK 963
Cdd:smart00353    1 NARERRRRRKINEAFDELRSLLpTLPKNKKLSKAEILRLAIEYIKSLQEELQK 53
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
55-253 1.12e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 49.75  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   55 TPQPLTGPQKFSIRPSPVMVVTPVVSSEQVQ--VCSTVAAAVTTSPQVflENVTAVPSLTANSDMGAKEATYSSSASTAG 132
Cdd:COG3469     13 GGASATAVTLLGAAATAASVTLTAATATTVVstTGSVVVAASGSAGSG--TGTTAASSTAATSSTTSTTATATAAAAAAT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  133 VVEISETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFAKPLVASPTITLPVASTASTSIVMV----TTAASSSVVTT 208
Cdd:COG3469     91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGtetaTGGTTTTSTTT 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1720399496  209 PTSSLSSVPiILSGINGSPPVSQRPENAPQIPVTTPQISSNNVKR 253
Cdd:COG3469    171 TTTSASTTP-SATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
PHA03255 PHA03255
BDLF3; Provisional
 125-262 2.39e-05

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 47.59  E-value: 2.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  125 SSSASTAGVVEISETNNTTLVTSTQSTATVNLTKTTGITTSPV---ASVSFAKPLVASPTITLPVASTAS--TSIVMVTT 199
Cdd:PHA03255    26 SSGSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPItttAILSTNTTTVTSTGTTVTPVPTTSnaSTINVTTK 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720399496  200 AASSSVVTTPTSSLSSVPIILSGINGSPPVSQRPENAPQIPVTTPQISS---NNVKRTGPRLLLIP 262
Cdd:PHA03255   106 VTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSkgtSNATKTTAELPTVP 171
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 162-339 3.20e-04

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 45.29  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  162 ITTSPVASVSFAKPLVASPTITLPVASTA-STSIvmvTTAASSSVVTTPTSS--LSSVPIILSGINGSPPVSQRPENAPQ 238
Cdd:cd22536    262 LVQPSDGGVSNGNQLVSTPITTASVSTMPeSPSS---STTCTTTASTSLTSSdtLVSSAETGQYASTAASSERTEEEPQT 338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  239 IPVTTPQISSNNVKRTGprllLIPVQQGSPTLrpiQNPQLQGQRMVLQPVRGPSGMNLFRHPNGQIVQLLPLHQIRGSNA 318
Cdd:cd22536    339 SAAESEAQSSSQLQSNG----LQNVQDQSNSL---QQVQIVGQPILQQIQIQQPQQQIIQAIQPQSFQLQSGQTIQTIQQ 411

                          170       180
                   ....*....|....*....|...
gi 1720399496  319 QP--SLQPVVFRNPgSMVGIRLP 339
Cdd:cd22536    412 QPlqNVQLQAVQSP-TQVLIRAP 433
 
Name Accession Description Interval E-value
bHLHzip_MGA cd18911
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and ...
 908-972 8.03e-33

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins; MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites.


Pssm-ID: 381481  Cd Length: 65  Bit Score: 121.82  E-value: 8.03e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLS 972
Cdd:cd18911      1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLTDQADRLIGQKTLLT 65
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
 908-971 4.01e-21

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 88.48  E-value: 4.01e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLL 971
Cdd:cd19682      1 RLRHKKRERERRSELRELFDKLKQLLGLDSDEKASKLAVLTEAIEEIQQLKREEDELQKEKARL 64
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 908-985 1.32e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 56.02  E-value: 1.32e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSSL 985
Cdd:cd11400      2 RRLHNVLERQRRNDLKNSFEKLRDLVpELADNEKASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRKKLERL 80
HLH pfam00010
Helix-loop-helix DNA-binding domain;
907-958 4.00e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 53.62  E-value: 4.00e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720399496  907 YRRTHTANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLT 958
Cdd:pfam00010    1 RREAHNERERRRRDRINDAFDELRELLpTLPPDKKLSKAEILRLAIEYIKHLQ 53
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
 908-964 6.92e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 53.62  E-value: 6.92e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKL 964
Cdd:cd19690      1 RVSHKLAERKRRKEMKELFEDLRDALPQERGTKASKWEILTKAISYIQQLKRHIREL 57
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 915-957 8.67e-08

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 49.83  E-value: 8.67e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720399496  915 ERRRRGEMRDLFEKLKITLGLLH-SSKVSKSLILNRAFSEIQGL 957
Cdd:cd00083      1 ERRRRDKINDAFEELKRLLPELPdSKKLSKASILQKAVEYIREL 44
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 6-267 8.02e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 8.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496    6 PATNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVRTpqpltgpqkfSIRPSPVMVVTPVVSSEQVQ 85
Cdd:pfam17823  150 CRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAA----------SSAPATLTPARGISTAATAT 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   86 V---CSTVAAAVTTSPQVfLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQS---TATVNLTKT 159
Cdd:pfam17823  220 GhpaAGTALAAVGNSSPA-AGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMpsdTMARNPAAP 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  160 TGITTS-PVASVSFAKPLVAS---PTITlPVASTASTSIVMVTTAASSSVVTTPTS-----SLSSVPIilsgingsPPVS 230
Cdd:pfam17823  299 MGAQAQgPIIQVSTDQPVHNTagePTPS-PSNTTLEPNTPKSVASTNLAVVTTTKAqakepSASPVPV--------LHTS 369

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1720399496  231 QRPENAPQIPVTTPQISSNNVKRTGPRLLLIPVQQGS 267
Cdd:pfam17823  370 MIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVAT 406
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 76-275 1.06e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.04  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   76 TPVVSSEQVQVCSTVAAAVTTSP---QVFLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQSTA 152
Cdd:pfam17823  139 SEAFSAPRAAACRANASAAPRAAiaaASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATA 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  153 TVNLTKTTGITTSPVASVSFAKPLVASPTITLPVASTASTSIVMVTTAA-----SSSVVTTPTSSlSSVPIILSGINGSP 227
Cdd:pfam17823  219 TGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAgtinmGDPHARRLSPA-KHMPSDTMARNPAA 297

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1720399496  228 PVSQRPEnAPQIPVTTPQISSNNVKRTGPRLLLIPVQQGSPTLRPIQN 275
Cdd:pfam17823  298 PMGAQAQ-GPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTN 344
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 908-975 3.62e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 46.14  E-value: 3.62e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKR 975
Cdd:cd11404      3 RLNHVRSEKKRRELIKKGYDELCALVPGLDPQKRTKADILQKAADWIQELKEENEKLEEQLDELKEAA 70
bHLHzip_L-Myc cd11457
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, ...
 908-987 4.01e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, also termed Class E basic helix-loop-helix protein 38 (bHLHe38), or protein L-Myc-1, or V-myc myelocytomatosis viral oncogene homolog, is a bHLHZip oncoprotein belonging to the Myc oncogene protein family. It binds DNA as a heterodimer with MAX. L-Myc is co-expressed with another Myc family member and has weaker transformation/transactivation activities. L-Myc knockout mouse did not exhibit any phenotypic abnormalities.


Pssm-ID: 381463 [Multi-domain]  Cd Length: 89  Bit Score: 46.71  E-value: 4.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSSLS 986
Cdd:cd11457      8 RKNHNFLERKRRNDLRSRFLALRDEVpGLASCSKTPKVVILSKATEYLRGLVSAERRMAAEKRQLKSRQQQLLRRIAQLK 87


                   .
gi 1720399496  987 G 987
Cdd:cd11457     88 G 88
HLH smart00353
helix loop helix domain;
912-963 6.35e-06

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 44.90  E-value: 6.35e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1720399496   912 TANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLTDQADK 963
Cdd:smart00353    1 NARERRRRRKINEAFDELRSLLpTLPKNKKLSKAEILRLAIEYIKSLQEELQK 53
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
55-253 1.12e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 49.75  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   55 TPQPLTGPQKFSIRPSPVMVVTPVVSSEQVQ--VCSTVAAAVTTSPQVflENVTAVPSLTANSDMGAKEATYSSSASTAG 132
Cdd:COG3469     13 GGASATAVTLLGAAATAASVTLTAATATTVVstTGSVVVAASGSAGSG--TGTTAASSTAATSSTTSTTATATAAAAAAT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  133 VVEISETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFAKPLVASPTITLPVASTASTSIVMV----TTAASSSVVTT 208
Cdd:COG3469     91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGtetaTGGTTTTSTTT 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1720399496  209 PTSSLSSVPiILSGINGSPPVSQRPENAPQIPVTTPQISSNNVKR 253
Cdd:COG3469    171 TTTSASTTP-SATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
 908-982 1.84e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 44.51  E-value: 1.84e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKV 982
Cdd:cd11456      6 RRNHNILERQRRNDLRSSFLTLRDHVpELVKNEKAAKVVILKKATEYVHSLQAEEQKLLLEKEKLQARQQQLLKKI 81
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
 908-955 2.30e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 43.88  E-value: 2.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQ 955
Cdd:cd11406      2 RAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILKKATEYIQ 49
PHA03255 PHA03255
BDLF3; Provisional
 125-262 2.39e-05

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 47.59  E-value: 2.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  125 SSSASTAGVVEISETNNTTLVTSTQSTATVNLTKTTGITTSPV---ASVSFAKPLVASPTITLPVASTAS--TSIVMVTT 199
Cdd:PHA03255    26 SSGSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPItttAILSTNTTTVTSTGTTVTPVPTTSnaSTINVTTK 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720399496  200 AASSSVVTTPTSSLSSVPIILSGINGSPPVSQRPENAPQIPVTTPQISS---NNVKRTGPRLLLIP 262
Cdd:PHA03255   106 VTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSkgtSNATKTTAELPTVP 171
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 53-280 2.55e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 49.14  E-value: 2.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   53 VRTPQP---LTGPQKFSIRPSPVMVVTpvvSSEQVQVCSTVAAAVTTSPQVflenVTAVPSLTANSDmGAKEATYSSSAS 129
Cdd:pfam05109  473 VTSPTPagtTSGASPVTPSPSPRDNGT---ESKAPDMTSPTSAVTTPTPNA----TSPTPAVTTPTP-NATSPTLGKTSP 544

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  130 TAGVVeiSETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFAKPLVASPTI--TLPVAS--------TASTSIVMVTT 199
Cdd:pfam05109  545 TSAVT--TPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVgeTSPQANttnhtlggTSSTPVVTSPP 622

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  200 AASSSVVTT-----PTSSLSSVPIILSGINGSPPVSQRPENAPQIPVTT---PQISSNNVKRTGPRLLLIPVQQGSPTLR 271
Cdd:pfam05109  623 KNATSAVTTgqhniTSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTsahPTGGENITQVTPASTSTHHVSTSSPAPR 702


                   ....*....
gi 1720399496  272 PIQNPQLQG 280
Cdd:pfam05109  703 PGTTSQASG 711
PHA03255 PHA03255
BDLF3; Provisional
 70-243 6.88e-05

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 46.05  E-value: 6.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   70 SPVMVVTPVVSSEQVQVCSTVAAAVTTSPqvflenVTAVPSLTANSDMGAKEATYSSSASTAgvveiseTNNTTLVTSTQ 149
Cdd:PHA03255    39 GTTAVTTPSPSASGPSTNQSTTLTTTSAP------ITTTAILSTNTTTVTSTGTTVTPVPTT-------SNASTINVTTK 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  150 STATVNLTKTTGITTSPvasvsfakPLVASPTITLPVASTASTSIVMVTTAA---SSSVVTTPTSSLSSVPiilsgingS 226
Cdd:PHA03255   106 VTAQNITATEAGTGTST--------GVTSNVTTRSSSTTSATTRITNATTLAptlSSKGTSNATKTTAELP--------T 169

                          170
                   ....*....|....*..
gi 1720399496  227 PPVSQRPENAPQIPVTT 243
Cdd:PHA03255   170 VPDERQPSLSYGLPLWT 186
bHLHzip_Mad4 cd18929
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-associated protein 4 (Mad4) and ...
 907-986 1.41e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-associated protein 4 (Mad4) and similar proteins; Mad4, also termed Max dimerization protein 4, or Max dimerizer 4 (MXD4), or Class C basic helix-loop-helix protein 12 (bHLHc12), or Max-interacting transcriptional repressor MAD4, is a bHLHZip Max-interacting transcriptional repressor that suppresses c-myc dependent transformation and is expressed during neural and epidermal differentiation. It is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.


Pssm-ID: 381499 [Multi-domain]  Cd Length: 88  Bit Score: 42.30  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  907 YRRTHTANERRRRGEMRDLFEKLK--ITLGLLHSSKVSKSLiLNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSS 984
Cdd:cd18929      2 NRSSHNELEKHRRAKLRLYLEQLKqlVPLGPDSTRHTTLSL-LKRAKMHIKKLEEQDRKALNIKEQLQREHRYLKRRLEQ 80


                   ..
gi 1720399496  985 LS 986
Cdd:cd18929     81 LS 82
PHA03255 PHA03255
BDLF3; Provisional
 86-212 1.41e-04

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 45.28  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   86 VCSTVAAAVTTSPQ-VFLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISET----NNTTLVTSTQSTATVNLTKTT 160
Cdd:PHA03255    17 ICETSLIWTSSGSStASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTailsTNTTTVTSTGTTVTPVPTTSN 96

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720399496  161 GITTSPVASVSfAKPLVASPTIT---LPVAS---TASTSIVMVTTAASSSVVTTPTSS 212
Cdd:PHA03255    97 ASTINVTTKVT-AQNITATEAGTgtsTGVTSnvtTRSSSTTSATTRITNATTLAPTLS 153
SSP160 pfam06933
Special lobe-specific silk protein SSP160; This family consists of several special ...
 75-190 3.05e-04

Special lobe-specific silk protein SSP160; This family consists of several special lobe-specific silk protein SSP160 sequences which appear to be specific to Chironomus (Midge) species.


Pssm-ID: 115579 [Multi-domain]  Cd Length: 758  Bit Score: 45.53  E-value: 3.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   75 VTPVVSSEQVQVCSTVAAAVTTSPQVFLENVTAVPSLTANSD--MGAKEATYSSSASTAGVVEISETNNTTLVTSTQSTA 152
Cdd:pfam06933  613 LTAFLASFNATINATIAAASANNSEVQSSEAACIESSLADAAaiLAMFEAAYQNCTAPGSVTVPAAANTTTSSTTTTTTT 692

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1720399496  153 TVNLTKTTgiTTSPVASVSFAKPL----------VASPTITLPVASTA 190
Cdd:pfam06933  693 TTTAAPTT--TTTKAANAPFTYPLcnlimsaacsAGGAGCTYPFISSA 738
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 85-250 3.16e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 3.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   85 QVCSTVAAAVTTSPQVFLENVTAvPSlTANSDMGAKEATYSSSASTAGVVeiSETNNTTLVTSTQSTATVNltkttgiTT 164
Cdd:pfam05109  453 HVPTNLTAPASTGPTVSTADVTS-PT-PAGTTSGASPVTPSPSPRDNGTE--SKAPDMTSPTSAVTTPTPN-------AT 521

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  165 SPVASVSFAKPLVASPTItlpvASTASTSIVMVTTAASSS---VVTTPTSSlSSVPIILSGINGSPPVSQRPE-NAPQIP 240
Cdd:pfam05109  522 SPTPAVTTPTPNATSPTL----GKTSPTSAVTTPTPNATSptpAVTTPTPN-ATIPTLGKTSPTSAVTTPTPNaTSPTVG 596

                          170
                   ....*....|
gi 1720399496  241 VTTPQISSNN 250
Cdd:pfam05109  597 ETSPQANTTN 606
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 162-339 3.20e-04

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 45.29  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  162 ITTSPVASVSFAKPLVASPTITLPVASTA-STSIvmvTTAASSSVVTTPTSS--LSSVPIILSGINGSPPVSQRPENAPQ 238
Cdd:cd22536    262 LVQPSDGGVSNGNQLVSTPITTASVSTMPeSPSS---STTCTTTASTSLTSSdtLVSSAETGQYASTAASSERTEEEPQT 338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  239 IPVTTPQISSNNVKRTGprllLIPVQQGSPTLrpiQNPQLQGQRMVLQPVRGPSGMNLFRHPNGQIVQLLPLHQIRGSNA 318
Cdd:cd22536    339 SAAESEAQSSSQLQSNG----LQNVQDQSNSL---QQVQIVGQPILQQIQIQQPQQQIIQAIQPQSFQLQSGQTIQTIQQ 411

                          170       180
                   ....*....|....*....|...
gi 1720399496  319 QP--SLQPVVFRNPgSMVGIRLP 339
Cdd:cd22536    412 QPlqNVQLQAVQSP-TQVLIRAP 433
bHLHzip_USF3 cd18910
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix ...
 905-965 3.29e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix domain-containing protein USF3 and similar proteins; USF3, also termed upstream transcription factor 3, is a bHLHzip protein that is involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.


Pssm-ID: 381480  Cd Length: 65  Bit Score: 40.36  E-value: 3.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720399496  905 AYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLI 965
Cdd:cd18910      3 EKKRESHNEVERRRKDKINAGINKIGELLPDRDAKKQSKNMILEQAYKYIVELKKKNDKLL 63
bHLHzip_c-Myc cd11458
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, ...
 908-985 4.78e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.


Pssm-ID: 381464 [Multi-domain]  Cd Length: 84  Bit Score: 40.63  E-value: 4.78e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITL-GLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSSL 985
Cdd:cd11458      6 RRTHNVLERQRRNELKLSFFALRDQIpEVANNEKAPKVVILKKATEYILSMQADEQRLISEKEQLRRRREQLKHRLEQL 84
PHA03247 PHA03247
large tegument protein UL36; Provisional
 8-388 5.74e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 5.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496    8 TNRSGKNLKAFVPAKRPI--AARPSPGgvftqfvmsKVGALQQKIPGVRTPQPltgpqkfsiRPSPVMVVTPVVSSEQVQ 85
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRrrAARPTVG---------SLTSLADPPPPPPTPEP---------APHALVSATPLPPGPAAA 2728

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   86 VCSTVAAAVTTSPQVfLENVTAVPSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQSTATVNLTKTTGITTS 165
Cdd:PHA03247  2729 RQASPALPAAPAPPA-VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP 2807

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  166 PVAsvsfakplVASPTITLPVASTASTSIVMVTTAASSSVVTTPTSSLSSVPIILSGINGSpPVSQRP--ENAPQIPVTT 243
Cdd:PHA03247  2808 PAA--------VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPpsRSPAAKPAAP 2878

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  244 PQISSNNVKRTGPRLLLIPVQQGSPTLRPIQNPQLQGQRMVLQPVRGPSGMNLFRHPNGQivQLLPLHQIRGSNAQPSLQ 323
Cdd:PHA03247  2879 ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR--PQPPLAPTTDPAGAGEPS 2956

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720399496  324 PVVfRNP--GSMVGIRLPAPckssetpsssasSSAFSVMSPVIQAVGSSPTVNVISQAPSLLSSGSS 388
Cdd:PHA03247  2957 GAV-PQPwlGALVPGRVAVP------------RFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010
bHLHzip_Mad cd11401
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Mad family; Members of the Mad ...
 908-982 6.05e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Mad family; Members of the Mad family (Mad1, Mxi, Mad3, and Mad4) bear the bHLHzip domain (also known as basic-helix-loop-helix-leucine-zipper or bHLH-LZ domain), which mediates heterodimerization to Max and the sequence-specific DNA binding ability to E-box DNA. Mad family proteins can repress transcription at the E-box through their interaction with co-repressors. Mad family proteins antagonize Myc function in transactivation and transformation and they are growth/tumor suppressors. The developmental phenotypes of the individual Mad family member knockout mice are relatively mild- all these mice have been shown to be viable and normal.


Pssm-ID: 381407 [Multi-domain]  Cd Length: 76  Bit Score: 39.89  E-value: 6.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLK------------ITLGLlhsskvsksliLNRAFSEIQGLTDQADKLIGQKNLLSRKR 975
Cdd:cd11401      1 RSTHNELEKNRRAHLRLCLERLKelvplgpdatrhTTLSL-----------LTKAKAYIKNLEDKEKRQRQQKEQLRREQ 69


                   ....*..
gi 1720399496  976 SILIRKV 982
Cdd:cd11401     70 RELKRRL 76
bHLHzip_MXI1 cd18930
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and ...
 907-985 1.17e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins; MXI1, also termed Max interactor 1, or Class C basic helix-loop-helix protein 11 (bHLHc11), is a bHLHZip transcriptional repressor that binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. It thus antagonizes MYC transcriptional activity by competing for MAX. It plays an important role in the regulation of cell proliferation.


Pssm-ID: 381500 [Multi-domain]  Cd Length: 80  Bit Score: 39.21  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  907 YRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSL-ILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSSL 985
Cdd:cd18930      1 NRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLgLLNKAKAHIKKLEEADRKSQHQLENLEREQRFLKRRLEQL 80
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 908-977 1.65e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 38.79  E-value: 1.65e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLK---ITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLsrKRSI 977
Cdd:cd11405      4 RLSHISAEQKRRFNIKSGFDTLQsliPSLGQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQL--RQEI 74
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
 908-974 3.06e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 37.79  E-value: 3.06e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLKITLGLLH------SSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLsRK 974
Cdd:cd19687      3 REAHTQAEQKRRDAIKKGYDDLQDIVPTCQqqddigSQKLSKATILQRSIDYIQFLHQQKKKQEEELSAL-RK 74
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
 908-964 3.10e-03

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 37.72  E-value: 3.10e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720399496  908 RRTHTANERRRRGEMRDLFEKLkitLGLLH------SSKVSKSLILNRAFSEIQGLTDQADKL 964
Cdd:cd11388      4 KWKHVEAEKKRRNQIKKGFEDL---INLINyprnnnEKRISKSELLNKAVDDIRGLLKANEQL 63
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 911-964 6.63e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 36.39  E-value: 6.63e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720399496  911 HTANERRRRGEMRDLFEKLKitlGLL-HSSKVSKSLILNRAFSEIQGLTDQADKL 964
Cdd:cd11393      1 HSIAERKRREKINERIRALR---SLVpNGGKTDKASILDEAIEYIKFLQEQVKVL 52
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
52-212 7.15e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.89  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496   52 GVRTPQPLTGPQKFSIRPSPVMVVTPVVSSEQVQVCSTVAAAVTTSPQVFLENVTAVPSLTANSDMGAKEATYSSSASTA 131
Cdd:COG3469     61 TGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASA 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720399496  132 GVVEISETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFAKPlvASPTITLPVASTASTsivmvTTAASSSVVTTPTS 211
Cdd:COG3469    141 TSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTT--ATATTASGATTPSAT-----TTATTTGPPTPGLP 213


                   .
gi 1720399496  212 S 212
Cdd:COG3469    214 K 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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