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Conserved domains on  [gi|1720405712|ref|XP_030108793|]
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WD repeat-containing protein 47 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
664-973 2.46e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 2.46e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 664 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 743
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 744 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 821
Cdd:COG2319   145 RL--WDL----ATGKLLrTLTGHSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV-A 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 822 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 899
Cdd:COG2319   212 FSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720405712 900 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 95-152 8.18e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.18e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720405712   95 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 152
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL super family cl39307
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 63-90 2.25e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


The actual alignment was detected with superfamily member pfam17814:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.99  E-value: 2.25e-05
                          10        20
                  ....*....|....*....|....*...
gi 1720405712  63 EIIKLILDFLNSKKLHISMLALEKESGV 90
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
664-973 2.46e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 2.46e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 664 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 743
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 744 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 821
Cdd:COG2319   145 RL--WDL----ATGKLLrTLTGHSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV-A 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 822 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 899
Cdd:COG2319   212 FSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720405712 900 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 657-973 4.52e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 4.52e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 657 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCAYpekmdasahdnpkQPVVRFKRNKHHKGSIYCVAWSPCGQLLA 735
Cdd:cd00200     1 LRRTLKGhTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-------------ETGELLRTLKGHTGPVRDVAASADGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 736 TGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGH 815
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRT-----LTGHTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 816 ILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 894
Cdd:cd00200   138 VNSVaFSPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720405712 895 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 95-152 8.18e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.18e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720405712   95 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 152
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 716-745 2.02e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 2.02e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720405712  716 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 745
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
716-745 1.84e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.84e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1720405712 716 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 745
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 63-90 2.25e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.99  E-value: 2.25e-05
                          10        20
                  ....*....|....*....|....*...
gi 1720405712  63 EIIKLILDFLNSKKLHISMLALEKESGV 90
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 822-976 1.87e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 822 WSGWM---IASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASV---AVDPSgrLLATGQEDSSCMLYDIRGGRMVQS 895
Cdd:PLN00181  540 WNSYIksqVASSNFEGVVQVWDVARSQLV----TEMKEHEKRVWSIdysSADPT--LLASGSDDGSVKLWSINQGVSIGT 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 896 YHPhSSDVRSVRF-SPGAHYLLTGSYDMKIKVTDLQgdlTKQLPLMVVGEHKDKVIQCRWhTQDLSFLSSSADRTVTLWT 974
Cdd:PLN00181  614 IKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688


                  ..
gi 1720405712 975 YS 976
Cdd:PLN00181  689 LS 690
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 59-92 3.20e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720405712   59 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 92
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
664-973 2.46e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 2.46e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 664 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAHDNPKQPvvrfkrnKHHKGSIYCVAWSPCGQLLATGSNDKYV 743
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 744 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmegpeSG-GAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyT 821
Cdd:COG2319   145 RL--WDL----ATGKLLrTLTGHSGAVTSVAF-----SPdGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSV-A 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 822 WS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPH 899
Cdd:COG2319   212 FSpdGKLLASGSADGTVRLWDLATGKLLR----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720405712 900 SSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
664-973 1.06e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 664 TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekMDASAhdnpKQPVVRFKrnkHHKGSIYCVAWSPCGQLLATGSNDKYV 743
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRL------WDLAT----GKLLRTLT---GHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 744 KVlpFNAetcnATGPDL-EFSMHDGTIRDLAFmeGPEsgGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGHILALyTW 822
Cdd:COG2319   187 RL--WDL----ATGKLLrTLTGHTGAVRSVAF--SPD--GKLLASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSV-AF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 823 S--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS 900
Cdd:COG2319   255 SpdGRLLASGSADGTVRLWDLATGELLR----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405712 901 SDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGdltkQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 657-973 4.52e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 4.52e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 657 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCAYpekmdasahdnpkQPVVRFKRNKHHKGSIYCVAWSPCGQLLA 735
Cdd:cd00200     1 LRRTLKGhTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-------------ETGELLRTLKGHTGPVRDVAASADGTYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 736 TGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGHTGH 815
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRT-----LTGHTSYVSSVAFSPDGR-----ILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 816 ILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 894
Cdd:cd00200   138 VNSVaFSPDGTFVASSSQDGTIKLWDLRTGKCVA----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720405712 895 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
657-931 6.61e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 6.61e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 657 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCaypekmDASAHdnpkQPVVRFKrnkHHKGSIYCVAWSPCGQLLA 735
Cdd:COG2319   154 LLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLW------DLATG----KLLRTLT---GHTGAVRSVAFSPDGKLLA 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 736 TGSNDKYVKVlpFNAETCNATGPdleFSMHDGTIRDLAFMegpeSGGAILISAGAgDCNIYTTDCQRGQGLHALSGHTGH 815
Cdd:COG2319   221 SGSADGTVRL--WDLATGKLLRT---LTGHSGSVRSVAFS----PDGRLLASGSA-DGTVRLWDLATGELLRTLTGHSGG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 816 ILALyTWS--GWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 893
Cdd:COG2319   291 VNSV-AFSpdGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1720405712 894 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQG 931
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 657-886 1.79e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 1.79e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 657 CINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVcaypekmdasaHDNPK-QPVVRFKrnkHHKGSIYCVAWSPCGQLL 734
Cdd:cd00200    85 CVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKV-----------WDVETgKCLTTLR---GHTDWVNSVAFSPDGTFV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 735 ATGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEgpeSGGAILISAGAGDCNIYttDCQRGQGLHALSGHTG 814
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVAT-----LTGHTGEVNSVAFSP---DGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGHEN 220

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720405712 815 HILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 886
Cdd:cd00200   221 GVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 654-840 1.86e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 1.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 654 QFVCINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRVCaypekmDASAHdnpkQPVVRFKrnkHHKGSIYCVAWSPCGQ 732
Cdd:cd00200   124 TGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLW------DLRTG----KCVATLT---GHTGEVNSVAFSPDGE 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 733 LLATGSNDKYVKVLPFNAETCNATgpdleFSMHDGTIRDLAFMEGPEsggaiLISAGAGDCNIYTTDCQRGQGLHALSGH 812
Cdd:cd00200   191 KLLSSSSDGTIKLWDLSTGKCLGT-----LRGHENGVNSVAFSPDGY-----LLASGSEDGTIRVWDLRTGECVQTLSGH 260

                         170       180       190
                  ....*....|....*....|....*....|
gi 1720405712 813 TGHILALyTWS--GWMIASGSQDKTVRFWD 840
Cdd:cd00200   261 TNSVTSL-AWSpdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
780-973 1.10e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 780 SGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRvvgtTFHGTG 858
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLA----TLLGHT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 859 SAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQL 937
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTL 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1720405712 938 PlmvvgEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:COG2319   159 T-----GHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 95-152 8.18e-13

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 63.74  E-value: 8.18e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720405712   95 FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS 152
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 899-977 8.65e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 8.65e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720405712 899 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLtkqlPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYSG 977
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 716-745 2.02e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 2.02e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720405712  716 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 745
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
716-745 1.84e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.84e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1720405712 716 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV 745
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 890-928 2.86e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.86e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720405712  890 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 928
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
890-928 9.87e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.87e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720405712 890 GRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 928
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 803-840 1.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720405712  803 GQGLHALSGHTGHILALyTWS--GWMIASGSQDKTVRFWD 840
Cdd:smart00320   2 GELLKTLKGHTGPVTSV-AFSpdGKYLASGSDDGTIKLWD 40
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 63-90 2.25e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.99  E-value: 2.25e-05
                          10        20
                  ....*....|....*....|....*...
gi 1720405712  63 EIIKLILDFLNSKKLHISMLALEKESGV 90
Cdd:pfam17814   3 DVVRLILQFLKENGLHRTLQALQTESGV 30
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 822-976 1.87e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 822 WSGWM---IASGSQDKTVRFWDLRVPSCVrvvgTTFHGTGSAVASV---AVDPSgrLLATGQEDSSCMLYDIRGGRMVQS 895
Cdd:PLN00181  540 WNSYIksqVASSNFEGVVQVWDVARSQLV----TEMKEHEKRVWSIdysSADPT--LLASGSDDGSVKLWSINQGVSIGT 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720405712 896 YHPhSSDVRSVRF-SPGAHYLLTGSYDMKIKVTDLQgdlTKQLPLMVVGEHKDKVIQCRWhTQDLSFLSSSADRTVTLWT 974
Cdd:PLN00181  614 IKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688


                  ..
gi 1720405712 975 YS 976
Cdd:PLN00181  689 LS 690
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 848-903 7.93e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 7.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720405712 848 RVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 903
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
WD40 pfam00400
WD domain, G-beta repeat;
806-840 1.04e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1720405712 806 LHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWD 840
Cdd:pfam00400   4 LKTLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 853-886 1.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720405712  853 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 886
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
852-886 2.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 2.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1720405712 852 TTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 886
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 59-92 3.20e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 35.87  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720405712   59 VKEVEIIKLILDFLNSKKLHISMLALEKESGVIN 92
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 654-690 3.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720405712  654 QFVCINTLED-TQAVRAVAFHPSGSLYAVGSNSKTLRV 690
Cdd:smart00320   1 SGELLKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 938-973 6.62e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 6.62e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720405712  938 PLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 973
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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