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Conserved domains on  [gi|1907132126|ref|XP_036017411|]
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very low-density lipoprotein receptor isoform X6 [Mus musculus]

Protein Classification

LDLa and Ldl_recept_b domain-containing protein( domain architecture ID 11081338)

protein containing domains LDLa, EGF_CA, Ldl_recept_b, and LY

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 464-504 2.90e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 72.96  E-value: 2.90e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907132126 464 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 504
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
133-169 1.97e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.88  E-value: 1.97e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126 133 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 169
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
172-208 2.11e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 2.11e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126 172 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 208
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
49-84 5.56e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 5.56e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907132126  49 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 84
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-461 7.75e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 7.75e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907132126 423 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 461
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
88-120 1.54e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.54e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907132126  88 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 120
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
7-45 1.57e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.57e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907132126   7 RTCRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 45
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 488-530 4.37e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 4.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907132126  488 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 530
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 377-418 1.33e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 1.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907132126 377 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 418
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
216-246 4.75e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 4.75e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907132126 216 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 246
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 551-591 8.22e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 8.22e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907132126 551 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 591
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 256-290 1.20e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.39  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907132126 256 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 290
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
292-322 3.73e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 3.73e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126  292 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 322
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 602-645 2.18e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 2.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907132126 602 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 645
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 464-504 2.90e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 72.96  E-value: 2.90e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907132126 464 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 504
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
133-169 1.97e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.88  E-value: 1.97e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126 133 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 169
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
172-208 2.11e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 2.11e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126 172 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 208
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 135-169 2.24e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907132126 135 CPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 169
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
49-84 5.56e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 5.56e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907132126  49 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 84
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-461 7.75e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 7.75e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907132126 423 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 461
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 50-84 1.78e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 1.78e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907132126  50 CSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 84
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 404-443 6.74e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.92  E-value: 6.74e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907132126  404 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKR 443
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 134-166 7.31e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 7.31e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126  134 KCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDE 166
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
88-120 1.54e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.54e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907132126  88 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 120
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
7-45 1.57e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.57e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907132126   7 RTCRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 45
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 88-120 1.71e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.71e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126   88 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 120
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 174-208 1.72e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.72e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907132126 174 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 208
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 49-81 2.04e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.04e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126   49 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDE 81
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.84e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 2.84e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907132126  446 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 487
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 488-530 4.37e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 4.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907132126  488 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 530
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 377-418 1.33e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 1.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907132126 377 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 418
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 89-120 2.49e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 2.49e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907132126  89 CGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 120
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 173-205 3.51e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 3.51e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126  173 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 205
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
216-246 4.75e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 4.75e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907132126 216 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 246
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 551-591 8.22e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 8.22e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907132126 551 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 591
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 256-290 1.20e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.39  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907132126 256 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 290
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 509-550 1.32e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907132126 509 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 550
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 9-45 1.46e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 1.46e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126   9 CRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 45
Cdd:cd00112     1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 216-246 3.24e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 3.24e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907132126  216 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 246
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 216-246 5.66e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.43  E-value: 5.66e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907132126 216 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 246
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
292-322 3.73e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 3.73e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126  292 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 322
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 8-42 6.64e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 6.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907132126    8 TCRINEISCGarSTQCIPVSWRCDGENDCDNGEDE 42
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
421-568 1.52e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 421 KTIYWTDAASKTISVatLDGAKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTEDIQ- 496
Cdd:COG3391    80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 497 --WPNGITLDLVKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 568
Cdd:COG3391   151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 292-322 1.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.64e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907132126 292 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 322
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 602-645 2.18e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 2.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907132126 602 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 645
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 411-577 1.49e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 411 PAAIAVDWVYKtIYWTDAASKTISVATLDGAKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 477
Cdd:cd14963    58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 478 EKAGMNGFDRrplvtEDIQWPNGITLDlVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 553
Cdd:cd14963   135 LEFGKPGSEP-----GELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208

                         170       180
                  ....*....|....*....|....
gi 1907132126 554 YWIDGENEAVYGANKfTGSELATL 577
Cdd:cd14963   209 YVVDNLSHRVYVFDE-QGKELFTF 231
EGF_CA pfam07645
Calcium-binding EGF domain;
292-320 2.60e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 2.60e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907132126 292 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 320
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 464-504 2.90e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 72.96  E-value: 2.90e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907132126 464 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 504
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
133-169 1.97e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.88  E-value: 1.97e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126 133 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 169
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
172-208 2.11e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 2.11e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126 172 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 208
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 135-169 2.24e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907132126 135 CPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 169
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
49-84 5.56e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 5.56e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907132126  49 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 84
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-461 7.75e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 7.75e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907132126 423 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 461
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 50-84 1.78e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 1.78e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907132126  50 CSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 84
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 404-443 6.74e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.92  E-value: 6.74e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907132126  404 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKR 443
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 134-166 7.31e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 7.31e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126  134 KCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDE 166
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
88-120 1.54e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.54e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907132126  88 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 120
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
7-45 1.57e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.57e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907132126   7 RTCRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 45
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 88-120 1.71e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.71e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126   88 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 120
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 174-208 1.72e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.72e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907132126 174 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 208
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 49-81 2.04e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.04e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126   49 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDE 81
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.84e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 2.84e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907132126  446 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 487
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 488-530 4.37e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 4.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907132126  488 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 530
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 377-418 1.33e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 1.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907132126 377 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 418
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 89-120 2.49e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 2.49e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907132126  89 CGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 120
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 173-205 3.51e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 3.51e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126  173 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 205
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
216-246 4.75e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 4.75e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907132126 216 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 246
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 551-591 8.22e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 8.22e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907132126 551 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 591
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 256-290 1.20e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.39  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907132126 256 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 290
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 509-550 1.32e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907132126 509 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 550
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 9-45 1.46e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 1.46e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907132126   9 CRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 45
Cdd:cd00112     1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 216-246 3.24e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 3.24e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907132126  216 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 246
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 216-246 5.66e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.43  E-value: 5.66e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907132126 216 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 246
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
292-322 3.73e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 3.73e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907132126  292 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 322
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 8-42 6.64e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 6.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907132126    8 TCRINEISCGarSTQCIPVSWRCDGENDCDNGEDE 42
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
421-568 1.52e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 421 KTIYWTDAASKTISVatLDGAKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTEDIQ- 496
Cdd:COG3391    80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 497 --WPNGITLDLVKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 568
Cdd:COG3391   151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 292-322 1.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.64e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907132126 292 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 322
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 602-645 2.18e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 2.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907132126 602 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 645
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
371-511 5.03e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 5.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 371 DADIAAQKLFWADLSQKAIfsASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVatLDGAKRKFLFNSD 450
Cdd:COG3391    74 DAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIP 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907132126 451 L-REPASIAVDPLSGFVYWSDWGEP------AKIEKAGMNgfdrrplVTEDI---QWPNGITLDLVKSRLY 511
Cdd:COG3391   150 VgAGPHGIAVDPDGKRLYVANSGSNtvsvivSVIDTATGK-------VVATIpvgGGPVGVAVSPDGRRLY 213
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 375-533 5.25e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 5.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 375 AAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNvyNPAAIAVD-----WV---YKTIYWTDAASKTISVATLDGAKRKFL 446
Cdd:COG3386    17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSG--RPNGLAFDpdgrlLVadhGRGLVRFDPADGEVTVLADEYGKPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 447 FNsDLRepasiaVDPlSGFVYWSDwgepakiekagMNGFDRRP------------LVTEDIQWPNGITLDLVKSRLYWLD 514
Cdd:COG3386    95 PN-DGV------VDP-DGRLYFTD-----------MGEYLPTGalyrvdpdgslrVLADGLTFPNGIAFSPDGRTLYVAD 155

                         170       180
                  ....*....|....*....|...
gi 1907132126 515 SKLHMLSSVDLNGQ----DRRIV 533
Cdd:COG3386   156 TGAGRIYRFDLDADgtlgNRRVF 178
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
339-472 1.26e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 339 LIFTNRRD--IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSasIDDKVGRHFKMIDNVYNPAAIAV 416
Cdd:COG3391    82 LYVANSGSgrVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAGPHGIAV 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907132126 417 DWVYKTIYWTDAASKTIS--VATLDGAKRKFLFNSDLRE-PASIAVDPLSGFVYWSDWG 472
Cdd:COG3391   160 DPDGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVGGgPVGVAVSPDGRRLYVANRG 218
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 411-577 1.49e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 411 PAAIAVDWVYKtIYWTDAASKTISVATLDGAKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 477
Cdd:cd14963    58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 478 EKAGMNGFDRrplvtEDIQWPNGITLDlVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 553
Cdd:cd14963   135 LEFGKPGSEP-----GELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208

                         170       180
                  ....*....|....*....|....
gi 1907132126 554 YWIDGENEAVYGANKfTGSELATL 577
Cdd:cd14963   209 YVVDNLSHRVYVFDE-QGKELFTF 231
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 367-470 2.38e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132126 367 TVALDADiaaQKLFWADLSQKAIFsasIDDKVGRHFKMIDN-----VYNPAAIAVDwVYKTIYWTDAASKTISVATLDGA 441
Cdd:cd14962    16 GVAADGR---GRIYVADTGRGAVF---VFDLPNGKVFVIGNagpnrFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGK 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907132126 442 KRKFLFNSDLRE-PASIAVDPLSGFVYWSD 470
Cdd:cd14962    89 FLRAIGAGALFKrPTGIAVDPAGKRLYVVD 118
EGF_CA pfam07645
Calcium-binding EGF domain;
292-320 2.60e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 2.60e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907132126 292 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 320
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 297-324 4.64e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.30  E-value: 4.64e-03
                          10        20
                  ....*....|....*....|....*...
gi 1907132126 297 QNPGICSQICINLKGGYKCECSRGYQMD 324
Cdd:pfam14670   3 VNNGGCSHLCLNTPGGYTCSCPEGYELQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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