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Conserved domains on  [gi|1953040370|ref|XP_038435312|]
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alpha-tocopherol transfer protein [Canis lupus familiaris]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10661233)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins; similar to phosphatidylinositol transfer proteins

CATH:  1.10.8.20|3.40.525.10
Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRAL_TRIO pfam00650
CRAL/TRIO domain;
99-247 3.16e-36

CRAL/TRIO domain;


:

Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 126.60  E-value: 3.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953040370  99 GYLGVLRARDPTGSKVLIYRIAQWDPKVFTAYDVFRVSLITSELIVQEV-ETQRNGIKAVFDLEGWQFSHAFQITPSVAK 177
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLMpEGQVEGLTVIIDLKGLSLSNMDWWSISLLK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953040370 178 KIAAVLTDSFPLKVRGIHLINEPIIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFP-DILPLEYGG 247
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEEELEKYIPpEQLPKEYGG 151
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
47-73 5.02e-09

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 51.01  E-value: 5.02e-09
                           10        20
                   ....*....|....*....|....*..
gi 1953040370   47 LTDAFLLRFLRARDFDLELAWRLLKNY 73
Cdd:smart01100  22 LDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
CRAL_TRIO pfam00650
CRAL/TRIO domain;
99-247 3.16e-36

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 126.60  E-value: 3.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953040370  99 GYLGVLRARDPTGSKVLIYRIAQWDPKVFTAYDVFRVSLITSELIVQEV-ETQRNGIKAVFDLEGWQFSHAFQITPSVAK 177
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLMpEGQVEGLTVIIDLKGLSLSNMDWWSISLLK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953040370 178 KIAAVLTDSFPLKVRGIHLINEPIIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFP-DILPLEYGG 247
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEEELEKYIPpEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 95-247 5.24e-36

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 126.26  E-value: 5.24e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953040370   95 LLKAGYLGVlRARDPTGSKVLIYRIAQWDPKVFTAYDVFRVSLITSELIVQE--VETQRNGIKAVFDLEGWQFSHafqIT 172
Cdd:smart00516   4 LLKAYIPGG-RGYDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKILQEekKTGGIEGFTVIFDLKGLSMSN---PD 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953040370  173 PSVAKKIAAVLTDSFPLKVRGIHLINEPIIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHF-PDILPLEYGG 247
Cdd:smart00516  80 LSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIdKEQLPEELGG 155
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 97-247 1.73e-35

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 124.75  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953040370  97 KAGYLGVLRARDPTGSKVLIYRIAQWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAVFDLEGWQFSHAFqiTPSVA 176
Cdd:cd00170     7 LLGGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953040370 177 KKIAAVLTDSFPLKVRGIHLINEPIIFHAVFSMIKPFLTEKIKERIHMHGNNYKqSLLQHF-PDILPLEYGG 247
Cdd:cd00170    85 KKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLE-ELLEYIdPDQLPKELGG 155
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
47-73 5.02e-09

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 51.01  E-value: 5.02e-09
                           10        20
                   ....*....|....*....|....*..
gi 1953040370   47 LTDAFLLRFLRARDFDLELAWRLLKNY 73
Cdd:smart01100  22 LDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 49-72 2.41e-05

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 41.10  E-value: 2.41e-05
                          10        20
                  ....*....|....*....|....
gi 1953040370  49 DAFLLRFLRARDFDLELAWRLLKN 72
Cdd:pfam03765  30 DVCLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
CRAL_TRIO pfam00650
CRAL/TRIO domain;
99-247 3.16e-36

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 126.60  E-value: 3.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953040370  99 GYLGVLRARDPTGSKVLIYRIAQWDPKVFTAYDVFRVSLITSELIVQEV-ETQRNGIKAVFDLEGWQFSHAFQITPSVAK 177
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLMpEGQVEGLTVIIDLKGLSLSNMDWWSISLLK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953040370 178 KIAAVLTDSFPLKVRGIHLINEPIIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFP-DILPLEYGG 247
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEEELEKYIPpEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 95-247 5.24e-36

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 126.26  E-value: 5.24e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953040370   95 LLKAGYLGVlRARDPTGSKVLIYRIAQWDPKVFTAYDVFRVSLITSELIVQE--VETQRNGIKAVFDLEGWQFSHafqIT 172
Cdd:smart00516   4 LLKAYIPGG-RGYDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKILQEekKTGGIEGFTVIFDLKGLSMSN---PD 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953040370  173 PSVAKKIAAVLTDSFPLKVRGIHLINEPIIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHF-PDILPLEYGG 247
Cdd:smart00516  80 LSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIdKEQLPEELGG 155
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 97-247 1.73e-35

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 124.75  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953040370  97 KAGYLGVLRARDPTGSKVLIYRIAQWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAVFDLEGWQFSHAFqiTPSVA 176
Cdd:cd00170     7 LLGGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953040370 177 KKIAAVLTDSFPLKVRGIHLINEPIIFHAVFSMIKPFLTEKIKERIHMHGNNYKqSLLQHF-PDILPLEYGG 247
Cdd:cd00170    85 KKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLE-ELLEYIdPDQLPKELGG 155
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
47-73 5.02e-09

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 51.01  E-value: 5.02e-09
                           10        20
                   ....*....|....*....|....*..
gi 1953040370   47 LTDAFLLRFLRARDFDLELAWRLLKNY 73
Cdd:smart01100  22 LDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 49-72 2.41e-05

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 41.10  E-value: 2.41e-05
                          10        20
                  ....*....|....*....|....
gi 1953040370  49 DAFLLRFLRARDFDLELAWRLLKN 72
Cdd:pfam03765  30 DVCLLRFLRARKWDVEKAIKMLED 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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