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Conserved domains on  [gi|2129557184|ref|XP_044878701|]
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vascular endothelial growth factor A-like isoform X3 [Mauremys mutica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
211-303 4.52e-51

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 163.52  E-value: 4.52e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 211 CPIKSRKGDVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRG-APPK 289
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 2129557184 290 IPGGATLIFEVELL 303
Cdd:pfam00254  81 IPPNATLVFEVELL 94
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 10-91 6.48e-28

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 103.65  E-value: 6.48e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184   10 SFCQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRY-LHSHLGQLAFVEHSACE 88
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRpLSQHLVEVSFEEHTKCE 80


                   ...
gi 2129557184   89 CRP 91
Cdd:smart00141  81 CRP 83
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
211-303 4.52e-51

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 163.52  E-value: 4.52e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 211 CPIKSRKGDVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRG-APPK 289
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 2129557184 290 IPGGATLIFEVELL 303
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 217-305 6.93e-49

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 158.42  E-value: 6.93e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 217 KGDVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRGAPPKIPGGATL 296
Cdd:COG0545    16 AGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNSTL 95


                  ....*....
gi 2129557184 297 IFEVELLKI 305
Cdd:COG0545    96 VFEVELLDV 104
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 10-91 6.48e-28

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 103.65  E-value: 6.48e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184   10 SFCQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRY-LHSHLGQLAFVEHSACE 88
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRpLSQHLVEVSFEEHTKCE 80


                   ...
gi 2129557184   89 CRP 91
Cdd:smart00141  81 CRP 83
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 200-305 2.30e-25

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 100.64  E-value: 2.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 200 LQIGVKKRVENcPIKSRKgDVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTgqVIKGWDQGLLGMCEGEKRKLVIPSEL 279
Cdd:PRK11570  104 LQFRVLTQGEG-AIPART-DRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHEL 179

                          90       100
                  ....*....|....*....|....*.
gi 2129557184 280 GYGDRGAPPKIPGGATLIFEVELLKI 305
Cdd:PRK11570  180 AYGERGAGASIPPFSTLVFEVELLEI 205
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 10-92 3.70e-25

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 96.28  E-value: 3.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184  10 SFCQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRY---LHSHLGQLAFVEHSA 86
Cdd:cd00135     1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPkrkPRSKLVEISFEEHTE 80


                  ....*.
gi 2129557184  87 CECRPK 92
Cdd:cd00135    81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
12-89 1.31e-23

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 91.96  E-value: 1.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184  12 CQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRYLHS----HLGQLAFVEHSAC 87
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRrpspELVEVSFEEHVQC 80


                  ..
gi 2129557184  88 EC 89
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 3-93 8.48e-22

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 89.29  E-value: 8.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184   3 WMEVYNRSFCQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRY-----LHSHLG 77
Cdd:PHA02661   39 WLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVsgstgATSNFQ 118

                          90
                  ....*....|....*.
gi 2129557184  78 QLAFVEHSACECRPKT 93
Cdd:PHA02661  119 TISVEEHTKCKCEFKT 134
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
211-303 4.52e-51

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 163.52  E-value: 4.52e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 211 CPIKSRKGDVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRG-APPK 289
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 2129557184 290 IPGGATLIFEVELL 303
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 217-305 6.93e-49

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 158.42  E-value: 6.93e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 217 KGDVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRGAPPKIPGGATL 296
Cdd:COG0545    16 AGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNSTL 95


                  ....*....
gi 2129557184 297 IFEVELLKI 305
Cdd:COG0545    96 VFEVELLDV 104
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 10-91 6.48e-28

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 103.65  E-value: 6.48e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184   10 SFCQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRY-LHSHLGQLAFVEHSACE 88
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRpLSQHLVEVSFEEHTKCE 80


                   ...
gi 2129557184   89 CRP 91
Cdd:smart00141  81 CRP 83
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 200-305 2.30e-25

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 100.64  E-value: 2.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 200 LQIGVKKRVENcPIKSRKgDVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTgqVIKGWDQGLLGMCEGEKRKLVIPSEL 279
Cdd:PRK11570  104 LQFRVLTQGEG-AIPART-DRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHEL 179

                          90       100
                  ....*....|....*....|....*.
gi 2129557184 280 GYGDRGAPPKIPGGATLIFEVELLKI 305
Cdd:PRK11570  180 AYGERGAGASIPPFSTLVFEVELLEI 205
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 10-92 3.70e-25

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 96.28  E-value: 3.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184  10 SFCQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRY---LHSHLGQLAFVEHSA 86
Cdd:cd00135     1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPkrkPRSKLVEISFEEHTE 80


                  ....*.
gi 2129557184  87 CECRPK 92
Cdd:cd00135    81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
12-89 1.31e-23

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 91.96  E-value: 1.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184  12 CQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRYLHS----HLGQLAFVEHSAC 87
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRrpspELVEVSFEEHVQC 80


                  ..
gi 2129557184  88 EC 89
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 3-93 8.48e-22

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 89.29  E-value: 8.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184   3 WMEVYNRSFCQPKEMLVPVSEEHPAEVEHLLAPSCVPLRRCAGCCADEGLQCVPTRMHMVVMEVMKTRY-----LHSHLG 77
Cdd:PHA02661   39 WLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVsgstgATSNFQ 118

                          90
                  ....*....|....*.
gi 2129557184  78 QLAFVEHSACECRPKT 93
Cdd:PHA02661  119 TISVEEHTKCKCEFKT 134
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 219-306 8.97e-22

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 92.52  E-value: 8.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 219 DVLHMHYTGKLEDGTEFDSSIPRDQPFIFSLGTgqVIKGWDQGLLGMCEGEKRKLVIPSELGYGDRGApPKIPGGATLIF 298
Cdd:PRK10902  165 DTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGV-PGIPANSTLVF 241


                  ....*...
gi 2129557184 299 EVELLKIE 306
Cdd:PRK10902  242 DVELLDVK 249
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 217-284 2.23e-20

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 85.15  E-value: 2.23e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2129557184 217 KGDVLHMHYTGKLEDGTEFDSSIpRDQPFIFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGDR 284
Cdd:COG1047     3 KGDVVTLHYTLKLEDGEVFDSTF-EGEPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYGER 69
PRK15095 PRK15095
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 223-282 8.15e-08

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 237908 [Multi-domain]  Cd Length: 156  Bit Score: 50.86  E-value: 8.15e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 223 MHYTGKLEDGTEFDSSIPRDQPFIFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYG 282
Cdd:PRK15095   13 VHFTLKLDDGSTAESTRNNGKPALFRLGDGSLSEGLEQQLLGLKVGDKKTFSLEPEAAFG 72
Tig COG0544
FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, ...
 214-311 9.89e-07

FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440310 [Multi-domain]  Cd Length: 424  Bit Score: 49.74  E-value: 9.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129557184 214 KSRKGDVLHMHYTGKLeDGTEFDSSIPRDQPFIfsLGTGQVIKGWDQGLLGMCEGEKR--KLVIPSELGYGDRgappkip 291
Cdd:COG0544   157 AAEEGDRVTIDFEGTI-DGEEFEGGKAEDYSLE--LGSGSFIPGFEEQLVGMKAGEEKtfEVTFPEDYHAEEL------- 226

                          90       100
                  ....*....|....*....|..
gi 2129557184 292 GGATLIFEVELLKIERR--PEL 311
Cdd:COG0544   227 AGKTATFKVTVKEVKEKelPEL 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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