NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217355376|ref|XP_047273001|]
View 

la-related protein 1 isoform X9 [Homo sapiens]

Protein Classification

LAM and DM15 domain-containing protein( domain architecture ID 13066634)

LAM and DM15 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LAM super family cl02755
LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins ...
 173-245 1.25e-44

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


The actual alignment was detected with superfamily member cd08037:

Pssm-ID: 470666  Cd Length: 73  Bit Score: 154.68  E-value: 1.25e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 245
Cdd:cd08037     1 KDYIKRQIEYYFSVDNLERDFFLRRKMDEDGFLPVTLIASFHRVQALTTDISLIIKALKDSKVVEIIDMKIRR 73
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 695-733 9.09e-15

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


:

Pssm-ID: 128927  Cd Length: 39  Bit Score: 68.55  E-value: 9.09e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217355376  695 HFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEK 733
Cdd:smart00684   1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
DM15 super family cl02733
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 654-694 9.72e-11

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


The actual alignment was detected with superfamily member smart00684:

Pssm-ID: 128927  Cd Length: 39  Bit Score: 57.38  E-value: 9.72e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217355376  654 FTQHVYHKYRRRCLNERKRLGigqSQEMNTLFRFWSFFLRD 694
Cdd:smart00684   2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
LHP1 super family cl34938
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 176-324 5.56e-09

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5193:

Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 59.29  E-value: 5.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355376 176 IKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKdskvvEIVDEKVRRREEPEKWPLP 255
Cdd:COG5193   274 KKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYRNLSFGGDKNLILAAMK-----EVVQNKATNHLEIALGSIE 348

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 256 PIVDYSQTDFSQL----LNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSE 324
Cdd:COG5193   349 DAQKNEAKDFSPGkkyfIRKKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPYSYMGYPNFFPSNENGKK 421
 
Name Accession Description Interval E-value
LARP_1 cd08037
La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related ...
 173-245 1.25e-44

La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related protein 1 (LARP1). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153406  Cd Length: 73  Bit Score: 154.68  E-value: 1.25e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 245
Cdd:cd08037     1 KDYIKRQIEYYFSVDNLERDFFLRRKMDEDGFLPVTLIASFHRVQALTTDISLIIKALKDSKVVEIIDMKIRR 73
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
170-246 8.83e-34

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 124.27  E-value: 8.83e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355376  170 ELLKDYIKRQIEYYFSVDNLERDFFLRRKMDA-DGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVRRR 246
Cdd:smart00715   1 EELKQKIKKQVEYYFSDENLPRDKFLRKKMDKnDGYVPISTIASFKRVKSLTTDVNLIVEALRSSPKLEVSEdgLKVRRR 80
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 176-232 8.85e-25

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 97.88  E-value: 8.85e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217355376 176 IKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLIFAALKD 232
Cdd:pfam05383   1 IKKQVEYYFSDENLPKDKFLRKQMDKdpDGYVPISVIASFKRMKKLTTDIDLIAEALRE 59
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 695-733 9.09e-15

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 68.55  E-value: 9.09e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217355376  695 HFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEK 733
Cdd:smart00684   1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 654-694 9.72e-11

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 57.38  E-value: 9.72e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217355376  654 FTQHVYHKYRRRCLNERKRLGigqSQEMNTLFRFWSFFLRD 694
Cdd:smart00684   2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
LHP1 COG5193
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 176-324 5.56e-09

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 59.29  E-value: 5.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355376 176 IKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKdskvvEIVDEKVRRREEPEKWPLP 255
Cdd:COG5193   274 KKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYRNLSFGGDKNLILAAMK-----EVVQNKATNHLEIALGSIE 348

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 256 PIVDYSQTDFSQL----LNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSE 324
Cdd:COG5193   349 DAQKNEAKDFSPGkkyfIRKKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPYSYMGYPNFFPSNENGKK 421
 
Name Accession Description Interval E-value
LARP_1 cd08037
La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related ...
 173-245 1.25e-44

La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related protein 1 (LARP1). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153406  Cd Length: 73  Bit Score: 154.68  E-value: 1.25e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 245
Cdd:cd08037     1 KDYIKRQIEYYFSVDNLERDFFLRRKMDEDGFLPVTLIASFHRVQALTTDISLIIKALKDSKVVEIIDMKIRR 73
LARP_1_2 cd08034
La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in ...
 173-245 1.97e-43

La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in proteins similar to vertebrate La-related proteins 1 and 2 (LARP1, LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153403  Cd Length: 73  Bit Score: 151.43  E-value: 1.97e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 245
Cdd:cd08034     1 KEYIKKQIEYYFSVDNLEKDFFLRRKMDPEGYLPIALIASFHRVQALTTDVNLILEALKDSTVVELVDEKVRC 73
LARP_2 cd08038
La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related ...
 173-245 2.17e-35

La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related protein 2 (LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153407  Cd Length: 73  Bit Score: 128.53  E-value: 2.17e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 245
Cdd:cd08038     1 KEYIKRQIEYYFSTENLERDFFLRRKMDLQGFLPISLIAGFYRVQALTTNVDLILEALKDSTEVEIVDQKIRR 73
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
170-246 8.83e-34

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 124.27  E-value: 8.83e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355376  170 ELLKDYIKRQIEYYFSVDNLERDFFLRRKMDA-DGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVRRR 246
Cdd:smart00715   1 EELKQKIKKQVEYYFSDENLPRDKFLRKKMDKnDGYVPISTIASFKRVKSLTTDVNLIVEALRSSPKLEVSEdgLKVRRR 80
LAM cd07323
LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins ...
 173-245 8.29e-32

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153396  Cd Length: 75  Bit Score: 118.40  E-value: 8.29e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVRR 245
Cdd:cd07323     1 LEKIKKQVEYYFSDENLCKDRFLRSLMDDDGWVPLSLLASFNRVKKLTTDVELILEALRDSSVVEVSEdgTKVRR 75
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 176-232 8.85e-25

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 97.88  E-value: 8.85e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217355376 176 IKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLIFAALKD 232
Cdd:pfam05383   1 IKKQVEYYFSDENLPKDKFLRKQMDKdpDGYVPISVIASFKRMKKLTTDIDLIAEALRE 59
LARP_4_5_like cd08031
La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found ...
 173-244 4.14e-19

La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found in proteins similar to La-related proteins 4 and 5 (LARP4, LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153400  Cd Length: 75  Bit Score: 82.10  E-value: 4.14e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVR 244
Cdd:cd08031     1 KELLKRQLEYYFSRENLANDAYLLSQMDSDQYVPIWTIANFNKIKKLTTDIDLIVEALRESPNVQVDEkgEKVR 74
LARP_6 cd08033
La RNA-binding domain of La-related protein 6; This domain is found in animal and plant ...
 173-245 3.67e-18

La RNA-binding domain of La-related protein 6; This domain is found in animal and plant proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153402  Cd Length: 77  Bit Score: 79.63  E-value: 3.67e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKM--DADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDE--KVRR 245
Cdd:cd08033     1 IQKIVKQVEYYFSDENLLKDAFLLKHVrrNKEGYVPIKLIASFKKVKALTRDWRVVAAALRRSSKLVVSEDgkKVRR 77
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 695-733 9.09e-15

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 68.55  E-value: 9.09e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217355376  695 HFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEK 733
Cdd:smart00684   1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
LARP_7 cd08032
La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key ...
 169-246 1.56e-14

La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key factor in the regulation of RNA polymerase II transcription. 7SK functionality is dependent on the presence of LARP7, which is thought to stabilize the 7SK RNA by interacting with its 3' end. The release of 7SK RNA from P-TEFb/HEXIM/7SK complexes activates the cyclin-dependent kinase P-TEFb, which in turn phosphorylates the C-terminal domain of RNA pol II and mediates a transition into productive transcription elongation.


Pssm-ID: 153401  Cd Length: 82  Bit Score: 69.58  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355376 169 QELLKDyIKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRR 246
Cdd:cd08032     3 KQLLAD-IAKQVDFWFGDVNLHKDRFLREQIEKsrDGYIDISLLVSFNKMKKLTTDGKLIARALKNSSVVELNLEGTRIR 81
LARP_3 cd08028
La RNA-binding domain of La-related protein 3; This domain is found at the N-terminus of the ...
 172-245 2.96e-14

La RNA-binding domain of La-related protein 3; This domain is found at the N-terminus of the La autoantigen and similar proteins, and co-occurs with an RNA-recognition motif (RRM). Together these domains function to bind primary transcripts of RNA polymerase III at their 3' terminus and protect them from exonucleolytic degradation. Binding is specific for the 3'-terminal UUU-OH motif. The La autoantigen is also called Lupus La protein, LARP3, or Sjoegren syndrome type B antigen (SS-B).


Pssm-ID: 153397  Cd Length: 82  Bit Score: 68.48  E-value: 2.96e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217355376 172 LKDYIKRQIEYYFSVDNLERDFFLRRKM-DADGFLPITLIASFHRVQALTTDISLIFAALKDSK--VVEIVDE--KVRR 245
Cdd:cd08028     4 LEKKIIRQIEYYFGDFNLPRDKFLKEQIkEDDGWVPMEVMLKFNRLKSLSSDPEVIAKALKKSKsgLIEVSEDktKIRR 82
LARP_4 cd08035
La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related ...
 173-244 3.49e-14

La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related protein 4 (LARP4), also known as c-MPL binding protein. La-type domains often co-occur with RNA-recognition motifs (RRMs). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153404  Cd Length: 75  Bit Score: 68.15  E-value: 3.49e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVR 244
Cdd:cd08035     1 RECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEGIKKLTTDMDLILDVLRSSPMVQVDEtgEKVR 74
LA_like_fungal cd08029
La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in ...
 173-245 3.14e-11

La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in fungal proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153398  Cd Length: 76  Bit Score: 60.01  E-value: 3.14e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKM--DADGFLPITLIASFHRVQALtTDISLIFAALKDSKVVEIVD--EKVRR 245
Cdd:cd08029     1 PEEIRKQVEFYFSDSNLPTDKFLWTLTggSNNGWVPIKTIASFKRMRRF-QPLEAVVEALRESELLEVSEdgENVRR 76
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 654-694 9.72e-11

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 57.38  E-value: 9.72e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217355376  654 FTQHVYHKYRRRCLNERKRLGigqSQEMNTLFRFWSFFLRD 694
Cdd:smart00684   2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
LARP_5 cd08036
La RNA-binding domain of La-related protein 5; This domain is found in vertebrate La-related ...
 173-244 4.15e-09

La RNA-binding domain of La-related protein 5; This domain is found in vertebrate La-related protein 5 (LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153405  Cd Length: 75  Bit Score: 53.87  E-value: 4.15e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217355376 173 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVR 244
Cdd:cd08036     1 RELLKKTLEFCLSRENLASDMYLISQMDSDQYVPIMTVANLDHIKKLSTDVDLIVDVLRSLPLVQVDEkgEKVR 74
LHP1 COG5193
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 176-324 5.56e-09

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 59.29  E-value: 5.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355376 176 IKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKdskvvEIVDEKVRRREEPEKWPLP 255
Cdd:COG5193   274 KKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYRNLSFGGDKNLILAAMK-----EVVQNKATNHLEIALGSIE 348

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217355376 256 PIVDYSQTDFSQL----LNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSE 324
Cdd:COG5193   349 DAQKNEAKDFSPGkkyfIRKKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPYSYMGYPNFFPSNENGKK 421
LA_like_plant cd08030
La-motif domain of plant proteins similar to the La autoantigen; This domain is found in plant ...
 176-245 2.81e-08

La-motif domain of plant proteins similar to the La autoantigen; This domain is found in plant proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153399  Cd Length: 90  Bit Score: 52.01  E-value: 2.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355376 176 IKRQIEYYFSVDNLERDFFLRRKM--DADGFLPITLIASFHRVQAL-------TTDISL-----IFAALKDSKVVEIVDE 241
Cdd:cd08030     5 VLRQVEFYFSDSNLPRDDFLLEEVeeDPDGMVSLALICSFSRMRSLlglgggkPEDVPEdtlkaVAEALRTSTLLKVSED 84


                  ....*.
gi 2217355376 242 --KVRR 245
Cdd:cd08030    85 gkRVGR 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH