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Conserved domains on  [gi|2217294188|ref|XP_047286239|]
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dolichyl-phosphate beta-glucosyltransferase isoform X1 [Homo sapiens]

Protein Classification

dolichyl-phosphate beta-glucosyltransferase( domain architecture ID 10135784)

dolichyl-phosphate beta-glucosyltransferase is a glycosyltransferase family 2 protein that catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate

CAZY:  GT2
EC:  2.4.1.117
Gene Ontology:  GO:0004581|GO:0006486
PubMed:  12200473|10521532|12691742|9445404

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 36-226 3.90e-109

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


:

Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 313.73  E-value: 3.90e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  36 PAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLEK 115
Cdd:cd04188    27 PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVRAGMLAARGDYILFADADLATPFEELEKLEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 116 glndlQPWPNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERW 195
Cdd:cd04188   106 -----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLGLGIKDTQCGFKLFTRDAARRLFPRLHLERW 180

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2217294188 196 AFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 226
Cdd:cd04188   181 AFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 36-226 3.90e-109

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 313.73  E-value: 3.90e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  36 PAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLEK 115
Cdd:cd04188    27 PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVRAGMLAARGDYILFADADLATPFEELEKLEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 116 glndlQPWPNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERW 195
Cdd:cd04188   106 -----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLGLGIKDTQCGFKLFTRDAARRLFPRLHLERW 180

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2217294188 196 AFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 226
Cdd:cd04188   181 AFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 10-255 1.73e-104

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 306.31  E-value: 1.73e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  10 PAYG--THLPNNFLSLCLHTMKKNGKrDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKV--RVITLVKNRGKGGAIR 85
Cdd:PTZ00260   77 PAYNeeDRLPKMLKETIKYLESRSRK-DPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGKGGAVR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  86 MGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPwpNQMAIACGSRAHLEK-ESIAQRSYFRTLLMYGFHFLVWFLC 164
Cdd:PTZ00260  156 IGMLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQ--NGLGIVFGSRNHLVDsDVVAKRKWYRNILMYGFHFIVNTIC 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 165 VKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKDLLFIR 244
Cdd:PTZ00260  234 GTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARDILLVR 313

                         250
                  ....*....|.
gi 2217294188 245 LRYLTGAWRLE 255
Cdd:PTZ00260  314 SFYLLGIWKVK 324
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 40-225 3.40e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 99.01  E-value: 3.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  40 YEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGatkFPDVEKLEKGLND 119
Cdd:COG0463    32 FEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 120 LQPWPNqmAIACGSRAHLEKESIaqrsyFRTLLMYGFHFLVWFLCvkgIRDTQCGFKLFTREAASRTFSSlhvERWAFDV 199
Cdd:COG0463   107 LEEGPA--DLVYGSRLIREGESD-----LRRLGSRLFNLVRLLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDT 173

                         170       180
                  ....*....|....*....|....*.
gi 2217294188 200 ELLYIAQfFKIPIAEIAVNWTEIEGS 225
Cdd:COG0463   174 ELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 24-185 2.59e-19

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 82.06  E-value: 2.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  24 CLHTMKKNGKRDpaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADG 103
Cdd:pfam00535  16 TLESLLNQTYPN----FEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGARNAGLRAATGDYIAFLDADD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 104 ATKFPDVEKLEKGLNDLQPwpnqmAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAA 183
Cdd:pfam00535  90 EVPPDWLEKLVEALEEDGA-----DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFALYRREAL 164


                  ..
gi 2217294188 184 SR 185
Cdd:pfam00535 165 EE 166
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 36-226 3.90e-109

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 313.73  E-value: 3.90e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  36 PAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLEK 115
Cdd:cd04188    27 PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVRAGMLAARGDYILFADADLATPFEELEKLEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 116 glndlQPWPNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERW 195
Cdd:cd04188   106 -----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLGLGIKDTQCGFKLFTRDAARRLFPRLHLERW 180

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2217294188 196 AFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 226
Cdd:cd04188   181 AFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 10-255 1.73e-104

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 306.31  E-value: 1.73e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  10 PAYG--THLPNNFLSLCLHTMKKNGKrDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKV--RVITLVKNRGKGGAIR 85
Cdd:PTZ00260   77 PAYNeeDRLPKMLKETIKYLESRSRK-DPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGKGGAVR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  86 MGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPwpNQMAIACGSRAHLEK-ESIAQRSYFRTLLMYGFHFLVWFLC 164
Cdd:PTZ00260  156 IGMLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQ--NGLGIVFGSRNHLVDsDVVAKRKWYRNILMYGFHFIVNTIC 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 165 VKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKDLLFIR 244
Cdd:PTZ00260  234 GTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARDILLVR 313

                         250
                  ....*....|.
gi 2217294188 245 LRYLTGAWRLE 255
Cdd:PTZ00260  314 SFYLLGIWKVK 324
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 35-205 2.88e-50

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 163.13  E-value: 2.88e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  35 DPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLE 114
Cdd:cd04179    24 EEGYDYEIIVVDDGSTDGTAEIARELAARVP--RVRVIRLSRNFGKGAAVRAGFKAARGDIVVTMDADLQHPPEDIPKLL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 115 KGLndlqpWPNQMAIACGSRAHleKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVER 194
Cdd:cd04179   102 EKL-----LEGGADVVIGSRFV--RGGGAGMPLLRRLGSRLFNFLIRLLLGVRISDTQSGFRLFRREVLEALLSLLESNG 174

                         170
                  ....*....|.
gi 2217294188 195 WAFDVELLYIA 205
Cdd:cd04179   175 FEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 40-225 3.40e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 99.01  E-value: 3.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  40 YEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGatkFPDVEKLEKGLND 119
Cdd:COG0463    32 FEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 120 LQPWPNqmAIACGSRAHLEKESIaqrsyFRTLLMYGFHFLVWFLCvkgIRDTQCGFKLFTREAASRTFSSlhvERWAFDV 199
Cdd:COG0463   107 LEEGPA--DLVYGSRLIREGESD-----LRRLGSRLFNLVRLLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDT 173

                         170       180
                  ....*....|....*....|....*.
gi 2217294188 200 ELLYIAQfFKIPIAEIAVNWTEIEGS 225
Cdd:COG0463   174 ELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 24-185 2.59e-19

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 82.06  E-value: 2.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  24 CLHTMKKNGKRDpaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADG 103
Cdd:pfam00535  16 TLESLLNQTYPN----FEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGARNAGLRAATGDYIAFLDADD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 104 ATKFPDVEKLEKGLNDLQPwpnqmAIACGSRAHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAA 183
Cdd:pfam00535  90 EVPPDWLEKLVEALEEDGA-----DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFALYRREAL 164


                  ..
gi 2217294188 184 SR 185
Cdd:pfam00535 165 EE 166
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 38-254 1.23e-16

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 76.42  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  38 FTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADG--ATKF-PD-VEKL 113
Cdd:cd06442    26 IDYEIIVVDDNSPDGTAEIVRELAKEYP--RVRLIVRPGKRGLGSAYIEGFKAARGDVIVVMDADLshPPEYiPElLEAQ 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 114 EKGLNDlqpwpnqmaIACGSRaHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVE 193
Cdd:cd06442   104 LEGGAD---------LVIGSR-YVEGGGVEGWGLKRKLISRGANLLARLLLGRKVSDPTSGFRAYRREVLEKLIDSLVSK 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217294188 194 RWAFDVELLYIAQFFKIPIAEIAVNWTE-IEG-SKLvpfwSWLQMgkdllfirLRYLTGAWRL 254
Cdd:cd06442   174 GYKFQLELLVRARRLGYRIVEVPITFVDrEHGeSKL----GGKEI--------VEYLKGLLRL 224
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 10-102 1.22e-14

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 69.46  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  10 PAYG--THLPNNFLSLCLHTMKKngkrdpaftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIRMG 87
Cdd:cd00761     4 PAYNeePYLERCLESLLAQTYPN---------FEVIVVDDGSTDGTLEILEEYAKKD--PRVIRVINEENQGLAAARNAG 72

                          90
                  ....*....|....*
gi 2217294188  88 IFSSRGEKILMADAD 102
Cdd:cd00761    73 LKAARGEYILFLDAD 87
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 36-102 1.64e-13

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 69.00  E-value: 1.64e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217294188  36 PAFTYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADAD 102
Cdd:COG1215    57 PKEKLEVIVVDDGSTDETAEIARELAAEY--PRVRVIERPENGGKAAALNAGLKAARGDIVVFLDAD 121
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 34-183 3.23e-13

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 65.96  E-value: 3.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  34 RDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADG---ATKFPD- 109
Cdd:cd04187    24 ESLGYDYEIIFVDDGSTDRTLEILRELAARD--PRVKVIRLSRNFGQQAALLAGLDHARGDAVITMDADLqdpPELIPEm 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217294188 110 VEKLEKGlNDlqpwpnqmaIACGSRAHlEKESIaqrsyFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAA 183
Cdd:cd04187   102 LAKWEEG-YD---------VVYGVRKN-RKESW-----LKRLTSKLFYRLINKLSGVDIPDNGGDFRLMDRKVV 159
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 40-102 1.66e-11

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 61.47  E-value: 1.66e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217294188  40 YEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLvKNRGKGGAIRMGIFSSRGEKILMADAD 102
Cdd:cd06423    27 LEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDK-ENGGKAGALNAGLRHAKGDIVVVLDAD 88
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 40-215 1.08e-10

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 60.10  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  40 YEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGA--TKF-PDV--EKLE 114
Cdd:PLN02726   41 FEIIVVDDGSPDGTQDVVKQLQKVYGEDRILLRPRPGKLGLGTAYIHGLKHASGDFVVIMDADLShhPKYlPSFikKQRE 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188 115 KGLNdlqpwpnqmaIACGSRaHLEKESIAQRSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVER 194
Cdd:PLN02726  121 TGAD----------IVTGTR-YVKGGGVHGWDLRRKLTSRGANVLAQTLLWPGVSDLTGSFRLYKRSALEDLVSSVVSKG 189

                         170       180
                  ....*....|....*....|.
gi 2217294188 195 WAFDVELLYIAQFFKIPIAEI 215
Cdd:PLN02726  190 YVFQMEIIVRASRKGYRIEEV 210
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
20-102 3.12e-08

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 52.30  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  20 FLSLCLHTMKKNGKRDpaftYEVIVVDDGSKDQTSKvafkYCQKYGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMA 99
Cdd:COG1216    17 LLRRCLESLLAQTYPP----FEVIVVDNGSTDGTAE----LLAALAFPRVRVIRNPENLGFAAARNLGLRAAGGDYLLFL 88


                  ...
gi 2217294188 100 DAD 102
Cdd:COG1216    89 DDD 91
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 36-102 3.85e-07

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 49.89  E-value: 3.85e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217294188  36 PAFTYEVIVVDDGSKDQTSKVAfkycQKYGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADAD 102
Cdd:cd06439    57 PRDRLEIIVVSDGSTDGTAEIA----REYADKGVKLLRFPERRGKAAALNRALALATGEIVVFTDAN 119
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 36-102 3.49e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 46.90  E-value: 3.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217294188  36 PAFTYEVIVVDDGSKDQTSKVAFKYCQKyGSDKVRVIT--LVKNRGKGGAIRMGIFSSRGEKILMADAD 102
Cdd:cd04192    25 PKEKFEVILVDDHSTDGTVQILEFAAAK-PNFQLKILNnsRVSISGKKNALTTAIKAAKGDWIVTTDAD 92
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 34-103 1.86e-05

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 44.92  E-value: 1.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217294188  34 RDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSdkvrvITLVKNRGK--GGAIRMGIFSSRGEKILMADADG 103
Cdd:cd02525    26 SYPKDLIEIIVVDGGSTDGTREIVQEYAAKDPR-----IRLIDNPKRiqSAGLNIGIRNSRGDIIIRVDAHA 92
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 41-118 3.47e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 43.77  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217294188  41 EVIVVDDGSKDQTSKVAFKYCQKYGsdkvRVITLVKNRGKGGAIR---MGIFSSRGEKILMADADgatkfpDV---EKLE 114
Cdd:cd04196    29 ELIISDDGSTDGTVEIIKEYIDKDP----FIIILIRNGKNLGVARnfeSLLQAADGDYVFFCDQD------DIwlpDKLE 98


                  ....
gi 2217294188 115 KGLN 118
Cdd:cd04196    99 RLLK 102
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 40-102 1.20e-04

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 42.73  E-value: 1.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217294188  40 YEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLvKNRGKGGAIRMGIFSSRGEKILMADAD 102
Cdd:PRK10073   36 LEIIIVNDGSTDNSVEIAKHYAENYP--HVRLLHQ-ANAGVSVARNTGLAVATGKYVAFPDAD 95
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 19-97 3.04e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 40.24  E-value: 3.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217294188  19 NFLSLCLHTMKKNGKRDpaftYEVIVVDDGSKDQTSKVAFKYcqkygSDKVRVITLVKNRGKGGAIRMGIFSSRGEKIL 97
Cdd:cd04186    10 EYLKACLDSLLAQTYPD----FEVIVVDNASTDGSVELLREL-----FPEVRLIRNGENLGFGAGNNQGIREAKGDYVL 79
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 40-102 1.32e-03

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 39.33  E-value: 1.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217294188  40 YEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVItLVKNRGKGGAIRMGIFSSRGEKILMADAD 102
Cdd:PRK10714   39 YEILLIDDGSSDNSAEMLVEAAQAPDSHIVAIL-LNRNYGQHSAIMAGFSHVTGDLIITLDAD 100
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 41-79 4.48e-03

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 37.57  E-value: 4.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217294188  41 EVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRG 79
Cdd:cd02510    32 EIILVDDFSDKPELKLLLEEYYKKYLPKVKVLRLKKREG 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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