|
Name |
Accession |
Description |
Interval |
E-value |
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
338-777 |
1.47e-124 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 379.29 E-value: 1.47e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 338 LAGVYALIIFEIVHRTLAAMLGSLAALAALaVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRL 417
Cdd:cd01116 1 FIITYALIIFEKVHRTVAALAGALWLVILG-LATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 418 SRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqe 497
Cdd:cd01116 80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 498 lrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllg 577
Cdd:cd01116 157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 578 kvlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVpgiHLDLGWIAILG 657
Cdd:cd01116 202 ------------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPL---GVSLGWIALLG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 658 AIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKmvpeeQRLIAAIVLVVWVSALASS 737
Cdd:cd01116 249 ALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVIL-----GRIAVAVILILWISALLSA 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 2217301385 738 LIDNIPFTATMAGL------PNDGCVLHCWDVLSPCGSCGGGMELI 777
Cdd:cd01116 324 FIDNIPVTATMIPIvkdlasQLGIPLLPLWWALALGACLGGNGTLI 369
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
330-751 |
2.15e-76 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 253.13 E-value: 2.15e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 330 QVTIATAILAGVYALIIFEI--VHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFF 407
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVV-----SLEDALEAIDWNTILFLLGMMIIVAILDESGFF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 408 DYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDP 487
Cdd:COG1055 76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 488 PNVIIVSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRltaqrispasre 567
Cdd:COG1055 156 TNIMIAS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRR------------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 568 etavrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgiLLAKCLTVLGFVIFMFFLNSFvpgIH 647
Cdd:COG1055 217 ------------------------------------------------------LLRISLLVLALLLVGFVLHSF---LG 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 648 LDLGWIAILGAIWLLILADIHDFEiILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIkmvpeEQRLIAAIVL 727
Cdd:COG1055 240 LPPALIALLGAAVLLLLARVDVRE-VLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLT-----GGNLLLAALL 313
|
410 420
....*....|....*....|....
gi 2217301385 728 VVWVSALASSLIDNIPFTATMAGL 751
Cdd:COG1055 314 ILWLSAILSAVVDNVPLVAALLPL 337
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
342-749 |
2.01e-64 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 218.72 E-value: 2.01e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 342 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 421
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVL-----TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 422 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkM 501
Cdd:pfam03600 76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----L 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 502 GLDFAGFTAHMFIGICLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKheihvwrltaqrispasreetavrrlllgkvl 580
Cdd:pfam03600 151 GLSFGDFGFFMFPPVGVALLLvGLLPLLLIFRKLLPVRKEEEAELEEL-------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 581 alehllarrlhtfhrqisqedknwetniqelqKKHRISDGILLAKCLTVLGFVIFMFFLNSfvpgihldlgwIAILGAIW 660
Cdd:pfam03600 199 --------------------------------RKRAIKDKLLLAISALVLALVILGFLLLS-----------VLALAGAL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 661 LLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEqtallikMVPEEQRLIAAIVLVVWVSALASSLID 740
Cdd:pfam03600 236 LLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD-------ALGGLSGLLVALALILWLSALLSAFIS 308
|
....*....
gi 2217301385 741 NIPFTATMA 749
Cdd:pfam03600 309 NVPTAALMA 317
|
|
| PLN00136 |
PLN00136 |
silicon transporter; Provisional |
383-777 |
3.79e-17 |
|
silicon transporter; Provisional
Pssm-ID: 215070 [Multi-domain] Cd Length: 482 Bit Score: 85.05 E-value: 3.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 383 IDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 461
Cdd:PLN00136 61 IDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERN 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 462 LDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG--ICLVLLVCfpllrlLYWNRKLYNK 539
Cdd:PLN00136 139 LPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGmaVNMVMLLC------MYWKDLDGGA 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 540 EPSEIVELKHEIHVWRLTAQRIS-PASREETAVRRLLLGKVLALEHLLARRLHTFHRqisqedknWETNIQELQKKHRIS 618
Cdd:PLN00136 212 ELSVDGKQMEAVEEGRSPASAKStKQQSPALLQAGLNGDGNGDMSSMMSENISTKHP--------WFMQCTEHRRKLFLK 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 619 DgilLAKCLTVLGFVIFMFFLNsfvpgihldLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALahl 698
Cdd:PLN00136 284 S---FAYVVTVGMVVAYMVGLN---------MSWTAITTAI-ALVVVDFRDAEPCLDTVSYSLLVFFSGMFITVSGF--- 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 699 hliEYVGEQTALLIKMVPEEQ-RLIAAIVLVVWVSALASSLIDNIPF-------TATMAGLPNDGCVLHCWDVLSPCGSC 770
Cdd:PLN00136 348 ---NKTGLPGAIWNFMAPYSKvNSVGGISVLSVIILLLSNLASNVPTvllmgdeVAAAAALISPAAVTRSWLLLAWVSTV 424
|
....*..
gi 2217301385 771 GGGMELI 777
Cdd:PLN00136 425 AGNLSLL 431
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
376-527 |
2.90e-05 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 47.34 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 376 LTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIAAVLSAFLDNVTTM 446
Cdd:TIGR00785 285 FLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFYIILYFFASNTAHT 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 447 LLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgftahmFIGICLVLL 521
Cdd:TIGR00785 365 AALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG------IVGLIVLLL 438
|
....*.
gi 2217301385 522 VCFPLL 527
Cdd:TIGR00785 439 VGTLWW 444
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
338-777 |
1.47e-124 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 379.29 E-value: 1.47e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 338 LAGVYALIIFEIVHRTLAAMLGSLAALAALaVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRL 417
Cdd:cd01116 1 FIITYALIIFEKVHRTVAALAGALWLVILG-LATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 418 SRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqe 497
Cdd:cd01116 80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 498 lrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllg 577
Cdd:cd01116 157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 578 kvlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVpgiHLDLGWIAILG 657
Cdd:cd01116 202 ------------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPL---GVSLGWIALLG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 658 AIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKmvpeeQRLIAAIVLVVWVSALASS 737
Cdd:cd01116 249 ALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVIL-----GRIAVAVILILWISALLSA 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 2217301385 738 LIDNIPFTATMAGL------PNDGCVLHCWDVLSPCGSCGGGMELI 777
Cdd:cd01116 324 FIDNIPVTATMIPIvkdlasQLGIPLLPLWWALALGACLGGNGTLI 369
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
330-751 |
2.15e-76 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 253.13 E-value: 2.15e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 330 QVTIATAILAGVYALIIFEI--VHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFF 407
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVV-----SLEDALEAIDWNTILFLLGMMIIVAILDESGFF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 408 DYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDP 487
Cdd:COG1055 76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 488 PNVIIVSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRltaqrispasre 567
Cdd:COG1055 156 TNIMIAS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRR------------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 568 etavrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgiLLAKCLTVLGFVIFMFFLNSFvpgIH 647
Cdd:COG1055 217 ------------------------------------------------------LLRISLLVLALLLVGFVLHSF---LG 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 648 LDLGWIAILGAIWLLILADIHDFEiILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIkmvpeEQRLIAAIVL 727
Cdd:COG1055 240 LPPALIALLGAAVLLLLARVDVRE-VLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLT-----GGNLLLAALL 313
|
410 420
....*....|....*....|....
gi 2217301385 728 VVWVSALASSLIDNIPFTATMAGL 751
Cdd:COG1055 314 ILWLSAILSAVVDNVPLVAALLPL 337
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
342-751 |
1.09e-67 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 229.06 E-value: 1.09e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 342 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 421
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVV-----SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 422 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQelrkm 501
Cdd:cd00625 76 RRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLS----- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 502 GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWnrklynkepseivelkheihvwrltaqrispasreetavrrlllgkvla 581
Cdd:cd00625 151 GLGFLDFLAFMAPPALGLLLLLLGLLYLLFR------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 582 lehllarrlhtfhRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLnsfvpgihLDLGWIAILGAIWL 661
Cdd:cd00625 182 -------------KKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFL--------IPLGLIALLGALLL 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 662 LILADI-HDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIkmvpeEQRLIAAIVLVVWVSALASSLID 740
Cdd:cd00625 241 LLLLVRgLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALV-----GLPPLAALLLIGLLSALLSNFIS 315
|
410
....*....|.
gi 2217301385 741 NIPFTATMAGL 751
Cdd:cd00625 316 NVPTVALLLPI 326
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
342-749 |
2.01e-64 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 218.72 E-value: 2.01e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 342 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 421
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVL-----TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 422 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkM 501
Cdd:pfam03600 76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----L 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 502 GLDFAGFTAHMFIGICLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKheihvwrltaqrispasreetavrrlllgkvl 580
Cdd:pfam03600 151 GLSFGDFGFFMFPPVGVALLLvGLLPLLLIFRKLLPVRKEEEAELEEL-------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 581 alehllarrlhtfhrqisqedknwetniqelqKKHRISDGILLAKCLTVLGFVIFMFFLNSfvpgihldlgwIAILGAIW 660
Cdd:pfam03600 199 --------------------------------RKRAIKDKLLLAISALVLALVILGFLLLS-----------VLALAGAL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 661 LLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEqtallikMVPEEQRLIAAIVLVVWVSALASSLID 740
Cdd:pfam03600 236 LLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD-------ALGGLSGLLVALALILWLSALLSAFIS 308
|
....*....
gi 2217301385 741 NIPFTATMA 749
Cdd:pfam03600 309 NVPTAALMA 317
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
374-746 |
1.71e-33 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 133.17 E-value: 1.71e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 374 PSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGrVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVT 453
Cdd:cd01117 30 ISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGS-PRRLLFLLVLLSGILSALLTNDTACLVFTPIV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 454 IRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqelrKMGLDFAGFTAHMF----IGICLVLLVCFpllrl 529
Cdd:cd01117 109 LELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIAS-----ESGISFPFFLAAMAplalLGLLLLLILLL----- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 530 LYWNRKLYNKEPSEIVELKHEIHVWRltaqrispasreetAVRRLLLgkvlalehllarrlhtfhrqisqedknwetniq 609
Cdd:cd01117 179 VLFPGELKGLPLDKATKEEGVGARKL--------------AVKLLVL--------------------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 610 elqkkhrisdgillakCLTVLGFVIFMFFLNSFvpgihldlgWIAILGAIWLLILADIHDFEIILhRVEWATLLFFAALF 689
Cdd:cd01117 212 ----------------ILLLLVAFLALLGVIPL---------WTAALVAAVLLLLTRLKPRRVLK-KVDWGLLLFFAGLF 265
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217301385 690 VLMEALAHLHLIEYVgeqTALLIkmvpeeqrLIAAIVLVVWVSALASSLIDNIPFTA 746
Cdd:cd01117 266 ILVGGFAQGLPLEGL---SRLLP--------LLDSVLSLFLVSIGLSQLISNVPAVL 311
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
392-749 |
1.88e-24 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 106.01 E-value: 1.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 392 FGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLD-----PRQ 466
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 467 VLIAEVIFTNIGGAATAIGDPPNVIIVSN-QELRKMGLDFAGFTAHMF-IGICLVLLVCFPLLRLLywnrklynkePSEI 544
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLlEEATGIPISFFEWMLVGLpVALVGLLLLWLVLYRLL----------PPEI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 545 VELKHEIHVWRLTAQRISPASREETAVrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgilla 624
Cdd:COG0471 151 KEVPGSKEVIREELAELGPLSRREKIA----------------------------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 625 kcLTVLGFVIFMFFLNSFvpgIHLDLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYV 704
Cdd:COG0471 178 --LAIFALTVLLWITGSL---HGIPIAVVALLGAV-LLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWL 251
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2217301385 705 GEQTALLIKMVPeeqrLIAAIVLVVWVSALASSLIDNIPFTATMA 749
Cdd:COG0471 252 ADALLPLLGGLS----PLLLLLLLALLTLLLTEFASNTATAALLL 292
|
|
| PLN00136 |
PLN00136 |
silicon transporter; Provisional |
383-777 |
3.79e-17 |
|
silicon transporter; Provisional
Pssm-ID: 215070 [Multi-domain] Cd Length: 482 Bit Score: 85.05 E-value: 3.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 383 IDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 461
Cdd:PLN00136 61 IDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERN 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 462 LDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG--ICLVLLVCfpllrlLYWNRKLYNK 539
Cdd:PLN00136 139 LPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGmaVNMVMLLC------MYWKDLDGGA 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 540 EPSEIVELKHEIHVWRLTAQRIS-PASREETAVRRLLLGKVLALEHLLARRLHTFHRqisqedknWETNIQELQKKHRIS 618
Cdd:PLN00136 212 ELSVDGKQMEAVEEGRSPASAKStKQQSPALLQAGLNGDGNGDMSSMMSENISTKHP--------WFMQCTEHRRKLFLK 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 619 DgilLAKCLTVLGFVIFMFFLNsfvpgihldLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALahl 698
Cdd:PLN00136 284 S---FAYVVTVGMVVAYMVGLN---------MSWTAITTAI-ALVVVDFRDAEPCLDTVSYSLLVFFSGMFITVSGF--- 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 699 hliEYVGEQTALLIKMVPEEQ-RLIAAIVLVVWVSALASSLIDNIPF-------TATMAGLPNDGCVLHCWDVLSPCGSC 770
Cdd:PLN00136 348 ---NKTGLPGAIWNFMAPYSKvNSVGGISVLSVIILLLSNLASNVPTvllmgdeVAAAAALISPAAVTRSWLLLAWVSTV 424
|
....*..
gi 2217301385 771 GGGMELI 777
Cdd:PLN00136 425 AGNLSLL 431
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
391-752 |
2.47e-16 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 81.93 E-value: 2.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 391 LFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIA 470
Cdd:cd01118 58 LIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPF 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 471 EVIFTNIGGAATA---IGDPPNVIIVSNqelrkMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKlynkepseivEL 547
Cdd:cd01118 138 LYACAFIADAASLplpISNLVNIVTAGY-----FGIGFTEYAALMFLPSIVSILATYVVLYLFF--RR----------AL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 548 KHEIHVWRLTAQRISpasreetavrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrISDGILLAKCL 627
Cdd:cd01118 201 PKRLETASVKKPSLA------------------------------------------------------IKDPLLFGLAW 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 628 TVLGFVIFMFFlnsfvpGIHLDLGWIAILGAIW---LLILADIHDFE---IILHRVEWATLLFFAALFVLMEALAHLHLI 701
Cdd:cd01118 227 TLLVLLVVSAF------GVDILLIPPSFIAGVLaliFLLLARRGGAInplKVLKEAPWGVLLFSLGLYVVVFGLKNAGLT 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2217301385 702 EYVGEQTALLIkmvpeEQRLIAAIVLVVWVSALASSLIDNIPftATMAGLP 752
Cdd:cd01118 301 AILADLLNWLV-----SQGLLAAILGVGLLAAFLSNVMNNLP--AVLIGAL 344
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
390-531 |
1.13e-13 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 73.39 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 390 LLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 469
Cdd:cd01115 51 LFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLM 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217301385 470 AEVIFTNIGGAATAIGDPPNVIIVSnqELRKMGLDFAGFTAHMFIGIcLVLLVCFPLLRLLY 531
Cdd:cd01115 131 PLAFAASIGGMLTLIGTPPNLVASG--YLESLGGQGFSFFEFTPIGL-PLLIIGLLYLWFIF 189
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
373-532 |
1.59e-13 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 73.24 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 373 RPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPV 452
Cdd:COG1055 258 RVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPL 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 453 TIRLCEVLNLDPrqVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYW 532
Cdd:COG1055 338 IPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
378-527 |
1.60e-12 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 69.97 E-value: 1.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 378 HVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLc 457
Cdd:cd00625 252 EVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL- 330
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 458 evlnLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLL 527
Cdd:cd00625 331 ----APPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
376-529 |
1.64e-11 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 66.72 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 376 LTHVVEW------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIAAVLSAFLDNVTTMLL 448
Cdd:COG0471 211 LTGVLTWkdayksIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGlSPLLLLLLLALLTLLLTEFASNTATAAL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 449 FTPVTIRLCEVLNLDPRQVLIAeVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFagftahMFIGICLVLLVC 523
Cdd:COG0471 291 LLPIAISLAQALGVNPLPLALA-VAFAASCAFLLPVGTPPNAIVygsgyYKFKDFLKVGLPL------NLIGLVVLLLLG 363
|
....*.
gi 2217301385 524 FPLLRL 529
Cdd:COG0471 364 PLWWPL 369
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
370-508 |
8.12e-09 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 58.42 E-value: 8.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 370 IGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLF 449
Cdd:cd01116 255 LADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATM 334
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217301385 450 TPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGF 508
Cdd:cd01116 335 IPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEF 393
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
333-469 |
4.85e-08 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 55.78 E-value: 4.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 333 IATAILAGVYALIIFEIVhrtlaAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAV 412
Cdd:pfam03600 207 LLLAISALVLALVILGFL-----LLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD 281
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217301385 413 KAYRLSrgRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 469
Cdd:pfam03600 282 ALGGLS--GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
383-531 |
5.41e-07 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 52.59 E-value: 5.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 383 IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 461
Cdd:cd01115 239 IDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGlPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLG 318
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217301385 462 LDPRQVLIAEVIftnIGGAA--TAIGDPPNVIIVSNQELRKMglDFagFTAHMFIGIcLVLLVCFPLLRLLY 531
Cdd:cd01115 319 LPPEALLLAVAI---GASCAfmLPVGTPPNAIVLGPGGYKFS--DF--AKVGLPLSI-LSLVVSVTMIPLIW 382
|
|
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
370-468 |
7.52e-07 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 52.48 E-value: 7.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 370 IGDRPSLTHVVeWIdfETLALLfGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLF 449
Cdd:PRK15445 42 LGDVPVVWGIV-WN--ATLTFI-AIIIISLLLDEAGFFEWAALHVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALIL 117
|
90
....*....|....*....
gi 2217301385 450 TPVTIRLCEVLNLDPRQVL 468
Cdd:PRK15445 118 TPIVLAMLLALGFSKKATL 136
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
646-752 |
1.90e-06 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 50.90 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 646 IHLDLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVgeqTALLIKMVPEEQRLIaaI 725
Cdd:COG1055 21 RGLNRAVAALLGAA-LLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWL---AIKLARRAKGSPRRL--L 94
|
90 100
....*....|....*....|....*..
gi 2217301385 726 VLVVWVSALASSLIDNIpfTATMAGLP 752
Cdd:COG1055 95 WLLGLLTALLSAFLDND--TTALLLTP 119
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
376-527 |
2.90e-05 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 47.34 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 376 LTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIAAVLSAFLDNVTTM 446
Cdd:TIGR00785 285 FLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFYIILYFFASNTAHT 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 447 LLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgftahmFIGICLVLL 521
Cdd:TIGR00785 365 AALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG------IVGLIVLLL 438
|
....*.
gi 2217301385 522 VCFPLL 527
Cdd:TIGR00785 439 VGTLWW 444
|
|
| PLN00137 |
PLN00137 |
NHAD transporter family protein; Provisional |
631-777 |
1.90e-03 |
|
NHAD transporter family protein; Provisional
Pssm-ID: 215071 Cd Length: 424 Bit Score: 41.60 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 631 GFVIFMFFLNS--FVP------GIHLDLGWIAILGAIWLLILAdIHDFEII---------LHRVEWATLLFFaaLFVLMe 693
Cdd:PLN00137 225 GQLVFGVGVGAllFVPvfkaltGLPPYMGMLLGLGVLWILTDA-IHYGESErqalkvpqaLSRIDTQGILFF--LGILL- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 694 ALAHLHLIEYVGEQTALLIKMVPEeQRLIAAIVlvvwvsALASSLIDNIPFTAT---MAGLPNDGCVLHCWDVLSPCGSC 770
Cdd:PLN00137 301 SVGSLDAAGILRELANYLDANIPN-VELIASAI------GVASAIIDNVPLVAAtmgMYDLTDYPMDSELWQLIALCAGT 373
|
....*..
gi 2217301385 771 GGGMELI 777
Cdd:PLN00137 374 GGSLLVI 380
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
376-492 |
2.76e-03 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 40.82 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 376 LTHVVEWID-------FETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAM--IIMLCLIAAVLSAFLDNVTTM 446
Cdd:pfam00939 306 LLRILDWKDivknkgaWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMafIIILSLFYLSHYLFASATAHT 385
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2217301385 447 LLFTPVTIRLCEVLNLDPRQVLIAEVIF-TNIGGAATAIGDPPNVII 492
Cdd:pfam00939 386 AAMLPIFAAVAQAIPGAPPLLAALLLGFaISLGGFLTPYGTGPGPIY 432
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
387-749 |
4.13e-03 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 40.41 E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 387 TLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR-----VWAMIIMLCLIAAVLSaflDNVTTMLLFTPVTIRLCEVLN 461
Cdd:TIGR00785 65 TIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGTtlglgYFLVFLETLLAPMWPS---NTARAGGILLPIIKSLLPLLG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 462 LDP-------RQVLIAEVIF-TNIGGAATAIGDPPNVIIVSNqeLRKMGLDFAGFTAHMFIGICLVlLVCFPLLRLLywn 533
Cdd:TIGR00785 142 SKPeksprkiGKYLMLGIAYsASIGSSGFLTGSAPNALAAGI--LSKILGIQISWGDWFLAGLPLG-IILLLLVPLL--- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 534 rkLYNKEPSEIvELKHEIHVWrltaqrispASREETAVRRLLLgkvlalehllarrlhtfhrqisqedknwetniqelqk 613
Cdd:TIGR00785 216 --LYVLFPPEL-KLKDEVDLW---------AKEELEEMGPMSF------------------------------------- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301385 614 KHRISDGILLakcLTVLGFVifmfflnsFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLME 693
Cdd:TIGR00785 247 REKALLGIFL---LALLLWI--------FGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2217301385 694 ALAHLHLIEYVGEqtaLLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMA 749
Cdd:TIGR00785 316 GLKKSGFIKWFSE---KLVGILDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALV 368
|
|
| |
