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Conserved domains on  [gi|2217315192|ref|XP_047293170|]
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small G protein signaling modulator 2 isoform X16 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 189-357 1.47e-98

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 307.34  E-value: 1.47e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 189 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 262
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 263 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 341
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                         170
                  ....*....|....*.
gi 2217315192 342 GTGRATDYVFRIIYPG 357
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
RUN super family cl45896
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 1-130 1.05e-84

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


The actual alignment was detected with superfamily member cd17704:

Pssm-ID: 459241  Cd Length: 180  Bit Score: 270.27  E-value: 1.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   1 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQY 80
Cdd:cd17704    51 VAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQY 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217315192  81 LAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 130
Cdd:cd17704   131 IVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 772-940 1.38e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 154.77  E-value: 1.38e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192  772 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 848
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192  849 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 926
Cdd:smart00164 127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                          170
                   ....*....|....
gi 2217315192  927 FIALALVEAYREII 940
Cdd:smart00164 202 RVALALLKLHRDVL 215
 
Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 189-357 1.47e-98

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 307.34  E-value: 1.47e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 189 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 262
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 263 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 341
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                         170
                  ....*....|....*.
gi 2217315192 342 GTGRATDYVFRIIYPG 357
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 1-130 1.05e-84

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 270.27  E-value: 1.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   1 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQY 80
Cdd:cd17704    51 VAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQY 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217315192  81 LAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 130
Cdd:cd17704   131 IVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 190-325 1.56e-50

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.01  E-value: 1.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 190 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 258
Cdd:pfam12068   1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217315192 259 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 325
Cdd:pfam12068  81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 772-940 1.38e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 154.77  E-value: 1.38e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192  772 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 848
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192  849 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 926
Cdd:smart00164 127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                          170
                   ....*....|....
gi 2217315192  927 FIALALVEAYREII 940
Cdd:smart00164 202 RVALALLKLHRDVL 215
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 773-940 1.78e-29

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 115.81  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 773 HRIDKDVQRCDRNYWYFT-PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKR------M 845
Cdd:pfam00566  10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 846 SQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAArhiSSEHFV 925
Cdd:pfam00566  90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162

                         170
                  ....*....|....*
gi 2217315192 926 LFIALALVEAYREII 940
Cdd:pfam00566 163 FRVALAILKRFREEL 177
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 1-122 1.11e-22

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 94.65  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   1 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasgkapalSPQALKHVWVRTALIEKVLDKVVQY 80
Cdd:pfam02759  33 FWALLERVGKLVPPAEELLSSVQELEQIHTPY-----------------------SPDGRGRAWIRLALNEKLLDQWLKL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217315192  81 LAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTA 122
Cdd:pfam02759  90 LLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
COG5210 COG5210
GTPase-activating protein [General function prediction only];
772-969 1.75e-20

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 96.02  E-value: 1.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 772 LHRIDKDVQRCDRNYWYF---TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMK--RMS 846
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 847 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarHISSEHFV 925
Cdd:COG5210   337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2217315192 926 LFIALALVEAYREIIRDNNMDFTDIIKFFNALHVSPQNVLSITM 969
Cdd:COG5210   414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKF 457
RUN smart00593
domain involved in Ras-like GTPase signaling;
61-117 6.44e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 6.44e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   61 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 117
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
 
Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 189-357 1.47e-98

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 307.34  E-value: 1.47e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 189 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 262
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 263 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 341
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                         170
                  ....*....|....*.
gi 2217315192 342 GTGRATDYVFRIIYPG 357
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 1-130 1.05e-84

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 270.27  E-value: 1.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   1 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQY 80
Cdd:cd17704    51 VAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQY 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217315192  81 LAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 130
Cdd:cd17704   131 IVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 1-130 7.95e-62

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 207.94  E-value: 7.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   1 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSG-VSQEALRRqgsaSGKAPALSPQALKHVWVRTALIEKVLDKVVQ 79
Cdd:cd17703    51 IAALFMKVGKSFPPAEELCRKVQELEQLLENKRNQMqGLQENVRK----MPKLPNLSPQAIKHLWIRTALFEKVLDKIVH 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217315192  80 YLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 130
Cdd:cd17703   127 YLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPS 177
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 190-325 1.56e-50

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.01  E-value: 1.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 190 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 258
Cdd:pfam12068   1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217315192 259 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 325
Cdd:pfam12068  81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 1-118 1.87e-45

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 160.91  E-value: 1.87e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   1 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSqealrrqGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQY 80
Cdd:cd17687    51 TFSLLQKVAKSCPPAADILRKVQEIENLSENKRSSSSS-------GSNSSNSHGNSSSNRKILWIRIALFEKVLDKIVDY 123

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2217315192  81 LAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTK 118
Cdd:cd17687   124 LVENASKYYEKEALMADPVDGPLLASLLVGPCALDYTK 161
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 772-940 1.38e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 154.77  E-value: 1.38e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192  772 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 848
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192  849 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 926
Cdd:smart00164 127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                          170
                   ....*....|....
gi 2217315192  927 FIALALVEAYREII 940
Cdd:smart00164 202 RVALALLKLHRDVL 215
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 773-940 1.78e-29

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 115.81  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 773 HRIDKDVQRCDRNYWYFT-PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKR------M 845
Cdd:pfam00566  10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 846 SQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAArhiSSEHFV 925
Cdd:pfam00566  90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162

                         170
                  ....*....|....*
gi 2217315192 926 LFIALALVEAYREII 940
Cdd:pfam00566 163 FRVALAILKRFREEL 177
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 1-122 1.11e-22

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 94.65  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   1 MAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasgkapalSPQALKHVWVRTALIEKVLDKVVQY 80
Cdd:pfam02759  33 FWALLERVGKLVPPAEELLSSVQELEQIHTPY-----------------------SPDGRGRAWIRLALNEKLLDQWLKL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217315192  81 LAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTA 122
Cdd:pfam02759  90 LLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
COG5210 COG5210
GTPase-activating protein [General function prediction only];
772-969 1.75e-20

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 96.02  E-value: 1.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 772 LHRIDKDVQRCDRNYWYF---TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMK--RMS 846
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 847 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarHISSEHFV 925
Cdd:COG5210   337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2217315192 926 LFIALALVEAYREIIRDNNMDFTDIIKFFNALHVSPQNVLSITM 969
Cdd:COG5210   414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKF 457
RUN smart00593
domain involved in Ras-like GTPase signaling;
61-117 6.44e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 6.44e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192   61 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 117
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 22-114 4.90e-08

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 53.20  E-value: 4.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192  22 VQELQQQAEGRKPSGVSQEA--LRRQGSASGKApalspqalkHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLA 96
Cdd:cd17671    62 LEALEKLLPAPSLKQAIRDInsLSNVKTDDGRG---------RAWIRLALNEKSLESYLAALLSDqslLRKYYEPWALLR 132

                          90
                  ....*....|....*...
gi 2217315192  97 DPVFGPILASLLVGPCAL 114
Cdd:cd17671   133 DPEEAELFLSLLVGLSSL 150
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 195-300 5.91e-07

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 48.16  E-value: 5.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315192 195 KNHVLVQPKEDMEAVPGYLSLHQSaeslTLKWTPNQLMngtlgdseleksvywDYALVVPFSQVVCIHCHQQ-KSGGTLV 273
Cdd:cd00900     2 KFRAVRVYREPTKRVEGTLYITSD----RLILRDKNDG---------------GLELSIPISDIVNVNVSPQgPSSRYLV 62

                          90       100
                  ....*....|....*....|....*..
gi 2217315192 274 LVSQDGIQRPPLHFPQGGHLLSFLSCL 300
Cdd:cd00900    63 LVLKDRGEFVGFSFPKEEDAIEISDAL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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