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Conserved domains on  [gi|2217321910|ref|XP_047295016|]
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zinc finger protein 331 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
5-46 2.12e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 2.12e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217321910   5 LVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-441 9.18e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 185 KPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKD--CGKAFRRGDELTQHQRFHTGEKDYECKDCGKtfSRVYKLIQHK 262
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 263 RIHSGEKPYECKDC------------------------------------------------------GKAFICGSSLIQ 288
Cdd:COG5048   110 LSSSSSNSNDNNLLsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 289 HKRIHTGEKPYECQECGKA---------FTRVNYLT------------------QHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSysipssssdQNLENSSSslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLPTAS 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2217321910 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC 441
Cdd:COG5048   350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSET 389
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-284 7.04e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910  32 WDVMLENYSNLVSLDLESAYENKSLptekniheirASKRNSDRRSKSLGRNwiCEGTLERPQRSRGRYVNQMIINYVKRP 111
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSS----------SSDQNLENSSSSLPLT--TNSQLSPKSLLSQSPSSLSSSDSSSSA 257
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 112 AT--REGTPPRTHQRHH-----------KENSFECKDCGKAFSRGYQLSQHQ--KIHTGE--KPYECKE--CKKAFRWGN 172
Cdd:COG5048   258 SEspRSSLPTASSQSSSpnesdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 173 QLTQHQKIHTGEKPYECKDC-------GKAFRWGSSLVIHKRIHTGEKPYEC--KDCGKAFRRGDELTQHQRFHTGEKDY 243
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2217321910 244 ECKD--CGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGS 284
Cdd:COG5048   418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
5-46 2.12e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 2.12e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217321910   5 LVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-48 6.43e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.80  E-value: 6.43e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217321910    6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLDLE 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
6-45 8.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 87.60  E-value: 8.31e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217321910   6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-441 9.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 185 KPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKD--CGKAFRRGDELTQHQRFHTGEKDYECKDCGKtfSRVYKLIQHK 262
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 263 RIHSGEKPYECKDC------------------------------------------------------GKAFICGSSLIQ 288
Cdd:COG5048   110 LSSSSSNSNDNNLLsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 289 HKRIHTGEKPYECQECGKA---------FTRVNYLT------------------QHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSysipssssdQNLENSSSslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLPTAS 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2217321910 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC 441
Cdd:COG5048   350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSET 389
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-284 7.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910  32 WDVMLENYSNLVSLDLESAYENKSLptekniheirASKRNSDRRSKSLGRNwiCEGTLERPQRSRGRYVNQMIINYVKRP 111
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSS----------SSDQNLENSSSSLPLT--TNSQLSPKSLLSQSPSSLSSSDSSSSA 257
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 112 AT--REGTPPRTHQRHH-----------KENSFECKDCGKAFSRGYQLSQHQ--KIHTGE--KPYECKE--CKKAFRWGN 172
Cdd:COG5048   258 SEspRSSLPTASSQSSSpnesdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 173 QLTQHQKIHTGEKPYECKDC-------GKAFRWGSSLVIHKRIHTGEKPYEC--KDCGKAFRRGDELTQHQRFHTGEKDY 243
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2217321910 244 ECKD--CGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGS 284
Cdd:COG5048   418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 1.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217321910 341 SLVKHERIHTGEKPYKCTECGKAFNC 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-168 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|...
gi 2217321910 146 LSQHQKIHTGEKPYECKECKKAF 168
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
5-46 2.12e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 2.12e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217321910   5 LVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-48 6.43e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.80  E-value: 6.43e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217321910    6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLDLE 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
6-45 8.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 87.60  E-value: 8.31e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217321910   6 VTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-441 9.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 185 KPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKD--CGKAFRRGDELTQHQRFHTGEKDYECKDCGKtfSRVYKLIQHK 262
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 263 RIHSGEKPYECKDC------------------------------------------------------GKAFICGSSLIQ 288
Cdd:COG5048   110 LSSSSSNSNDNNLLsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 289 HKRIHTGEKPYECQECGKA---------FTRVNYLT------------------QHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSysipssssdQNLENSSSslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLPTAS 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2217321910 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC 441
Cdd:COG5048   350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSET 389
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
32-284 7.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910  32 WDVMLENYSNLVSLDLESAYENKSLptekniheirASKRNSDRRSKSLGRNwiCEGTLERPQRSRGRYVNQMIINYVKRP 111
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSS----------SSDQNLENSSSSLPLT--TNSQLSPKSLLSQSPSSLSSSDSSSSA 257
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 112 AT--REGTPPRTHQRHH-----------KENSFECKDCGKAFSRGYQLSQHQ--KIHTGE--KPYECKE--CKKAFRWGN 172
Cdd:COG5048   258 SEspRSSLPTASSQSSSpnesdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 173 QLTQHQKIHTGEKPYECKDC-------GKAFRWGSSLVIHKRIHTGEKPYEC--KDCGKAFRRGDELTQHQRFHTGEKDY 243
Cdd:COG5048   338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2217321910 244 ECKD--CGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGS 284
Cdd:COG5048   418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-463 1.23e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 127 KENSFECKDCGKAFSRGYQLSQHQKIHTGEKPYEC--KECKKAF-RWGNQLTQHQKIHTGEKPYECKDCGKAFRWGSSLV 203
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 204 IHKRIHTGEKPYECKDCGKAFRRGDELTQHQRFHTGEKDYECKDC----GKTFSRVYKLIQHKRIHSGEKPYECKD--CG 277
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssVNTPQSNSLHPPLPANSLSKDPSSNLSllIS 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 278 KAFICG----------------SSLIQHKRIHTGEKPYECQECGKAFTRVNYLTQHQKIHTGEKPHECKECGKAFRWGSS 341
Cdd:COG5048   190 SNVSTSipsssensplsssysiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 342 LVKHERIHTGE-------KPYKCTECGKAFNCGYHLTQHER--IHTGE--TPYKCKE--CGKAFIYGSSLVKHERIHTGV 408
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 409 KPYGCTECGKSFSHG-------HQLTQHQKTHSGAKSYEC--------------------------------KECGKACN 449
Cdd:COG5048   350 SPAKEKLLNSSSKFSpllnnepPQSLQQYKDLKNDKKSETlsnscirnfkrdsnlslhiithlsfrpyncknPPCSKSFN 429
                         410
                  ....*....|....
gi 2217321910 450 HLNHLREHQRIHNS 463
Cdd:COG5048   430 RHYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-306 7.50e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 7.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 157 KPYECKECKKAFRWGNQLTQHQ--KIHTGE--KPYEC--KDCGKAFRWGSSLVIHKRIHTGEKPYECK--DCGKAFRRGD 228
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 229 ELTQHQRFH-----TGEKDYEC--KDCGKTFSRVYKLIQHKRIHSGEKPYECKD--CGKAFICGSSLIQHKRIHTGEKPY 299
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                  ....*..
gi 2217321910 300 ECQECGK 306
Cdd:COG5048   448 LCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 1.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217321910 341 SLVKHERIHTGEKPYKCTECGKAFNC 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 2.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217321910 285 SLIQHKRIHTGEKPYECQECGKAFTR 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 4.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.43e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217321910 369 HLTQHERIHTGETPYKCKECGKAFIY 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-336 7.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.90e-04
                          10        20
                  ....*....|....*....|....
gi 2217321910 313 YLTQHQKIHTGEKPHECKECGKAF 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217321910 201 SLVIHKRIHTGEKPYECKDCGKAFRR 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-421 1.25e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 269 KPYECKDCGKAFICGSSLIQHKR--IHTGE--KPYEC--QECGKAFTRVNYLTQHQKIHTGEKPHECKEC-------GKA 335
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321910 336 FRWGSSLVKHERIHTGEKPYKCT--ECGKAFNCGYHLTQHERIHTGETP--YKCKECGKAFIYGSSLVKHERIHTGVKPY 411
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
                         170
                  ....*....|
gi 2217321910 412 GCTECGKSFS 421
Cdd:COG5048   448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 1.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.36e-03
                          10        20
                  ....*....|....*....|....*
gi 2217321910 258 LIQHKRIHSGEKPYECKDCGKAFIC 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-196 1.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|...
gi 2217321910 174 LTQHQKIHTGEKPYECKDCGKAF 196
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-168 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|...
gi 2217321910 146 LSQHQKIHTGEKPYECKECKKAF 168
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 2.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.95e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217321910 229 ELTQHQRFHTGEKDYECKDCGKTFSR 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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