|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
24-472 |
0e+00 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 592.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17422 161 LVVGALQLNIVVCGALLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17422 179 ------------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAG 423
Cdd:cd17422 235 RISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALG 314
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 2462558654 424 VYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR 472
Cdd:cd17422 315 VYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
24-472 |
1.78e-107 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 324.89 E-value: 1.78e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17352 179 ------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAG 423
Cdd:cd17352 235 RILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILA--DLVGLEKLSNAYG 312
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 2462558654 424 VYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR 472
Cdd:cd17352 313 LVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
19-508 |
5.77e-86 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 272.77 E-value: 5.77e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 19 PDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGG 98
Cdd:TIGR00892 12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 99 LLVSTGMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIG 178
Cdd:TIGR00892 92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 179 WRYSLLFVGLLQLNIVIFGALLRPIfirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelTTSPKNVPTHTNLE 258
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPV-----------------------------------------GPSQRVSKSKSKEG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 259 LEPKADMQQVLVKTSPRPSEKkapLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAI 338
Cdd:TIGR00892 211 LPPDGSTKKLSKKSTAEKINR---FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 339 AEVFGRIGAGFVLNREPIR--KIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIE 416
Cdd:TIGR00892 288 VDIFARPSCGLIAGLKWIRphVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLM--DLVGAQ 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 417 KMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALvrpcKMGLCQHHHSGETKVVSHRGKT 496
Cdd:TIGR00892 366 RFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAI----GNYINYRLLAKEQKAALEREGA 441
|
490
....*....|....
gi 2462558654 497 L--QDIPEDFLEMD 508
Cdd:TIGR00892 442 RdkKDAEGDSRESE 455
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
24-468 |
4.96e-74 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 239.60 E-value: 4.96e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPIFIRGpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPG-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqVLVKTSPRPSEkkapLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17423 185 ----DPPAPPRSLSA----AFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVG 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSAAG 423
Cdd:cd17423 257 RLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPE--LVGVERVLNATG 334
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2462558654 424 VYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCL 468
Cdd:cd17423 335 LLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLIL 379
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
24-470 |
3.53e-59 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 200.00 E-value: 3.53e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPIFirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRPFC----------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsilKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17425 182 --------------------------SNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFM 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGfVLNREPI---RKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSS 420
Cdd:cd17425 236 RPLAG-LLSGLPVfkgRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM--DTVEMDRFPS 312
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 2462558654 421 AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLAL 470
Cdd:cd17425 313 ALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
24-470 |
3.01e-58 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 197.64 E-value: 3.01e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17430 180 --------------------LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIRKIYIELICVILLTVSL--FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSA 421
Cdd:cd17430 240 RPACGVVAGLKWVRPRVVYLFSFAMLFNGLtdLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMA--IVGTQKFSSA 317
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 2462558654 422 AGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLAL 470
Cdd:cd17430 318 IGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
24-468 |
1.08e-51 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 180.01 E-value: 1.08e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPIfirGPaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL---GP------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17427 183 ------------------------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFA 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIR-KI-YIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSA 421
Cdd:cd17427 239 RPSMGLVANSKWIRpRIqYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLM--DLVGAQRFSSA 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 2462558654 422 AGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCL 468
Cdd:cd17427 317 VGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
24-468 |
8.54e-50 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 175.45 E-value: 8.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPIfirGPaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPI---GP------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17426 183 -----------------KPFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVA 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIRK--IYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSA 421
Cdd:cd17426 246 RPSMGIVANTKWVRPriQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLM--DLVGAQRFSSA 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 2462558654 422 AGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCL 468
Cdd:cd17426 324 VGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
24-471 |
6.64e-45 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 161.91 E-value: 6.64e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFaVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPIfirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI------------------------------------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkapllDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17421 180 ---------------------DFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVA 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAG 423
Cdd:cd17421 239 QLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLV--DLVGVTKVNSSLG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2462558654 424 VYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALV 471
Cdd:cd17421 317 FSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLE 364
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
24-472 |
1.75e-44 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 160.75 E-value: 1.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17424 161 LILGGFVLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFG 343
Cdd:cd17424 179 ------------------------FLLMPDFLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 344 RIGAGFVLNREPIRKIYielICVILLTVSLFAFTFAteFWGLMSCSIF---FGFMVGTIGGTHIPLL--AEDDVVGIEKM 418
Cdd:cd17424 235 NITFGWLTDRRCLKKYR---YFCYLFAVGMDGLCCL--FLPILKTFPLlvpFSFTFGYFDGAYVALIpvVTSDVVGTSSL 309
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 2462558654 419 SSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR 472
Cdd:cd17424 310 SSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-472 |
1.41e-33 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 131.16 E-value: 1.41e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVAtGIISGLGYCFSFLPTVTILSQYF-GKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:COG2223 84 LLLLALAVSYWLLLLL-GLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLqlnIVIFGALLrpifirgpaspkiviqdnrkeAQYMlenektrtsidsidsgvelttspKNVPTHtnlelepka 263
Cdd:COG2223 163 LILGIL---LLVVAVLA---------------------WLFL-----------------------RDPPAG--------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktspRPSEKKAPLLDF-SILKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDQDRAAFLLSTMAIAEV 341
Cdd:COG2223 187 -----------AAAAAKASLRDQlEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGA 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 342 FGRIGAGFVLNREPIRKIYieLICVILLTVSLFAFTFATE-FWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSS 420
Cdd:COG2223 256 LGRPLGGWLSDRIGGRRVL--LIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVP--DIFPTKNAGA 331
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 2462558654 421 AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR 472
Cdd:COG2223 332 VYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
24-466 |
1.05e-32 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 128.93 E-value: 1.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGY-CFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYS 182
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 183 LLFVGLLQLNIVIFGALLRpifIRGPASPKIVIQDNRKEAqymlenektrtsidsidsgvelttspknvpthtnlelepk 262
Cdd:cd17355 161 LLVLALLALLVLVPVLLLL---RRRPADLALRAYDDASPA---------------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 263 admqqvlvktSPRPSEKKAplldfsiLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVF 342
Cdd:cd17355 198 ----------SPGSTLKEA-------LRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 343 GRIGAGFVLNRepIRKIYIELICVILLTVSLFAFTFATE-FWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSA 421
Cdd:cd17355 261 GRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGWGATVPLTAALAAR--YFGARSYGTL 336
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2462558654 422 AGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAV 466
Cdd:cd17355 337 FGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-473 |
1.47e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 116.51 E-value: 1.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 21 GGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLL 100
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 101 VSTGMVAASFSQEVSHMYVATGIIsGLGYCFSFLPTVTILSQYF-GKRRSIVTAVASTGECFAVFAFAPAIMALKERIGW 179
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLL-GLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 180 RYSLLFVGLlqlnIVIFGALLRpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlel 259
Cdd:COG2271 164 RAAFLILGL----PGLLLALLR---------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 260 epkadmqqvlvktsprpsekkaplldfsilkeksFICYALFGLFATLGFFAPSLYIIP-LGISLGIDQDRAAFLLSTMAI 338
Cdd:COG2271 182 ----------------------------------FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFL 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 339 AEVFGRIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKM 418
Cdd:COG2271 228 AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE--LFPKKAR 305
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 2462558654 419 SSAAGVYIFIQSIAGLAGPPLAGLLVDQSKiYSRAFYSCAAGMALAAVCLALVRP 473
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
24-473 |
4.16e-28 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 115.31 E-value: 4.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAF-LLSTMAIAEVF 342
Cdd:cd17429 179 ------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIF 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 343 GRIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIggTHIPLLAEdDVVGIEKMSSAA 422
Cdd:cd17429 235 GKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYF--SLMPVVTE-DLVGIKNLANAY 311
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2462558654 423 GVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLaLVRP 473
Cdd:cd17429 312 GIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICL-LLKP 361
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
24-470 |
2.44e-27 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 112.99 E-value: 2.44e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAF-LLSTMAIAEVF 342
Cdd:cd17428 179 ------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAI 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 343 GRIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGgthIPLLAEDDVVGIEKMSSAA 422
Cdd:cd17428 235 GKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS---IFPYVTTKTVGIEKLGHAY 311
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2462558654 423 GVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLAL 470
Cdd:cd17428 312 GILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
45-473 |
1.92e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 111.12 E-value: 1.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 45 FGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVATGII 124
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 125 sGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAvFAFAPAIMA-LKERIGWRYSLLFVGLLqlnIVIFGALLRPI 203
Cdd:COG2807 117 -GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLG-AALAAGLTVpLAAALGWRGALAVWALL---ALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 204 FIRGPAspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepkadmqqvlvktSPRPSEKKAPL 283
Cdd:COG2807 192 LRRRPA---------------------------------------------------------------AAAAAPAAASL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 284 LdfSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIeL 363
Cdd:COG2807 209 R--SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL-L 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 364 ICVILLTVSLFAFTFATEFWGLMSCsIFFGFMVG---TIGGTHIPLLAEDDvvgiekmSSAAGVYIFIQSIAGL---AGP 437
Cdd:COG2807 286 LLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGglfPLALTLIGLRARTP-------AEAAALSGMAQSVGYLlaaLGP 357
|
410 420 430
....*....|....*....|....*....|....*..
gi 2462558654 438 PLAGLLVDQSKIYSRAFYSCAAGMALAAVC-LALVRP 473
Cdd:COG2807 358 LLVGALHDATGSWTAALLLLAALAVLMLVAgLLAGRP 394
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
24-471 |
2.02e-25 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 108.00 E-value: 2.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSF-----NESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGG 98
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 99 LLVSTGMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIG 178
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 179 WRYSLLFVGLLQLNIVIFGALLRPifirgpaspkiviqdnrkeaqymlenektrtsidsidsgveLTTSPKNVPTHTNle 258
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRP-----------------------------------------LHPSPEDPKSKPG-- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 259 lepkadmqqvlvkTSPRPSEKKAPL---LDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLST 335
Cdd:cd17420 198 -------------RRTLHSRINLFLrkiFNVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMC 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 336 MAIAEVFGRIGAGFVLNREP-IRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVG 414
Cdd:cd17420 265 IGITSGIGRLIFGVIADMPPgVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFE--LVG 342
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462558654 415 IEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALV 471
Cdd:cd17420 343 PSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
24-471 |
9.43e-22 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 97.10 E-value: 9.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVST 103
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPifirgpaspkiviqdnrkeaqymlenektRTSIDSidsgvelttspkNVPTHTNlelepka 263
Cdd:cd17314 161 TILGILAAIVLSVVSLLGF-----------------------------KEPPDN------------QARLHVQ------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsEKKAPLLDFSILKEKSFICYALFGLFATlGFFAPSLYIIPLGISLGIDQDR-AAFLLSTMAIAEVF 342
Cdd:cd17314 193 --------------KKKTQTMGEIFRDKVFWILFIAIFLVLI-GGFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAF 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 343 GRIGAGFVLNREpIRKIYIELICVILLTVSLFAFTFATEF--WGLMSCSIFFGFMVGtiGGTHIPLLAEDDVVGIEKMSS 420
Cdd:cd17314 258 GRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYG--GLFTVYPATVSTVFGTESFAT 334
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2462558654 421 AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALV 471
Cdd:cd17314 335 LYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
25-471 |
1.54e-21 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 96.53 E-value: 1.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVeVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:cd17353 3 WLVLLGAVLM-HLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLL 184
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 185 FVGLLQLNIVIFGAllrpIFIRGPAspkiviqdnrkeaqymlenektrtsidsidsgvelttSPKNVPTHTNLELEPKAD 264
Cdd:cd17353 162 ILGIIFLIIIVIGA----FLIRDPP-------------------------------------KGWVPPGVDPLANNAENS 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 265 MQQVlvktspRPSEkkaplldfsILKEKSFIC-YALFGLFATLGFFAPSlYIIPLGISLGIDQDR-AAFLLSTMAIAEVF 342
Cdd:cd17353 201 PRDY------TPRE---------MLRTPTFWLlWLMFFLNATAGLMLIG-QAKPIGQEFAGLDAGiAALAVSILSIFNGG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 343 GRIGAGFVLNREPIRKIYIeLICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAA 422
Cdd:cd17353 265 GRPFWGWLSDKIGRKNTLS-IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTA--DFFGTKNAGTNY 341
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 2462558654 423 GVYIFIQSIAGLAGPPLAGlLVDQSKIYSRAFYSCAAGMALAAVCLALV 471
Cdd:cd17353 342 GLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-468 |
3.77e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.19 E-value: 3.77e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 31 FFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASF 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 111 SQEVSHMYVAtGIISGLGYCFSFLPTVTILSQYFGKR-RSIVTAVASTGECFAVFAFAPAIMALKERI--GWRYSLLFVG 187
Cdd:cd06174 81 APSFWLLLLG-RFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 188 LLqlniVIFGALLRPIFIRGPASPKIVIQDNRKEAQYMLENektrtsidsidsgvelttspknvpthtnlelepkadmqq 267
Cdd:cd06174 160 AL----ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL--------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 268 vlvktsprpsekkaplldFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDQDRAAFLLSTMAIAEVFGRIG 346
Cdd:cd06174 197 ------------------KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 347 AGFVLNREPIRKiYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGthIPLLAEDDVVGIEKMSSAAGVYI 426
Cdd:cd06174 259 LGLLSDRLIGRK-PLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP--LSFALIAELFPPEIRGTAFGLLN 335
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2462558654 427 FIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCL 468
Cdd:cd06174 336 TFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
25-433 |
1.38e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.11 E-value: 1.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVeVFTYGIIktfGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:COG2814 13 LALALGAFLS-GLGIGIV---LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVATgIISGLGYCFSFLPTVTILSQYF-GKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:COG2814 89 SLLCALAPSLWLLLAAR-FLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLnIVIFGALLrpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:COG2814 168 LVNAVLAL-LALLLLLR--------------------------------------------------------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvLVKTSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDQDRAAFLLSTMAIAEVF 342
Cdd:COG2814 184 -----LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 343 GRIGAGFVLNREPIRKIYIelICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSAA 422
Cdd:COG2814 259 GALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE--LAPPEARGRAS 334
|
410
....*....|.
gi 2462558654 423 GVYIFIQSIAG 433
Cdd:COG2814 335 GLYNSAFFLGG 345
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
24-455 |
2.99e-19 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 89.85 E-value: 2.99e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNS-----RISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGG 98
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDaqmrfKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 99 LLVSTGMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIG 178
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 179 WRYSLLFVGLLQLNIVIFGALLRPifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnle 258
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKP-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 259 LEPKADMQQVLVKTSPRPSEKKapLLDFSILKEKSFICYAlFGLFATL-GFFAPSLYIIPLGISLGIDQDRAAFLLSTMA 337
Cdd:cd17464 185 LVPMKKDKEGKKRKFKCPPLKK--IFNFNIWKSTGYRIWA-FGIPAALfGYFVPYVHLMNHVKERFGEDVNKEVLLMCIG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 338 IAEVFGRIGAGFVLNREP-IRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIE 416
Cdd:cd17464 262 ITSGIGRLIFGRVADYIPgVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFE--LVGAQ 339
|
410 420 430
....*....|....*....|....*....|....*....
gi 2462558654 417 KMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFY 455
Cdd:cd17464 340 NVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFY 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-437 |
1.38e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.09 E-value: 1.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 31 FFFVEVFTYGIIKTFGVFF-NDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAAS 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 110 FSQEVSHMYVAtGIISGLGYCFSFLPTVTILSQYFGK-RRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGL 188
Cdd:pfam07690 81 FASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 189 lqlnIVIFGALLRPIFIRGPASPKIviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepkadmqqv 268
Cdd:pfam07690 160 ----LSLLAAVLLLLPRPPPESKRP------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 269 lvktSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAG 348
Cdd:pfam07690 181 ----KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 349 FVLNR-EPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIF 427
Cdd:pfam07690 257 RLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS--DLAPKEERGTASGLYNT 334
|
410
....*....|
gi 2462558654 428 IQSIAGLAGP 437
Cdd:pfam07690 335 AGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-472 |
2.07e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.78 E-value: 2.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 32 FFVEVFTYGIIktfGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFS 111
Cdd:cd17325 5 LFLDMLGYGII---IPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 112 QEVSHMYVATgIISGLGYCFSFLPTVTILSQYFG-KRRSIVTAVASTGEcFAVFAFAPAIM-ALKERIGWRYSLLFVGLL 189
Cdd:cd17325 82 TSYWQLLLAR-FLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAI-GLGFLIGPLLGgLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 190 qlniVIFGALLRPIFIRGPASPKIviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepkadmqqvl 269
Cdd:cd17325 160 ----ALLALVLALLLLPEPRPPPN-------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 270 vKTSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAP--SLYIIPLGislGIDQDRAAFLLSTMAIAEVFGRIGA 347
Cdd:cd17325 180 -KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPflPLYAAELG---GLSPAQIGLLFGAQGLASALSQPPA 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 348 GFVLNRePIRKIYIeLICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIF 427
Cdd:cd17325 256 GKLSDR-IGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA--DIVPPEGRGTAMGLFNT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2462558654 428 IQSIAGLAGPPLAGLLVDQSKIYSrAFYSCAAGMALAAVCLALVR 472
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAFGFAT-PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
24-469 |
1.02e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.66 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVevfTYGIIkTFGVFfndLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGglLVST 103
Cdd:cd17475 1 ATLAQAAASLV---AQGIP-ALAPF---LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVG--LLLM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGII-SGLGYCFSFLPTVTILSQYFGKR-RSIVTAVASTGECFAVFAFAPAIMALKERIGWRY 181
Cdd:cd17475 72 GAAALLMALVGSYPVLLVLLFlVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 182 SLLFVGLLqlniVIFGALLRPIFIRGPASPKIVIQdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelep 261
Cdd:cd17475 152 AFVVAGLV----SILAAVLFWLFYREPPAASAATE--------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 262 kadmqqvlvKTSPRPSEKKAPLLDfSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIdqdrAAFLLSTMAIAEV 341
Cdd:cd17475 183 ---------SASTLLRSLKEVLRN-RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA----AGALLAVAQLGGA 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 342 FGRIGAGFVLNR--EPIRKIYIELI-CVILLTVSLFAF-TFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEK 417
Cdd:cd17475 249 LGRIGLGRVSDRvfGGRRRPVLVITaAIAAAALLVLSLlSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE--SAGPEQ 326
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 2462558654 418 MSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLA 469
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
24-455 |
3.18e-12 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 67.90 E-value: 3.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 24 GWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSR-----ISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGG 98
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 99 LLVSTGMVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIG 178
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 179 WRYSLLFVGLLQLNIVIFGallrpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnle 258
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLS------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 259 lepkadmqqvlvktsprpsekkaplLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAI 338
Cdd:cd17465 180 -------------------------LTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGA 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 339 AEVFGRIGAGFVLNREP-IRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEK 417
Cdd:cd17465 235 SSGIGRLMSGKIGDLIPgLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFE--LVGPMQ 312
|
410 420 430
....*....|....*....|....*....|....*...
gi 2462558654 418 MSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFY 455
Cdd:cd17465 313 ASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFY 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
292-473 |
9.12e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 66.54 E-value: 9.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 292 KSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTV 371
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--LLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 372 SLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSkIYS 451
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIA--DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWR 164
|
170 180
....*....|....*....|..
gi 2462558654 452 RAFYSCAAGMALAAVCLALVRP 473
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLP 186
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
270-472 |
4.14e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 4.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 270 VKTSPRPSEKKAPLLDF--SILKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDQDRAAFLLSTMAIAEVFGRIG 346
Cdd:COG2211 204 TKERPVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 347 AGFVLNREPIRKIYIelICVILLTVSLFAFTFA--TEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVV-------GIEK 417
Cdd:COG2211 284 WPRLAKRFGKKKAFI--IGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLA--DVVdydewktGRRR 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462558654 418 MSSAAGVYIFIQSIAGLAGPPLAGLLVD--------------QSKIYSRAFYSCAAGMALAAVCLALVR 472
Cdd:COG2211 360 EGLYFGIFTFAIKLGQALAGALAGLLLAlfgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
25-471 |
8.87e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 8.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVEVFTYgiikTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:COG0738 11 IAIYLLFFLWGFATA----LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVATGIIsglGYCFSFL-----PTVTILSQYFGKRR-SIVTAVASTGECFAVFAFApAIMALKERIG 178
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLL---GLGLGLLdvaanPYVAALGPETAASRlNLLHAFFSLGALLGPLLGG-LLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 179 WRYSLLFVGLLQLNIVIFGALLRpifirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnle 258
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSK--------------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 259 lepkadmqqvLVKTSPRPSEKKAPLLDF-SILKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDQDRAAFLLSTM 336
Cdd:COG0738 186 ----------LPEIEEEEEEAAGSAASLkSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLF 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 337 AIAEVFGRIGAGFVLNREPIRKIYieLICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDdvVGiE 416
Cdd:COG0738 256 WGGMTIGRFLGGFLLKRFGPVRLL--RLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDG--LG-K 330
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 2462558654 417 KMSSAAGVYIFIQSIAGLAGPPLAGLLVDQskiysrafYSCAAGMALAAVCLALV 471
Cdd:COG0738 331 RTAAAVSAVLIMGIVGGAIGPPLIGFLADA--------FGLRAAFLVPLVCYLLI 377
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
52-471 |
1.69e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.51 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 52 LMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMyVATGIISGLGYCF 131
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 132 SFLPTVTILSQYF-GKRRS----IVTAVASTGEcfavfAFAPAIMALKERIGWRYSllFVGLLQLNIVIFGALLrpifir 206
Cdd:cd17474 104 LGPLALTLIGDLFeGGERAkamgLYEAALGLGI-----AVGPLLGGLLAAISWRYP--FFLLAALIPVAFLAIL------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 207 gpaspkiviqdnrkeaqYMLENEKTrtsidsidsgvelttspknvpthtnlelepKADMQQVLVKTSPRPSEKKAPLLDF 286
Cdd:cd17474 171 -----------------FLLPEPKE------------------------------KAKSSSATKLRDLKKALRGRGLLTF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 287 SILkekSFICYalFGLFATLGFFApslyiIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREpIRKIYIELICV 366
Cdd:cd17474 204 LVS---AFLYF--FLYFAFLTYLP-----FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR-FGARRILVIGL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 367 ILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQ 446
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE--LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
410 420
....*....|....*....|....*
gi 2462558654 447 SKIYSrAFYSCAAGMALAAVCLALV 471
Cdd:cd17474 351 FGLSA-PFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
294-473 |
1.74e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.35 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 294 FICYALFGLFATLgffAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTVSL 373
Cdd:pfam07690 2 FLAAFLAALGRSL---LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 374 FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSrA 453
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA--DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-A 153
|
170 180
....*....|....*....|
gi 2462558654 454 FYSCAAGMALAAVCLALVRP 473
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
297-473 |
1.99e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.36 E-value: 1.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 297 YALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTVSLFAF 376
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLL--LGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 377 TFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSR-AFY 455
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIA--DLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFL 156
|
170
....*....|....*...
gi 2462558654 456 SCAAGMALAAVCLALVRP 473
Cdd:cd06174 157 IAAALALLAAILLLLVVP 174
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
295-473 |
3.21e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.74 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 295 ICYALFGLFATLGFFAPslyIIPLGI-SLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTVSL 373
Cdd:cd17325 1 LSLALFLDMLGYGIIIP---ILPLYAeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL--LGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 374 FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKiYSRA 453
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIA--DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAP 152
|
170 180
....*....|....*....|
gi 2462558654 454 FYSCAAGMALAAVCLALVRP 473
Cdd:cd17325 153 FLVCAALALLALVLALLLLP 172
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-471 |
8.07e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.58 E-value: 8.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVATgIISGLGYCFSFLPTVTILSQYFGKR-RSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17319 82 TALTGFATSLTSLYVLR-FLLGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 184 LFVGLLQLNIVIFGALLRPIFIrgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnlelepka 263
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQVW---------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 264 dmqqvlvktsprpsekkaplldfsilkeksFICYALFGLFATLGFFapsLYIIPLGI--SLGIDQDRAAFLLSTMAIAEV 341
Cdd:cd17319 183 ------------------------------GLALGYFGINYALYGL---LTWLPTYLkqARGFSLKQVGLLAAIPFLAGA 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 342 FGRIGAGFVLNR-EPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSS 420
Cdd:cd17319 230 IGMILGGRLSDRlLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPA--DLLPGEAAAT 307
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 2462558654 421 AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALV 471
Cdd:cd17319 308 AGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
298-471 |
1.03e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.10 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 298 ALFGLFATlGFFAPSLY-IIPL-GISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPiRKIYIELICVILLTVSLFA 375
Cdd:cd17477 193 ALLGAFVA-GFLEGAFYsLLPLyGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD-RRRVLLGCALLGALAALLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 376 FTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKiySRAFY 455
Cdd:cd17477 271 PLVPGLPLALLVLLFLWGGAAGPLYTLALALAG--DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG--PHGLF 346
|
170
....*....|....*.
gi 2462558654 456 scaagMALAAVCLALV 471
Cdd:cd17477 347 -----LFLAAVALLFL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
23-200 |
1.56e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.89 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 23 WGWAVAVSF-FFVEVFTYGIIktfGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLV 101
Cdd:COG0477 13 RRALLALALgTFLEGLDFTIV---NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 102 STGMVAASFSQEVSHMYVAtGIISGLGYCFSFLPTVTILSQYF-GKRRSIVTAVASTGECFAvFAFAPAIM-ALKERIGW 179
Cdd:COG0477 90 GLASLLCGLAPSPELLIAA-RALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLG-LALGPLLGgLLVAALGW 167
|
170 180
....*....|....*....|.
gi 2462558654 180 RYSLLFVGLLQLNIVIFGALL 200
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-467 |
1.93e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.32 E-value: 1.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 51 DLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEvSHMYVATGIISGLGYC 130
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 131 FSFLPTVTILSQYFGK-RRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLlqLNIVIFGALLRPifirgpa 209
Cdd:cd17324 103 GFWAIAAAYAADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV--LALLAALLLWRL------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 210 spkiviqdnrkeaqymlenektrtsidsidsgveLTTSPKNVPTHTNLELEPKAdmqqvlvktsprpsekkaplldfsIL 289
Cdd:cd17324 174 ----------------------------------LPSLPPKKPGSLGLLSSLLL------------------------LL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 290 KEKSFICYALFGLFATLGFFAPSLYIIPLGISL-GIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyieLICVIL 368
Cdd:cd17324 196 RNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL---LIALLL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 369 LTVSLFAFTFATEFWGLMSCSIFF----GFMVGTIGGTHIPLLAEDDVvgiekmSSAAGVYIFIQSIAGLAGPPLAGLLV 444
Cdd:cd17324 273 LAAALLLLTLLGPSPLLLLVGLVLwglgFFAAHSALQTRVLRLAPEAR------GLASSLYLAAYNLGGALGAALGGLVL 346
|
410 420
....*....|....*....|...
gi 2462558654 445 DQSKiYSRAFYSCAAGMALAAVC 467
Cdd:cd17324 347 DHGG-WAGVGWVGAALLLLALLL 368
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
299-499 |
1.01e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.01 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 299 LFGLFATLGFFAPSLYII-----PLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTVSL 373
Cdd:cd17324 1 LLALALAAFAIGTTEYVIqgllpDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL--LVLLLLFILGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 374 FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKiYSRA 453
Cdd:cd17324 79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA--DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAA 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2462558654 454 FYSCAAGMALAAVCLALVRPcKMglcQHHHSGETKVVSHRGKTLQD 499
Cdd:cd17324 156 FLAIAVLALLAALLLWRLLP-SL---PPKKPGSLGLLSSLLLLLRN 197
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-201 |
1.93e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.88 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVEVFTYGIIKTFGVFFNDLmdsFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAEL---GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVATgIISGLGYCFSFLPTVTILSQYFGKR-RSIVTAVASTGECFAvFAFAPAIM-ALKERIGWRYS 182
Cdd:cd17325 279 LLLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPPEgRGTAMGLFNTAFSLG-MVLGPLLGgFLYDAFGFATP 356
|
170
....*....|....*....
gi 2462558654 183 LLFVGLLQLNIVIFGALLR 201
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
265-466 |
3.67e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.13 E-value: 3.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 265 MQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQdrAAFLLSTMAIAEVFGR 344
Cdd:cd17489 167 VFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN--AGLFFTVYAIALLLSR 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 345 IGAGFVLNRepIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIggthIP-LLAED-DVVGIEKMSSAA 422
Cdd:cd17489 245 PFSGKLSDR--KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLL----FPaLQALAvDLVPPHRRGAAN 318
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2462558654 423 GVYIFIQSIAGLAGPPLAGLLVDQSKIysRAFYSCAAGMALAAV 466
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELFGY--RAMFLLAAVVVLLAL 360
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
71-468 |
4.74e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.77 E-value: 4.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 71 VFVLTFS--APLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVATGIIS-GLGYCFSFLPTvtILSQYF-GK 146
Cdd:cd17328 42 VFIISYMvlSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGiGEASYSPIAPT--IIADLFpKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 147 RRSIVTAV---ASTGECFAVFAFAPAIMALKerIGWRYSLLFVGLLQlniVIFGALLRpIFIRGPAspkiviqdnRKEAQ 223
Cdd:cd17328 120 KRTRALGVfyfAIPLGSGLGYVVGGLVAQAT--GGWRWAFRVTGVLG---VLLAILLL-LFVREPP---------RGAAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 224 YMLENEKTRTSIdsidsgvelttspknvpthtnlelepKADMQQVLvktsprpsekkaplldfsilKEKSFICYAL---F 300
Cdd:cd17328 185 GGVMAKSTATSF--------------------------LADLKALA--------------------KNPSFILSTLgftA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 301 GLFAT--LGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIE--------LICVILLT 370
Cdd:cd17328 219 VSFVTgaLAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADplvcavglLAAAPFLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 371 VSL-FAFTFATEFWGLMSCSIFFGFMvgtiggTHIPLLAEDDVVGIEKM-SSAAGVYIFIQSIAGLAGPPLAGLLV---- 444
Cdd:cd17328 299 LALvLALSNLLLAWVLLFLGEFLLSL------NWAPVFAILLYVVIPTRrSTASAIQILLSHLLGDAGSPYLIGLIsdll 372
|
410 420 430
....*....|....*....|....*....|..
gi 2462558654 445 --------DQSKIYSRAFYSCAAGMALAAVCL 468
Cdd:cd17328 373 rqnkdsplAEAASLQYALLLCSFVLVLGGFFF 404
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
46-196 |
2.39e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.42 E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 46 GVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVsHMYVATGIIS 125
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSV-LQLALLRFLT 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462558654 126 GLGYCFSfLPTV-TILSQYF-GKRRSIVTAVASTGecFAVFAFAPAIMA--LKERIGWRYSLLFVGLLQLNIVIF 196
Cdd:cd17365 98 GLGLGAA-MPNAiTLVSEYApARRRSLAVTLMFCG--YPLGAALGGFLAaaLIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
25-201 |
2.75e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.39 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVeVFTYGIIKTFGVFFndLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:COG0738 213 LLGGLAIFLY-VGAEGAIGDWLPLY--LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSqevSHMYVATGIISGLGYCFSFL-PTV-TILSQYFGKRR----SIVTAVASTGecfavFAFAPAIM-ALKERI 177
Cdd:COG0738 290 LLLALLA---PGPWLALIGLALVGLGLSLMfPTIfSLALDGLGKRTaaavSAVLIMGIVG-----GAIGPPLIgFLADAF 361
|
170 180
....*....|....*....|....
gi 2462558654 178 GWRYSLLFVGLLQLNIVIFGALLR 201
Cdd:COG0738 362 GLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
287-472 |
4.13e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.68 E-value: 4.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 287 SILKEKSFICYALFGLFATLGFFAPSLYI-IPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelIC 365
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLpVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILM--IG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 366 VILLTVSLFAFTFATEFWGLMSCSIFFGF---MVGTIGGTHIPLLAEDDVVGiekmsSAAGVYIFIQSIAGLAGPPLAGL 442
Cdd:cd17329 273 ILLFAIGFAVLAFANTLAVLILAMIVLTLgemLVFPAVQTLVAALAPPDKRG-----SYMGFYALAWGLGRAIGPLVGGL 347
|
170 180 190
....*....|....*....|....*....|
gi 2462558654 443 LVDQSkIYSRAFYSCAAGMALAAVCLALVR 472
Cdd:cd17329 348 LLDLL-GPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
281-446 |
4.16e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 281 APLLDFSILKEKSFICYALFGLFATLGFFApSLYIIP--LGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK 358
Cdd:cd17503 167 APLLDLRLFKDRNFTLGLLLSFLLGLGLFG-AMFLLPlyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 359 IYIelICVILLTVSLFAFTFATE---FWGLMSCSIFFGFMVG-------TIGGTHIPllaeddvvgIEKMSSAAGVYIFI 428
Cdd:cd17503 246 LLL--AGLLLLALGTLLLAFLTPdtsLWLIILPLFIRGLGMGlvfmplnTLALNSLP---------PEQIGDATALFNTI 314
|
170
....*....|....*...
gi 2462558654 429 QSIAGLAGPPLAGLLVDQ 446
Cdd:cd17503 315 RQLGGSIGTALLATLLTN 332
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
63-180 |
5.91e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.70 E-value: 5.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 63 ISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVShMYVATGIISGLGYCFSFLPTVTILSQ 142
Cdd:cd06179 34 STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVN-MLIGGQALIGIGAGTQGLGAAVASEL 112
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2462558654 143 YFGKRRSIVTAVASTGeCFAVFAFAPAI---MALKERIGWR 180
Cdd:cd06179 113 VPNKYRGLVQGVVNLV-ASPGSALGPLIagaLVEANAAGWR 152
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
268-466 |
5.98e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 5.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 268 VLVKTSPRPSEKKAPLLDFSILK-EKSFICYALFGLFATLGFFAPSLYIIPLGiSLGIDQDRAAFLLSTMAIAEVFGRIG 346
Cdd:cd17370 175 FVVKEYPRPPKLRKKSKKTSLKKlPKAFWLYLLAVALFALGNFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYP 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 347 AGFVLNREPIRKIYIelICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSSAAGVYI 426
Cdd:cd17370 254 AGRLSDRIGRKKLLI--LGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA--DLVPAELRGTAYGLFN 329
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2462558654 427 FIQSIAGLAGPPLAGLLVDQSKiYSRAFYSCAAGMALAAV 466
Cdd:cd17370 330 TVVGIGWLLASLIAGYLWDLIS-PSAAFLFSAVLALIALL 368
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
301-466 |
7.52e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 7.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 301 GLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTVSLFAFTFAT 380
Cdd:cd06173 218 ALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL--IGALLLGLALLVLGLSP 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 381 EFWGLMSCSIFFGFMVGTIG---GTHIPLLAEDDVVGiekmsSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIySRAFYSC 457
Cdd:cd06173 296 SLWLLLAALFLLGLAGGLFNvplNTLLQLRVPDELRG-----RVFSVYNALNSGAMPLGALLAGLLADALGL-SAVFLLA 369
|
....*....
gi 2462558654 458 AAGMALAAV 466
Cdd:cd06173 370 GALLLLAAL 378
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
51-204 |
9.90e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 9.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 51 DLMDSFNESNSRISWIISIcvFVLTFSA--PLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVShMYVATGIISGLG 128
Cdd:cd17321 21 TIARDLGASPSQLQWVVNA--YLLAFAAllLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA-FLIAARALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 129 YCFSFLPTVTILSQYF-GKRR----SIVTAVASTGecfavFAFAPAIM-ALKERIGWRySLLFVGLLqlnIVIFGALLRP 202
Cdd:cd17321 98 AAAIMPASLALIAATFpGERRgralGLWGAVVGIG-----AALGPLLGgLLLELFGWR-WIFLINVP---IGLVALLLAR 168
|
..
gi 2462558654 203 IF 204
Cdd:cd17321 169 TF 170
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
299-468 |
1.16e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 299 LFGLFATLGFFAPSLYII--PLGIS--LGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNRepIRKIYIELICVILLTVSLF 374
Cdd:cd17471 203 LLFAAFTLLFAANSMYIIamPLYVTneLGGSESWVGLLFGLAAALEIPIMLLAGLLAKR--FGKRRLLLAGFLAGVLFYL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 375 AFTFATEFWGLMSCSIFFGFMVGTIGGthipllaeddvVGI--------EKMSSAAGVYIFIQSIAGLAGPPLAGLLVdQ 446
Cdd:cd17471 281 GLALATSLWQLIALQLLNAIFIGITAG-----------LGIsyfqdlmpGQPGLATTLYSNASRIGSLLGGLLAGVIA-Q 348
|
170 180
....*....|....*....|..
gi 2462558654 447 SKIYSRAFYSCAAGMALAAVCL 468
Cdd:cd17471 349 YFGYRAVFLVCAVLALLALVLL 370
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
37-471 |
1.36e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.23 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 37 FTYGIIKTF-GVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVS 115
Cdd:cd17333 6 FSNGLTDALlGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 116 HMYVATGIIsglGYCFSFLPTV--TILSQYFGKRRSIVTAVASTGECFAVFAFaPAIMALKERIGWRYSLLFVGLLQLNI 193
Cdd:cd17333 86 LFVVLMFLA---GLGAGILDTGanTFVGALFEESSATRLNVLHGFFGLGALIG-PLIATSLLTSELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 194 VIFGALLRPIFirgpaspkiviqdnrkeaqymlenektrtsidsidsgvelttspknvpthtnLELEPKADMQQVLVKTS 273
Cdd:cd17333 162 LLAILILLTLF----------------------------------------------------PELPSARNPQQSVGAFS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 274 PRPSEKK--APLLDFSILkeksFICYAlfGLFATLGFFAPSLYIIPLGISLGIdqdrAAFLLSTMAIAEVFGRIGAGFVL 351
Cdd:cd17333 190 ASASRLLrnPSIILGALA----LFLYV--GAETAFSSWVPSYLVEKKHVSDGL----AGYLLSGFWVGITIGRLLGGPIS 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 352 NREPIRKiYIELICV---ILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIpllaedDVVGIEKmSSAAGVYIFI 428
Cdd:cd17333 260 RRIKPHT-LLVLSGSgalLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGI------SNLPYAK-GKGTSVLLAA 331
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 2462558654 429 QSIAGLAGPPLAGLLVDQSKIYSraFYSCAAGMALAAVCLALV 471
Cdd:cd17333 332 GSIGGAIIPFIMGFIAEAVGIQT--AMLLITILYAIIFVLALL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
295-475 |
1.41e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.12 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 295 ICYALFGLFATLGFFAP--SLYIIPLGISLGIdqdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTVS 372
Cdd:cd17489 1 ILLANFFFFLSFYLLLPvlPLYAHDLGGSEAV----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLL--LIGLLIFALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 373 LFAFTFATEFWGLMSCSIFFGF---MVGTIGGTHIpllaeDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSkI 449
Cdd:cd17489 75 TLLYLLATSVALLLVLRLIHGIgwgAFTTAAATLV-----ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-G 148
|
170 180
....*....|....*....|....*.
gi 2462558654 450 YSRAFYSCAAGMALAAVCLALVRPCK 475
Cdd:cd17489 149 FAVLFIVAAVLALLALLLVFLVKDPP 174
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
286-469 |
3.34e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 3.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 286 FSILKEKSFICYALFGLFATLGFF-----APSLYIIPLGISLGIdqdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY 360
Cdd:cd17320 195 KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQLGLSPAQ----FGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 361 IE---LICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGG--THIPLLAEDDVVGiekmsSAAGVYIFIQSIAGLA 435
Cdd:cd17320 271 RLgllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPnaTSLALEPFPHVAG-----TASALLGFLQFLIGAL 345
|
170 180 190
....*....|....*....|....*....|....
gi 2462558654 436 GPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLA 469
Cdd:cd17320 346 AGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
52-440 |
3.51e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 43.14 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 52 LMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVATGIISGLGYCF 131
Cdd:TIGR00711 28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 132 SFLPTVTILSQYFGKRRSIVTAVASTGECFAVfAFAPAIMA-LKERIGWR---YSLLFVGLLQLNIVIF----------- 196
Cdd:TIGR00711 108 IPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAP-ALGPTLGGwIIENYHWRwifLINVPIGIIVVVVAFFilprdkpaase 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 197 -----GALLrpiFIRGPASPKIVIQDNRKEAqYMLENEKTRTSIDSIDSGVELTTSPKnvpTHTNlelepkadmqqvlvk 271
Cdd:TIGR00711 187 nfdflGLLL---LSVGLGSLLYGLSEGPERG-WFDSNEILILSITGLVAIIAFVVWEL---TDDN--------------- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 272 tsprpsekkaPLLDFSILKEKSFICYALFGLFATLGFFApSLYIIPLGIS--LGIDQDRAAFLLSTMAIAEVFGRIGAGF 349
Cdd:TIGR00711 245 ----------PLVDLRLFKYRNFTIGCVYMSLLGLGLYG-SFYLLPLYLQqvLGYTALQAGLHILPVGLAPMLSSPIAGR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 350 VLNREPIRKIYIELICVILLTVSLFAFTFA--TEFWGLMSCSIFFGFMVGTIggtHIPLL-AEDDVVGIEKMSSAAGVYI 426
Cdd:TIGR00711 314 MGDKIDPRKLVTIGLILYAVGFYWRAFTFTpdTPFLAIALPQFIRGFGMGCF---FMPLTtIALSGLPPHKIARGSSLSN 390
|
410
....*....|....
gi 2462558654 427 FIQSIAGLAGPPLA 440
Cdd:TIGR00711 391 FTRQLGGSIGTALI 404
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
25-196 |
3.84e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.65 E-value: 3.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVATGiISGLGYCFSFLPTVTILSQYFG-KRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSL 183
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWG-LNGLFQSMGWPPCVKLLGNWFSkKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170
....*....|...
gi 2462558654 184 LFVGLLQLNIVIF 196
Cdd:cd17312 161 LVPGIVGLVVAII 173
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-173 |
3.98e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 23 WGWAVAVSFFFVevFTYGIIKTFGVFFndLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVS 102
Cdd:COG2211 230 FLLLLLAYLLFF--LALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 103 TGMVAASFSQEVSH-MYVATGIISGLGY------CFSFLPTVTILSQY-FGKRR-SIVTAVASTGECFAvFAFAPAIMAL 173
Cdd:COG2211 306 LGLLLLFFLGPGNLwLLLVLAALAGIGLgailvlPWAMLADVVDYDEWkTGRRReGLYFGIFTFAIKLG-QALAGALAGL 384
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
281-472 |
4.46e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.56 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 281 APLLDFSILKEKSFICYALFGLFATLGFFA-----PSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREP 355
Cdd:cd17504 166 VPLIDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 356 IRKIYIelICVILLTVSLFAF-TFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSAAGVYIFIQSIAGL 434
Cdd:cd17504 246 PRRVLL--IGLVISAVGLLLLaLLHSSLWALVVALLLIGIGLGLAFASLPNIVVE--SVPPDRTGIATGMNTVLRTIGSA 321
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2462558654 435 AGPPLAGLLVDQSKI------------YSRAFYSCAAGMALAAVCLALVR 472
Cdd:cd17504 322 IGPAIAGAILTTYTVsitsggvptegaYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
274-472 |
7.29e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 7.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 274 PRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISL------GIDQDRAAFLLSTMAIAEVFGRIGA 347
Cdd:cd17473 174 PEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFllqergGGSAALIGLALAIASLAGAIGALLF 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 348 GFVLNRepIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSAAGVYIF 427
Cdd:cd17473 254 GRLKRR--LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS--LVPPELRGRAMGIVTS 329
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2462558654 428 IQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR 472
Cdd:cd17473 330 AFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
331-474 |
9.19e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 41.44 E-value: 9.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 331 FLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFmVGTIGGTHIPLLaED 410
Cdd:cd17390 212 YLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSI-SSAVLRTCSTSL-LL 289
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462558654 411 DVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFyscAAGMALAAVCLALVRPC 474
Cdd:cd17390 290 SRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLL---GAVLALAAILLMLARQR 350
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-201 |
9.38e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.49 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVEVFTYGIIKTFGVFfndlMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:cd17355 213 WLLALAFFLCGFAVVGLIVHLVPY----LADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 105 MVAASFSQEVSHMYVATGIISGLGYCFSFLPTVTILSQYFGKRR-----SIVTAVASTGECFAVFAFApaimALKERIGw 179
Cdd:cd17355 289 LALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSygtlfGLVFAPHQLGSALGPWLGG----LLYDRTG- 363
|
170 180
....*....|....*....|..
gi 2462558654 180 RYSLLFVGLLQLNIVIFGALLR 201
Cdd:cd17355 364 SYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
297-473 |
1.05e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 297 YALFGLFATLGFFAPSLYIIPLGISLgIDQDRAAFLLSTMAIAEVFGRIG----AGFVLNREPIRKIYI---ELICVILL 369
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLV-LQLTGSALLVGLVLAAFFLPFLLfspfAGVLADRFDRRRLLIladLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 370 TVSLFAFTFATEFWGLMscsiFFGFMVGTIGGTHIP----LLAEddVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVD 445
Cdd:cd06173 80 VLALLALLGSLSLWLLL----VLAFLLGIASAFFGParqaLLPE--LVPKEQLVRANALNSLATQLARIIGPALGGLLVA 153
|
170 180
....*....|....*....|....*...
gi 2462558654 446 QSKIYSrAFYSCAAGMALAAVCLALVRP 473
Cdd:cd06173 154 LLGPGG-AFAINALSFLLSALLLLFIRR 180
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
293-472 |
1.61e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.62 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 293 SFICYALFGLFATLGFFAPSLYiIPL---GIsLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK--IYIELICVI 367
Cdd:cd17502 168 TILLSSIFGFLFGGALFGLIYY-LPLyfqLV-LGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKplIVIGTILMS 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 368 LLTVSLFAFTFATEFWGLMSCSIFFGFMVGTigGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAgllvdqs 447
Cdd:cd17502 246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGI--GFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT------- 316
|
170 180
....*....|....*....|....*
gi 2462558654 448 kiysRAFYSCAAGMALAAVCLALVR 472
Cdd:cd17502 317 ----DVFLVALALAALAFLLSLFLP 337
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
42-191 |
1.70e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 40.64 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 42 IKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSqEVSHMYVAT 121
Cdd:cd17339 15 ITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLG-GIALLFLGT 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462558654 122 GIIsGLGYCFS--FLPTVtiLSQYFGKRRSIVTAVASTGECFAVfAFAPAIMALKER---IGWRYSLLFVGLLQL 191
Cdd:cd17339 94 ALA-GAGIAVGnvLLPSL--IKRDFPRRVGLMTGLYTTSMNLGA-ALASGLSVPLAQalgGGWRGALAIWALPAL 164
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
292-469 |
1.78e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 292 KSFICYALFGLFATLGFFAPSLYIiP--LGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILL 369
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFL-PtyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 370 TVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEkmSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKI 449
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR--ATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 2462558654 450 YSRAFYSCAAGMALAAVCLA 469
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
37-443 |
2.51e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 40.32 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 37 FTYGIIKTFGVFFND-LMDSFNE------SNSRISWIISICVFVL----TFSAPLATVLSNRFGHRLVVMLGGLL--VST 103
Cdd:cd17357 14 YNIGVVNAPQEVFKEfINDTLVDryglnlSDSELDLLWSLIVSIFfiggAIGSFISAFLANRFGRKNGLLISNALlvVSS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 104 GMVAASFSQEVSHMYVATGIISGL--GYCFSFLPT-VTILSQYfgKRRSIVTAVASTGECFAVfaFAPAIMALKERIG-- 178
Cdd:cd17357 94 LLMFLSKSAKSPELLIFGRFLVGIacGLSTGFVPMyLQEISPS--ELRGALGSLTQIGVTLGI--LLGQVFGLPSVLGte 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 179 --WRYSLLFVGLlqlnIVIFGALLRPIFirgPASPK-IVIQDNRKEA-----QYmLENEKTRTSIDSIDSGVELT--TSP 248
Cdd:cd17357 170 tlWPYLLFFPGI----PALLQLAALPFF---PESPKfLLISKGDEEEaekslKF-LRGIEDDVDQELEEIKKESEqmGDQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 249 KNVpthtnlelepkaDMQQVLVKTSPRpsekkaplldfsilKEKSFICYALFGLfATLGFFAPSLYIIPLGISLGIDQDR 328
Cdd:cd17357 242 KQV------------SLMQLLRDPSLR--------------LPLLLVLVVSASQ-QFSGINAIFFYSTFIFENAGFSPQL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 329 AAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIE-----LICVILLTVSLFAFTFATEF-WGLMSCSIFFGFMVGtIGGT 402
Cdd:cd17357 295 AEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLIslsvcAVALLLMSVFLFLSEQNSWMsYGCIVAIFLFIFFFA-IGLG 373
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 2462558654 403 HIPLLAEDDVVGIEKMSSAAGVYIFIQSIA----GLAGPPLAGLL 443
Cdd:cd17357 374 PIPWFIGAELFPQAPRSAAQSLGSSVNWTSnfivGMAFPPLQSIG 418
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
44-473 |
2.70e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.98 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 44 TFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVATgI 123
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR-A 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 124 ISGLGYCFSFLPTVTILSQYF-----GKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSllfvgllqlniVIFGA 198
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVparhrGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVL-----------FLLGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 199 LlrpifirgPASPKIVIQDNRKEAQYMLENEKTRTSIDSIDSGVELttspknvpthtnlelepkadmqqvlvktsprpse 278
Cdd:cd17371 165 L--------PALLVLFIRRFVKEPPQWQAARAARRHFADRPSLREL---------------------------------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 279 KKAPLLDFSILKEKSFICyALFGLFATLGFFaPSLYIIPLGISLGidqdRAAFLLSTMAIAEVFGRIGAGF---VLNREP 355
Cdd:cd17371 203 FSPPLLRTTLLASLLATG-ALGGYYGITTWL-PSYLTGERGLSFE----GSAGYLVVTILGGFLGYLAGGFladRIGRRN 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 356 IRKIYIELICVILLTVSLFAFTFaTEFWGLMscsIFFGFMVGTIGGTHIPLLAEDDVVGIeKMSSAAGVYIFIQSIAGLa 435
Cdd:cd17371 277 NFALFALGSAISILLYFFLPLSP-TLILILG---FPLGFFASGPFSGMGAYLTELFPTAV-RATAQGFCYNVGRIIGAL- 350
|
410 420 430
....*....|....*....|....*....|....*...
gi 2462558654 436 GPPLAGLLVDQSKIYSrAFYSCAAGMALAAVCLALVRP 473
Cdd:cd17371 351 FPFLVGFLATSGSLGT-AIAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
290-470 |
3.82e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 290 KEKSFICYALFGLFATLGFFAPSLYI------------IPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIR 357
Cdd:cd17313 232 MPRSLLRLLLVIFFWWIAFFPFELFFtdymgeevyhgtSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRK 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 358 KIYieLICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGP 437
Cdd:cd17313 312 KVY--LIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILVS 389
|
170 180 190
....*....|....*....|....*....|...
gi 2462558654 438 PLAGLLVDqSKIYSRAFYSCAAGMALAAVCLAL 470
Cdd:cd17313 390 LLAGPIID-VKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-129 |
6.32e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 25 WAVAVSFFFVEvFTYGIIKTFGVFFndlMDSFNESNSRISWIISICVFVLtfSAPLATVLSNRFGHRLVVMLGGLLVSTG 104
Cdd:cd17489 197 LPPALILFLAS-IAYGAISTFLPLY---AAERGISNAGLFFTVYAIALLL--SRPFSGKLSDRKGPKTVIIPGLLLLALG 270
|
90 100
....*....|....*....|....*
gi 2462558654 105 MVAASFSQEVSHMYVAtGIISGLGY 129
Cdd:cd17489 271 LLLLSFAGSPWMLLLA-AVLYGLGF 294
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
294-471 |
9.26e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 9.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 294 FICYALFGLFATLGFFAPSlyiiplgiSLGIDQDRAAFLLSTMAIAEVFGRIG-AGFVLNREPIRKIYIelICVILLTVS 372
Cdd:cd17330 185 LIALAFAGLESVFSLFLKD--------RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLR--LGLLLAIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 373 LFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEddVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLvdQSKIYSR 452
Cdd:cd17330 255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK--SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL--YSFLGPG 330
|
170
....*....|....*....
gi 2462558654 453 AFYSCAAGMALAAVCLALV 471
Cdd:cd17330 331 VPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
270-443 |
9.95e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.35 E-value: 9.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 270 VKTSPRPSEKKAPLLDF-SILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAG 348
Cdd:cd17332 198 VVPPEEEKSKLPLLKSLkALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWP 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558654 349 FVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAedDVVGIEKMSS-------A 421
Cdd:cd17332 278 PLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA--DVIDYGELKTgkrregiF 355
|
170 180
....*....|....*....|..
gi 2462558654 422 AGVYIFIQSIAGLAGPPLAGLL 443
Cdd:cd17332 356 YSVMTFFRKLGLALAGALVGLI 377
|
|
| |
