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Conserved domains on  [gi|2462561445|ref|XP_054175077|]
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rho GTPase-activating protein 28 isoform X3 [Homo sapiens]

Protein Classification

rho GTPase-activating protein( domain architecture ID 10138216)

rho GTPase-activating protein (GAP) acts by converting Rho-type GTPases to an inactive GDP-bound state, similar to human Rho GAP 18 that suppresses F-actin polymerization by inhibiting Rho

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-536 6.39e-118

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239856  Cd Length: 216  Bit Score: 351.26  E-value: 6.39e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAA 404
Cdd:cd04391     1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 405 VMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 484
Cdd:cd04391    81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462561445 485 TVMAPNLFFSRSKHS-----DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVR 536
Cdd:cd04391   160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-536 6.39e-118

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 351.26  E-value: 6.39e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAA 404
Cdd:cd04391     1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 405 VMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 484
Cdd:cd04391    81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462561445 485 TVMAPNLFFSRSKHS-----DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVR 536
Cdd:cd04391   160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 347-496 1.31e-42

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 150.77  E-value: 1.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 347 PLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFkWDKMCHREAAVMLKAFFRELPTSLFPVEYIPA 426
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLD-LEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 427 FISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS 496
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 346-502 9.80e-33

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 124.30  E-value: 9.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445  346 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELD--AKFNADKFKWDKMChreAAVMLKAFFRELPTSLFPVEY 423
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462561445  424 IPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYE 502
Cdd:smart00324  80 YEEFIEAAKLEDETE-RLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASL 157
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-536 6.39e-118

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 351.26  E-value: 6.39e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAA 404
Cdd:cd04391     1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 405 VMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 484
Cdd:cd04391    81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462561445 485 TVMAPNLFFSRSKHS-----DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVR 536
Cdd:cd04391   160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 347-496 1.31e-42

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 150.77  E-value: 1.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 347 PLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFkWDKMCHREAAVMLKAFFRELPTSLFPVEYIPA 426
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLD-LEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 427 FISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRS 496
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 347-520 8.51e-38

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 138.20  E-value: 8.51e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 347 PLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDA-KFNADKFKWDkmCHrEAAVMLKAFFRELPTSLFPVEYIP 425
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRgEDIDDLEDYD--VH-DVASLLKLYLRELPEPLIPFELYD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 426 AFISLMERGPHvKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFfsRSKHSDYEELL 505
Cdd:cd00159    78 EFIELAKIEDE-EERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLL--RPPDSDDELLE 154

                         170
                  ....*....|....*
gi 2462561445 506 LANTAAHIIRLMLKY 520
Cdd:cd00159   155 DIKKLNEIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 346-502 9.80e-33

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 124.30  E-value: 9.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445  346 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELD--AKFNADKFKWDKMChreAAVMLKAFFRELPTSLFPVEY 423
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462561445  424 IPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYE 502
Cdd:smart00324  80 YEEFIEAAKLEDETE-RLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASL 157
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 326-492 1.54e-26

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 107.10  E-value: 1.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDrkkdpGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKF------NADKFKWDKMC 399
Cdd:cd04398     1 FGVPLEDLILRE-----GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPlnvlliSPEDYESDIHS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 400 hreAAVMLKAFFRELPTSLFPVEYIPAFI-SLMERGPHVKVQFqaLHLMVMALPDANRDAAQALMTFFNKVIANESKNRM 478
Cdd:cd04398    76 ---VASLLKLFFRELPEPLLTKALSREFIeAAKIEDESRRRDA--LHGLINDLPDANYATLRALMFHLARIKEHESVNRM 150

                         170
                  ....*....|....
gi 2462561445 479 SLWNISTVMAPNLF 492
Cdd:cd04398   151 SVNNLAIIWGPTLM 164
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 322-529 3.97e-25

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 104.04  E-value: 3.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 322 DNGIFGVPLTVLLdgdrkKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHR 401
Cdd:cd04375     1 DKNVFGVPLLVNL-----QRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIES--STDNVNYDGQQAY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 402 EAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPhVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLW 481
Cdd:cd04375    74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVP-KEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTAT 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462561445 482 NISTVMAPNLFF-----------SRSKHSDY------EELLLANTAAHI-IRLMLKYQKILWKVPS 529
Cdd:cd04375   153 NLAVCLAPSLFHlntsrrensspARRMQRKKslgkpdQKELSENKAAHQcLAYMIEECNTLFMVPK 218
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 326-518 1.11e-23

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 98.62  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDgdRKKDpgvKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREEL--DAKFNADKFKWDKMCHREA 403
Cdd:cd04403     1 FGCHLEALCQ--RENS---TVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVdhDEKLDLDDSKWEDIHVITG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 404 AvmLKAFFRELPTSLFPVEYIPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNI 483
Cdd:cd04403    76 A--LKLFFRELPEPLFPYSLFNDFVAAIKL-SDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNL 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462561445 484 STVMAPNLFfsrskHSDYEElllANTAAH------IIRLML 518
Cdd:cd04403   153 AIVFGPTLL-----RPEQET---GNIAVHmvyqnqIVELIL 185
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 326-489 3.65e-23

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 97.12  E-value: 3.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRKkdpgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAV 405
Cdd:cd04377     1 FGVSLSSLTSEDRS------VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDT--DPDSVNLEDYPIHVITS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 406 MLKAFFRELPTSLFPVEYIPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 485
Cdd:cd04377    73 VLKQWLRELPEPLMTFELYENFLRAMEL-EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAI 151


                  ....
gi 2462561445 486 VMAP 489
Cdd:cd04377   152 VFAP 155
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-514 7.04e-23

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 96.38  E-value: 7.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTVLldgDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMChrEAA 404
Cdd:cd04393     2 VFGVPLQEL---QQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVC--SAA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 405 VMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIS 484
Cdd:cd04393    77 SLLRLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLA 156

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462561445 485 TVMAPNLFFSRSKHSDYEELLLAN-TAAHII 514
Cdd:cd04393   157 AVFGPDVFHVYTDVEDMKEQEICSrIMAKLL 187
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 345-528 9.68e-23

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 96.74  E-value: 9.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 345 KVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYI 424
Cdd:cd04376     8 QVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 425 PAFISLMERGPhvKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANE-----------SKNRMSLWNISTVMAPNLfF 493
Cdd:cd04376    86 TAFIGTALLEP--DEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPNL-L 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462561445 494 SRSKHSDYEELLLANTAAH------IIRLMLKYQKILWKVP 528
Cdd:cd04376   163 HKQKSGEREFVQASLRIEEstaiinVVQTMIDNYEELFMVS 203
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 325-491 2.09e-21

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 92.42  E-value: 2.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLE-SEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREA 403
Cdd:cd04400     1 IFGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIyEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 404 -AVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 482
Cdd:cd04400    81 vAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160


                  ....*....
gi 2462561445 483 ISTVMAPNL 491
Cdd:cd04400   161 VCIVFSPTL 169
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 326-531 3.17e-21

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 92.43  E-value: 3.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLL-----DGDRKKDPGV-KVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMC 399
Cdd:cd04397     1 FGVPLEILVekfgaDSTLGVGPGKlRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSKENP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 400 HREAAvMLKAFFRELPTSLFPVEYIPAFISlMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKV-----IANES 474
Cdd:cd04397    81 VQLAA-LLKKFLRELPDPLLTFKLYRLWIS-SQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVssfshIDEET 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462561445 475 KNRMSLWNISTVMAPNLFFSRSKHSDY-EELLLANTAAHiirLMLKYQKILWKVPSFL 531
Cdd:cd04397   159 GSKMDIHNLATVITPNILYSKTDNPNTgDEYFLAIEAVN---YLIENNEEFCEVPDEL 213
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 326-522 1.48e-20

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 90.09  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRKKDPgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKqyreELDAKFNADK---FKWDKMCHRe 402
Cdd:cd04404     6 FGVSLQFLKEKNPEQEP---IPPVVRETVEYLQAHALTTEGIFRRSANTQVVK----EVQQKYNMGEpvdFDQYEDVHL- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 403 AAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQfqALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 482
Cdd:cd04404    78 PAVILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVE--RVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSN 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462561445 483 ISTVMAPNLFFSRSKHSDYEELLLANTaahIIRLMLKYQK 522
Cdd:cd04404   156 LAVVFGPNLLWAKDASMSLSAINPINT---FTKFLLDHQD 192
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 326-512 2.20e-20

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 89.60  E-value: 2.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRkkdpgVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAV 405
Cdd:cd04387     1 FGVKISTVTKRER-----SKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEMDVNAIAG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 406 MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMvMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 485
Cdd:cd04387    76 TLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLNLL-LSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLAT 154

                         170       180
                  ....*....|....*....|....*..
gi 2462561445 486 VMAPNLFFSRSKHSDYEELLLANTAAH 512
Cdd:cd04387   155 VFGPTLLRPSEKESKIPTNTMTDSWSL 181
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-519 2.37e-20

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 89.82  E-value: 2.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTvlldgDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAK-FNADKFKWDKMCHREA 403
Cdd:cd04386     4 VFGTPLE-----EHLKRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEFYSDPHAVA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 404 AVmLKAFFRELPTSLFPVEYIPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNI 483
Cdd:cd04386    79 SA-LKSYLRELPDPLLTYNLYEDWVQAANKPDEDE-RLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNI 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462561445 484 STVMAPNLFFSRSKHSDYEelLLANTAAH---IIRLMLK 519
Cdd:cd04386   157 AIVLAPNLLWAKNEGSLAE--MAAGTSVHvvaIVELIIS 193
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 326-518 2.60e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 83.27  E-value: 2.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRKkdpgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHrEAAV 405
Cdd:cd04373     1 FGVPLANVVTSEKP------IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFTVN-AVAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 406 MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 485
Cdd:cd04373    74 ALKSFFSELPDPLIPYSMHLELVEAAKINDREQ-RLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSI 152

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462561445 486 VMAPNLFfsRSKHSDYEELLLANTAAHIIRLML 518
Cdd:cd04373   153 CFWPTLM--RPDFTSMEALSATRIYQTIIETFI 183
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 326-491 4.73e-18

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 82.83  E-value: 4.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRKKdpgvKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKF---NADKFKWDKMchRE 402
Cdd:cd04395     2 FGVPLDDCPPSSENP----YVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGfdiDLQDPRWRDV--NV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 403 AAVMLKAFFRELPTSLFPVEYIPAFISL--MErGPHVKVqfQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSL 480
Cdd:cd04395    76 VSSLLKSFFRKLPEPLFTNELYPDFIEAnrIE-DPVERL--KELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEP 152

                         170
                  ....*....|.
gi 2462561445 481 WNISTVMAPNL 491
Cdd:cd04395   153 RNLAIVFGPTL 163
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 359-532 1.11e-17

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 81.75  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 359 ESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKwdKMChrEAAVMLKAFFRELPTSLFPVEYIPAFISLMERgPHVK 438
Cdd:cd04394    32 LDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSA--LPC--DVAGLLKQFFRELPEPLLPYDLHEALLKAQEL-PTDE 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 439 VQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYE---ELLLANTAAhIIR 515
Cdd:cd04394   107 ERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLFQSEEGGEKMSsstEKRLRLQAA-VVQ 185

                         170
                  ....*....|....*..
gi 2462561445 516 LMLKYQKILWKVPSFLI 532
Cdd:cd04394   186 TLIDNASNIGIVPDFIL 202
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 326-494 1.63e-17

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 80.94  E-value: 1.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRKKDpGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKmchREAAV 405
Cdd:cd04381     1 FGASLSLAVERSRCHD-GIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEP---PTVAS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 406 MLKAFFRELPTSLFPVEYIPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 485
Cdd:cd04381    77 LLKQYLRELPEPLLTKELMPRFEEACGR-PTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISI 155


                  ....*....
gi 2462561445 486 VMAPNLFFS 494
Cdd:cd04381   156 VLSPTVQIS 164
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 346-492 2.71e-17

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 80.43  E-value: 2.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 346 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAV--MLKAFFRELPTSLFPVEY 423
Cdd:cd04385    15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRK--DARSVQLREGEYTVHDVadVLKRFLRDLPDPLLTSEL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462561445 424 IPAFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLF 492
Cdd:cd04385    93 HAEWIEAAEL-ENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLF 160
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 346-492 6.48e-17

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 79.27  E-value: 6.48e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 346 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKwDKMCHREAAVmLKAFFRELPTSLFPVEYIP 425
Cdd:cd04407    15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLE-NYPIHAITGL-LKQWLRELPEPLMTFAQYN 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462561445 426 AFISLMERgPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLF 492
Cdd:cd04407    93 DFLRAVEL-PEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLL 158
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 326-491 8.06e-17

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 79.10  E-value: 8.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLdgdrkKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVkqyrEELDAKFNADKFKWDKMCHREAAV 405
Cdd:cd04372     1 YGCDLTTLV-----KAHNTQRPMVVDMCIREIEARGLQSEGLYRVSGFAEEI----EDVKMAFDRDGEKADISATVYPDI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 406 -----MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSL 480
Cdd:cd04372    72 nvitgALKLYFRDLPIPVITYDTYPKFIDAAKISNPDE-RLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNA 150

                         170
                  ....*....|.
gi 2462561445 481 WNISTVMAPNL 491
Cdd:cd04372   151 ENLGIVFGPTL 161
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 326-501 1.70e-16

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 78.66  E-value: 1.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLdgdRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREA-A 404
Cdd:cd04379     1 FGVPLSRLV---EREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINViT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 405 VMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVM--ALPDANRDAAQALMTFFNKVIANESKNRMSLWN 482
Cdd:cd04379    78 GVLKDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIidCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQN 157

                         170
                  ....*....|....*....
gi 2462561445 483 ISTVMAPNLFFSRSKHSDY 501
Cdd:cd04379   158 LAVCFGPVLMFCSQEFSRY 176
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 324-500 3.89e-15

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 74.40  E-value: 3.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 324 GIFGVPLTVLLDGDRKKDPGVkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKfNADKFKWDKMCHREA 403
Cdd:cd04390     1 GVFGQRLEDTVAYERKFGPRL-VPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAG-ERPSFDSDTDVHTVA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 404 AvMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQ-FQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 482
Cdd:cd04390    79 S-LLKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKgLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQN 157

                         170
                  ....*....|....*...
gi 2462561445 483 ISTVMAPNLFfsRSKHSD 500
Cdd:cd04390   158 LATVFGPNIL--RPKVED 173
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-513 5.59e-15

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 74.08  E-value: 5.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTVLLdgdrkKDPGVKVPLVLQKFFEKVEESGLeSEGIFRLSGCTAKVKQYREELDAKFNADKFKwDKMCHREAA 404
Cdd:cd04384     2 VFGCDLTEHL-----LNSGQDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIPDLTK-DVYIQDIHS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 405 V--MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKvQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWN 482
Cdd:cd04384    75 VssLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEE-RLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKN 153

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462561445 483 ISTVMAPNLFfsRSKHSdyEELLLANTAAHI 513
Cdd:cd04384   154 LAIVWAPNLL--RSKQI--ESACFSGTAAFM 180
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 325-524 1.22e-12

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 67.82  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLT----------VLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKqyreELDAKFNA---- 390
Cdd:cd04396     1 VFGVSLEeslkyasvaiSIVDEDGEQYVYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIR----ELQLIFSTppdy 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 391 -DKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALH----------------LMVMALPD 453
Cdd:cd04396    77 gKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFRNPLRKRPRILQYMKGRIneplntdidqaikeyrDLITRLPN 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462561445 454 ANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTaahIIRLMLKYQKIL 524
Cdd:cd04396   157 LNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDPKEYKLSRL---VVEFLIEHQDKF 224
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 359-536 1.67e-12

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 67.10  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 359 ESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHrEAAVMLKAFFRELPTSLFPVEYIPAFISLME------ 432
Cdd:cd04392    21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAH-DCATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfde 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 433 -----RGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKH-SDYEEllL 506
Cdd:cd04392   100 kgnktSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTpEDLHE--N 177

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462561445 507 ANTAAHIIRLMLKYQKILWKVPSFLITQVR 536
Cdd:cd04392   178 AQKLNSIVTFMIKHSQKLFKAPAYLREDAR 207
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-491 1.58e-11

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 63.86  E-value: 1.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 325 IFGVPLTVLLDGDrkkdpgvKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADkfkwdkmCHREA- 403
Cdd:cd04402     1 LFGQPLSNICEDD-------NLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVD-------LKAEPv 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 404 ---AVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQfQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSL 480
Cdd:cd04402    67 lllASVLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKI-AELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDA 145

                         170
                  ....*....|.
gi 2462561445 481 WNISTVMAPNL 491
Cdd:cd04402   146 FNLAVCIAPSL 156
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 326-489 3.01e-11

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 62.71  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRKkdpgvkVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCHREAAV 405
Cdd:cd04406     1 FGVELSRLTSEDRS------VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDT--DANSVNLDDYNIHVIAS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 406 MLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVqFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNIST 485
Cdd:cd04406    73 VFKQWLRDLPNPLMTFELYEEFLRAMGLQERRET-VRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAI 151


                  ....
gi 2462561445 486 VMAP 489
Cdd:cd04406   152 VFAP 155
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 326-500 5.32e-11

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 62.02  E-value: 5.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 326 FGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEES-GLESEGIFRLSGCTAKVKQYREELD-AKFNADKFKwDKmchREA 403
Cdd:cd04389     1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALgGFQTEGIFRVPGDIDEVNELKLRVDqWDYPLSGLE-DP---HVP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 404 AVMLKAFFRELPTSLFPVEYIPAFISlmergpHVKVQFQALHLmVMALPDANRDAAQALMTFFNKVI--ANESKNRMSLW 481
Cdd:cd04389    77 ASLLKLWLRELEEPLIPDALYQQCIS------ASEDPDKAVEI-VQKLPIINRLVLCYLINFLQVFAqpENVAHTKMDVS 149

                         170
                  ....*....|....*....
gi 2462561445 482 NISTVMAPNlfFSRSKHSD 500
Cdd:cd04389   150 NLAMVFAPN--ILRCTSDD 166
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 357-505 2.83e-10

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 60.00  E-value: 2.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 357 VEESGLESEGIFRLSGCTAKVKQYREE-LDAKFNADKFKWD--KMCHreaavMLKAFFRELPTSLFPVEYIPAFISLMER 433
Cdd:cd04382    28 IEARGLTEEGLYRVSGSEREVKALKEKfLRGKTVPNLSKVDihVICG-----CLKDFLRSLKEPLITFALWKEFMEAAEI 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462561445 434 GPHVKVQfQALHLMVMALPDANRDAAQALMTFFNKViANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELL 505
Cdd:cd04382   103 LDEDNSR-AALYQAISELPQPNRDTLAFLILHLQRV-AQSPECKMDINNLARVFGPTIVGYSVPNPDPMTIL 172
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 350-523 2.99e-10

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 60.48  E-value: 2.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 350 LQKFFEKVEESGLESEGIFRLSGCTAKVKQY-------REELDAKFNADKFKWDKmchREAAVMLKAFFRELPTSLFPVE 422
Cdd:cd04374    32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLlslgldpKTSTPGDVDLDNSEWEI---KTITSALKTYLRNLPEPLMTYE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 423 YIPAFISLMERG-PHVKVQfqALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFfsRSKhsdy 501
Cdd:cd04374   109 LHNDFINAAKSEnLESRVN--AIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLL--RPQ---- 180

                         170       180
                  ....*....|....*....|..
gi 2462561445 502 EElllanTAAHIirLMLKYQKI 523
Cdd:cd04374   181 EE-----TVAAI--MDIKFQNI 195
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 345-491 2.58e-09

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 57.52  E-value: 2.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 345 KVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVkqyrEELDAKFNADKFKWDKMCH--REAAVMLKAFFRELPTSLFPVE 422
Cdd:cd04408    15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARV----EKLCQAFENGRDLVDLSGHspHDITSVLKHFLKELPEPVLPFQ 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 423 YIPAFISL---MERGPHVKVQ--------FQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNL 491
Cdd:cd04408    91 LYDDFIALakeLQRDSEKAAEspsiveniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTL 170
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 338-491 3.41e-09

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 57.05  E-value: 3.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 338 RKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAkfNADKFKWDKMCH--REAAVMLKAFFRELP 415
Cdd:cd04383    10 YIQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFER--GEDPLADDQNDHdiNSVAGVLKLYFRGLE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 416 TSLFPVEYIPAFIS------LMERGPHVKvqfqalhLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAP 489
Cdd:cd04383    88 NPLFPKERFEDLMScvklenPTERVHQIR-------EILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGP 160


                  ..
gi 2462561445 490 NL 491
Cdd:cd04383   161 TL 162
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 346-520 4.73e-09

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 56.66  E-value: 4.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 346 VPLVLQKFFEKVEESGLESEGIFRLSGCTAKVkqyrEELDAKFNADKFKWDKMCHREAAV--MLKAFFRELPTSLFPVEY 423
Cdd:cd04378    16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARV----EKLCQAFENGKDLVELSELSPHDIssVLKLFLRQLPEPLILFRL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462561445 424 IPAFISLMERGPHVKVQFQALHL-------------MVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPN 490
Cdd:cd04378    92 YNDFIALAKEIQRDTEEDKAPNTpievnriirklkdLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPT 171

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462561445 491 LFFSRSKHSDYEELLLANTA--AHIIRLMLKY 520
Cdd:cd04378   172 LIRPRPGDADVSLSSLVDYGyqARLVEFLITN 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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