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Conserved domains on  [gi|2462585166|ref|XP_054181746|]
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tetratricopeptide repeat protein 38 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACL4-like super family cl23710
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 60-206 5.65e-51

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


The actual alignment was detected with superfamily member cd05804:

Pssm-ID: 474029 [Multi-domain]  Cd Length: 355  Bit Score: 171.70  E-value: 5.65e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585166  60 ADPTFVMGHAMATGLVLIGTGSSVKLdkeldlAVKTMVEISRTQPLTRREQLHVSAVETFANGNFPKACELWEQILQDHP 139
Cdd:cd05804     1 ADPDFALGHAAAALLLLLGGERPAAA------AKAAAAAQALAARATERERAHVEALSAWIAGDLPKALALLEQLLDDYP 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462585166 140 TDMLALKFsHDAYFYLGYQEQMRDSVARIYPFWTPDIPLSSYVKGIYSFGLMETNFYDQAEKLAKEA 206
Cdd:cd05804    75 RDLLALKL-HLGAFGLGDFSGMRDHVARVLPLWAPENPDYWYLLGMLAFGLEEAGQYDRAEEAARRA 140
 
Name Accession Description Interval E-value
StaR_like cd05804
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member ...
 60-206 5.65e-51

StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.


Pssm-ID: 100115 [Multi-domain]  Cd Length: 355  Bit Score: 171.70  E-value: 5.65e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585166  60 ADPTFVMGHAMATGLVLIGTGSSVKLdkeldlAVKTMVEISRTQPLTRREQLHVSAVETFANGNFPKACELWEQILQDHP 139
Cdd:cd05804     1 ADPDFALGHAAAALLLLLGGERPAAA------AKAAAAAQALAARATERERAHVEALSAWIAGDLPKALALLEQLLDDYP 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462585166 140 TDMLALKFsHDAYFYLGYQEQMRDSVARIYPFWTPDIPLSSYVKGIYSFGLMETNFYDQAEKLAKEA 206
Cdd:cd05804    75 RDLLALKL-HLGAFGLGDFSGMRDHVARVLPLWAPENPDYWYLLGMLAFGLEEAGQYDRAEEAARRA 140
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 46-160 4.98e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585166  46 SLGGIEGCLS---KLKAADPTFVMGHAmATGLVLIGTGSSVKLDKELDlavkTMVEISRTQPLTRREQLHVSavetFANG 122
Cdd:TIGR02917 205 SLGNIELALAayrKAIALRPNNIAVLL-ALATILIEAGEFEEAEKHAD----ALLKKAPNSPLAHYLKALVD----FQKK 275

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462585166 123 NFPKACELWEQILQDHPTDMLALKFSHDAYFYLGYQEQ 160
Cdd:TIGR02917 276 NYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQ 313
 
Name Accession Description Interval E-value
StaR_like cd05804
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member ...
 60-206 5.65e-51

StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.


Pssm-ID: 100115 [Multi-domain]  Cd Length: 355  Bit Score: 171.70  E-value: 5.65e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585166  60 ADPTFVMGHAMATGLVLIGTGSSVKLdkeldlAVKTMVEISRTQPLTRREQLHVSAVETFANGNFPKACELWEQILQDHP 139
Cdd:cd05804     1 ADPDFALGHAAAALLLLLGGERPAAA------AKAAAAAQALAARATERERAHVEALSAWIAGDLPKALALLEQLLDDYP 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462585166 140 TDMLALKFsHDAYFYLGYQEQMRDSVARIYPFWTPDIPLSSYVKGIYSFGLMETNFYDQAEKLAKEA 206
Cdd:cd05804    75 RDLLALKL-HLGAFGLGDFSGMRDHVARVLPLWAPENPDYWYLLGMLAFGLEEAGQYDRAEEAARRA 140
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 46-160 4.98e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585166  46 SLGGIEGCLS---KLKAADPTFVMGHAmATGLVLIGTGSSVKLDKELDlavkTMVEISRTQPLTRREQLHVSavetFANG 122
Cdd:TIGR02917 205 SLGNIELALAayrKAIALRPNNIAVLL-ALATILIEAGEFEEAEKHAD----ALLKKAPNSPLAHYLKALVD----FQKK 275

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462585166 123 NFPKACELWEQILQDHPTDMLALKFSHDAYFYLGYQEQ 160
Cdd:TIGR02917 276 NYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQ 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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