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Conserved domains on  [gi|2462501935|ref|XP_054189701|]
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tetraspanin-1 isoform X1 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 13626501)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 110-212 2.02e-26

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


:

Pssm-ID: 239409  Cd Length: 114  Bit Score: 99.14  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 110 YTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFK-----ENSAFPPFCCNDNVTNTAN 184
Cdd:cd03156     5 FKKDLEDSFKNLLKNNYGNYNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSFFrqknePNSPYPESCCKRNSNSQIV 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462501935 185 ETCT--KQKAHDQKVEGCFNQLLYDIRTNA 212
Cdd:cd03156    85 DLDCpkLGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
7-151 7.60e-19

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 81.21  E-value: 7.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935   7 IKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLkifgplSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCAL 86
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLL------LGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLL 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462501935  87 VTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDF----TQVWNTTMKGLKCCG 151
Cdd:pfam00335  75 LTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLysclNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 110-212 2.02e-26

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 99.14  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 110 YTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFK-----ENSAFPPFCCNDNVTNTAN 184
Cdd:cd03156     5 FKKDLEDSFKNLLKNNYGNYNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSFFrqknePNSPYPESCCKRNSNSQIV 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462501935 185 ETCT--KQKAHDQKVEGCFNQLLYDIRTNA 212
Cdd:cd03156    85 DLDCpkLGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
7-151 7.60e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 81.21  E-value: 7.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935   7 IKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLkifgplSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCAL 86
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLL------LGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLL 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462501935  87 VTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDF----TQVWNTTMKGLKCCG 151
Cdd:pfam00335  75 LTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLysclNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 110-212 2.02e-26

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 99.14  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 110 YTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFK-----ENSAFPPFCCNDNVTNTAN 184
Cdd:cd03156     5 FKKDLEDSFKNLLKNNYGNYNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSFFrqknePNSPYPESCCKRNSNSQIV 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462501935 185 ETCT--KQKAHDQKVEGCFNQLLYDIRTNA 212
Cdd:cd03156    85 DLDCpkLGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
7-151 7.60e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 81.21  E-value: 7.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935   7 IKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLkifgplSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCAL 86
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLL------LGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLL 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462501935  87 VTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDF----TQVWNTTMKGLKCCG 151
Cdd:pfam00335  75 LTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLysclNSALDSLQSEFGCCG 143
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 128-211 5.82e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 55.06  E-value: 5.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 128 KDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSaFPPFCCND----NVTNTANETCTKQKAHDQkveGCFNQ 203
Cdd:cd03161    20 SNYNGDDERSDAVDTVQRTLHCCGVENYTDWLNSPYFLEKG-IPLSCCKNrsdcSPQDLKNLTKAATKVYQQ---GCFTL 95


                  ....*...
gi 2462501935 204 LLYDIRTN 211
Cdd:cd03161    96 VTSFMEAN 103
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 147-204 3.80e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 52.81  E-value: 3.80e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462501935 147 LKCCGFTNYTDFEDSPYFKE--NSAFPPFCCNDNVTNtanetCTKQKAH--DQKVEGCFNQL 204
Cdd:cd03163    40 LQCCGIHNYTDWENTPWFKEskNNSVPLSCCKETFTS-----CTGSLTQpkDLYQEGCEAKL 96
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 126-211 7.36e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 49.65  E-value: 7.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 126 IKKDYG--SQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFK----ENSAFPPFCCNDNVTNtanetCTKQKAHDQ---K 196
Cdd:cd03155    19 MQENYGqsGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWINsneaNGRLVPDSCCKTVVDR-----CGCLRDHPSniyK 93

                          90
                  ....*....|....*.
gi 2462501935 197 VE-GCFNQLLYDIRTN 211
Cdd:cd03155    94 VEgGCIPKLEDFLYDH 109
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 128-212 9.57e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 45.96  E-value: 9.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 128 KDYGSQEDFTQVWNTTMKGLKCCGFTNYTDfedspYFKENSAFPPFCCNDNVTNTANETCTkqkahdqkvEGCFNQLLYD 207
Cdd:cd03127    20 DEYYVDDDFQEAMDALQSTFECCGVNGPTD-----YLDLRLLVPSSCCKGTDGNCGLNLYT---------EGCLEKLVDF 85


                  ....*
gi 2462501935 208 IRTNA 212
Cdd:cd03127    86 LRSNL 90
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 122-204 2.58e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 42.37  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 122 VVPAIKKDYGSQEDFTQV---WNTTMKGLKCCGFTNYTDFEDSPYFKENS--AFPPFCCNDNVTNTA----NETCTKQKA 192
Cdd:cd03160    15 IVEKVIQNYGGNPENKTAeeaWDYVQFQLQCCGWTGPQDWTDNSLIKNSSepLYPCSCCNSSATADSprpsKGFCEAPAS 94

                          90
                  ....*....|....
gi 2462501935 193 HDQKV--EGCFNQL 204
Cdd:cd03160    95 LDWPVyqEGCMEKL 108
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 130-180 7.99e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 37.84  E-value: 7.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462501935 130 YGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSAfPPFCCNdNVT 180
Cdd:cd03166    22 YNKTNDFRKILDRMQKDLKCCGANNYTDWENIPSLDTDSV-PDSCCI-NVT 70
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 110-182 1.52e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 37.67  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 110 YTTMAEHFLTLLVVPAIKKdYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSAFP-----PF-CC----NDNV 179
Cdd:cd03158     3 FSNQTIDLLEENIRKAIVH-YYDDLDLQNIIDFVQKEFKCCGGDDYRDWSKNMYFNCSSPNPeacgvPYsCCirakDQEV 81


                  ...
gi 2462501935 180 TNT 182
Cdd:cd03158    82 INT 84
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 146-212 2.02e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 37.06  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462501935 146 GLKCCGFTNYTDFEDSPYFKENSA------FPPFCC-----NDNVTNTANETCTKQKAHD--QKV---EGCFNQLLYDIR 209
Cdd:cd03167    38 GLQCCGASSYQDWQQNLYFNCSSPgvqacsLPASCCidpreDGAVVNDQCGFGALGLDEDaaQRVvhlGGCGPPLRRWLR 117


                  ...
gi 2462501935 210 TNA 212
Cdd:cd03167   118 GNL 120
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 137-212 5.96e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 35.42  E-value: 5.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462501935 137 TQVWNTTMKGLKCCGFTNYTDFEDspYFKENSaFPPFCCNDNvtntaNETCTKQKAHDQKVEGCFNQLLYDIRTNA 212
Cdd:cd03165    31 TNAWDITQTEFRCCGVTNYTDWYE--VLGENR-VPDSCCQED-----SQDCGRNPTELWWKTGCYEKVQQWLVDNL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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