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Conserved domains on  [gi|2462509284|ref|XP_054192622|]
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membrane cofactor protein isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 54-285 1.11e-40

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 144.41  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLpvsDDACYRETCPYIRDPLNGQAvpANGTYEFGYQMHFICNEGYYL 133
Cdd:PHA02927   44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTL---FNQCIKRRCPSPRDIDNGQL--DIGGVDFGSSITYSCNSGYQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 134 IGEEILYCEL--KGSVaIWSGKPPICEKVLCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESTIYCG 211
Cdd:PHA02927  119 IGESKSYCELgsTGSM-VWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLCS 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462509284 212 DNSvWSRAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02927  192 GGE-WSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 54-285 1.11e-40

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 144.41  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLpvsDDACYRETCPYIRDPLNGQAvpANGTYEFGYQMHFICNEGYYL 133
Cdd:PHA02927   44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTL---FNQCIKRRCPSPRDIDNGQL--DIGGVDFGSSITYSCNSGYQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 134 IGEEILYCEL--KGSVaIWSGKPPICEKVLCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESTIYCG 211
Cdd:PHA02927  119 IGESKSYCELgsTGSM-VWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLCS 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462509284 212 DNSvWSRAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02927  192 GGE-WSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 99-158 1.69e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.01  E-value: 1.69e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPICE 158
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 99-157 2.27e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.61  E-value: 2.27e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462509284   99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPIC 157
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
231-283 2.58e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 2.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462509284 231 PVVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 54-285 1.11e-40

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 144.41  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLpvsDDACYRETCPYIRDPLNGQAvpANGTYEFGYQMHFICNEGYYL 133
Cdd:PHA02927   44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTL---FNQCIKRRCPSPRDIDNGQL--DIGGVDFGSSITYSCNSGYQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 134 IGEEILYCEL--KGSVaIWSGKPPICEKVLCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESTIYCG 211
Cdd:PHA02927  119 IGESKSYCELgsTGSM-VWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLCS 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462509284 212 DNSvWSRAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02927  192 GGE-WSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
 99-285 9.53e-32

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 121.69  E-value: 9.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKhTFSEV 178
Cdd:PHA02639   22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGK-IYNKR 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 179 EVFEYLDAVTYSCDPAPGPDpFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGkQISGF--GKKFYYKATVMFEC 256
Cdd:PHA02639  101 EMYKVGDEIYYVCNEHKGVQ-YSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGIpsNKKFYYKTRVGFSC 178

                         170       180
                  ....*....|....*....|....*....
gi 2462509284 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02639  179 KSGFDLVGEKYSTCNINATWFPSIPTCVR 207
PHA02817 PHA02817
EEV Host range protein; Provisional
 157-289 2.68e-25

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 102.33  E-value: 2.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 157 CEKVLCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Cdd:PHA02817   19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462509284 237 kQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTS 289
Cdd:PHA02817   98 -FVNGIpdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSRDNIT 151
PHA02831 PHA02831
EEV host range protein; Provisional
 114-294 2.07e-24

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 100.84  E-value: 2.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 114 NGTYEFGYQMHFICNEGYYLIgeeILYCElKGSvaiWSGKPPICEKVLCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDp 193
Cdd:PHA02831   37 NKVYEENENLEYKCNNNFDKV---FVTCN-NGS---WSTKNMCIGKRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACK- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 194 APGPDPFSLIGESTIYCGDNSvWSRAAPECKVVKCRFPVVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSN 273
Cdd:PHA02831  108 VNKLEKYSIVGNETVKCINKQ-WVPKYPVCKLIRCKYPALQNGF-LNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDIN 185

                         170       180
                  ....*....|....*....|.
gi 2462509284 274 STWDPPVPKCLKVSTSSTTKS 294
Cdd:PHA02831  186 SIWYPGIPKCVKDKVHNEIQP 206
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 85-306 1.72e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 69.68  E-value: 1.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  85 TWLPVSDDACYRETCPYIRDPLNGQ-----AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKppiCEK 159
Cdd:PHA02927    7 TFLTLLGIGCVLSCCTIPSRPINMKfknsvETDANANYNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTLFNQ---CIK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284 160 VLCTPPPKIKNGKHTFSEVEvfeYLDAVTYSCDPApgpdpFSLIGESTIYCGDNS----VWSRAAPECKVVKCRF-PVVE 234
Cdd:PHA02927   84 RRCPSPRDIDNGQLDIGGVD---FGSSITYSCNSG-----YQLIGESKSYCELGStgsmVWNPEAPICESVKCQSpPSIS 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462509284 235 NGKQiSGFGKKFYYKATVMFECDKGFYLDGSDTIVCdSNSTWDPPvPKCLKVSTSSTTKSPASSASGPRPTY 306
Cdd:PHA02927  156 NGRH-NGYEDFYTDGSVVTYSCNSGYSLIGNSGVLC-SGGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSY 224
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 99-158 1.69e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.01  E-value: 1.69e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPICE 158
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 228-283 2.38e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.63  E-value: 2.38e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462509284 228 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:cd00033     1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 99-157 2.27e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.61  E-value: 2.27e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462509284   99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPIC 157
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 231-283 2.53e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.61  E-value: 2.53e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462509284  231 PVVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:smart00032   5 PDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
231-283 2.58e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 2.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462509284 231 PVVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 162-224 6.81e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.39  E-value: 6.81e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462509284 162 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESTIYCGDNSVWSRAAPECK 224
Cdd:cd00033     1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 162-223 2.34e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.91  E-value: 2.34e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462509284  162 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESTIYCGDNSVWSRAAPEC 223
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
162-223 1.73e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 1.73e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462509284 162 CTPPPKIKNGKHTfSEVEVFEYLDAVTYSCDPapgpdPFSLIGESTIYCGDNSVWSRAAPEC 223
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDP-----GYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
99-157 4.90e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.34  E-value: 4.90e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462509284  99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPIC 157
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGT---WSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 29-159 5.53e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 41.08  E-value: 5.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509284  29 YSFSD--ACEEPPTFEAMELIGKpKPYYEIGERVDYKC---KKGYFYIPPLATHTICDRNHTWLPvSDDACYRETC--PY 101
Cdd:PHA02817   16 YSLCDlnKCCYPPSIKNGYIYNK-KTEYNIGSNVTFFCgnnTRGVRYTLVGEKNIICEKDGKWNK-EFPVCKIIRCrfPA 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462509284 102 IRDP-LNGqaVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPICEK 159
Cdd:PHA02817   94 LQNGfVNG--IPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSS---WIPKVPICSR 147
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 35-88 1.68e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 36.35  E-value: 1.68e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462509284   35 CEEPPTFEAMELIGkPKPYYEIGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 88
Cdd:smart00032   1 CPPPPDIENGTVTS-SSGTYSYGDTVTYSCDPGYTLIGS--STITCLENGTWSP 51
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 35-88 3.00e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 35.52  E-value: 3.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462509284  35 CEEPPTFEAMELIGkPKPYYEIGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 88
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGS--STITCTENGGWSP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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