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Conserved domains on  [gi|2462622469|ref|XP_054217870|]
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WD repeat-containing protein 31 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-328 1.94e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 1.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  83 VACIPKSSQFFSASRDRMVMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR 162
Cdd:COG2319   168 VAFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 163 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTR 242
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATG 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 243 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRG 321
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDG----KTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGT 395


                  ....*..
gi 2462622469 322 IHLLRMD 328
Cdd:COG2319   396 VRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-328 1.94e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 1.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  83 VACIPKSSQFFSASRDRMVMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR 162
Cdd:COG2319   168 VAFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 163 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTR 242
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATG 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 243 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRG 321
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDG----KTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGT 395


                  ....*..
gi 2462622469 322 IHLLRMD 328
Cdd:COG2319   396 VRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-324 3.80e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  60 HMDTVSVVAAL-NSDLCVSGGKDK-------------------------VACIPKSSQFFSASRDRMVMMWDLHgSSQPR 113
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGtikvwdletgellrtlkghtgpvrdVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 114 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 193
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 194 LQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALalmpLI 271
Cdd:cd00200   167 GKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----LL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462622469 272 ATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 324
Cdd:cd00200   235 ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 109-148 7.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462622469  109 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 148
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
110-148 4.69e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 4.69e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462622469 110 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 148
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 89-240 6.47e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 6.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  89 SSQFFSASRDRMVMMWDL------HGSSQPRQQLCGHAMVVTGLAVSPDSSQ-LCTGSRDNTLLLWDVVTGQSVERASVS 161
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCH 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 162 RNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQhiqtycevSVDGHKCISC--SNGFGGEGC------EA 233
Cdd:PTZ00421  168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA--------SAKSQRCLWAkrKDLIITLGCsksqqrQI 239


                  ....*..
gi 2462622469 234 TLWDLRQ 240
Cdd:PTZ00421  240 MLWDTRK 246
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-328 1.94e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 1.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  83 VACIPKSSQFFSASRDRMVMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR 162
Cdd:COG2319   168 VAFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 163 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTR 242
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATG 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 243 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRG 321
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDG----KTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGT 395


                  ....*..
gi 2462622469 322 IHLLRMD 328
Cdd:COG2319   396 VRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
83-307 1.98e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 1.98e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  83 VACIPKSSQFFSASRDRMVMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR 162
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 163 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTR 242
Cdd:COG2319   205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-----GSADGTVRLWDL-ATG 278

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462622469 243 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV 307
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAFSPDG----KLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-324 3.80e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  60 HMDTVSVVAAL-NSDLCVSGGKDK-------------------------VACIPKSSQFFSASRDRMVMMWDLHgSSQPR 113
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGtikvwdletgellrtlkghtgpvrdVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 114 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 193
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 194 LQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALalmpLI 271
Cdd:cd00200   167 GKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----LL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462622469 272 ATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 324
Cdd:cd00200   235 ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
83-287 4.45e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 4.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  83 VACIPKSSQFFSASRDRMVMMWDLHGSsQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR 162
Cdd:COG2319   210 VAFSPDGKLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 163 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTR 242
Cdd:COG2319   289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS-----GSDDGTVRLWDL-ATG 362

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2462622469 243 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDT 287
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSPDG----RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-284 3.81e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 3.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  60 HMDTVSVVAAL-NSDLCVSGGKDK-------------------------VACIPKSSQFFSASRDRMVMMWDLHgSSQPR 113
Cdd:cd00200    50 HTGPVRDVAASaDGTYLASGSSDKtirlwdletgecvrtltghtsyvssVAFSPDGRILSSSSRDKTIKVWDVE-TGKCL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 114 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 193
Cdd:cd00200   129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 194 LQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRqTRNRICEYKGHFQTVASCVFLPRALALmpliAT 273
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGS-----EDGTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPDGKRL----AS 278

                         250
                  ....*....|.
gi 2462622469 274 SSHDCKVKIWN 284
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
83-324 1.93e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  83 VACIPKSSQFFSASRDRMVMMWDLhGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR 162
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLLDA-AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 163 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLRqTR 242
Cdd:COG2319   121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS-----GSDDGTVRLWDLA-TG 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 243 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRG 321
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDG----KLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFsPDGRLLASGSADGT 269


                  ...
gi 2462622469 322 IHL 324
Cdd:COG2319   270 VRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-324 4.61e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 4.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 112 PRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDS 191
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 192 RGLQVAHMFpaKQHIQ--TYCEVSVDGHkCISCSngfgGEGCEATLWDLRQTRNRICeYKGHFQTVASCVFLPRALalmp 269
Cdd:cd00200    81 ETGECVRTL--TGHTSyvSSVAFSPDGR-ILSSS----SRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGT---- 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462622469 270 LIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHL 324
Cdd:cd00200   149 FVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFsPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
87-324 2.70e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 2.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  87 PKSSQFFSASRDRMVMMWDLHGSSQPRQQLcGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVT 166
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLL-GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 167 HLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRIC 246
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS-----GSADGTVRLWDL-ATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 247 EYKGHFQTVASCVFLP--RalalmpLIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLavgdAIS-----LLCASFN 319
Cdd:COG2319   157 TLTGHSGAVTSVAFSPdgK------LLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSV----AFSpdgklLASGSAD 225


                  ....*
gi 2462622469 320 RGIHL 324
Cdd:COG2319   226 GTVRL 230
WD40 COG2319
WD40 repeat [General function prediction only];
127-324 5.57e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 5.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 127 AVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHI 206
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 207 QTYCEVSVDGHKCIScsngfGGEGCEATLWDLrQTRNRICEYKGHFQTVASCVFLPRALalmpLIATSSHDCKVKIWNQD 286
Cdd:COG2319    81 VLSVAFSPDGRLLAS-----ASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGK----TLASGSADGTVRLWDLA 150

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462622469 287 TGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHL 324
Cdd:COG2319   151 TGKLLRTLT-GHSGAVTSVAFsPDGKLLASGSDDGTVRL 188
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 109-148 7.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462622469  109 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 148
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
110-148 4.69e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 4.69e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462622469 110 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 148
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 89-240 6.47e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 6.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  89 SSQFFSASRDRMVMMWDL------HGSSQPRQQLCGHAMVVTGLAVSPDSSQ-LCTGSRDNTLLLWDVVTGQSVERASVS 161
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCH 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 162 RNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQhiqtycevSVDGHKCISC--SNGFGGEGC------EA 233
Cdd:PTZ00421  168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA--------SAKSQRCLWAkrKDLIITLGCsksqqrQI 239


                  ....*..
gi 2462622469 234 TLWDLRQ 240
Cdd:PTZ00421  240 MLWDTRK 246
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 89-170 1.03e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.60  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469  89 SSQFFSASRDRMVmmwdlhgssqprQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERAsvSRNVVTHL 168
Cdd:pfam20426 105 SFQVISLNDGRMV------------QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKR--SRNTQTEF 170


                  ..
gi 2462622469 169 CW 170
Cdd:pfam20426 171 PR 172
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 133-305 3.75e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 133 SQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT-SEDKTLRLWD-SRGLQVAHMfPAKQHIqtyC 210
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSiNQGVSIGTI-KTKANI---C 621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462622469 211 EVSVDGHKCISCSngFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRAlalmpLIATSSHDCKVKIWNqdtgac 290
Cdd:PLN00181  622 CVQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSS-----TLVSSSTDNTLKLWD------ 688

                         170
                  ....*....|....*....
gi 2462622469 291 lftLSLDGSG----PLTSL 305
Cdd:PLN00181  689 ---LSMSISGinetPLHSF 704
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 241-284 3.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.07e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462622469  241 TRNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWN 284
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG----KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-190 7.53e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.53e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462622469  151 TGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD 190
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
242-284 7.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2462622469 242 RNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWN 284
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG----KLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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