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Conserved domains on  [gi|2462543627|ref|XP_054233689|]
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D-glucuronyl C5-epimerase isoform X1 [Homo sapiens]

Protein Classification

D-glucuronyl C5-epimerase family protein( domain architecture ID 10535253)

D-glucuronyl C5-epimerase family protein similar to D-glucuronyl C5-epimerase that converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate and heparin chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C5-epim_C pfam06662
D-glucuronyl C5-epimerase C-terminus; This family represents the C-terminus of D-glucuronyl ...
 444-635 3.20e-90

D-glucuronyl C5-epimerase C-terminus; This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.


:

Pssm-ID: 461978  Cd Length: 187  Bit Score: 277.70  E-value: 3.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543627 444 QDEKGGWPIMVTRKLGEGFKsLEPGWYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNkHD 523
Cdd:pfam06662   1 QDKLGGWRYNFSYKHYEGNK-LSPGWYSAMAQGQAISVLLRAYQLTGDEKYLDAAKKALNSFLIPVEKGGVKDTFMD-GP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543627 524 WYEEYPTTPSSFVLNGFMYSLIGLYDLketAGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLAR 603
Cdd:pfam06662  79 WYEEYPTSPPSYVLNGFIFSLIGLYDL---STYTYDDEALELFDKGLKSLKAMLPKFDTGSWSYYDLRHVTIGNPPNLAR 155

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462543627 604 WDYHTTHINQLQLLSTIDESPIFKEFVKRWKS 635
Cdd:pfam06662 156 WDYHKLHILLLNALYYITGDSIFKDYAKRWNS 187
 
Name Accession Description Interval E-value
C5-epim_C pfam06662
D-glucuronyl C5-epimerase C-terminus; This family represents the C-terminus of D-glucuronyl ...
 444-635 3.20e-90

D-glucuronyl C5-epimerase C-terminus; This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.


Pssm-ID: 461978  Cd Length: 187  Bit Score: 277.70  E-value: 3.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543627 444 QDEKGGWPIMVTRKLGEGFKsLEPGWYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNkHD 523
Cdd:pfam06662   1 QDKLGGWRYNFSYKHYEGNK-LSPGWYSAMAQGQAISVLLRAYQLTGDEKYLDAAKKALNSFLIPVEKGGVKDTFMD-GP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543627 524 WYEEYPTTPSSFVLNGFMYSLIGLYDLketAGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLAR 603
Cdd:pfam06662  79 WYEEYPTSPPSYVLNGFIFSLIGLYDL---STYTYDDEALELFDKGLKSLKAMLPKFDTGSWSYYDLRHVTIGNPPNLAR 155

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462543627 604 WDYHTTHINQLQLLSTIDESPIFKEFVKRWKS 635
Cdd:pfam06662 156 WDYHKLHILLLNALYYITGDSIFKDYAKRWNS 187
 
Name Accession Description Interval E-value
C5-epim_C pfam06662
D-glucuronyl C5-epimerase C-terminus; This family represents the C-terminus of D-glucuronyl ...
 444-635 3.20e-90

D-glucuronyl C5-epimerase C-terminus; This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.


Pssm-ID: 461978  Cd Length: 187  Bit Score: 277.70  E-value: 3.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543627 444 QDEKGGWPIMVTRKLGEGFKsLEPGWYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNkHD 523
Cdd:pfam06662   1 QDKLGGWRYNFSYKHYEGNK-LSPGWYSAMAQGQAISVLLRAYQLTGDEKYLDAAKKALNSFLIPVEKGGVKDTFMD-GP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543627 524 WYEEYPTTPSSFVLNGFMYSLIGLYDLketAGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLAR 603
Cdd:pfam06662  79 WYEEYPTSPPSYVLNGFIFSLIGLYDL---STYTYDDEALELFDKGLKSLKAMLPKFDTGSWSYYDLRHVTIGNPPNLAR 155

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462543627 604 WDYHTTHINQLQLLSTIDESPIFKEFVKRWKS 635
Cdd:pfam06662 156 WDYHKLHILLLNALYYITGDSIFKDYAKRWNS 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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