NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1952696772|ref|XP_855179|]
View 

transmembrane protein 132A isoform X1 [Canis lupus familiaris]

Protein Classification

transmembrane protein 132( domain architecture ID 12174329)

transmembrane protein 132 (TMEM132) such as Rattus norvegicus TMEM132D, also called mature oligodendrocytes transmembrane protein (MOLT), that may serve as a cell-surface marker for oligodendrocyte differentiation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 409-751 1.04e-140

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


:

Pssm-ID: 465003  Cd Length: 344  Bit Score: 425.16  E-value: 1.04e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  409 ELVNTAPLTGEPRHVPIRLVTVDNGGALVEVTEHIGCESTNTQVLQVSETCDAVFVSGKESRGAQGVQVDFWWRRLRASL 488
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  489 QMTVWAPLLPLRIELTDTTLEQVRGWRVPGPTEGMPEPEAAAEEAERRPRS--CRLQYQRAGVRFLVPFAAHPLDGGRrL 566
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEDDRKGrgCRLQYQHATVRVLARFVAEDADTGQ-V 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  567 THLLGPDWLLDVTHLVAPHARVQDPRVASLEGGRILVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELQVQPVM 646
Cdd:pfam16070  160 SYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  647 GISLALSRGTAHPGEVTATCWAQSAFPAPKQEVALSLWLSFSDHTLVPAELYNQHDLGLSVSAEEPGAILPAKDQGAQLG 726
Cdd:pfam16070  240 GLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWP 319

                          330       340
                   ....*....|....*....|....*
gi 1952696772  727 VVVSGAGAEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  320 VVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 49-169 2.50e-41

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 147.75  E-value: 2.50e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772   49 ATLELLDAPEHFRVQQVGHYPPANSSLGSRSETFLLLQPWPrvQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 121
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQARQ--PPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1952696772  122 WDVRAVSVEAAVTPAEPHARVLFHLKGQDW--PPGPGSLPCAWLHATHPA 169
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWddYDPSERLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 831-896 3.05e-27

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464814  Cd Length: 84  Bit Score: 105.84  E-value: 3.05e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952696772  831 MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPAsPQPHNWVWLGTD 896
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 409-751 1.04e-140

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 425.16  E-value: 1.04e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  409 ELVNTAPLTGEPRHVPIRLVTVDNGGALVEVTEHIGCESTNTQVLQVSETCDAVFVSGKESRGAQGVQVDFWWRRLRASL 488
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  489 QMTVWAPLLPLRIELTDTTLEQVRGWRVPGPTEGMPEPEAAAEEAERRPRS--CRLQYQRAGVRFLVPFAAHPLDGGRrL 566
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEDDRKGrgCRLQYQHATVRVLARFVAEDADTGQ-V 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  567 THLLGPDWLLDVTHLVAPHARVQDPRVASLEGGRILVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELQVQPVM 646
Cdd:pfam16070  160 SYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  647 GISLALSRGTAHPGEVTATCWAQSAFPAPKQEVALSLWLSFSDHTLVPAELYNQHDLGLSVSAEEPGAILPAKDQGAQLG 726
Cdd:pfam16070  240 GLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWP 319

                          330       340
                   ....*....|....*....|....*
gi 1952696772  727 VVVSGAGAEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  320 VVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 49-169 2.50e-41

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 147.75  E-value: 2.50e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772   49 ATLELLDAPEHFRVQQVGHYPPANSSLGSRSETFLLLQPWPrvQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 121
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQARQ--PPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1952696772  122 WDVRAVSVEAAVTPAEPHARVLFHLKGQDW--PPGPGSLPCAWLHATHPA 169
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWddYDPSERLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 831-896 3.05e-27

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 105.84  E-value: 3.05e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952696772  831 MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPAsPQPHNWVWLGTD 896
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 409-751 1.04e-140

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 425.16  E-value: 1.04e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  409 ELVNTAPLTGEPRHVPIRLVTVDNGGALVEVTEHIGCESTNTQVLQVSETCDAVFVSGKESRGAQGVQVDFWWRRLRASL 488
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  489 QMTVWAPLLPLRIELTDTTLEQVRGWRVPGPTEGMPEPEAAAEEAERRPRS--CRLQYQRAGVRFLVPFAAHPLDGGRrL 566
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEDDRKGrgCRLQYQHATVRVLARFVAEDADTGQ-V 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  567 THLLGPDWLLDVTHLVAPHARVQDPRVASLEGGRILVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELQVQPVM 646
Cdd:pfam16070  160 SYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  647 GISLALSRGTAHPGEVTATCWAQSAFPAPKQEVALSLWLSFSDHTLVPAELYNQHDLGLSVSAEEPGAILPAKDQGAQLG 726
Cdd:pfam16070  240 GLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWP 319

                          330       340
                   ....*....|....*....|....*
gi 1952696772  727 VVVSGAGAEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  320 VVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 49-169 2.50e-41

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 147.75  E-value: 2.50e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772   49 ATLELLDAPEHFRVQQVGHYPPANSSLGSRSETFLLLQPWPrvQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 121
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQARQ--PPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1952696772  122 WDVRAVSVEAAVTPAEPHARVLFHLKGQDW--PPGPGSLPCAWLHATHPA 169
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWddYDPSERLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 831-896 3.05e-27

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 105.84  E-value: 3.05e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952696772  831 MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPAsPQPHNWVWLGTD 896
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 69-252 5.24e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 5.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772   69 PPANSSLGSR----SETFLLLQPWPRVQPLLRASYPPFA-------TQQVVPPRVTEPHQrpvPWDVRAVSVEAAVTPAE 137
Cdd:pfam03154  188 PPGTTQAATAgptpSAPSVPPQGSPATSQPPNQTQSTAAphtliqqTPTLHPQRLPSPHP---PLQPMTQPPPPSQVSPQ 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952696772  138 PHARVLFHLKGqdwPPGPGSLPCAWLHATHPAGTahQACHFQPSLGACVVELEfPSHWFSQGSTTRAELAytlepaaegP 217
Cdd:pfam03154  265 PLPQPSLHGQM---PPMPHSLQTGPSHMQHPVPP--QPFPLTPQSSQSQVPPG-PSPAAPGQSQQRIHTP---------P 329

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1952696772  218 GGCGPSQEEDPREQALPVGGVELRPADPPQYQEVP 252
Cdd:pfam03154  330 SQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIP 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH